Dexamethasone_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.314015
PLAT plasminogen activator, tissue 0.135076
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0874275
ZMYND8 zinc finger, MYND-type containing 8 0.0847004
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0799666
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0764173
MT1X metallothionein 1X 0.0740652
MT2A metallothionein 2A 0.0739156
FKBP5 FK506 binding protein 5 0.065752
FN1 fibronectin 1 0.0618976
SORBS2 sorbin and SH3 domain containing 2 0.0558259
ERRFI1 ERBB receptor feedback inhibitor 1 0.0556505
HIPK2 homeodomain interacting protein kinase 2 0.0533247
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0528243
EFNA5 ephrin-A5 0.0521838
AHNAK AHNAK nucleoprotein 0.0510681
PRELID2 PRELI domain containing 2 0.0506478
DNER delta/notch-like EGF repeat containing 0.0485617
FRMD4A FERM domain containing 4A 0.0483789
GLIS3 GLIS family zinc finger 3 0.0476499
SOD2 superoxide dismutase 2, mitochondrial 0.0470503
NEBL nebulette 0.0464267
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0453349
NAV2 neuron navigator 2 0.0444232
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0429526
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0425485
MBNL1 muscleblind-like splicing regulator 1 0.0423744
LOX lysyl oxidase 0.0416721
SAA2 serum amyloid A2 0.0396322
COL3A1 collagen, type III, alpha 1 0.038292
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.03636
ABLIM3 actin binding LIM protein family, member 3 0.0359152
CDH13 cadherin 13 0.0352218
PTX3 pentraxin 3, long 0.0352187
TOP1 topoisomerase (DNA) I 0.034141
GPC6 glypican 6 0.0340304
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 0.0337579
VIM vimentin 0.0326617
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0319531
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0318696
BPTF bromodomain PHD finger transcription factor 0.0318564
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0315616
JCAD junctional cadherin 5 associated 0.0311873
RABGAP1L RAB GTPase activating protein 1-like 0.0309874
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0301999
CHD9 chromodomain helicase DNA binding protein 9 0.0299851
LPP LIM domain containing preferred translocation partner in lipoma 0.0299349
MAML2 mastermind-like 2 (Drosophila) 0.0295602
ANKRD12 ankyrin repeat domain 12 0.0292879
PDZD2 PDZ domain containing 2 0.0291426
CENPF centromere protein F, 350/400kDa 0.0285929
ANTXR1 anthrax toxin receptor 1 0.0285173
SAA2-SAA4 SAA2-SAA4 readthrough 0.0281978
MYO9A myosin IXA 0.0271706
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0267653
TNS3 tensin 3 0.0267486
FTH1 ferritin, heavy polypeptide 1 0.0266831
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0266474
ITSN1 intersectin 1 (SH3 domain protein) 0.0258414
SH3RF3 SH3 domain containing ring finger 3 0.0257421
SMYD3 SET and MYND domain containing 3 0.0242103
SBF2 SET binding factor 2 0.0238602
HIP1 huntingtin interacting protein 1 0.023436
ANGPTL4 angiopoietin-like 4 0.0232295
CDK6 cyclin-dependent kinase 6 0.0232208
GREB1L growth regulation by estrogen in breast cancer-like 0.023201
KLF6 Kruppel-like factor 6 0.0231878
COL5A1 collagen, type V, alpha 1 0.0231627
PID1 phosphotyrosine interaction domain containing 1 0.0231048
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0223982
UGP2 UDP-glucose pyrophosphorylase 2 0.0222263
GDI2 GDP dissociation inhibitor 2 0.0221713
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.02198
ALCAM activated leukocyte cell adhesion molecule 0.0218888
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0218815
JAK1 Janus kinase 1 0.021798
BIRC6 baculoviral IAP repeat containing 6 0.021555
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0215243
CDK13 cyclin-dependent kinase 13 0.0214876
CD99 CD99 molecule 0.0214068
SDCCAG8 serologically defined colon cancer antigen 8 0.0211093
DGKG diacylglycerol kinase, gamma 90kDa 0.0209279
IL6ST interleukin 6 signal transducer 0.0208406
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0208227
GOLGB1 golgin B1 0.0206582
PCDH7 protocadherin 7 0.0206408
ARB2A ARB2 cotranscriptional regulator A 0.02056
CUX1 cut-like homeobox 1 0.0202712
RAI14 retinoic acid induced 14 0.0200356
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0200166
BBS9 Bardet-Biedl syndrome 9 0.0198427
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.0198372
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.0197867
MMP12 matrix metallopeptidase 12 0.0195905
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0195797
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0194358
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0192409
ITGAV integrin, alpha V 0.0192029
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0190039
CDK19 cyclin-dependent kinase 19 0.0189386

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.232011
NDRG1 N-myc downstream regulated 1 -0.180021
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.179756
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.153972
