Dexamethasone_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexamethasone perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexamethasone_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.177702
FN1 fibronectin 1 0.14315
AKAP12 A kinase (PRKA) anchor protein 12 0.138848
HMGA2 high mobility group AT-hook 2 0.135524
IRAK3 interleukin-1 receptor-associated kinase 3 0.102354
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0893804
SAMD4A sterile alpha motif domain containing 4A 0.0889796
FKBP5 FK506 binding protein 5 0.0888305
MT2A metallothionein 2A 0.0821687
ERRFI1 ERBB receptor feedback inhibitor 1 0.0783271
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0770303
GLUL glutamate-ammonia ligase 0.075309
TXNIP thioredoxin interacting protein 0.070024
HIPK2 homeodomain interacting protein kinase 2 0.0662941
ITGA1 integrin, alpha 1 0.0660548
EFNA5 ephrin-A5 0.0652309
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0607579
PRELID2 PRELI domain containing 2 0.0593225
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0582141
HOMER2 homer scaffolding protein 2 0.0542942
MBNL1 muscleblind-like splicing regulator 1 0.0524824
IRS2 insulin receptor substrate 2 0.0521901
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0518777
ASPH aspartate beta-hydroxylase 0.0497394
VCL vinculin 0.0491004
SLC38A2 solute carrier family 38, member 2 0.0488293
MT1X metallothionein 1X 0.0480473
ACTG1 actin gamma 1 0.0480312
IL6ST interleukin 6 signal transducer 0.0469092
NAMPT nicotinamide phosphoribosyltransferase 0.0467061
FRY furry homolog (Drosophila) 0.046262
ZFP36L1 ZFP36 ring finger protein-like 1 0.0459747
DPYD dihydropyrimidine dehydrogenase 0.0457345
BIRC3 baculoviral IAP repeat containing 3 0.0450763
ZMYND8 zinc finger, MYND-type containing 8 0.043515
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0430671
LOC102724023 ES1 protein homolog, mitochondrial 0.0424997
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0420736
JAK2 Janus kinase 2 0.0418771
ETV1 ets variant 1 0.0397019
FBXO32 F-box protein 32 0.0387703
MCL1 myeloid cell leukemia 1 0.0385778
POTEF POTE ankyrin domain family, member F 0.0363919
TNS3 tensin 3 0.0352289
PLIN2 perilipin 2 0.034921
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0347678
PALLD palladin, cytoskeletal associated protein 0.0340818
TOP1 topoisomerase (DNA) I 0.0337545
AREG amphiregulin 0.0327927
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0325781
TMSB10 thymosin beta 10 0.0322299
PTMA prothymosin, alpha 0.0315917
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0309253
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.03062
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0303717
TGFB2 transforming growth factor, beta 2 0.0299962
LIMCH1 LIM and calponin homology domains 1 0.0298624
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0297144
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0294489
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.029338
ZBTB16 zinc finger and BTB domain containing 16 0.0287207
DOCK5 dedicator of cytokinesis 5 0.0285704
S100A6 S100 calcium binding protein A6 0.0284248
DUSP6 dual specificity phosphatase 6 0.0283991
ENO2 enolase 2 (gamma, neuronal) 0.0283167
TMEM156 transmembrane protein 156 0.0281523
ENO1 enolase 1, (alpha) 0.0279757
OXR1 oxidation resistance 1 0.0271783
AEBP2 AE binding protein 2 0.0258717
EGR1 early growth response 1 0.0252937
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0247834
EPS8 epidermal growth factor receptor pathway substrate 8 0.024727
TMEM165 transmembrane protein 165 0.024163
CCND3 cyclin D3 0.0234769
PKP2 plakophilin 2 0.0233488
ENAH enabled homolog (Drosophila) 0.0232247
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0230958
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0230366
TAS2R14 taste receptor, type 2, member 14 0.0226299
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0225035
IFI27 interferon, alpha-inducible protein 27 0.0224576
TGM2 transglutaminase 2 0.0222269
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0220273
STC2 stanniocalcin 2 0.0220196
GHR growth hormone receptor 0.0218428
GPC6 glypican 6 0.0218235
MAML2 mastermind-like 2 (Drosophila) 0.0216189
MT1E metallothionein 1E 0.0211219
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0210812
STK39 serine threonine kinase 39 0.0208049
ZC3H12C zinc finger CCCH-type containing 12C 0.0204073
PTPRD protein tyrosine phosphatase, receptor type, D 0.0200822
LOX lysyl oxidase 0.0199711
SDK1 sidekick cell adhesion molecule 1 0.0198852
TPCN1 two pore segment channel 1 0.0194803
TSC22D3 TSC22 domain family, member 3 0.0193289
ELOVL6 ELOVL fatty acid elongase 6 0.0189408
STOM stomatin 0.0187101
IGFBP5 insulin-like growth factor binding protein 5 0.0183814
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0180123

