Dexamethasone_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.521266
MT2A metallothionein 2A 0.233302
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.201187
ANKRD28 ankyrin repeat domain 28 0.118289
FKBP5 FK506 binding protein 5 0.116808
FN1 fibronectin 1 0.115173
HIPK2 homeodomain interacting protein kinase 2 0.113241
IRAK3 interleukin-1 receptor-associated kinase 3 0.112898
HMGA2 high mobility group AT-hook 2 0.112092
NAMPT nicotinamide phosphoribosyltransferase 0.0931076
UGP2 UDP-glucose pyrophosphorylase 2 0.0907054
NRCAM neuronal cell adhesion molecule 0.0853323
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0754921
TOP1 topoisomerase (DNA) I 0.074974
MT1X metallothionein 1X 0.0702951
ZMYND8 zinc finger, MYND-type containing 8 0.0641069
SORBS2 sorbin and SH3 domain containing 2 0.0635725
USP34 ubiquitin specific peptidase 34 0.0632035
PID1 phosphotyrosine interaction domain containing 1 0.0618279
TSC22D3 TSC22 domain family, member 3 0.0608493
MBNL1 muscleblind-like splicing regulator 1 0.0605147
TGM2 transglutaminase 2 0.0602594
LOX lysyl oxidase 0.0592414
SOD2 superoxide dismutase 2, mitochondrial 0.0576531
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0569968
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0567985
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0537942
AHNAK AHNAK nucleoprotein 0.0519016
NRG1 neuregulin 1 0.0514089
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0512437
ERRFI1 ERBB receptor feedback inhibitor 1 0.0503132
ANGPTL4 angiopoietin-like 4 0.0498974
PCNX1 pecanex 1 0.0482708
ZC3H12C zinc finger CCCH-type containing 12C 0.0474075
ESYT2 extended synaptotagmin-like protein 2 0.047143
ZFP36L1 ZFP36 ring finger protein-like 1 0.0468288
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0458039
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0450582
DNER delta/notch-like EGF repeat containing 0.0437831
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0433998
DPYD dihydropyrimidine dehydrogenase 0.043286
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0431809
EPS8 epidermal growth factor receptor pathway substrate 8 0.0423295
IL6ST interleukin 6 signal transducer 0.0420519
GPC6 glypican 6 0.0420051
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.041886
SH3RF3 SH3 domain containing ring finger 3 0.0418026
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0414517
CLMP CXADR-like membrane protein 0.0400683
ZFHX3 zinc finger homeobox 3 0.0398883
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0397588
BIRC3 baculoviral IAP repeat containing 3 0.038959
ZBTB16 zinc finger and BTB domain containing 16 0.0382977
TPST1 tyrosylprotein sulfotransferase 1 0.0379692
TRIO trio Rho guanine nucleotide exchange factor 0.0374101
TLR2 toll-like receptor 2 0.0370071
TMSB10 thymosin beta 10 0.0369095
NEBL nebulette 0.0364839
MYO1E myosin IE 0.0361325
DCN decorin 0.0353692
ZHX3 zinc fingers and homeoboxes 3 0.0352409
CD109 CD109 molecule 0.0344216
IRS2 insulin receptor substrate 2 0.033565
ABLIM3 actin binding LIM protein family, member 3 0.0333973
MYOF myoferlin 0.0330137
JAK1 Janus kinase 1 0.0306259
PNRC1 proline-rich nuclear receptor coactivator 1 0.0301301
PELI1 pellino E3 ubiquitin protein ligase 1 0.0297137
SRGN serglycin 0.0290823
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0287479
SECISBP2L SECIS binding protein 2-like 0.0280009
NNMT nicotinamide N-methyltransferase 0.0277498
RPGR retinitis pigmentosa GTPase regulator 0.0277477
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0268582
PHF20 PHD finger protein 20 0.0268492
IL18R1 interleukin 18 receptor 1 0.026809
RAD51B RAD51 paralog B 0.0265834
METAP2 methionyl aminopeptidase 2 0.0265146
SLC38A1 solute carrier family 38, member 1 0.0263195
SLC38A2 solute carrier family 38, member 2 0.025562
LDHA lactate dehydrogenase A 0.0250581
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0248031
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0246583
TXNIP thioredoxin interacting protein 0.0243691
SSBP2 single-stranded DNA binding protein 2 0.0241697
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0240754
COPS8 COP9 signalosome subunit 8 0.02405
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0238407
ITGA10 integrin, alpha 10 0.023562
CUL4B cullin 4B 0.0234449
PRELID2 PRELI domain containing 2 0.0233465
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.023039
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0228291
PLIN2 perilipin 2 0.0228006
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0226693
ELL2 elongation factor, RNA polymerase II, 2 0.0221406
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0221186
ZMYND11 zinc finger, MYND-type containing 11 0.0219785
ALCAM activated leukocyte cell adhesion molecule 0.0214189
RTN4 reticulon 4 0.0214049

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.136036
FNDC3B fibronectin type III domain containing 3B -0.10628
