| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dexmedetomidine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.39415 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.128709 |
| MMP12 | matrix metallopeptidase 12 | 0.0977416 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0954938 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0887716 |
| TMEM41B | transmembrane protein 41B | 0.0872762 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0799825 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0797611 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0762175 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.071547 |
| RTN4 | reticulon 4 | 0.068876 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0667295 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0614707 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0554922 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0551104 |
| MAP1B | microtubule-associated protein 1B | 0.0549456 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0546892 |
| TMSB10 | thymosin beta 10 | 0.053018 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0511141 |
| ANXA1 | annexin A1 | 0.0504927 |
| XPO1 | exportin 1 | 0.0503452 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0493387 |
| YBX3 | Y box binding protein 3 | 0.0483098 |
| TPM3 | tropomyosin 3 | 0.04615 |
| PTMS | parathymosin | 0.0461473 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0460474 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0454747 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0447755 |
| VMP1 | vacuole membrane protein 1 | 0.0442461 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0440865 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0437775 |
| TXNRD1 | thioredoxin reductase 1 | 0.0436204 |
| ACTG1 | actin gamma 1 | 0.0415003 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0410054 |
| MKI67 | marker of proliferation Ki-67 | 0.0409158 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0407989 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0406387 |
| WDR43 | WD repeat domain 43 | 0.0395088 |
| PGK1 | phosphoglycerate kinase 1 | 0.039134 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0382382 |
| PCDH7 | protocadherin 7 | 0.0381351 |
| IPO7 | importin 7 | 0.0380196 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0380164 |
| KIF5B | kinesin family member 5B | 0.0376245 |
| DST | dystonin | 0.0369531 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0362796 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0362457 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0361502 |
| YEATS2 | YEATS domain containing 2 | 0.0354648 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0350492 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0350442 |
| TMEM123 | transmembrane protein 123 | 0.0348561 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0343613 |
| AHNAK | AHNAK nucleoprotein | 0.0342637 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.033833 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0335115 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.033177 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0329858 |
| TPI1 | triosephosphate isomerase 1 | 0.0322459 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0320521 |
| CENPF | centromere protein F, 350/400kDa | 0.0319258 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0318585 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0315475 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0314973 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0314452 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0314438 |
| KIF18B | kinesin family member 18B | 0.0311086 |
| FUS | FUS RNA binding protein | 0.0310452 |
| PREPL | prolyl endopeptidase-like | 0.0306962 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0306723 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0303194 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0296748 |
| POTEF | POTE ankyrin domain family, member F | 0.0292497 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.029012 |
| TNPO1 | transportin 1 | 0.0289274 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0287892 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 0.0287782 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0287626 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0287588 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0287495 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0286913 |
| RRM2 | ribonucleotide reductase M2 | 0.0284666 |
| PCBP2 | poly(rC) binding protein 2 | 0.0284069 |
| BCHE | butyrylcholinesterase | 0.0283909 |
| JMJD1C | jumonji domain containing 1C | 0.0282287 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.028177 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0281391 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0280661 |
| SMYD3 | SET and MYND domain containing 3 | 0.0280277 |
| CCN2 | cellular communication network factor 2 | 0.0279695 |
| EZR | ezrin | 0.0279616 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0278239 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0277934 |
| ATP11A | ATPase, class VI, type 11A | 0.0277779 |
| ZNF292 | zinc finger protein 292 | 0.0276723 |
| CLTC | clathrin, heavy chain (Hc) | 0.0273554 |
| AREG | amphiregulin | 0.0273468 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0267322 |
| H1-0 | H1.0 linker histone | 0.0266886 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.0266583 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGA2 | high mobility group AT-hook 2 | -0.0688866 |
