Dexamethasone Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids. (Chemical Entities of Biological Interest Ontology, CHEBI_41879)
External Link http://ctdbase.org/detail.go?type=chem&acc=D003907
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Genes

332 genes/proteins interacting with the chemical Dexamethasone from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACHE acetylcholinesterase (Yt blood group)
ACP5 acid phosphatase 5, tartrate resistant
ADORA3 adenosine A3 receptor
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AHSG alpha-2-HS-glycoprotein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
ALPL alkaline phosphatase, liver/bone/kidney
ANXA1 annexin A1
APOB apolipoprotein B
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
AVP arginine vasopressin
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDKRB1 bradykinin receptor B1
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
BMP8A bone morphogenetic protein 8a
C5 complement component 5
CALCA calcitonin-related polypeptide alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL26 chemokine (C-C motif) ligand 26
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCND2 cyclin D2
CCR3 chemokine (C-C motif) receptor 3
CD14 CD14 molecule
CD163 CD163 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD68 CD68 molecule
CDA cytidine deaminase
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CES3 carboxylesterase 3
CHID1 chitinase domain containing 1
CHUK conserved helix-loop-helix ubiquitous kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKM creatine kinase, muscle
CPN1 carboxypeptidase N, polypeptide 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREB1 cAMP responsive element binding protein 1
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
CYP3A cytochrome P450, family 3, subfamily A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDIT4 DNA-damage-inducible transcript 4
DIABLO diablo, IAP-binding mitochondrial protein
DIO3 deiodinase, iodothyronine, type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EP300 E1A binding protein p300
EPO erythropoietin
EPX eosinophil peroxidase
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGFR3 fibroblast growth factor receptor 3
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC glucose-6-phosphatase, catalytic subunit
G6PD glucose-6-phosphate dehydrogenase
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GFAP glial fibrillary acidic protein
GJA1 gap junction protein, alpha 1, 43kDa
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GRB2 growth factor receptor-bound protein 2
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTA2 glutathione S-transferase alpha 2
GSTM1 glutathione S-transferase mu 1
GUSB glucuronidase, beta
GYS1 glycogen synthase 1 (muscle)
HDAC1 histone deacetylase 1
HDC histidine decarboxylase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST4H4 histone cluster 4, H4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSF1 heat shock transcription factor 1
HSPB1 heat shock 27kDa protein 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KNG1 kininogen 1
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
LYN LYN proto-oncogene, Src family tyrosine kinase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MGMT O-6-methylguanine-DNA methyltransferase
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSTN myostatin
MT1A metallothionein 1A
MUC1 mucin 1, cell surface associated
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCOA1 nuclear receptor coactivator 1
NDRG1 N-myc downstream regulated 1
NEFM neurofilament, medium polypeptide
NES nestin
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NKX2-1 NK2 homeobox 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PARP1 poly (ADP-ribose) polymerase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDCD5 programmed cell death 5
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PLG plasminogen
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRL prolactin
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTMA prothymosin, alpha
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RXRA retinoid X receptor, alpha
SCARB1 scavenger receptor class B, member 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC1 syndecan 1
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA1 surfactant protein A1
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC30A2 solute carrier family 30 (zinc transporter), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP7 Sp7 transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYP synaptophysin
TAC1 tachykinin, precursor 1
TAT tyrosine aminotransferase
TDO2 tryptophan 2,3-dioxygenase
TF transferrin
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TP53 tumor protein p53
TRH thyrotropin-releasing hormone
TSC22D3 TSC22 domain family, member 3
TSHB thyroid stimulating hormone, beta
UBE2I ubiquitin-conjugating enzyme E2I
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
USP3 ubiquitin specific peptidase 3
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNT3A wingless-type MMTV integration site family, member 3A
XDH xanthine dehydrogenase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZFP36 ZFP36 ring finger protein