Dexamethasone_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FKBP5 FK506 binding protein 5 0.192323
TXNIP thioredoxin interacting protein 0.158285
KRT6A keratin 6A, type II 0.113582
ZMYND8 zinc finger, MYND-type containing 8 0.0975936
ESYT2 extended synaptotagmin-like protein 2 0.0930008
ANXA1 annexin A1 0.0923039
NAMPT nicotinamide phosphoribosyltransferase 0.0767366
MT1X metallothionein 1X 0.0696627
BIRC3 baculoviral IAP repeat containing 3 0.0662475
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0636674
EZR ezrin 0.0624544
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.062006
AKAP13 A kinase (PRKA) anchor protein 13 0.0591651
CAPRIN2 caprin family member 2 0.0583935
HMGA2 high mobility group AT-hook 2 0.057423
IGF2 insulin-like growth factor 2 0.053219
ZFP36L1 ZFP36 ring finger protein-like 1 0.0531284
POTEF POTE ankyrin domain family, member F 0.0520712
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0508287
VCL vinculin 0.049874
GLUL glutamate-ammonia ligase 0.0484967
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0464261
ZFHX3 zinc finger homeobox 3 0.0453033
NDRG1 N-myc downstream regulated 1 0.0448522
EPS8 epidermal growth factor receptor pathway substrate 8 0.0420193
FOXN2 forkhead box N2 0.0409385
MCL1 myeloid cell leukemia 1 0.0407619
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0406065
LAMB1 laminin, beta 1 0.0401606
ALCAM activated leukocyte cell adhesion molecule 0.0399801
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0379503
PID1 phosphotyrosine interaction domain containing 1 0.0376715
CDKL5 cyclin-dependent kinase-like 5 0.036398
ERRFI1 ERBB receptor feedback inhibitor 1 0.0360512
PHF20 PHD finger protein 20 0.0346237
AHNAK AHNAK nucleoprotein 0.03344
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.032586
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0305769
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0304581
GRID1 glutamate receptor, ionotropic, delta 1 0.0303987
WASF2 WAS protein family, member 2 0.0303933
IRS2 insulin receptor substrate 2 0.0301557
EGR1 early growth response 1 0.030115
CLU clusterin 0.0298443
AFAP1L1 actin filament associated protein 1-like 1 0.0286907
ABLIM3 actin binding LIM protein family, member 3 0.0286746
TES testin LIM domain protein 0.0283009
ZHX3 zinc fingers and homeoboxes 3 0.0282787
KLF6 Kruppel-like factor 6 0.0282119
EFNA5 ephrin-A5 0.0279327
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0277589
DDIT4 DNA-damage-inducible transcript 4 0.0275869
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0275144
RBM39 RNA binding motif protein 39 0.0262516
NCOA3 nuclear receptor coactivator 3 0.0262465
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.026064
FOS FBJ murine osteosarcoma viral oncogene homolog 0.026053
TMEM165 transmembrane protein 165 0.0255828
KLF9 Kruppel-like factor 9 0.0255389
ZC3H12C zinc finger CCCH-type containing 12C 0.0255059
EMP1 epithelial membrane protein 1 0.0252527
FBXO11 F-box protein 11 0.0246505
WNK1 WNK lysine deficient protein kinase 1 0.0245024
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0243281
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0243125
CAVIN2 caveolae associated protein 2 0.0238198
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236399
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0236158
JPH2 junctophilin 2 0.0235386
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0233819
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0231395
ZBTB38 zinc finger and BTB domain containing 38 0.0230963
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0229277
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0224981
SOD2 superoxide dismutase 2, mitochondrial 0.0224613
NRCAM neuronal cell adhesion molecule 0.0221553
WEE1 WEE1 G2 checkpoint kinase 0.0219749
OGA O-GlcNAcase 0.0218094
IL6ST interleukin 6 signal transducer 0.0216033
HIPK2 homeodomain interacting protein kinase 2 0.0214519
CUL4B cullin 4B 0.0214348
CLMB calcimembrin 0.0214047
KRT17 keratin 17, type I 0.0213081
DOCK5 dedicator of cytokinesis 5 0.0210154
BIRC2 baculoviral IAP repeat containing 2 0.0208321
JARID2 jumonji, AT rich interactive domain 2 0.0207769
MT2A metallothionein 2A 0.0207063
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0206021
CSNK1A1 casein kinase 1, alpha 1 0.0205897
LOC102724023 ES1 protein homolog, mitochondrial 0.0205226
YAP1 Yes-associated protein 1 0.0204766
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0201531
PKP2 plakophilin 2 0.0201137
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0200569
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0200561
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0197681
ABHD2 abhydrolase domain containing 2 0.0195487
ZBTB43 zinc finger and BTB domain containing 43 0.0194805
