Dexamethasone_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.188698
CAV1 caveolin 1, caveolae protein, 22kDa 0.162062
MT2A metallothionein 2A 0.150823
S100P S100 calcium binding protein P 0.13836
PDE4D phosphodiesterase 4D, cAMP-specific 0.123407
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.101601
MAP2K1 mitogen-activated protein kinase kinase 1 0.0934663
BIRC3 baculoviral IAP repeat containing 3 0.0819159
IRS2 insulin receptor substrate 2 0.0718425
TOP1 topoisomerase (DNA) I 0.0637066
TES testin LIM domain protein 0.0617034
MT1X metallothionein 1X 0.061324
CD109 CD109 molecule 0.061205
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.0606513
FRY furry homolog (Drosophila) 0.0592341
NAMPT nicotinamide phosphoribosyltransferase 0.0554458
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0544118
AHNAK AHNAK nucleoprotein 0.0524226
MCL1 myeloid cell leukemia 1 0.0497225
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0497178
ZFP36L1 ZFP36 ring finger protein-like 1 0.0491642
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0439601
RNF145 ring finger protein 145 0.0430448
ESYT2 extended synaptotagmin-like protein 2 0.0405513
MGST1 microsomal glutathione S-transferase 1 0.0397504
MLKL mixed lineage kinase domain-like 0.0380098
SPTSSA serine palmitoyltransferase, small subunit A 0.0366758
NEBL nebulette 0.0350939
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0327684
AKAP13 A kinase (PRKA) anchor protein 13 0.0319681
AKR1C1 aldo-keto reductase family 1, member C1 0.0295122
CES1 carboxylesterase 1 0.0284963
UVRAG UV radiation resistance associated 0.0282981
FKBP5 FK506 binding protein 5 0.0274336
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0274197
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0271862
IGF1R insulin-like growth factor 1 receptor 0.0262438
MKI67 marker of proliferation Ki-67 0.0260332
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0258844
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0258181
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0257084
SSBP2 single-stranded DNA binding protein 2 0.0250513
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0249349
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0247558
ARHGAP32 Rho GTPase activating protein 32 0.0247048
DNER delta/notch-like EGF repeat containing 0.0243315
JAK1 Janus kinase 1 0.0242787
MTSS1 metastasis suppressor 1 0.0242424
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0236273
CCNH cyclin H 0.0233716
DSPP dentin sialophosphoprotein 0.0231468
HELZ helicase with zinc finger 0.0230837
SOD2 superoxide dismutase 2, mitochondrial 0.0228154
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0222887
CALD1 caldesmon 1 0.0222301
RPS3 ribosomal protein S3 0.0221904
HOMER2 homer scaffolding protein 2 0.0219106
METTL9 methyltransferase like 9 0.0219053
ANXA1 annexin A1 0.0217748
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0216357
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0213479
ARGLU1 arginine and glutamate rich 1 0.0209226
AFF1 AF4/FMR2 family, member 1 0.0206798
ALCAM activated leukocyte cell adhesion molecule 0.0201359
EFNA5 ephrin-A5 0.0200193
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0198136
ERRFI1 ERBB receptor feedback inhibitor 1 0.0194428
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0192283
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0191652
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0190512
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.01903
MCTP1 multiple C2 domains, transmembrane 1 0.0188755
ITPKC inositol-trisphosphate 3-kinase C 0.0186797
HIP1 huntingtin interacting protein 1 0.0186621
UBC ubiquitin C 0.018641
GCLC glutamate-cysteine ligase, catalytic subunit 0.0186229
RNF149 ring finger protein 149 0.0186065
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0186061
EPAS1 endothelial PAS domain protein 1 0.0185847
CLMN calmin (calponin-like, transmembrane) 0.0182291
GADD45A growth arrest and DNA-damage-inducible, alpha 0.017931
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0179008
CAPRIN2 caprin family member 2 0.0178953
MAML3 mastermind-like 3 (Drosophila) 0.0177099
MACF1 microtubule-actin crosslinking factor 1 0.0175142
NPHP3 nephronophthisis 3 (adolescent) 0.0173369
USP47 ubiquitin specific peptidase 47 0.0172989
YAP1 Yes-associated protein 1 0.0168529
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0165429
TP53BP2 tumor protein p53 binding protein 2 0.0160811
SOS1 son of sevenless homolog 1 (Drosophila) 0.0159367
DGKH diacylglycerol kinase, eta 0.0158032
CYRIB CYFIP related Rac1 interactor B 0.0157757
SNED1 sushi, nidogen and EGF-like domains 1 0.0155303
ANXA2 annexin A2 0.0154838
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.01545
SQOR sulfide quinone oxidoreductase 0.0153594
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0150869
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0150591
TRIM29 tripartite motif containing 29 0.0150526

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.375289
EGFR epidermal growth factor receptor -0.279832
ASPH aspartate beta-hydroxylase -0.204258
TXNRD1 thioredoxin reductase 1 -0.191782
