Dexamethasone_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.298011
COL6A3 collagen, type VI, alpha 3 0.20025
MT2A metallothionein 2A 0.145267
ERRFI1 ERBB receptor feedback inhibitor 1 0.117115
LOX lysyl oxidase 0.116896
MT1X metallothionein 1X 0.104038
LDHA lactate dehydrogenase A 0.0782818
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0780655
TGFBI transforming growth factor, beta-induced, 68kDa 0.0669033
LTBP1 latent transforming growth factor beta binding protein 1 0.0645124
HIPK2 homeodomain interacting protein kinase 2 0.0590007
HMGA2 high mobility group AT-hook 2 0.0566381
COL1A1 collagen, type I, alpha 1 0.0540214
AKAP12 A kinase (PRKA) anchor protein 12 0.0509893
IL6ST interleukin 6 signal transducer 0.0509523
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0471891
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0461853
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0438265
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0428055
EPS8 epidermal growth factor receptor pathway substrate 8 0.0415873
MAML2 mastermind-like 2 (Drosophila) 0.0413354
ANXA2 annexin A2 0.041329
MBNL1 muscleblind-like splicing regulator 1 0.0403399
PID1 phosphotyrosine interaction domain containing 1 0.0396425
PRELID2 PRELI domain containing 2 0.0393699
SORBS2 sorbin and SH3 domain containing 2 0.0382758
AHNAK AHNAK nucleoprotein 0.0380813
MED13L mediator complex subunit 13-like 0.0378358
ANGPTL4 angiopoietin-like 4 0.0369769
POSTN periostin, osteoblast specific factor 0.0369205
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0369119
JAK1 Janus kinase 1 0.0345367
LPP LIM domain containing preferred translocation partner in lipoma 0.0335667
FTH1 ferritin, heavy polypeptide 1 0.0334285
STC1 stanniocalcin 1 0.0310146
MYO1B myosin IB 0.0307442
JAK2 Janus kinase 2 0.0303971
BIRC3 baculoviral IAP repeat containing 3 0.0300028
ZMYND8 zinc finger, MYND-type containing 8 0.0298626
ANKRD28 ankyrin repeat domain 28 0.0296168
SLC38A2 solute carrier family 38, member 2 0.0291436
TMSB4X thymosin beta 4, X-linked 0.0283719
DPYD dihydropyrimidine dehydrogenase 0.0282386
PTPRG protein tyrosine phosphatase, receptor type, G 0.0282281
TOP1 topoisomerase (DNA) I 0.0278458
ABLIM3 actin binding LIM protein family, member 3 0.026744
KLF6 Kruppel-like factor 6 0.0264363
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0264156
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0261868
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.025619
DNER delta/notch-like EGF repeat containing 0.0250201
IL1R1 interleukin 1 receptor, type I 0.0245626
VCL vinculin 0.0244513
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0239843
SOD2 superoxide dismutase 2, mitochondrial 0.0235872
MGP matrix Gla protein 0.0234842
NRP1 neuropilin 1 0.0233309
AKAP13 A kinase (PRKA) anchor protein 13 0.0228727
ZFHX3 zinc finger homeobox 3 0.0225859
ENO1 enolase 1, (alpha) 0.0222624
CD109 CD109 molecule 0.0221846
IGFBP7 insulin-like growth factor binding protein 7 0.0212004
FOXO3 forkhead box O3 0.0195373
FKBP5 FK506 binding protein 5 0.019283
SH3RF3 SH3 domain containing ring finger 3 0.0192234
HIP1 huntingtin interacting protein 1 0.0191004
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0186982
ZFP36L1 ZFP36 ring finger protein-like 1 0.0184607
ALCAM activated leukocyte cell adhesion molecule 0.0183821
CTSB cathepsin B 0.0182707
ZBTB38 zinc finger and BTB domain containing 38 0.0181852
WNT5A wingless-type MMTV integration site family, member 5A 0.0180475
F3 coagulation factor III (thromboplastin, tissue factor) 0.0180419
FOXC2 forkhead box C2 0.0179205
TSC22D3 TSC22 domain family, member 3 0.0179202
DCLK1 doublecortin-like kinase 1 0.0171519
VCAN versican 0.017134
TGFBR3 transforming growth factor, beta receptor III 0.0171062
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0167523
PDLIM5 PDZ and LIM domain 5 0.0166692
COL3A1 collagen, type III, alpha 1 0.0165207
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0164059
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0163784
CNTN5 contactin 5 0.0162592
PTEN phosphatase and tensin homolog 0.016011
DCN decorin 0.0151961
PDIA5 protein disulfide isomerase family A, member 5 0.01509
CCN4 cellular communication network factor 4 0.0149877
NAV2 neuron navigator 2 0.0147124
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0146441
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0143732
UGP2 UDP-glucose pyrophosphorylase 2 0.0142615
GLIS3 GLIS family zinc finger 3 0.0140798
CD59 CD59 molecule, complement regulatory protein 0.0139828
KLF9 Kruppel-like factor 9 0.0139135
ZBTB20 zinc finger and BTB domain containing 20 0.0139132
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0139038
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0135997
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0134457
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0131748

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.460961
NDRG1 N-myc downstream regulated 1 -0.289014
