Dexamethasone_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0889093
EREG epiregulin 0.0598547
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0577228
ITGA6 integrin, alpha 6 0.0552654
UBC ubiquitin C 0.049406
LMO7 LIM domain 7 0.0482811
FAT1 FAT atypical cadherin 1 0.0473569
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0466546
PTEN phosphatase and tensin homolog 0.046001
BIRC6 baculoviral IAP repeat containing 6 0.0443617
AREG amphiregulin 0.0416404
EEF2 eukaryotic translation elongation factor 2 0.0377779
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0371129
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364095
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0359026
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0355656
KDM7A lysine (K)-specific demethylase 7A 0.0348427
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0341277
PTBP3 polypyrimidine tract binding protein 3 0.0332923
CSNK1A1 casein kinase 1, alpha 1 0.0330365
SHROOM3 shroom family member 3 0.032919
PTPRR protein tyrosine phosphatase, receptor type, R 0.0329157
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0322073
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0313089
GOLGA4 golgin A4 0.0310968
GDF15 growth differentiation factor 15 0.0308056
EHF ets homologous factor 0.0295567
OGA O-GlcNAcase 0.0295399
ITPRID2 ITPR interacting domain containing 2 0.0293396
FOS FBJ murine osteosarcoma viral oncogene homolog 0.029333
USP6NL USP6 N-terminal like 0.0290291
DSPP dentin sialophosphoprotein 0.028821
EIF4A2 eukaryotic translation initiation factor 4A2 0.0287518
TRIM2 tripartite motif containing 2 0.0287436
CSDE1 cold shock domain containing E1, RNA-binding 0.0280972
ANTXR2 anthrax toxin receptor 2 0.0275606
DENND4C DENN/MADD domain containing 4C 0.0268005
TBC1D5 TBC1 domain family, member 5 0.0263064
CDK19 cyclin-dependent kinase 19 0.0262307
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0261906
INSIG1 insulin induced gene 1 0.0260282
EZR ezrin 0.0250386
PLS1 plastin 1 0.0242154
SLK STE20-like kinase 0.0242022
DSCAM Down syndrome cell adhesion molecule 0.0235485
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0234868
EIF4B eukaryotic translation initiation factor 4B 0.0233782
ABHD2 abhydrolase domain containing 2 0.0231933
NCOR1 nuclear receptor corepressor 1 0.0228171
USP34 ubiquitin specific peptidase 34 0.0222739
RNF145 ring finger protein 145 0.021878
RHPN2 rhophilin, Rho GTPase binding protein 2 0.02173
TKT transketolase 0.0216268
PERP PERP, TP53 apoptosis effector 0.0216141
EXOC1 exocyst complex component 1 0.0215032
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0214691
ZFAND3 zinc finger, AN1-type domain 3 0.0211758
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.021169
NEK7 NIMA-related kinase 7 0.0211645
BPTF bromodomain PHD finger transcription factor 0.0210126
KDM2A lysine (K)-specific demethylase 2A 0.0209333
SET SET nuclear proto-oncogene 0.0208976
UBAC2 UBA domain containing 2 0.0208308
WAPL WAPL cohesin release factor 0.0207439
ARHGAP5 Rho GTPase activating protein 5 0.0205599
RNF43 ring finger protein 43 0.0205078
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0201208
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0199697
PDZD8 PDZ domain containing 8 0.0199297
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0197367
ZFC3H1 zinc finger, C3H1-type containing 0.0194978
AKAP9 A kinase (PRKA) anchor protein 9 0.0191786
BRWD1 bromodomain and WD repeat domain containing 1 0.0191509
KIF5B kinesin family member 5B 0.0190891
ANKRD17 ankyrin repeat domain 17 0.0190135
TGFBR3 transforming growth factor, beta receptor III 0.0187904
TAOK1 TAO kinase 1 0.018765
EMP1 epithelial membrane protein 1 0.0187647
EPS8 epidermal growth factor receptor pathway substrate 8 0.0187163
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0186637
CEP350 centrosomal protein 350kDa 0.0186041
SRRM1 serine/arginine repetitive matrix 1 0.0185348
ZNF638 zinc finger protein 638 0.0185326
USO1 USO1 vesicle transport factor 0.0184579
JMJD1C jumonji domain containing 1C 0.0184501
ANXA1 annexin A1 0.0184447
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.018399
RERE arginine-glutamic acid dipeptide (RE) repeats 0.018186
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0180831
PCBP2 poly(rC) binding protein 2 0.0179905
MON2 MON2 homolog (S. cerevisiae) 0.0179253
EPCAM epithelial cell adhesion molecule 0.0179194
SOX9 SRY (sex determining region Y)-box 9 0.0177828
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0177308
UBE2K ubiquitin-conjugating enzyme E2K 0.0175443
SNX13 sorting nexin 13 0.0173435
YME1L1 YME1-like 1 ATPase 0.0171818
