Deubiquitination Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5688426
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Genes

268 proteins participating in the Deubiquitination pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABRAXAS1 abraxas 1, BRCA1 A complex subunit
ABRAXAS2 abraxas 2, BRISC complex subunit
ACTB actin, beta
ACTL6A actin-like 6A
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADRB2 adrenoceptor beta 2, surface
ADRM1 adhesion regulating molecule 1
APC adenomatous polyposis coli
AR androgen receptor
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASXL1 additional sex combs like transcriptional regulator 1
ASXL2 additional sex combs like transcriptional regulator 2
ATXN3 ataxin 3
ATXN3L ataxin 3-like
ATXN7 ataxin 7
AXIN1 axin 1
AXIN2 axin 2
BABAM1 BRISC and BRCA1 A complex member 1
BABAM2 BRISC and BRCA1 A complex member 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BARD1 BRCA1 associated RING domain 1
BECN1 beclin 1, autophagy related
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRCA1 breast cancer 1, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
CCNA1 cyclin A1
CCNA2 cyclin A2
CCP110 centriolar coiled coil protein 110kDa
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLSPN claspin
CYLD cylindromatosis (turban tumor syndrome)
DDB2 damage-specific DNA binding protein 2, 48kDa
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
FKBP8 FK506 binding protein 8, 38kDa
FOXK1 forkhead box K1
FOXK2 forkhead box K2
FOXO4 forkhead box O4
GATA3 GATA binding protein 3
H2AC1 H2A clustered histone 1
H2AC11 H2A clustered histone 11
H2AC12 H2A clustered histone 12
H2AC14 H2A clustered histone 14
H2AC18 H2A clustered histone 18
H2AC20 H2A clustered histone 20
H2AC21 H2A clustered histone 21
H2AC25 H2A clustered histone 25
H2AC4 H2A clustered histone 4
H2AC6 H2A clustered histone 6
H2AC7 H2A clustered histone 7
H2BC1 H2B clustered histone 1
H2BC11 H2B clustered histone 11
H2BC12 H2B clustered histone 12
H2BC13 H2B clustered histone 13
H2BC14 H2B clustered histone 14
H2BC15 H2B clustered histone 15
H2BC17 H2B clustered histone 17
H2BC18 H2B clustered histone 18
H2BC21 H2B clustered histone 21
H2BC26 H2B clustered histone 26
H2BC3 H2B clustered histone 3
H2BC4 H2B clustered histone 4
H2BC5 H2B clustered histone 5
H2BC9 H2B clustered histone 9
HCFC1 host cell factor C1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IDE insulin-degrading enzyme
IFIH1 interferon induced with helicase C domain 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL33 interleukin 33
INO80 INO80 complex subunit
INO80B INO80 complex subunit B
INO80C INO80 complex subunit C
INO80D INO80 complex subunit D
INO80E INO80 complex subunit E
JOSD1 Josephin domain containing 1
JOSD2 Josephin domain containing 2
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KDM1B lysine (K)-specific demethylase 1B
KEAP1 kelch-like ECH-associated protein 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAT2B methionine adenosyltransferase II, beta
MAVS mitochondrial antiviral signaling protein
MBD5 methyl-CpG binding domain protein 5
MBD6 methyl-CpG binding domain protein 6
MCRS1 microspherule protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYSM1 Myb-like, SWIRM and MPN domains 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFRKB nuclear factor related to kappaB binding protein
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OTUD3 OTU deubiquitinase 3
OTUD5 OTU deubiquitinase 5
OTUD7A OTU deubiquitinase 7A
OTUD7B OTU deubiquitinase 7B
POLB polymerase (DNA directed), beta
PRKN parkin RBR E3 ubiquitin protein ligase
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTEN phosphatase and tensin homolog
PTRH2 peptidyl-tRNA hydrolase 2
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RCE1 Ras converting CAAX endopeptidase 1
RHOA ras homolog family member A
RHOT1 ras homolog family member T1
RIGI RNA sensor RIG-I
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF123 ring finger protein 123
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF135 ring finger protein 135
RNF146 ring finger protein 146
RPS27A ribosomal protein S27a
RUVBL1 RuvB-like AAA ATPase 1
SEM1 SEM1 26S proteasome subunit
SENP8 SUMO/sentrin specific peptidase family member 8
SIAH2 siah E3 ubiquitin protein ligase 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNX3 sorting nexin 3
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAMBP STAM binding protein
STAMBPL1 STAM binding protein-like 1
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TADA2B transcriptional adaptor 2B
TADA3 transcriptional adaptor 3
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TNIP2 TNFAIP3 interacting protein 2
TNIP3 TNFAIP3 interacting protein 3
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOMM70 translocase of outer mitochondrial membrane 70
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM25 tripartite motif containing 25
TRIM4 tripartite motif containing 4
TRRAP transformation/transcription domain-associated protein
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UFD1 ubiquitin recognition factor in ER associated degradation 1
UIMC1 ubiquitin interaction motif containing 1
USP10 ubiquitin specific peptidase 10
USP11 ubiquitin specific peptidase 11
USP12 ubiquitin specific peptidase 12
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP16 ubiquitin specific peptidase 16
USP17L1 ubiquitin specific peptidase 17-like family member 1
USP17L10 ubiquitin specific peptidase 17-like family member 10
USP17L11 ubiquitin specific peptidase 17-like family member 11
USP17L12 ubiquitin specific peptidase 17-like family member 12
USP17L13 ubiquitin specific peptidase 17-like family member 13
USP17L15 ubiquitin specific peptidase 17-like family member 15
USP17L17 ubiquitin specific peptidase 17-like family member 17
USP17L18 ubiquitin specific peptidase 17-like family member 18
USP17L19 ubiquitin specific peptidase 17-like family member 19
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP17L20 ubiquitin specific peptidase 17-like family member 20
USP17L21 ubiquitin specific peptidase 17-like family member 21
USP17L22 ubiquitin specific peptidase 17-like family member 22
USP17L24 ubiquitin specific peptidase 17-like family member 24
USP17L3 ubiquitin specific peptidase 17-like family member 3
USP17L4 ubiquitin specific peptidase 17-like family member 4
USP17L5 ubiquitin specific peptidase 17-like family member 5
USP17L8 ubiquitin specific peptidase 17-like family member 8
USP18 ubiquitin specific peptidase 18
USP19 ubiquitin specific peptidase 19
USP2 ubiquitin specific peptidase 2
USP20 ubiquitin specific peptidase 20
USP21 ubiquitin specific peptidase 21
USP22 ubiquitin specific peptidase 22
USP24 ubiquitin specific peptidase 24
USP25 ubiquitin specific peptidase 25
USP26 ubiquitin specific peptidase 26
USP28 ubiquitin specific peptidase 28
USP3 ubiquitin specific peptidase 3
USP30 ubiquitin specific peptidase 30
USP33 ubiquitin specific peptidase 33
USP34 ubiquitin specific peptidase 34
USP37 ubiquitin specific peptidase 37
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP42 ubiquitin specific peptidase 42
USP44 ubiquitin specific peptidase 44
USP47 ubiquitin specific peptidase 47
USP48 ubiquitin specific peptidase 48
USP49 ubiquitin specific peptidase 49
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
VCP valosin containing protein
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
WDR20 WD repeat domain 20
WDR48 WD repeat domain 48
YOD1 YOD1 deubiquitinase
YY1 YY1 transcription factor
ZRANB1 zinc finger, RAN-binding domain containing 1