GRB10 growth factor receptor-bound protein 10 -0.105229
PDE4D phosphodiesterase 4D, cAMP-specific -0.1046
CD44 CD44 molecule (Indian blood group) -0.0996691
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.09847
IGFBP3 insulin-like growth factor binding protein 3 -0.0953724
SMAD3 SMAD family member 3 -0.0786645
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.072111
NDRG1 N-myc downstream regulated 1 -0.0629136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0628403
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0606859
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0601448
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.057047
STC1 stanniocalcin 1 -0.0557559
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0531082
EXT1 exostosin glycosyltransferase 1 -0.0529612
CDCP1 CUB domain containing protein 1 -0.0506202
ETV6 ets variant 6 -0.0486592
FAM107B family with sequence similarity 107, member B -0.047397
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0460945
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0444915
DLG1 discs, large homolog 1 (Drosophila) -0.0432536
GLCCI1 glucocorticoid induced 1 -0.0432288
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0429701
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0393289
MRPS6 mitochondrial ribosomal protein S6 -0.039061
PSD3 pleckstrin and Sec7 domain containing 3 -0.0379828
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0376031
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0366717
ANTXR2 anthrax toxin receptor 2 -0.0358898
NCOA7 nuclear receptor coactivator 7 -0.0358139
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0357869
VEGFA vascular endothelial growth factor A -0.035473
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.035144
C15ORF48 chromosome 15 open reading frame 48 -0.0338434
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0336037
IER3 immediate early response 3 -0.0324427
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0322827
LRRC49 leucine rich repeat containing 49 -0.0322515
ATXN1 ataxin 1 -0.0313667
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0311044
HDAC9 histone deacetylase 9 -0.0310015
MEF2A myocyte enhancer factor 2A -0.0306744
NAV2 neuron navigator 2 -0.0304966
NRP1 neuropilin 1 -0.030306
RAP1B RAP1B, member of RAS oncogene family -0.0301155
DPYSL3 dihydropyrimidinase-like 3 -0.0290335
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0288723
ATP13A3 ATPase type 13A3 -0.0287923
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0283638
MAP1B microtubule-associated protein 1B -0.0278056
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.027531
RUNX1 runt-related transcription factor 1 -0.0274184
OSMR oncostatin M receptor -0.0273686
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0273507
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.027307
LIMCH1 LIM and calponin homology domains 1 -0.0269402
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0267102
SIK3 SIK family kinase 3 -0.0259681
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0258759
PCBP2 poly(rC) binding protein 2 -0.0257982
FRMD4A FERM domain containing 4A -0.0255472
SYNJ2 synaptojanin 2 -0.0253874
ADD3 adducin 3 (gamma) -0.0252154
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0249854
FNBP1 formin binding protein 1 -0.0249659
AOPEP aminopeptidase O (putative) -0.0247423
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0243865
VEGFC vascular endothelial growth factor C -0.0243668
FRMD5 FERM domain containing 5 -0.0243148
BHLHE40 basic helix-loop-helix family, member e40 -0.0242825
LOXL2 lysyl oxidase-like 2 -0.0242617
FAM3C family with sequence similarity 3, member C -0.0240136
ECE1 endothelin converting enzyme 1 -0.0239794
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0238925
SHB Src homology 2 domain containing adaptor protein B -0.0232951
ARHGAP42 Rho GTPase activating protein 42 -0.0230488
HMGA1 high mobility group AT-hook 1 -0.0228629
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0228428
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0227557
BMAL2 basic helix-loop-helix ARNT like 2 -0.0227045
USP3 ubiquitin specific peptidase 3 -0.0225536
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0221218
AHR aryl hydrocarbon receptor -0.0219844
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0218627
KIAA1217 KIAA1217 -0.0218596
RAI14 retinoic acid induced 14 -0.0218426
EGFR epidermal growth factor receptor -0.0215832
TNNC1 troponin C type 1 (slow) -0.0215327
OPTN optineurin -0.0213232
SYT1 synaptotagmin I -0.0212982
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0211128
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0209126
SNX9 sorting nexin 9 -0.0208001
PDE8A phosphodiesterase 8A -0.0206118
CREB5 cAMP responsive element binding protein 5 -0.0205281
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0204299
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0200999
VIM vimentin -0.0200173