Dexamethasone_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MMP12 matrix metallopeptidase 12 0.11696
ANXA1 annexin A1 0.111747
VMP1 vacuole membrane protein 1 0.0767004
AREG amphiregulin 0.0728518
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0704952
CLDN1 claudin 1 0.0673988
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0625825
EHBP1 EH domain binding protein 1 0.0616452
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0608571
ERRFI1 ERBB receptor feedback inhibitor 1 0.0606573
FBXO11 F-box protein 11 0.0588738
DPYD dihydropyrimidine dehydrogenase 0.0578644
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0578415
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0569208
GJA1 gap junction protein, alpha 1, 43kDa 0.0563092
ZBTB20 zinc finger and BTB domain containing 20 0.0474249
HDAC9 histone deacetylase 9 0.0473336
RAB1A RAB1A, member RAS oncogene family 0.0471837
KIF5B kinesin family member 5B 0.0468694
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0444794
EEF2 eukaryotic translation elongation factor 2 0.0419645
RAB10 RAB10, member RAS oncogene family 0.0403254
KLF6 Kruppel-like factor 6 0.0400366
BIRC3 baculoviral IAP repeat containing 3 0.0398221
SERINC1 serine incorporator 1 0.0397896
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0391397
TMEM41B transmembrane protein 41B 0.0383576
JMJD1C jumonji domain containing 1C 0.038118
LMO7 LIM domain 7 0.0375669
EDN1 endothelin 1 0.036995
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0365065
ADIPOR2 adiponectin receptor 2 0.0360342
ANKRD17 ankyrin repeat domain 17 0.035252
USP34 ubiquitin specific peptidase 34 0.0349878
PCDH7 protocadherin 7 0.0347232
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0346552
PGK1 phosphoglycerate kinase 1 0.0346401
RABGAP1L RAB GTPase activating protein 1-like 0.0334459
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330756
UBE2K ubiquitin-conjugating enzyme E2K 0.0329114
ARFGEF3 ARFGEF family member 3 0.0325467
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.032517
PRKCI protein kinase C, iota 0.03248
ASXL1 additional sex combs like transcriptional regulator 1 0.0320973
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0315247
TSNAX translin-associated factor X 0.0312414
RPS3 ribosomal protein S3 0.0310502
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0299194
RSL1D1 ribosomal L1 domain containing 1 0.0290759
KDM5A lysine (K)-specific demethylase 5A 0.0286004
MBD5 methyl-CpG binding domain protein 5 0.0281861
SBNO1 strawberry notch homolog 1 (Drosophila) 0.027649
SEC24B SEC24 family member B 0.0274212
KLHL24 kelch-like family member 24 0.0272747
ZNF638 zinc finger protein 638 0.0271933
CSMD1 CUB and Sushi multiple domains 1 0.0270462
NBEAL1 neurobeachin-like 1 0.0266387
PHF21A PHD finger protein 21A 0.0262709
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0261737
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0255637
KDM2A lysine (K)-specific demethylase 2A 0.0254726
SBF2 SET binding factor 2 0.0251556
BIRC2 baculoviral IAP repeat containing 2 0.02473
XRN1 5'-3' exoribonuclease 1 0.0245618
CEP95 centrosomal protein 95kDa 0.0244481
MYO1D myosin ID 0.0243907
USP53 ubiquitin specific peptidase 53 0.0241482
SEC31A SEC31 homolog A (S. cerevisiae) 0.0239473
CCNI cyclin I 0.0239262
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0239025
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.0239021
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0238804
PARM1 prostate androgen-regulated mucin-like protein 1 0.0236225
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0236121
NSUN6 NOP2/Sun domain family, member 6 0.0235559
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0232997
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.023225
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0231506
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0229371
TTC27 tetratricopeptide repeat domain 27 0.0227742
GSK3B glycogen synthase kinase 3 beta 0.0227547
ZBTB35 zinc finger and BTB domain containing 35 0.0226929
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0224954
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.022488
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0224642
CLTC clathrin, heavy chain (Hc) 0.0223808
HM13 histocompatibility (minor) 13 0.0222871
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0221753
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0221023
TRIO trio Rho guanine nucleotide exchange factor 0.0219528
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0219465
ATRN attractin 0.0218723
MPG N-methylpurine-DNA glycosylase 0.0217193
AKAP12 A kinase (PRKA) anchor protein 12 0.021718
RNMT RNA (guanine-7-) methyltransferase 0.0216421
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0212735
KPNB1 karyopherin (importin) beta 1 0.0212058
