Dexamethasone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.33096
AKAP12 A kinase (PRKA) anchor protein 12 0.261217
PLAT plasminogen activator, tissue 0.0969689
GPC5 glypican 5 0.0530485
DPH6 diphthamine biosynthesis 6 0.0508166
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0492183
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0479037
KLF9 Kruppel-like factor 9 0.0451145
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0438396
TRIO trio Rho guanine nucleotide exchange factor 0.0427666
TOP1 topoisomerase (DNA) I 0.0393672
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0361311
CTSB cathepsin B 0.0351987
FNBP1 formin binding protein 1 0.0339878
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0337084
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.033478
ZFP36L1 ZFP36 ring finger protein-like 1 0.0320375
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0312063
HMGA2 high mobility group AT-hook 2 0.0294964
PTMA prothymosin, alpha 0.0290821
UBA6 ubiquitin-like modifier activating enzyme 6 0.0288248
MYO6 myosin VI 0.0271441
FAM13A family with sequence similarity 13, member A 0.0265791
LPIN1 lipin 1 0.0257764
RPL19 ribosomal protein L19 0.0255274
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0248058
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0242902
BRWD1 bromodomain and WD repeat domain containing 1 0.0241977
GDF15 growth differentiation factor 15 0.0238711
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0236567
SEC31A SEC31 homolog A (S. cerevisiae) 0.0234057
SEPTIN2 septin 2 0.0231714
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0227206
USP53 ubiquitin specific peptidase 53 0.0225744
SMC5 structural maintenance of chromosomes 5 0.0223386
VIM vimentin 0.0223157
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0222934
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0221386
FKBP5 FK506 binding protein 5 0.0219138
SCG2 secretogranin II 0.0218262
WDR43 WD repeat domain 43 0.0214414
HMGA1 high mobility group AT-hook 1 0.0212007
TNRC6B trinucleotide repeat containing 6B 0.0208144
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0206707
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0206151
EPAS1 endothelial PAS domain protein 1 0.02058
UBC ubiquitin C 0.0203144
TOP2B topoisomerase (DNA) II beta 180kDa 0.0202431
IFI16 interferon, gamma-inducible protein 16 0.0201188
RGS4 regulator of G-protein signaling 4 0.0200968
B2M beta-2-microglobulin 0.0200863
RPL36 ribosomal protein L36 0.02007
RAB1A RAB1A, member RAS oncogene family 0.0199823
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0199264
NT5E 5'-nucleotidase, ecto (CD73) 0.019575
IARS1 isoleucyl-tRNA synthetase 1 0.0194189
UGCG UDP-glucose ceramide glucosyltransferase 0.0191009
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0189367
MLXIP MLX interacting protein 0.0189294
PRRC2C proline-rich coiled-coil 2C 0.0186843
EIF4A1 eukaryotic translation initiation factor 4A1 0.0184185
PHIP pleckstrin homology domain interacting protein 0.0183299
COL4A1 collagen, type IV, alpha 1 0.0182284
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.018217
TXNRD1 thioredoxin reductase 1 0.0182076
NAP1L1 nucleosome assembly protein 1-like 1 0.0181168
AHCTF1 AT hook containing transcription factor 1 0.017847
PITPNB phosphatidylinositol transfer protein, beta 0.0177456
COPS2 COP9 signalosome subunit 2 0.0176774
EIF5B eukaryotic translation initiation factor 5B 0.0174826
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0172001
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0171748
RPLP0 ribosomal protein, large, P0 0.0171511
SPIRE1 spire-type actin nucleation factor 1 0.0171106
HIP1 huntingtin interacting protein 1 0.0169181
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.0167979
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0165086
RO60 Ro60, Y RNA binding protein 0.0164624
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0164327
VDAC1 voltage-dependent anion channel 1 0.0162235
NPR2 natriuretic peptide receptor 2 0.0162138
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0161473
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0160187
CALU calumenin 0.0159412
MCL1 myeloid cell leukemia 1 0.0159043
RPL8 ribosomal protein L8 0.0158622
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.015815
PA2G4 proliferation-associated 2G4, 38kDa 0.0157808
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0156694
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0156444
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0156071
FXR1 fragile X mental retardation, autosomal homolog 1 0.0154059
YTHDC1 YTH domain containing 1 0.0153952
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0153078
FKBP10 FK506 binding protein 10, 65 kDa 0.0152441
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0151651
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0151515
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0150294
AFDN afadin, adherens junction formation factor 0.0149849
ZBTB10 zinc finger and BTB domain containing 10 0.0148049

decreased expression