PPARG peroxisome proliferator-activated receptor gamma 0.0171539
COG5 component of oligomeric golgi complex 5 0.017148
FOXO1 forkhead box O1 0.0171358

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.376148
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.208482
TMSB10 thymosin beta 10 -0.173767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119741
TPT1 tumor protein, translationally-controlled 1 -0.107982
RPS6 ribosomal protein S6 -0.102931
RPLP1 ribosomal protein, large, P1 -0.0962403
RPL35A ribosomal protein L35a -0.0912008
RPS8 ribosomal protein S8 -0.0795076
RPS19 ribosomal protein S19 -0.0738362
MT2A metallothionein 2A -0.0707169
GMDS GDP-mannose 4,6-dehydratase -0.0695904
NPSR1 neuropeptide S receptor 1 -0.067293
RPL34 ribosomal protein L34 -0.0669812
RPL36 ribosomal protein L36 -0.0666499
ACTG1 actin gamma 1 -0.0664048
VCL vinculin -0.0663607
RPL23 ribosomal protein L23 -0.0654332
NDRG1 N-myc downstream regulated 1 -0.0591194
RPL37A ribosomal protein L37a -0.0573088
RPL12 ribosomal protein L12 -0.0541498
FTH1 ferritin, heavy polypeptide 1 -0.0523953
ONECUT3 one cut homeobox 3 -0.0508537
RPL26 ribosomal protein L26 -0.0493754
AGR2 anterior gradient 2 -0.0447402
RPL11 ribosomal protein L11 -0.0439987
RPS12 ribosomal protein S12 -0.0434206
LAMA4 laminin, alpha 4 -0.0428098
RPS24 ribosomal protein S24 -0.0423566
LOC112694756 uncharaterized LOC112694756 -0.0417945
RPL9 ribosomal protein L9 -0.0416731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0415355
RPS27 ribosomal protein S27 -0.0395723
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0394112
RPS23 ribosomal protein S23 -0.0393748
PDE4D phosphodiesterase 4D, cAMP-specific -0.0390867
RPS2 ribosomal protein S2 -0.0375513
RPL13A ribosomal protein L13a -0.0374677
CALR calreticulin -0.0372243
RPS29 ribosomal protein S29 -0.0365796
RPL28 ribosomal protein L28 -0.0361102
RPL31 ribosomal protein L31 -0.0347559
RPS14 ribosomal protein S14 -0.0345447
TPM4 tropomyosin 4 -0.0329054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0327033
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0323719
RPL19 ribosomal protein L19 -0.0320665
RPS20 ribosomal protein S20 -0.0318158
SLC35F3 solute carrier family 35, member F3 -0.0317961
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0317515
PTMA prothymosin, alpha -0.031747
RPL32 ribosomal protein L32 -0.0314952
S100A10 S100 calcium binding protein A10 -0.0311651
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0310823
RPS25 ribosomal protein S25 -0.0310473
EXT1 exostosin glycosyltransferase 1 -0.0309988
FTL ferritin, light polypeptide -0.0307951
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0306838
RPS21 ribosomal protein S21 -0.0305079
RPLP2 ribosomal protein, large, P2 -0.029763
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0294154
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0292151
KLF5 Kruppel-like factor 5 (intestinal) -0.0289346
FHIT fragile histidine triad -0.0287587
LPP LIM domain containing preferred translocation partner in lipoma -0.028619
RPS17 ribosomal protein S17 -0.0284293
IER3 immediate early response 3 -0.0283626
RPL35 ribosomal protein L35 -0.027999
MT1E metallothionein 1E -0.0278928
RAD51B RAD51 paralog B -0.027851
RPS11 ribosomal protein S11 -0.0274549
YBX1 Y box binding protein 1 -0.0270669
ISG15 ISG15 ubiquitin-like modifier -0.0264966
MT1X metallothionein 1X -0.0261352
FLNB filamin B, beta -0.0249846
RPS16 ribosomal protein S16 -0.0249665
RPS10 ribosomal protein S10 -0.0248394
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0247903
RPL27 ribosomal protein L27 -0.0247292
EGFR epidermal growth factor receptor -0.023607
RPL30 ribosomal protein L30 -0.0234375
ANXA2 annexin A2 -0.0234035
GREB1L growth regulation by estrogen in breast cancer-like -0.0233974
RPS4X ribosomal protein S4, X-linked -0.0231886
DENND1A DENN/MADD domain containing 1A -0.0231612
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0229979
PALLD palladin, cytoskeletal associated protein -0.0229519
MAML3 mastermind-like 3 (Drosophila) -0.0229156
RPLP0 ribosomal protein, large, P0 -0.0228413
HMGB1 high mobility group box 1 -0.0224694
RAB1A RAB1A, member RAS oncogene family -0.0224126
RACK1 receptor for activated C kinase 1 -0.0222671
B2M beta-2-microglobulin -0.0219103
RPL38 ribosomal protein L38 -0.0215953
NALF1 NALCN channel auxiliary factor 1 -0.0215853
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0215225
RPL5 ribosomal protein L5 -0.0214322
PKM pyruvate kinase, muscle -0.0213644
SOX4 SRY (sex determining region Y)-box 4 -0.0210402
PTPRB protein tyrosine phosphatase, receptor type, B -0.0210343