Dexamethasone_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

130 genes differentially expressed following the Dexamethasone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.166987
VIM vimentin 0.119188
CCNI cyclin I 0.113696
FN1 fibronectin 1 0.112377
AKAP12 A kinase (PRKA) anchor protein 12 0.106864
PDE4D phosphodiesterase 4D, cAMP-specific 0.0949246
IRS2 insulin receptor substrate 2 0.0790983
RPS6 ribosomal protein S6 0.0779236
ENO1 enolase 1, (alpha) 0.0751519
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0745298
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0729745
RPL23 ribosomal protein L23 0.0671437
FMN1 formin 1 0.0662548
PDE10A phosphodiesterase 10A 0.0650118
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0619293
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0610059
ELL2 elongation factor, RNA polymerase II, 2 0.0607586
NDRG1 N-myc downstream regulated 1 0.0605503
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0575958
NCOA3 nuclear receptor coactivator 3 0.0556248
USP47 ubiquitin specific peptidase 47 0.0492428
HELZ helicase with zinc finger 0.048769
PRRC2C proline-rich coiled-coil 2C 0.0472931
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0466215
TSC22D2 TSC22 domain family, member 2 0.046075
FRMD4A FERM domain containing 4A 0.0450864
KMT2E lysine (K)-specific methyltransferase 2E 0.0435783
CSNK1A1 casein kinase 1, alpha 1 0.0428995
ACTG1 actin gamma 1 0.0422488
ANXA2 annexin A2 0.0412747
PTMA prothymosin, alpha 0.0393902
PM20D1 peptidase M20 domain containing 1 0.0370935
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0357359
EFNA5 ephrin-A5 0.0352776
FLNB filamin B, beta 0.0349404
ZMYND8 zinc finger, MYND-type containing 8 0.0347167
GPC6 glypican 6 0.03368
ANKRD11 ankyrin repeat domain 11 0.0332828
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0318325
ZNF292 zinc finger protein 292 0.0309938
KMT2C lysine (K)-specific methyltransferase 2C 0.028867
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0284055
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0255539
LIMCH1 LIM and calponin homology domains 1 0.0252977
EIF1 eukaryotic translation initiation factor 1 0.0250412
PGK1 phosphoglycerate kinase 1 0.0249511
TMSB10 thymosin beta 10 0.0249229
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0241252
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0229292
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0215323
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0197614
TTC17 tetratricopeptide repeat domain 17 0.0182531
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0167013
SPAG9 sperm associated antigen 9 0.0160701
NAP1L1 nucleosome assembly protein 1-like 1 0.0153246
MCL1 myeloid cell leukemia 1 0.0147807
GOLGA4 golgin A4 0.0147354
BHLHE40 basic helix-loop-helix family, member e40 0.0144563
EPS8 epidermal growth factor receptor pathway substrate 8 0.0142316
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0113805
CEP350 centrosomal protein 350kDa 0.0109555
ATXN1 ataxin 1 0.0105722
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00956383
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00934312
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00926471
JMJD1C jumonji domain containing 1C 0.0081338
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.00757229
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.00681309
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.00339996
FNDC3B fibronectin type III domain containing 3B 0.00296578
RPS12 ribosomal protein S12 0.00229173
MED13L mediator complex subunit 13-like 0.00213988
FTL ferritin, light polypeptide 0.00196512
DOCK4 dedicator of cytokinesis 4 3.94874E-4

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.354648
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.205227
NKD1 naked cuticle homolog 1 (Drosophila) -0.176322
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.171449
MAML2 mastermind-like 2 (Drosophila) -0.134346
NAV2 neuron navigator 2 -0.127549
INTS6 integrator complex subunit 6 -0.114059
HMGA2 high mobility group AT-hook 2 -0.109544
SYT1 synaptotagmin I -0.0955409
EXT1 exostosin glycosyltransferase 1 -0.08921
CMIP c-Maf inducing protein -0.0838413
TRIO trio Rho guanine nucleotide exchange factor -0.081892
ZBTB20 zinc finger and BTB domain containing 20 -0.0797489
ASPH aspartate beta-hydroxylase -0.0779464
TBC1D22A TBC1 domain family, member 22A -0.0760186
VCL vinculin -0.0747421
RABGAP1L RAB GTPase activating protein 1-like -0.0700047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0670204
CDH13 cadherin 13 -0.0651244
CARD16 caspase recruitment domain family, member 16 -0.0635351
MYO1E myosin IE -0.0630229
IGFBP3 insulin-like growth factor binding protein 3 -0.0620502
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0601185
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0591352
MBD5 methyl-CpG binding domain protein 5 -0.0577626
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0527581
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0499013
SLC38A2 solute carrier family 38, member 2 -0.0496351
AHNAK AHNAK nucleoprotein -0.043076
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0394461
AKAP9 A kinase (PRKA) anchor protein 9 -0.0386571
TPT1 tumor protein, translationally-controlled 1 -0.038422
RPS25 ribosomal protein S25 -0.0362043
RPS8 ribosomal protein S8 -0.0348619
PSD3 pleckstrin and Sec7 domain containing 3 -0.0310532
MT2A metallothionein 2A -0.0245955
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0237514
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0234929
RUNX1 runt-related transcription factor 1 -0.0219292
LDHA lactate dehydrogenase A -0.0200937
AKAP13 A kinase (PRKA) anchor protein 13 -0.0190876
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0188968
DSCAM Down syndrome cell adhesion molecule -0.0168531
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0166347
SMYD3 SET and MYND domain containing 3 -0.0163649
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0137198
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0122806
GOLGB1 golgin B1 -0.00775441
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00735426
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.00617309
FAF1 Fas (TNFRSF6) associated factor 1 -0.00601984
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00544826
RPS19 ribosomal protein S19 -0.00429675
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00174872
NALF1 NALCN channel auxiliary factor 1 -6.26217E-4
STC1 stanniocalcin 1 -3.51645E-4