Dexmedetomidine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.217708
IGF2 insulin-like growth factor 2 0.172158
PTMA prothymosin, alpha 0.165379
VIM vimentin 0.118503
RPS6 ribosomal protein S6 0.0770996
RPL37A ribosomal protein L37a 0.0766991
RPL23 ribosomal protein L23 0.0713167
RPL19 ribosomal protein L19 0.0702975
RPLP1 ribosomal protein, large, P1 0.0698883
TMSB10 thymosin beta 10 0.0637977
RPS12 ribosomal protein S12 0.0598313
RPS24 ribosomal protein S24 0.0585715
TPT1 tumor protein, translationally-controlled 1 0.0566099
RPL35A ribosomal protein L35a 0.0555039
RPL26 ribosomal protein L26 0.0519218
RPS8 ribosomal protein S8 0.0495958
EIF1 eukaryotic translation initiation factor 1 0.0492598
RPS3 ribosomal protein S3 0.0485373
COL1A1 collagen, type I, alpha 1 0.0478273
RPL12 ribosomal protein L12 0.0467875
RPL36 ribosomal protein L36 0.0462656
RPL34 ribosomal protein L34 0.0462645
ACTG1 actin gamma 1 0.0460744
RPS19 ribosomal protein S19 0.0452899
B2M beta-2-microglobulin 0.0441144
RPL31 ribosomal protein L31 0.0441052
FTL ferritin, light polypeptide 0.0434614
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0424438
RPL32 ribosomal protein L32 0.0408947
S100A9 S100 calcium binding protein A9 0.0407277
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0402497
RPS29 ribosomal protein S29 0.0395262
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0394105
RPS27A ribosomal protein S27a 0.0392797
RPL27 ribosomal protein L27 0.0390025
RPS23 ribosomal protein S23 0.0367557
RPL11 ribosomal protein L11 0.0362214
PRRC2C proline-rich coiled-coil 2C 0.0355787
RPS25 ribosomal protein S25 0.0354951
RPL36A ribosomal protein L36a 0.0349128
RACK1 receptor for activated C kinase 1 0.0348969
RPL7A ribosomal protein L7a 0.0344198
RPS17 ribosomal protein S17 0.0337102
LMNA lamin A/C 0.0335138
POTEF POTE ankyrin domain family, member F 0.0334913
RPS11 ribosomal protein S11 0.0334675
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0325665
RPL5 ribosomal protein L5 0.0322973
RPL35 ribosomal protein L35 0.0320798
NAP1L1 nucleosome assembly protein 1-like 1 0.0318603
RPLP2 ribosomal protein, large, P2 0.0317587
RPL38 ribosomal protein L38 0.0313603
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.031129
MKI67 marker of proliferation Ki-67 0.0302935
RPS16 ribosomal protein S16 0.0299265
ZMIZ1 zinc finger, MIZ-type containing 1 0.0298011
RPS14 ribosomal protein S14 0.0296791
SRRM2 serine/arginine repetitive matrix 2 0.0296378
NACA nascent polypeptide-associated complex alpha subunit 0.0295537
RPS21 ribosomal protein S21 0.0282786
RPL37 ribosomal protein L37 0.0279341
RPS20 ribosomal protein S20 0.0277072
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0274851
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0270791
RPS27 ribosomal protein S27 0.0270332
RPL13A ribosomal protein L13a 0.0269921
RPL8 ribosomal protein L8 0.0265736
EEF2 eukaryotic translation elongation factor 2 0.026247
RPL9 ribosomal protein L9 0.0254294
RPS5 ribosomal protein S5 0.0237371
RSL1D1 ribosomal L1 domain containing 1 0.0232138
TBX2 T-box 2 0.0230913
GOLGA4 golgin A4 0.0230379
RPS15 ribosomal protein S15 0.0226902
RPL28 ribosomal protein L28 0.0226573
RPL7 ribosomal protein L7 0.022186
RPS4X ribosomal protein S4, X-linked 0.0217851
S100A10 S100 calcium binding protein A10 0.0216575
RPL18 ribosomal protein L18 0.0215797
H3-3B H3.3 histone B 0.0215011
RPS13 ribosomal protein S13 0.0214669
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.021093
EIF4A1 eukaryotic translation initiation factor 4A1 0.0207228
STC1 stanniocalcin 1 0.0205915
HMGB1 high mobility group box 1 0.0200403
EIF5B eukaryotic translation initiation factor 5B 0.0199625
S100A6 S100 calcium binding protein A6 0.019913
CALR calreticulin 0.0195422
MT2A metallothionein 2A 0.0194829
PKM pyruvate kinase, muscle 0.0193686
HDGF hepatoma-derived growth factor 0.0192716
RPL15 ribosomal protein L15 0.0191931
CD99 CD99 molecule 0.0187856
YBX1 Y box binding protein 1 0.0187838
IER3 immediate early response 3 0.018706
RPL30 ribosomal protein L30 0.0185808
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0185249
RPS2 ribosomal protein S2 0.0185068
RPS10 ribosomal protein S10 0.0183975
EGR1 early growth response 1 0.0183858

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.150573
NALF1 NALCN channel auxiliary factor 1 -0.0873724
LSAMP limbic system-associated membrane protein -0.0773436
NRG1 neuregulin 1 -0.0770965
FMN1 formin 1 -0.0769383
SYT1 synaptotagmin I -0.0624034
EXT1 exostosin glycosyltransferase 1 -0.0601127
PTPRD protein tyrosine phosphatase, receptor type, D -0.054451
HELZ helicase with zinc finger -0.0538574
