Dexmedetomidine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0943472
S100A10 S100 calcium binding protein A10 0.0404484
POTEF POTE ankyrin domain family, member F 0.035766
RPLP1 ribosomal protein, large, P1 0.0350814
TMSB10 thymosin beta 10 0.0328129
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.032626
FLNA filamin A, alpha 0.0308902
RPLP2 ribosomal protein, large, P2 0.0288126
ANKRD11 ankyrin repeat domain 11 0.0281154
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0271678
RPL28 ribosomal protein L28 0.0270984
RPL12 ribosomal protein L12 0.027048
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0268944
PTMA prothymosin, alpha 0.0268468
RPL37A ribosomal protein L37a 0.02534
RPS24 ribosomal protein S24 0.0252411
RPS8 ribosomal protein S8 0.024502
ZMIZ1 zinc finger, MIZ-type containing 1 0.0241372
RPS6 ribosomal protein S6 0.0239036
PODXL podocalyxin-like 0.021973
RPL26 ribosomal protein L26 0.0218012
RPS12 ribosomal protein S12 0.0212884
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0209249
RPL35 ribosomal protein L35 0.0209155
RPL23 ribosomal protein L23 0.0206259
FOSL1 FOS-like antigen 1 0.0201762
RPS16 ribosomal protein S16 0.0201684
RPS19 ribosomal protein S19 0.0195459
TPT1 tumor protein, translationally-controlled 1 0.0192849
RPS20 ribosomal protein S20 0.0190374
RPL34 ribosomal protein L34 0.0189576
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0186747
RPL35A ribosomal protein L35a 0.0184009
RPL37 ribosomal protein L37 0.0183153
RPL31 ribosomal protein L31 0.0180396
LENG8 leukocyte receptor cluster (LRC) member 8 0.0179255
RPS3 ribosomal protein S3 0.0178407
RPL36 ribosomal protein L36 0.0178287
RACK1 receptor for activated C kinase 1 0.0176065
RPS23 ribosomal protein S23 0.0170921
CSTB cystatin B (stefin B) 0.0163489
RPS21 ribosomal protein S21 0.0163367
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0162396
RPL30 ribosomal protein L30 0.0158262
BHLHE40 basic helix-loop-helix family, member e40 0.0156067
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0155463
RPL19 ribosomal protein L19 0.0154896
RPL11 ribosomal protein L11 0.0154631
RPL38 ribosomal protein L38 0.0154347
RPL32 ribosomal protein L32 0.0152187
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0151697
RPS14 ribosomal protein S14 0.0151513
RPL9 ribosomal protein L9 0.0149428
RRM2 ribonucleotide reductase M2 0.0146496
SEC61G Sec61 gamma subunit 0.0143721
RPS2 ribosomal protein S2 0.0142917
HMGB1 high mobility group box 1 0.0142222
RPS27 ribosomal protein S27 0.0140003
H1-10 H1.10 linker histone 0.0139186
SPDL1 spindle apparatus coiled-coil protein 1 0.0139144
SMAD3 SMAD family member 3 0.0138977
RPS29 ribosomal protein S29 0.0136367
RPL5 ribosomal protein L5 0.0135926
MT1X metallothionein 1X 0.0135896
ADARB1 adenosine deaminase, RNA-specific, B1 0.0134361
RPL27 ribosomal protein L27 0.0131486
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0129433
RPL7A ribosomal protein L7a 0.0128389
RPS27A ribosomal protein S27a 0.0128354
RPL13A ribosomal protein L13a 0.0128185
RPS17 ribosomal protein S17 0.0127634
RHOBTB3 Rho-related BTB domain containing 3 0.012674
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0126445
PLEC plectin 0.0126245
S100A11 S100 calcium binding protein A11 0.0125721
RPS11 ribosomal protein S11 0.0124279
MYH9 myosin, heavy chain 9, non-muscle 0.0122335
ATP5F1E ATP synthase F1 subunit epsilon 0.012077
DCLK2 doublecortin-like kinase 2 0.0115233
RASA3 RAS p21 protein activator 3 0.0114887
NCOR2 nuclear receptor corepressor 2 0.0112837
SHB Src homology 2 domain containing adaptor protein B 0.0112074
RPS13 ribosomal protein S13 0.0112049
LMNA lamin A/C 0.0111465
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0110299
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0108343
RPS15 ribosomal protein S15 0.010787
LGALS1 lectin, galactoside-binding, soluble, 1 0.0106334
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0104764
TSPAN5 tetraspanin 5 0.010373
ULK1 unc-51 like autophagy activating kinase 1 0.0103528
MKI67 marker of proliferation Ki-67 0.0102959
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0102443
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0101665
YBX1 Y box binding protein 1 0.0100451
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0100305
XPO6 exportin 6 0.00996466
RPL4 ribosomal protein L4 0.00991713
RPL10A ribosomal protein L10a 0.00991379
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.00986096

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.266494
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.226046
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.19886
LOX lysyl oxidase -0.147904
COL8A1 collagen, type VIII, alpha 1 -0.146233
FBN1 fibrillin 1 -0.132892