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.224532
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196242
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126735
CXCL8 chemokine (C-X-C motif) ligand 8 -0.119868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115068
SQSTM1 sequestosome 1 -0.0892488
EXT1 exostosin glycosyltransferase 1 -0.0854844
CANX calnexin -0.0817989
TRIO trio Rho guanine nucleotide exchange factor -0.0808519
AHR aryl hydrocarbon receptor -0.080596
FTH1 ferritin, heavy polypeptide 1 -0.0757376
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0728466
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0720282
SMAD3 SMAD family member 3 -0.0530395
MCTP2 multiple C2 domains, transmembrane 2 -0.0524323
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.05183
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0489372
MAP1B microtubule-associated protein 1B -0.0479743
CD44 CD44 molecule (Indian blood group) -0.045865
FNBP1 formin binding protein 1 -0.0443285
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0441003
SUCO SUN domain containing ossification factor -0.0436357
RBM39 RNA binding motif protein 39 -0.0421837
DST dystonin -0.0407116
CDC73 cell division cycle 73 -0.0401503
SPAG9 sperm associated antigen 9 -0.0394635
FNDC3B fibronectin type III domain containing 3B -0.0391547
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0384966
NDRG1 N-myc downstream regulated 1 -0.0374254
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0369868
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0369697
RPL26 ribosomal protein L26 -0.0369595
PTBP3 polypyrimidine tract binding protein 3 -0.0363539
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0353277
LOC112694756 uncharaterized LOC112694756 -0.0352494
COG5 component of oligomeric golgi complex 5 -0.0350775
ETV6 ets variant 6 -0.0340095
MYO10 myosin X -0.0340049
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0339348
BHLHE40 basic helix-loop-helix family, member e40 -0.033623
RPL12 ribosomal protein L12 -0.0334295
KMT2C lysine (K)-specific methyltransferase 2C -0.0334073
CD109 CD109 molecule -0.0333886
GARS1 glycyl-tRNA synthetase 1 -0.0329567
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0324391
RPS6 ribosomal protein S6 -0.032369
ARF1 ADP-ribosylation factor 1 -0.031958
RHEB Ras homolog enriched in brain -0.0317078
ZFAND3 zinc finger, AN1-type domain 3 -0.0316516
RPL23 ribosomal protein L23 -0.0315755
GOLGA4 golgin A4 -0.0313575
PDE8A phosphodiesterase 8A -0.0312545
TXNRD1 thioredoxin reductase 1 -0.0311198
RPLP1 ribosomal protein, large, P1 -0.0306555
RTN4 reticulon 4 -0.0303686
SYT1 synaptotagmin I -0.0302095
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0301959
PTK2 protein tyrosine kinase 2 -0.0301776
ELL2 elongation factor, RNA polymerase II, 2 -0.0298744
SEPTIN7 septin 7 -0.0296117
ZNF292 zinc finger protein 292 -0.029418
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0290076
AFDN afadin, adherens junction formation factor -0.0288816
RPS20 ribosomal protein S20 -0.028712
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0286739
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0284324
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0283293
ETNK1 ethanolamine kinase 1 -0.0281094
WTAP Wilms tumor 1 associated protein -0.0278149
RPL35A ribosomal protein L35a -0.0276357
HLA-B major histocompatibility complex, class I, B -0.0268886
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0268369
FBXW11 F-box and WD repeat domain containing 11 -0.0267728
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.02637
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0262487
VIM vimentin -0.0259872
RPS12 ribosomal protein S12 -0.0255046
RPS27 ribosomal protein S27 -0.0254351
USP3 ubiquitin specific peptidase 3 -0.0251044
RPL37A ribosomal protein L37a -0.0249695
OGA O-GlcNAcase -0.0247884
SYNJ2 synaptojanin 2 -0.0247632
RB1CC1 RB1-inducible coiled-coil 1 -0.0247167
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0246309
UGDH UDP-glucose 6-dehydrogenase -0.0245718
PUM2 pumilio RNA-binding family member 2 -0.0245456
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0245283
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0244358
TPD52 tumor protein D52 -0.0242989
SRPK2 SRSF protein kinase 2 -0.0240854
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0240219
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0238846
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0236023
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0235216
FAM3C family with sequence similarity 3, member C -0.0234481
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0231039
CALR calreticulin -0.0230543
SDCBP syndecan binding protein (syntenin) -0.0228161
DENND5B DENN/MADD domain containing 5B -0.022775
HBP1 HMG-box transcription factor 1 -0.0226817