CADM1 cell adhesion molecule 1 -0.102647
TRIO trio Rho guanine nucleotide exchange factor -0.101001
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0740829
VEGFA vascular endothelial growth factor A -0.0701704
PDE10A phosphodiesterase 10A -0.0655093
CD44 CD44 molecule (Indian blood group) -0.0575396
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0563331
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0528809
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.051
ATP13A3 ATPase type 13A3 -0.0482542
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0456322
EXT1 exostosin glycosyltransferase 1 -0.0429737
IER3 immediate early response 3 -0.0424831
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0390424
LOXL2 lysyl oxidase-like 2 -0.0349235
CDH13 cadherin 13 -0.0310887
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0310665
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0309812
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0302746
HILPDA hypoxia inducible lipid droplet-associated -0.0291453
JARID2 jumonji, AT rich interactive domain 2 -0.0290088
FTL ferritin, light polypeptide -0.0275421
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0272393
MRPS6 mitochondrial ribosomal protein S6 -0.0261914
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0260436
PTMA prothymosin, alpha -0.0256786
EGFR epidermal growth factor receptor -0.0242897
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0242495
BHLHE40 basic helix-loop-helix family, member e40 -0.0232167
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.022136
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0220224
RUNX1 runt-related transcription factor 1 -0.0219852
QKI QKI, KH domain containing, RNA binding -0.0213332
SMAD3 SMAD family member 3 -0.0211402
IL6 interleukin 6 -0.02113
MYO10 myosin X -0.020852
VIM vimentin -0.0203305
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0201269
FOSL1 FOS-like antigen 1 -0.0197787
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0197372
SHB Src homology 2 domain containing adaptor protein B -0.0193331
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0192805
MRTFA myocardin related transcription factor A -0.0188977
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0187009
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0186388
HOOK2 hook microtubule-tethering protein 2 -0.0178677
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0177404
DLG1 discs, large homolog 1 (Drosophila) -0.0168735
FGFR1 fibroblast growth factor receptor 1 -0.0165801
FAT1 FAT atypical cadherin 1 -0.0162491
GOLGA4 golgin A4 -0.0157448
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0155576
CMIP c-Maf inducing protein -0.0153607
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0152819
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0150648
HLA-A major histocompatibility complex, class I, A -0.0150569
FNDC3B fibronectin type III domain containing 3B -0.0150367
CCDC80 coiled-coil domain containing 80 -0.0150025
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0149508
TMEM165 transmembrane protein 165 -0.0147976
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0147967
NALF1 NALCN channel auxiliary factor 1 -0.0146199
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0146019
USP3 ubiquitin specific peptidase 3 -0.0144909
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0143325
IRF1 interferon regulatory factor 1 -0.0141812
SESN2 sestrin 2 -0.0141417
JUN jun proto-oncogene -0.0140857
HLA-B major histocompatibility complex, class I, B -0.0138855
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0138215
ECE1 endothelin converting enzyme 1 -0.0136778
DDIT4 DNA-damage-inducible transcript 4 -0.0136635
TNIP1 TNFAIP3 interacting protein 1 -0.0136208
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0135891
RLF rearranged L-myc fusion -0.0135556
SEC24A SEC24 family member A -0.0133257
WSB1 WD repeat and SOCS box containing 1 -0.013302
FBXO32 F-box protein 32 -0.0132636
STC2 stanniocalcin 2 -0.0131166
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0131019
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0129408
PDE8A phosphodiesterase 8A -0.0129301
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0127243
PKM pyruvate kinase, muscle -0.0125835
CDON cell adhesion associated, oncogene regulated -0.0125017
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.01248
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0123847
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0123295
TAPBP TAP binding protein (tapasin) -0.0122969
CYB5R3 cytochrome b5 reductase 3 -0.0122435
TSC22D2 TSC22 domain family, member 2 -0.0119297
KIAA1217 KIAA1217 -0.0118416
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0118149
ICAM1 intercellular adhesion molecule 1 -0.0117866
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0117281
KMT2E lysine (K)-specific methyltransferase 2E -0.0116603
SYNJ2 synaptojanin 2 -0.0116177
HYOU1 hypoxia up-regulated 1 -0.0115586