GRB2 growth factor receptor-bound protein 2 0.0211686
MSRB3 methionine sulfoxide reductase B3 0.0210703
CHD8 chromodomain helicase DNA binding protein 8 0.0210512

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111473
RPL23 ribosomal protein L23 -0.0913496
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0829111
TMSB10 thymosin beta 10 -0.0778439
RPL12 ribosomal protein L12 -0.0771201
RPS6 ribosomal protein S6 -0.0746085
FTL ferritin, light polypeptide -0.0733286
YBX1 Y box binding protein 1 -0.0718654
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0670634
NLGN1 neuroligin 1 -0.0649644
PTMA prothymosin, alpha -0.0595833
TPI1 triosephosphate isomerase 1 -0.0565284
RPL35A ribosomal protein L35a -0.0564712
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0542038
RPLP0 ribosomal protein, large, P0 -0.0515504
RPS19 ribosomal protein S19 -0.049955
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0496684
RPL26 ribosomal protein L26 -0.049606
TUBA1B tubulin, alpha 1b -0.0491731
POTEF POTE ankyrin domain family, member F -0.0488613
RRM2 ribonucleotide reductase M2 -0.0485656
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0482446
RPS12 ribosomal protein S12 -0.0480074
LDHB lactate dehydrogenase B -0.0462763
RPL9 ribosomal protein L9 -0.0462417
FTH1 ferritin, heavy polypeptide 1 -0.0450267
HMGA1 high mobility group AT-hook 1 -0.0446316
VIM vimentin -0.0444314
RPLP1 ribosomal protein, large, P1 -0.0440321
RPS8 ribosomal protein S8 -0.0431289
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0425181
GCG glucagon -0.0423041
PCBP2 poly(rC) binding protein 2 -0.0414573
ATP5F1B ATP synthase F1 subunit beta -0.0410559
RPL19 ribosomal protein L19 -0.0391931
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0391407
ATAD2 ATPase family, AAA domain containing 2 -0.0385493
MYL12B myosin, light chain 12B, regulatory -0.0383566
ATP5F1E ATP synthase F1 subunit epsilon -0.0378375
FNDC3B fibronectin type III domain containing 3B -0.0376565
RPL36 ribosomal protein L36 -0.036644
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.035908
SMC4 structural maintenance of chromosomes 4 -0.0357217
SP3 Sp3 transcription factor -0.0356868
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0356297
TGM2 transglutaminase 2 -0.0353202
TENT4A terminal nucleotidyltransferase 4A -0.034449
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0343394
RPL28 ribosomal protein L28 -0.0341297
RPS20 ribosomal protein S20 -0.033859
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0335226
HMGB1 high mobility group box 1 -0.0334772
CENPF centromere protein F, 350/400kDa -0.0333365
ANXA2 annexin A2 -0.0333288
CCND1 cyclin D1 -0.0332727
RPL7 ribosomal protein L7 -0.0330708
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0330117
HLA-A major histocompatibility complex, class I, A -0.0327065
CCNL1 cyclin L1 -0.0317733
RPS15 ribosomal protein S15 -0.0317323
AXIN2 axin 2 -0.0312944
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0310687
MAP1B microtubule-associated protein 1B -0.0308828
RPL37 ribosomal protein L37 -0.0306869
CDK6 cyclin-dependent kinase 6 -0.0302549
DNAH14 dynein, axonemal, heavy chain 14 -0.0301427
HMGA2 high mobility group AT-hook 2 -0.0300057
SMYD3 SET and MYND domain containing 3 -0.0299545
RPL10A ribosomal protein L10a -0.0299328
EIF5B eukaryotic translation initiation factor 5B -0.029493
RPS24 ribosomal protein S24 -0.0294527
RPLP2 ribosomal protein, large, P2 -0.0294056
DIAPH3 diaphanous-related formin 3 -0.0293016
PDE8A phosphodiesterase 8A -0.02929
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0292842
FAT1 FAT atypical cadherin 1 -0.0287106
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0286142
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0284922
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0284071
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0283696
ANKRD11 ankyrin repeat domain 11 -0.0281913
SLC38A1 solute carrier family 38, member 1 -0.0280841
RPS23 ribosomal protein S23 -0.0277287
RPL3 ribosomal protein L3 -0.0276549
NAP1L1 nucleosome assembly protein 1-like 1 -0.0273872
C1QBP complement component 1, q subcomponent binding protein -0.0273758
RPL4 ribosomal protein L4 -0.0272891
LDHA lactate dehydrogenase A -0.0269942
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0268603
MATR3 matrin 3 -0.0266609
TRA2B transformer 2 beta homolog (Drosophila) -0.0265965
CNRIP1 cannabinoid receptor interacting protein 1 -0.0265961
GLO1 glyoxalase I -0.0265679
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0265566
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0264914
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0264823
YAP1 Yes-associated protein 1 -0.0264105
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.026393
S100A11 S100 calcium binding protein A11 -0.0263537
H1-0 H1.0 linker histone -0.0262111