Dexmedetomidine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.178025
TPT1 tumor protein, translationally-controlled 1 0.128191
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.120954
PTMA prothymosin, alpha 0.10816
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.106435
ZMYND8 zinc finger, MYND-type containing 8 0.0881539
HLA-B major histocompatibility complex, class I, B 0.0865929
RPS6 ribosomal protein S6 0.0864225
LCN2 lipocalin 2 0.0857704
TXNIP thioredoxin interacting protein 0.0770461
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0766993
EIF1 eukaryotic translation initiation factor 1 0.0715817
FTL ferritin, light polypeptide 0.0662568
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0607802
IFI6 interferon, alpha-inducible protein 6 0.0551764
TMSB10 thymosin beta 10 0.0519826
RPL35A ribosomal protein L35a 0.0518807
RPLP1 ribosomal protein, large, P1 0.0517435
RPS8 ribosomal protein S8 0.0508729
RPL23 ribosomal protein L23 0.0504399
RPL19 ribosomal protein L19 0.0485925
PDIA3 protein disulfide isomerase family A, member 3 0.0474383
LYZ lysozyme 0.0473547
RPL34 ribosomal protein L34 0.047149
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0456951
NDRG1 N-myc downstream regulated 1 0.0452116
SRRM2 serine/arginine repetitive matrix 2 0.044378
HLA-A major histocompatibility complex, class I, A 0.0431281
RPL11 ribosomal protein L11 0.0428619
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0427379
RPS19 ribosomal protein S19 0.0415523
RPL26 ribosomal protein L26 0.0412282
IFI27 interferon, alpha-inducible protein 27 0.0407374
H1-0 H1.0 linker histone 0.0402788
PRRC2C proline-rich coiled-coil 2C 0.0393131
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0392491
C6ORF132 chromosome 6 open reading frame 132 0.0389663
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0385028
RPL12 ribosomal protein L12 0.0380299
RHOBTB3 Rho-related BTB domain containing 3 0.0378822
RNF149 ring finger protein 149 0.0376422
DSTN destrin (actin depolymerizing factor) 0.0372964
RPL37 ribosomal protein L37 0.0369694
RPL37A ribosomal protein L37a 0.0368341
ACBD3 acyl-CoA binding domain containing 3 0.0359262
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0358832
FTH1 ferritin, heavy polypeptide 1 0.0356504
RPS3 ribosomal protein S3 0.0354951
RPS27 ribosomal protein S27 0.0353136
CALR calreticulin 0.0352065
RPS12 ribosomal protein S12 0.0341754
RPS24 ribosomal protein S24 0.0335609
AKAP9 A kinase (PRKA) anchor protein 9 0.0332833
N4BP2L2 NEDD4 binding protein 2-like 2 0.0328902
RPL31 ribosomal protein L31 0.03227
PGK1 phosphoglycerate kinase 1 0.0320304
POTEF POTE ankyrin domain family, member F 0.0318451
PKM pyruvate kinase, muscle 0.0315719
MT2A metallothionein 2A 0.031151
RPS13 ribosomal protein S13 0.0309736
SREBF2 sterol regulatory element binding transcription factor 2 0.0308126
PTBP3 polypyrimidine tract binding protein 3 0.030755
TSC22D1 TSC22 domain family, member 1 0.0304849
SERF2 small EDRK-rich factor 2 0.0303611
LOC112694756 uncharaterized LOC112694756 0.0302866
S100A9 S100 calcium binding protein A9 0.0302459
RPS29 ribosomal protein S29 0.0298785
TPI1 triosephosphate isomerase 1 0.0297657
MPHOSPH8 M-phase phosphoprotein 8 0.0297219
RPLP2 ribosomal protein, large, P2 0.0295544
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0295335
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0293768
GOLGA4 golgin A4 0.0293636
RPS23 ribosomal protein S23 0.0290287
RPL36A ribosomal protein L36a 0.0287327
SLC38A1 solute carrier family 38, member 1 0.0286259
KRT19 keratin 19, type I 0.0283216
WDR45B WD repeat domain 45B 0.0281434
CSTB cystatin B (stefin B) 0.0280122
H3-3B H3.3 histone B 0.0278127
UBC ubiquitin C 0.0277784
RPS25 ribosomal protein S25 0.0273051
AHI1 Abelson helper integration site 1 0.0272157
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0270269
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0270011
S100A6 S100 calcium binding protein A6 0.0269927
IFITM3 interferon induced transmembrane protein 3 0.0266771
RPL7A ribosomal protein L7a 0.0262013
RPLP0 ribosomal protein, large, P0 0.0260975
MTDH metadherin 0.0260343
BCLAF1 BCL2-associated transcription factor 1 0.0260175
NCOR1 nuclear receptor corepressor 1 0.026004
RPL18 ribosomal protein L18 0.0257853
LOC102724023 ES1 protein homolog, mitochondrial 0.0255585
RPL9 ribosomal protein L9 0.025496
ENO1 enolase 1, (alpha) 0.0254814
RPL32 ribosomal protein L32 0.0254361
TMC5 transmembrane channel-like 5 0.0251687
RPS17 ribosomal protein S17 0.0250058
RPL30 ribosomal protein L30 0.024995

decreased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 -0.184764
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.162044
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.156309
LMO7 LIM domain 7 -0.12175
RNF213 ring finger protein 213 -0.0900996