Symbol Name Standardized Value
SYT1 synaptotagmin I -0.142033
LSAMP limbic system-associated membrane protein -0.128746
PTPRD protein tyrosine phosphatase, receptor type, D -0.104292
VCL vinculin -0.097278
NALF1 NALCN channel auxiliary factor 1 -0.095457
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0930358
MEIS2 Meis homeobox 2 -0.0703798
TLE4 transducin-like enhancer of split 4 -0.069264
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0671671
EXT1 exostosin glycosyltransferase 1 -0.0668438
LINGO2 leucine rich repeat and Ig domain containing 2 -0.065856
PRKCA protein kinase C, alpha -0.0635977
ZNF804A zinc finger protein 804A -0.0601198
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0596978
MED13 mediator complex subunit 13 -0.058458
CENPF centromere protein F, 350/400kDa -0.0551411
BCAS3 breast carcinoma amplified sequence 3 -0.0537233
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0537072
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0532002
GREM2 gremlin 2, DAN family BMP antagonist -0.0531419
RNF213 ring finger protein 213 -0.0503042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0481454
PLPP1 phospholipid phosphatase 1 -0.0478181
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0473435
TPST1 tyrosylprotein sulfotransferase 1 -0.0464298
GLCCI1 glucocorticoid induced 1 -0.046221
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0452877
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0447955
SLIT2 slit homolog 2 (Drosophila) -0.0444778
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0437586
NREP neuronal regeneration related protein -0.0437106
UNC5C unc-5 homolog C (C. elegans) -0.0435369
THSD4 thrombospondin, type I, domain containing 4 -0.0435199
NCAM2 neural cell adhesion molecule 2 -0.0431534
DNM3 dynamin 3 -0.0411188
MAPK10 mitogen-activated protein kinase 10 -0.0398343
KLHL13 kelch-like family member 13 -0.0387694
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0382785
RPTOR regulatory associated protein of MTOR, complex 1 -0.0374396
TPM4 tropomyosin 4 -0.0371844
PTPRK protein tyrosine phosphatase, receptor type, K -0.0369771
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0356374
CUX1 cut-like homeobox 1 -0.035538
ADGRB3 adhesion G protein-coupled receptor B3 -0.0353821
PDE10A phosphodiesterase 10A -0.0349599
TRIB2 tribbles pseudokinase 2 -0.0346856
LPP LIM domain containing preferred translocation partner in lipoma -0.0344898
CHD9 chromodomain helicase DNA binding protein 9 -0.0341613
ATXN1 ataxin 1 -0.0340232
PBX1 pre-B-cell leukemia homeobox 1 -0.0339986
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0338776
PDZRN3 PDZ domain containing ring finger 3 -0.0338067
EXOC4 exocyst complex component 4 -0.0336094
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0334457
BPTF bromodomain PHD finger transcription factor -0.0333323
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0333181
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0330996
TENM4 teneurin transmembrane protein 4 -0.032963
SIK2 salt-inducible kinase 2 -0.0328556
KDM3A lysine (K)-specific demethylase 3A -0.0328311
ZBTB20 zinc finger and BTB domain containing 20 -0.0325914
LCORL ligand dependent nuclear receptor corepressor-like -0.0323832
TENT5A terminal nucleotidyltransferase 5A -0.0323295
PDE4D phosphodiesterase 4D, cAMP-specific -0.0321255
PCDH9 protocadherin 9 -0.0321065
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0320514
MBNL2 muscleblind-like splicing regulator 2 -0.0315518
TAS2R14 taste receptor, type 2, member 14 -0.0314179
FRMD4A FERM domain containing 4A -0.0312459
GOLGB1 golgin B1 -0.0311657
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0309649
SDK1 sidekick cell adhesion molecule 1 -0.0304473
TTC17 tetratricopeptide repeat domain 17 -0.030309
TPM1 tropomyosin 1 (alpha) -0.0300855
ZC3H11A zinc finger CCCH-type containing 11A -0.0299437
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0297636
PTEN phosphatase and tensin homolog -0.0293435
CADM2 cell adhesion molecule 2 -0.0292594
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0292551
AUTS2 autism susceptibility candidate 2 -0.0286859
HMBOX1 homeobox containing 1 -0.0285759
INTS6 integrator complex subunit 6 -0.0283794
DST dystonin -0.0281481
STK38L serine/threonine kinase 38 like -0.0279713
TOX thymocyte selection-associated high mobility group box -0.0279303
RPS6 ribosomal protein S6 -0.0278095
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0275313
PCBP2 poly(rC) binding protein 2 -0.0270188
KCNIP4 Kv channel interacting protein 4 -0.0269956
MKI67 marker of proliferation Ki-67 -0.0268656
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -0.0268295
CADM1 cell adhesion molecule 1 -0.0267235
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.026723
DACH2 dachshund family transcription factor 2 -0.0267196
EGR1 early growth response 1 -0.0264076
SLC38A2 solute carrier family 38, member 2 -0.0261604
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0257869
VMP1 vacuole membrane protein 1 -0.0256843
RAD51B RAD51 paralog B -0.0255671
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0252884