NDRG1 N-myc downstream regulated 1 -0.159304
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.113999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101177
PKM pyruvate kinase, muscle -0.0937742
PTPRM protein tyrosine phosphatase, receptor type, M -0.0889754
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0821449
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0763528
LAMC2 laminin, gamma 2 -0.0733862
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0730442
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.072749
IGFBP3 insulin-like growth factor binding protein 3 -0.0714402
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0699727
LRP1B low density lipoprotein receptor-related protein 1B -0.0693189
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0672408
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0638433
STC1 stanniocalcin 1 -0.0618777
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0592032
TMSB10 thymosin beta 10 -0.0584561
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.058309
THSD4 thrombospondin, type I, domain containing 4 -0.0580695
ACTG1 actin gamma 1 -0.0574884
SLTM SAFB-like, transcription modulator -0.0524511
FNDC3B fibronectin type III domain containing 3B -0.0520918
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0497382
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0484514
LMO7 LIM domain 7 -0.0475546
LOC112694756 uncharaterized LOC112694756 -0.046303
RAB27B RAB27B, member RAS oncogene family -0.0459252
GRAMD1B GRAM domain containing 1B -0.0446291
SAMD4A sterile alpha motif domain containing 4A -0.0435893
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0419408
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0413227
RNF213 ring finger protein 213 -0.040741
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0404798
PATJ PATJ crumbs cell polarity complex component -0.0396984
GSK3B glycogen synthase kinase 3 beta -0.039018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0388189
CDCP1 CUB domain containing protein 1 -0.0385145
OSMR oncostatin M receptor -0.0381747
NGLY1 N-glycanase 1 -0.038151
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0379682
IGFBP5 insulin-like growth factor binding protein 5 -0.0376798
GRB10 growth factor receptor-bound protein 10 -0.0369901
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0358832
DSCAM Down syndrome cell adhesion molecule -0.0343768
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.034344
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0337135
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0334446
ABLIM1 actin binding LIM protein 1 -0.0330243
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0329012
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0326045
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0323297
EXT1 exostosin glycosyltransferase 1 -0.0309548
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308243
PDE8A phosphodiesterase 8A -0.030469
ARRDC3 arrestin domain containing 3 -0.0300999
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0300316
PDLIM5 PDZ and LIM domain 5 -0.0296058
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0294412
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.029402
RIN2 Ras and Rab interactor 2 -0.0293991
KMT2E lysine (K)-specific methyltransferase 2E -0.0291129
NPAS2 neuronal PAS domain protein 2 -0.029069
EGR1 early growth response 1 -0.0288052
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0286819
SMAD3 SMAD family member 3 -0.0285638
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0277231
PTMA prothymosin, alpha -0.0268351
MAP7 microtubule-associated protein 7 -0.0267184
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0257549
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0252286
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0251758
KRT18 keratin 18, type I -0.0249051
TRAPPC9 trafficking protein particle complex 9 -0.0247748
HMGA1 high mobility group AT-hook 1 -0.0244378
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0242215
SEC61G Sec61 gamma subunit -0.0241481
CEMIP cell migration inducing protein, hyaluronan binding -0.0239689
NBEAL1 neurobeachin-like 1 -0.0237533
BIRC6 baculoviral IAP repeat containing 6 -0.0234526
ZBTB20 zinc finger and BTB domain containing 20 -0.0229923
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0228897
RIMS2 regulating synaptic membrane exocytosis 2 -0.0223331
PTK2 protein tyrosine kinase 2 -0.0219826
TBC1D22A TBC1 domain family, member 22A -0.0218021
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0216526
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0215485
AHR aryl hydrocarbon receptor -0.0212128
BMP7 bone morphogenetic protein 7 -0.0212071
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0211602
ADGRF1 adhesion G protein-coupled receptor F1 -0.0210059
ZMYM2 zinc finger, MYM-type 2 -0.0208677
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0208552
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0208485
BTG1 B-cell translocation gene 1, anti-proliferative -0.0205792
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0205293