| INTS6 | integrator complex subunit 6 | -0.055105 |
| DENND5A | DENN/MADD domain containing 5A | -0.0264621 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0251088 |
| RPS3 | ribosomal protein S3 | -0.024918 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0246628 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.023874 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0235351 |
| RPS24 | ribosomal protein S24 | -0.0233384 |
| EHBP1 | EH domain binding protein 1 | -0.0224148 |
| RPS29 | ribosomal protein S29 | -0.0222448 |
| RPL31 | ribosomal protein L31 | -0.0217331 |
| ZNF804A | zinc finger protein 804A | -0.0211751 |
| RPS12 | ribosomal protein S12 | -0.020822 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0197577 |
| EXOC4 | exocyst complex component 4 | -0.0195572 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | -0.0192131 |
| FSTL5 | follistatin-like 5 | -0.0189774 |
| RPS8 | ribosomal protein S8 | -0.0188572 |
| RCC1 | regulator of chromosome condensation 1 | -0.018839 |
| SERTAD2 | SERTA domain containing 2 | -0.0187955 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.018738 |
| RPL13A | ribosomal protein L13a | -0.018647 |
| RPL21 | ribosomal protein L21 | -0.0177338 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0174707 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0173459 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0170842 |
| PCDH9 | protocadherin 9 | -0.0168523 |
| UBAP2 | ubiquitin associated protein 2 | -0.0168424 |
| NFIB | nuclear factor I/B | -0.0168254 |
| EPHA5 | EPH receptor A5 | -0.0168045 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0168012 |
| RPLP2 | ribosomal protein, large, P2 | -0.0167206 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0166168 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0166131 |
| AEBP2 | AE binding protein 2 | -0.0165993 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0156758 |
| LRRC23 | leucine rich repeat containing 23 | -0.0155193 |
| RPS10 | ribosomal protein S10 | -0.0152329 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0151567 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0151318 |
| CFAP70 | cilia and flagella associated protein 70 | -0.0151128 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0150023 |
| RPS19 | ribosomal protein S19 | -0.0147422 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0146086 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.01446 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.0143033 |
| RPS25 | ribosomal protein S25 | -0.0141632 |
| DUSP16 | dual specificity phosphatase 16 | -0.0137487 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0137485 |
| RPS2 | ribosomal protein S2 | -0.013636 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0135779 |
| HOMER1 | homer scaffolding protein 1 | -0.0134886 |
| RPL26 | ribosomal protein L26 | -0.0133263 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0133119 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0129996 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0129387 |
| NABP1 | nucleic acid binding protein 1 | -0.0126845 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0125018 |
| TEX14 | testis expressed 14 | -0.0124702 |
| TTC27 | tetratricopeptide repeat domain 27 | -0.0124329 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0124212 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0122257 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0121748 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0121494 |
| DTNA | dystrobrevin, alpha | -0.0120311 |
| KAT6A | K(lysine) acetyltransferase 6A | -0.011937 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0118882 |
| HDAC9 | histone deacetylase 9 | -0.0118334 |
| RPL12 | ribosomal protein L12 | -0.0117849 |
| STXBP4 | syntaxin binding protein 4 | -0.0117523 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0116344 |
| TMEM108 | transmembrane protein 108 | -0.0116237 |
| LNPEP | leucyl/cystinyl aminopeptidase | -0.0114775 |
| SYT1 | synaptotagmin I | -0.0114301 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0114256 |
| RPL36 | ribosomal protein L36 | -0.0114016 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0113299 |
| C1S | complement component 1, s subcomponent | -0.0113185 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | -0.0112169 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.011205 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0111857 |
| TMEM144 | transmembrane protein 144 | -0.0110522 |
| CFAP44 | cilia and flagella associated protein 44 | -0.0110093 |
| RPS23 | ribosomal protein S23 | -0.0109433 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0109378 |
| TBCA | tubulin folding cofactor A | -0.0109309 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.010811 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.010766 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0107613 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0107569 |
| RPL34 | ribosomal protein L34 | -0.0106926 |
| ZNF407 | zinc finger protein 407 | -0.0105894 |
| APTX | aprataxin | -0.0105329 |
| METTL15 | methyltransferase like 15 | -0.0103531 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0103364 |
| RSU1 | Ras suppressor protein 1 | -0.0102566 |
| PTPRC | protein tyrosine phosphatase, receptor type, C | -0.0102135 |
| FN1 | fibronectin 1 | -0.0102121 |
| PUM3 | pumilio RNA binding family member 3 | -0.0102098 |
