Dexamethasone_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.212371
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0822573
ENO1 enolase 1, (alpha) 0.0806254
TPT1 tumor protein, translationally-controlled 1 0.0787458
ADAM10 ADAM metallopeptidase domain 10 0.0787297
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0735538
ARL4C ADP-ribosylation factor-like 4C 0.0733119
MKI67 marker of proliferation Ki-67 0.0725233
TMSB4X thymosin beta 4, X-linked 0.0696315
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0689564
CENPF centromere protein F, 350/400kDa 0.0685747
PRELID2 PRELI domain containing 2 0.0683011
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0632354
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0569812
HJURP Holliday junction recognition protein 0.0561777
VCL vinculin 0.0554187
KIF5B kinesin family member 5B 0.0510661
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0507521
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0495173
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0492766
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0489766
DUSP6 dual specificity phosphatase 6 0.048126
EIF4A2 eukaryotic translation initiation factor 4A2 0.0455907
SMC4 structural maintenance of chromosomes 4 0.0445936
RPS12 ribosomal protein S12 0.0439961
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0433718
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0429076
USP34 ubiquitin specific peptidase 34 0.0428168
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0423699
SQSTM1 sequestosome 1 0.0420309
FAF1 Fas (TNFRSF6) associated factor 1 0.0417916
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.039912
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0396664
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0394713
TPX2 TPX2, microtubule-associated 0.0385515
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0379222
RPS8 ribosomal protein S8 0.0376518
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0364301
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0362558
PNISR PNN-interacting serine/arginine-rich protein 0.036192
EEF2 eukaryotic translation elongation factor 2 0.0349799
FHIT fragile histidine triad 0.0349301
CCND1 cyclin D1 0.0348861
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0347891
TAS2R14 taste receptor, type 2, member 14 0.0339676
CLIP1 CAP-GLY domain containing linker protein 1 0.0333004
RPL12 ribosomal protein L12 0.0326627
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0317964
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0317884
RPL32 ribosomal protein L32 0.0315639
DIAPH3 diaphanous-related formin 3 0.031515
CKAP2 cytoskeleton associated protein 2 0.0314755
NSD2 nuclear receptor binding SET domain protein 2 0.0313536
RPL7 ribosomal protein L7 0.0312999
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0311699
NIPBL Nipped-B homolog (Drosophila) 0.0308828
DARS1 aspartyl-tRNA synthetase 1 0.0306026
AHNAK AHNAK nucleoprotein 0.0305945
NAP1L1 nucleosome assembly protein 1-like 1 0.0301813
YEATS2 YEATS domain containing 2 0.030014
OSBPL8 oxysterol binding protein-like 8 0.0293349
CANX calnexin 0.0291119
RBM25 RNA binding motif protein 25 0.0286446
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0285414
ATM ATM serine/threonine kinase 0.0273348
NAV2 neuron navigator 2 0.0270343
RPL11 ribosomal protein L11 0.0264003
CCNI cyclin I 0.0261342
BRWD1 bromodomain and WD repeat domain containing 1 0.0258087
PSIP1 PC4 and SFRS1 interacting protein 1 0.0255491
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0254868
MT2A metallothionein 2A 0.0253021
RNF24 ring finger protein 24 0.0251489
ANKRD12 ankyrin repeat domain 12 0.0250388
LARS1 leucyl-tRNA synthetase 1 0.0248629
FCHO2 FCH domain only 2 0.0247755
RSL1D1 ribosomal L1 domain containing 1 0.024727
FNIP1 folliculin interacting protein 1 0.0247187
SMYD3 SET and MYND domain containing 3 0.0246868
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0246362
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.024617
TMEM14B transmembrane protein 14B 0.0246135
SUGP2 SURP and G patch domain containing 2 0.0244897
WSB1 WD repeat and SOCS box containing 1 0.0244034
TPM4 tropomyosin 4 0.0243778
SERBP1 SERPINE1 mRNA binding protein 1 0.0243401
CRYBG3 beta-gamma crystallin domain containing 3 0.0242432
EXOC1 exocyst complex component 1 0.0241248
MAP2K5 mitogen-activated protein kinase kinase 5 0.0239377
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236592
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.023361
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0233488
RPS3 ribosomal protein S3 0.0232283
EZR ezrin 0.0231
GAS2L3 growth arrest-specific 2 like 3 0.0230559
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0230493
ANKRD36 ankyrin repeat domain 36 0.022873
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0228532
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0228504
VDAC1 voltage-dependent anion channel 1 0.0225848

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0993683