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0519498
FNDC3B fibronectin type III domain containing 3B -0.0502202
MEIS2 Meis homeobox 2 -0.0497511
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0484513
DST dystonin -0.0481324
NCAM2 neural cell adhesion molecule 2 -0.0466427
VCL vinculin -0.0455004
UNC5C unc-5 homolog C (C. elegans) -0.0420473
SOS1 son of sevenless homolog 1 (Drosophila) -0.0417362
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0405958
KLHL13 kelch-like family member 13 -0.0398571
MSI2 musashi RNA-binding protein 2 -0.0387138
TRIO trio Rho guanine nucleotide exchange factor -0.0366761
LPIN1 lipin 1 -0.035949
MAP1B microtubule-associated protein 1B -0.0334965
NAMPT nicotinamide phosphoribosyltransferase -0.0330196
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0316473
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0301001
ZNF804A zinc finger protein 804A -0.0299434
TRIB2 tribbles pseudokinase 2 -0.0296561
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0293228
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0291824
THSD4 thrombospondin, type I, domain containing 4 -0.0291547
AUTS2 autism susceptibility candidate 2 -0.0289707
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0289176
MYO6 myosin VI -0.0288614
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0283032
ZMYM2 zinc finger, MYM-type 2 -0.0275237
NREP neuronal regeneration related protein -0.0271028
DNAH14 dynein, axonemal, heavy chain 14 -0.0270658
MEF2A myocyte enhancer factor 2A -0.0270224
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0269198
COL3A1 collagen, type III, alpha 1 -0.0262297
ENAH enabled homolog (Drosophila) -0.0260758
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.026043
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0253153
PTK2 protein tyrosine kinase 2 -0.0249558
WAC WW domain containing adaptor with coiled-coil -0.024908
TLE4 transducin-like enhancer of split 4 -0.0248788
CD36 CD36 molecule (thrombospondin receptor) -0.0248598
LPP LIM domain containing preferred translocation partner in lipoma -0.0244509
AHR aryl hydrocarbon receptor -0.0242952
KDM3A lysine (K)-specific demethylase 3A -0.0241496
MBNL2 muscleblind-like splicing regulator 2 -0.0238864
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0238148
CADM2 cell adhesion molecule 2 -0.0236892
NUP58 nucleoporin 58 -0.023384
C1ORF21 chromosome 1 open reading frame 21 -0.0233805
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0233284
DPH6 diphthamine biosynthesis 6 -0.0233282
MBNL1 muscleblind-like splicing regulator 1 -0.0231776
CEMIP cell migration inducing protein, hyaluronan binding -0.0230884
ADGRG6 adhesion G protein-coupled receptor G6 -0.0227312
CADM1 cell adhesion molecule 1 -0.022543
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0225346
ITPRID2 ITPR interacting domain containing 2 -0.02251
PTPRE protein tyrosine phosphatase, receptor type, E -0.0224473
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0221612
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0221023
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0220745
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0220575
DLC1 DLC1 Rho GTPase activating protein -0.0217634
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0217538
KCNIP4 Kv channel interacting protein 4 -0.0217214
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.02167
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0216624
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0214949
SSBP2 single-stranded DNA binding protein 2 -0.0213512
ANKRD17 ankyrin repeat domain 17 -0.0208561
PLPP1 phospholipid phosphatase 1 -0.0206402
ZNF292 zinc finger protein 292 -0.02062
ZC3H11A zinc finger CCCH-type containing 11A -0.0205679
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0203711
ATRNL1 attractin-like 1 -0.020319
NEK7 NIMA-related kinase 7 -0.0201139
TPST1 tyrosylprotein sulfotransferase 1 -0.0198657
RYBP RING1 and YY1 binding protein -0.0198483
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0198463
GAB2 GRB2-associated binding protein 2 -0.0197717
PTEN phosphatase and tensin homolog -0.0196205
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0195689
PRKCA protein kinase C, alpha -0.0194595
MYH9 myosin, heavy chain 9, non-muscle -0.0193472
OXSR1 oxidative stress responsive 1 -0.0189983
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0189452
SOX5 SRY (sex determining region Y)-box 5 -0.0188296
ZFAND3 zinc finger, AN1-type domain 3 -0.0187833
ZEB1 zinc finger E-box binding homeobox 1 -0.018691
CNTN4 contactin 4 -0.0186088
NRIP1 nuclear receptor interacting protein 1 -0.0184204
DGKH diacylglycerol kinase, eta -0.0184081