IGFBP3 insulin-like growth factor binding protein 3 -0.125923
DLG1 discs, large homolog 1 (Drosophila) -0.125439
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.114223
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105704
CD44 CD44 molecule (Indian blood group) -0.0978289
ELL2 elongation factor, RNA polymerase II, 2 -0.0838707
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0767053
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0674532
BHLHE40 basic helix-loop-helix family, member e40 -0.0622603
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0520541
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0515985
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0510027
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0504119
LOXL2 lysyl oxidase-like 2 -0.0494148
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0480819
SQSTM1 sequestosome 1 -0.0479578
PKM pyruvate kinase, muscle -0.0459843
AUTS2 autism susceptibility candidate 2 -0.0456706
THBS2 thrombospondin 2 -0.0448551
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0427906
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0414846
FBN1 fibrillin 1 -0.0389876
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0388025
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0375333
LOC112694756 uncharaterized LOC112694756 -0.0367051
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0361842
ADM adrenomedullin -0.0354449
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0354168
FBXL7 F-box and leucine-rich repeat protein 7 -0.0343774
RUNX1 runt-related transcription factor 1 -0.034151
C1D C1D nuclear receptor corepressor -0.0340436
TMSB10 thymosin beta 10 -0.0339663
RHOBTB3 Rho-related BTB domain containing 3 -0.0338726
FAM107B family with sequence similarity 107, member B -0.0338636
ZEB1 zinc finger E-box binding homeobox 1 -0.0334071
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0329404
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0322185
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0320169
PSD3 pleckstrin and Sec7 domain containing 3 -0.0317598
CCND1 cyclin D1 -0.0316796
FLNB filamin B, beta -0.0316246
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.031287
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0311883
HILPDA hypoxia inducible lipid droplet-associated -0.0311755
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0306859
MBNL2 muscleblind-like splicing regulator 2 -0.0301454
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0300753
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0299566
ADAM19 ADAM metallopeptidase domain 19 -0.0296497
AFDN afadin, adherens junction formation factor -0.0294906
SP3 Sp3 transcription factor -0.0293824
SOX9 SRY (sex determining region Y)-box 9 -0.0286254
RNMT RNA (guanine-7-) methyltransferase -0.0286149
SHB Src homology 2 domain containing adaptor protein B -0.0282102
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0280888
FOSL1 FOS-like antigen 1 -0.0278659
MRPS6 mitochondrial ribosomal protein S6 -0.0276001
DPYSL3 dihydropyrimidinase-like 3 -0.0275429
PLAUR plasminogen activator, urokinase receptor -0.0275144
SLC22A23 solute carrier family 22, member 23 -0.0271412
TAPBP TAP binding protein (tapasin) -0.0270143
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0270007
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0265354
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0262363
TSC22D2 TSC22 domain family, member 2 -0.0262082
RAI1 retinoic acid induced 1 -0.0262026
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0258581
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.025551
MYADM myeloid-associated differentiation marker -0.0253987
IFITM3 interferon induced transmembrane protein 3 -0.025345
KIAA1217 KIAA1217 -0.0251451
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0250438
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0249542
INSIG1 insulin induced gene 1 -0.0248562
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0248192
PTMA prothymosin, alpha -0.0245383
TMOD1 tropomodulin 1 -0.0245109
MSI2 musashi RNA-binding protein 2 -0.0238719
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0236412
MXI1 MAX interactor 1, dimerization protein -0.0235941
ZBTB7C zinc finger and BTB domain containing 7C -0.0235277
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0235144
ACTN4 actinin, alpha 4 -0.0231048
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0230971
VEGFA vascular endothelial growth factor A -0.0229485
WARS1 tryptophanyl-tRNA synthetase 1 -0.0228742
WDFY1 WD repeat and FYVE domain containing 1 -0.0228468
SLC39A11 solute carrier family 39, member 11 -0.0228286
TNIP1 TNFAIP3 interacting protein 1 -0.0227714
AFF4 AF4/FMR2 family, member 4 -0.0225914
PGK1 phosphoglycerate kinase 1 -0.0225154
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0224318
ARL15 ADP-ribosylation factor-like 15 -0.0217669
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0216114
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0214323
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0213246