MLKL mixed lineage kinase domain-like 0.0194669
MYO1B myosin IB 0.0191581

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.183917
TIMP3 TIMP metallopeptidase inhibitor 3 -0.153575
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.114983
CD44 CD44 molecule (Indian blood group) -0.0925506
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0822337
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0799108
ASPH aspartate beta-hydroxylase -0.0792696
SLC35F3 solute carrier family 35, member F3 -0.0784283
MEF2A myocyte enhancer factor 2A -0.0728183
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.068368
EXT1 exostosin glycosyltransferase 1 -0.0635913
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0632198
LOC112694756 uncharaterized LOC112694756 -0.0621844
AOPEP aminopeptidase O (putative) -0.061428
DPYD dihydropyrimidine dehydrogenase -0.0612682
GRB10 growth factor receptor-bound protein 10 -0.0598421
HSPG2 heparan sulfate proteoglycan 2 -0.0596281
CEMIP cell migration inducing protein, hyaluronan binding -0.0584266
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0580969
KIAA1217 KIAA1217 -0.0562777
NRG1 neuregulin 1 -0.0559027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0558637
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0550381
PTMA prothymosin, alpha -0.0543552
RPS8 ribosomal protein S8 -0.0537246
SULF1 sulfatase 1 -0.0529926
FOXO1 forkhead box O1 -0.052197
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0502038
MECOM MDS1 and EVI1 complex locus -0.0491577
TMSB4X thymosin beta 4, X-linked -0.0485103
RPLP2 ribosomal protein, large, P2 -0.0482132
RPS6 ribosomal protein S6 -0.0478216
ITGA6 integrin, alpha 6 -0.0476955
PODXL podocalyxin-like -0.0471917
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0470153
MTSS1 metastasis suppressor 1 -0.0457405
NRIP1 nuclear receptor interacting protein 1 -0.045657
DOK5 docking protein 5 -0.0455328
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0450503
RAI14 retinoic acid induced 14 -0.0434416
SAMD9 sterile alpha motif domain containing 9 -0.0432337
RPLP1 ribosomal protein, large, P1 -0.0429703
GNAS GNAS complex locus -0.0425705
TPT1 tumor protein, translationally-controlled 1 -0.0424517
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0421981
DST dystonin -0.0417484
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.041733
RPL23 ribosomal protein L23 -0.0411187
RPL11 ribosomal protein L11 -0.041084
B2M beta-2-microglobulin -0.0410394
RPS21 ribosomal protein S21 -0.0406928
FLNB filamin B, beta -0.0402927
FTH1 ferritin, heavy polypeptide 1 -0.0401574
MYOF myoferlin -0.0400308
MACF1 microtubule-actin crosslinking factor 1 -0.0396834
SMAD3 SMAD family member 3 -0.0392783
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0388613
MYO10 myosin X -0.037069
RIGI RNA sensor RIG-I -0.0369288
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0368462
BMAL2 basic helix-loop-helix ARNT like 2 -0.0366373
PLEC plectin -0.0364014
RPL26 ribosomal protein L26 -0.0361576
BLCAP bladder cancer associated protein -0.0359114
CANX calnexin -0.0354096
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0351944
ARHGAP21 Rho GTPase activating protein 21 -0.0350705
SULF2 sulfatase 2 -0.0348469
SYNJ2 synaptojanin 2 -0.0347509
PSD3 pleckstrin and Sec7 domain containing 3 -0.0347503
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0347018
OSMR oncostatin M receptor -0.0345384
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.034463
RPL12 ribosomal protein L12 -0.0344014
IFITM3 interferon induced transmembrane protein 3 -0.0343492
AMOTL1 angiomotin like 1 -0.0340718
SQSTM1 sequestosome 1 -0.0340137
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0339905
RPL37 ribosomal protein L37 -0.033908
PRSS23 protease, serine, 23 -0.0338761
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0336685
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0335502
RPL30 ribosomal protein L30 -0.0334911
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0333677
RPL35A ribosomal protein L35a -0.0332891
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0332774
HLA-B major histocompatibility complex, class I, B -0.033003
GRK5 G protein-coupled receptor kinase 5 -0.0328624
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0328173
YBX1 Y box binding protein 1 -0.0327621
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0323934
MYH9 myosin, heavy chain 9, non-muscle -0.0318231
CMIP c-Maf inducing protein -0.0317895
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0316737
RPS19 ribosomal protein S19 -0.0315298
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0310447
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0310221
FRMD5 FERM domain containing 5 -0.0308734
TMSB10 thymosin beta 10 -0.0297048
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0296465