ANXA2 annexin A2 -0.089676
GMDS GDP-mannose 4,6-dehydratase -0.0884028
PLSCR2 phospholipid scramblase 2 -0.0873569
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0866828
ARHGAP26 Rho GTPase activating protein 26 -0.0768626
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0722947
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0703172
STS steroid sulfatase (microsomal), isozyme S -0.0670903
RIGI RNA sensor RIG-I -0.0664593
EFNB2 ephrin-B2 -0.0578517
SQSTM1 sequestosome 1 -0.0545609
EXT1 exostosin glycosyltransferase 1 -0.0537021
NPSR1 neuropeptide S receptor 1 -0.0536736
SP100 SP100 nuclear antigen -0.0481982
PRKCA protein kinase C, alpha -0.0468594
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0463887
VCL vinculin -0.0460872
SMAD3 SMAD family member 3 -0.0444423
ANKRD10 ankyrin repeat domain 10 -0.0443617
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0441953
RSAD2 radical S-adenosyl methionine domain containing 2 -0.04417
NABP1 nucleic acid binding protein 1 -0.0429958
CATSPERB catsper channel auxiliary subunit beta -0.041781
POF1B premature ovarian failure, 1B -0.0408778
AREG amphiregulin -0.0398003
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0368006
VMP1 vacuole membrane protein 1 -0.0345796
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0345386
GCLC glutamate-cysteine ligase, catalytic subunit -0.0344921
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.033884
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0338192
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0338188
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0333584
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0332948
BTBD9 BTB (POZ) domain containing 9 -0.0332302
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0330675
FNDC3B fibronectin type III domain containing 3B -0.0325502
ERBIN erbb2 interacting protein -0.0317912
IGF1R insulin-like growth factor 1 receptor -0.0314474
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0313665
TRIO trio Rho guanine nucleotide exchange factor -0.0304546
MAML2 mastermind-like 2 (Drosophila) -0.0302212
UBAP2 ubiquitin associated protein 2 -0.0296703
FBXO39 F-box protein 39 -0.0291116
PLSCR1 phospholipid scramblase 1 -0.0281402
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0280567
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0278359
MX1 MX dynamin-like GTPase 1 -0.0272771
TSHZ2 teashirt zinc finger homeobox 2 -0.02645
LPP LIM domain containing preferred translocation partner in lipoma -0.0263267
UTRN utrophin -0.0260796
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.025803
PDLIM5 PDZ and LIM domain 5 -0.025687
XAF1 XIAP associated factor 1 -0.0252898
SHB Src homology 2 domain containing adaptor protein B -0.0249982
TM4SF19 transmembrane 4 L six family member 19 -0.0246426
TOX3 TOX high mobility group box family member 3 -0.0237108
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0237022
LARP4B La ribonucleoprotein domain family, member 4B -0.0230882
NCOA7 nuclear receptor coactivator 7 -0.0230856
TJP1 tight junction protein 1 -0.0227217
RAB7A RAB7A, member RAS oncogene family -0.0226685
CEMIP cell migration inducing protein, hyaluronan binding -0.0224176
MYO1E myosin IE -0.0218533
RAD51B RAD51 paralog B -0.0215983
SDCBP syndecan binding protein (syntenin) -0.0215909
SAMD9 sterile alpha motif domain containing 9 -0.0215092
HOMER1 homer scaffolding protein 1 -0.0212445
MX2 MX dynamin-like GTPase 2 -0.020988
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0204949
MSI2 musashi RNA-binding protein 2 -0.0199619
KYNU kynureninase -0.0199403
SAMD12 sterile alpha motif domain containing 12 -0.0194945
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -0.0194294
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0193148
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0192064
PRELID2 PRELI domain containing 2 -0.0186359
NCEH1 neutral cholesterol ester hydrolase 1 -0.0186126
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0185302
LAMA4 laminin, alpha 4 -0.018348
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0182355
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0181538
FNIP2 folliculin interacting protein 2 -0.0179791
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0177453
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.017585
TLE4 transducin-like enhancer of split 4 -0.0175601
DOCK1 dedicator of cytokinesis 1 -0.0175247
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0173416
RDH10 retinol dehydrogenase 10 (all-trans) -0.0172986
ZHX2 zinc fingers and homeoboxes 2 -0.0172668
MCU mitochondrial calcium uniporter -0.0172252
FHIT fragile histidine triad -0.0171662
ZBTB20 zinc finger and BTB domain containing 20 -0.0170048
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0169096
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.0168859