ZBTB20 zinc finger and BTB domain containing 20 -0.107252
AKAP12 A kinase (PRKA) anchor protein 12 -0.0994438
COL1A2 collagen, type I, alpha 2 -0.0923769
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0919098
COL5A2 collagen, type V, alpha 2 -0.0909075
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0900027
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0886221
LOXL2 lysyl oxidase-like 2 -0.0853335
SOD2 superoxide dismutase 2, mitochondrial -0.0847889
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0661804
DST dystonin -0.0654634
UBC ubiquitin C -0.0642059
RSAD2 radical S-adenosyl methionine domain containing 2 -0.05896
ARL15 ADP-ribosylation factor-like 15 -0.0579689
MAP1B microtubule-associated protein 1B -0.0576068
CANX calnexin -0.0550126
LDHA lactate dehydrogenase A -0.054371
VIM vimentin -0.0520542
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0518997
MRPS6 mitochondrial ribosomal protein S6 -0.0474505
AUTS2 autism susceptibility candidate 2 -0.0473048
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.044986
PLAT plasminogen activator, tissue -0.0449437
JAZF1 JAZF zinc finger 1 -0.0448616
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0437544
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0435596
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0435554
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0433827
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0432683
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0426657
PDE4D phosphodiesterase 4D, cAMP-specific -0.0423578
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0420584
COL3A1 collagen, type III, alpha 1 -0.0417571
MYADM myeloid-associated differentiation marker -0.0417453
PSD3 pleckstrin and Sec7 domain containing 3 -0.0417023
COPA coatomer protein complex, subunit alpha -0.0415231
FRMD5 FERM domain containing 5 -0.0410028
DLG1 discs, large homolog 1 (Drosophila) -0.0408732
B2M beta-2-microglobulin -0.0388668
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0386801
MEIS2 Meis homeobox 2 -0.0381181
SPAG9 sperm associated antigen 9 -0.0376205
FNDC3B fibronectin type III domain containing 3B -0.0373132
MX2 MX dynamin-like GTPase 2 -0.0367949
SBF2 SET binding factor 2 -0.0365767
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0355512
GPC6 glypican 6 -0.0345623
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0336274
FNDC3A fibronectin type III domain containing 3A -0.0334447
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0333759
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0333668
ZEB1 zinc finger E-box binding homeobox 1 -0.0331639
HDLBP high density lipoprotein binding protein -0.0330662
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0330413
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.032715
FBXL7 F-box and leucine-rich repeat protein 7 -0.0325454
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0319542
BIRC6 baculoviral IAP repeat containing 6 -0.0318467
NBEAL1 neurobeachin-like 1 -0.0313971
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0309085
WARS1 tryptophanyl-tRNA synthetase 1 -0.0299173
TAGLN2 transgelin 2 -0.0297728
USP34 ubiquitin specific peptidase 34 -0.0294281
TTC3 tetratricopeptide repeat domain 3 -0.0292427
MMP12 matrix metallopeptidase 12 -0.0292373
SRPK2 SRSF protein kinase 2 -0.0292073
MAP4 microtubule-associated protein 4 -0.0288055
THBS2 thrombospondin 2 -0.0286227
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0285074
FNIP1 folliculin interacting protein 1 -0.0279302
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0277322
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0277113
KIFAP3 kinesin-associated protein 3 -0.0275523
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.027361
RIGI RNA sensor RIG-I -0.0272831
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0270081
GLIS3 GLIS family zinc finger 3 -0.026735
DPYSL3 dihydropyrimidinase-like 3 -0.0264273
RASAL2 RAS protein activator like 2 -0.0263793
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0262452
TPM4 tropomyosin 4 -0.0262283
ZEB2 zinc finger E-box binding homeobox 2 -0.0257064
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0256327
SEC31A SEC31 homolog A (S. cerevisiae) -0.0254196
ACBD3 acyl-CoA binding domain containing 3 -0.0251924
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0251598
LMAN1 lectin, mannose-binding, 1 -0.0250911
ZNF148 zinc finger protein 148 -0.024991
GOLGA2 golgin A2 -0.0249389
AHNAK AHNAK nucleoprotein -0.0249344
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0248464
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0246987
EHBP1 EH domain binding protein 1 -0.0244712
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0242783