SSBP2 single-stranded DNA binding protein 2 -0.0984904
PDE4D phosphodiesterase 4D, cAMP-specific -0.0949381
EGFR epidermal growth factor receptor -0.0924684
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0868456
ZFAND3 zinc finger, AN1-type domain 3 -0.0850509
HDAC9 histone deacetylase 9 -0.0740423
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0739749
PKM pyruvate kinase, muscle -0.070581
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0655496
LOC112694756 uncharaterized LOC112694756 -0.0635445
RTN4 reticulon 4 -0.060756
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0602791
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0574828
FNDC3B fibronectin type III domain containing 3B -0.0509066
ANKRD11 ankyrin repeat domain 11 -0.0500382
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.04962
PDGFC platelet derived growth factor C -0.0492862
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0482796
CCNL1 cyclin L1 -0.0466116
IARS1 isoleucyl-tRNA synthetase 1 -0.0465969
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0439542
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0438151
GLI2 GLI family zinc finger 2 -0.043367
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0431605
NCEH1 neutral cholesterol ester hydrolase 1 -0.0431604
DSCAM Down syndrome cell adhesion molecule -0.0421969
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0419813
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0418591
MSI2 musashi RNA-binding protein 2 -0.0408951
JMJD1C jumonji domain containing 1C -0.0401808
PARD3 par-3 family cell polarity regulator -0.0398845
RIGI RNA sensor RIG-I -0.0397245
SP100 SP100 nuclear antigen -0.0392989
NUP58 nucleoporin 58 -0.037895
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0366375
VMP1 vacuole membrane protein 1 -0.0363379
EXT1 exostosin glycosyltransferase 1 -0.035202
GLI3 GLI family zinc finger 3 -0.0351081
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0350036
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0348468
TJP1 tight junction protein 1 -0.0342595
NPAS2 neuronal PAS domain protein 2 -0.034108
ECT2 epithelial cell transforming 2 -0.0338783
MLIP muscular LMNA-interacting protein -0.0336884
EEF1G eukaryotic translation elongation factor 1 gamma -0.0333645
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0330661
YAP1 Yes-associated protein 1 -0.032899
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0326099
WDR43 WD repeat domain 43 -0.032466
ZNF207 zinc finger protein 207 -0.032327
MEMO1 mediator of cell motility 1 -0.0321224
PCBP2 poly(rC) binding protein 2 -0.0319415
RPL13A ribosomal protein L13a -0.0318103
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0317939
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0317406
NCKAP1 NCK-associated protein 1 -0.0308746
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0305205
BTBD9 BTB (POZ) domain containing 9 -0.0304478
DLG1 discs, large homolog 1 (Drosophila) -0.0300603
POTEF POTE ankyrin domain family, member F -0.0299613
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0299396
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.029893
QKI QKI, KH domain containing, RNA binding -0.0298789
CHD1 chromodomain helicase DNA binding protein 1 -0.0295991
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0294244
ETNK1 ethanolamine kinase 1 -0.0294197
LDHA lactate dehydrogenase A -0.0291245
SREBF2 sterol regulatory element binding transcription factor 2 -0.0288761
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0287912
CUL3 cullin 3 -0.0285636
PLSCR1 phospholipid scramblase 1 -0.0279189
AZIN1 antizyme inhibitor 1 -0.0277496
ZEB1 zinc finger E-box binding homeobox 1 -0.0274432
SRRM2 serine/arginine repetitive matrix 2 -0.0274354
SPRY4 sprouty homolog 4 (Drosophila) -0.0272957
ARHGAP25 Rho GTPase activating protein 25 -0.027245
RBM39 RNA binding motif protein 39 -0.0271683
USP47 ubiquitin specific peptidase 47 -0.026792
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0265741
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0265367
ASXL1 additional sex combs like transcriptional regulator 1 -0.0261924
RHOA ras homolog family member A -0.0258679
IFI6 interferon, alpha-inducible protein 6 -0.0256226
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0255034
PDIA3 protein disulfide isomerase family A, member 3 -0.025265
EIF5 eukaryotic translation initiation factor 5 -0.0250942
YBX1 Y box binding protein 1 -0.0248776
PIWIL1 piwi-like RNA-mediated gene silencing 1 -0.024839
ZNF292 zinc finger protein 292 -0.0248317
CSF1 colony stimulating factor 1 (macrophage) -0.0247077
ZNF438 zinc finger protein 438 -0.0245233
ZNF644 zinc finger protein 644 -0.0244283
WAC WW domain containing adaptor with coiled-coil -0.0242123
NT5C2 5'-nucleotidase, cytosolic II -0.0239376
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0238575
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0238305
TAPBP TAP binding protein (tapasin) -0.0237891
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.023624
TFG TRK-fused gene -0.0235436