Dexmedetomidine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 0.20144
VIM vimentin 0.120658
TIMP3 TIMP metallopeptidase inhibitor 3 0.115197
CDH13 cadherin 13 0.0916785
STC1 stanniocalcin 1 0.0826596
COL1A2 collagen, type I, alpha 2 0.0821271
TGFBI transforming growth factor, beta-induced, 68kDa 0.0815766
EXT1 exostosin glycosyltransferase 1 0.0783655
COL6A3 collagen, type VI, alpha 3 0.0781418
COL5A1 collagen, type V, alpha 1 0.0712903
TMSB10 thymosin beta 10 0.0691379
PSD3 pleckstrin and Sec7 domain containing 3 0.0628812
FBN1 fibrillin 1 0.0616613
ASPH aspartate beta-hydroxylase 0.0608793
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.056682
ACTG1 actin gamma 1 0.0519255
NAV1 neuron navigator 1 0.0473307
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0469273
LIMS1 LIM and senescent cell antigen-like domains 1 0.0458394
GLIS3 GLIS family zinc finger 3 0.04397
INHBA inhibin, beta A 0.0437184
CALD1 caldesmon 1 0.0436026
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0435078
TM4SF1 transmembrane 4 L six family member 1 0.0427887
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0425563
HMGA2 high mobility group AT-hook 2 0.0398829
F3 coagulation factor III (thromboplastin, tissue factor) 0.0387429
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0345458
SDC2 syndecan 2 0.0341742
CLMP CXADR-like membrane protein 0.0322548
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0314716
AHNAK AHNAK nucleoprotein 0.0313707
TPT1 tumor protein, translationally-controlled 1 0.0310292
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0306808
S100A9 S100 calcium binding protein A9 0.0304578
RRBP1 ribosome binding protein 1 0.0280466
ZBTB20 zinc finger and BTB domain containing 20 0.0277841
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0269794
COL6A2 collagen, type VI, alpha 2 0.026936
RPL26 ribosomal protein L26 0.0259555
VCL vinculin 0.0258254
TRPS1 trichorhinophalangeal syndrome I 0.0254345
ENO1 enolase 1, (alpha) 0.0245901
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0242009
ADAM12 ADAM metallopeptidase domain 12 0.0240174
LTBP1 latent transforming growth factor beta binding protein 1 0.0236075
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.023567
CAVIN1 caveolae associated protein 1 0.0229967
DOCK5 dedicator of cytokinesis 5 0.0228996
DPYD dihydropyrimidine dehydrogenase 0.0225294
TMSB4X thymosin beta 4, X-linked 0.022513
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.0219998
IER3 immediate early response 3 0.0211046
LMO4 LIM domain only 4 0.0209526
OSMR oncostatin M receptor 0.0206407
TPM4 tropomyosin 4 0.0206215
ZMYND8 zinc finger, MYND-type containing 8 0.0206087
RPS24 ribosomal protein S24 0.0205343
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0203343
HLA-B major histocompatibility complex, class I, B 0.020198
JARID2 jumonji, AT rich interactive domain 2 0.0201533
CUX1 cut-like homeobox 1 0.0198686
LMNA lamin A/C 0.0197284
FRMD4A FERM domain containing 4A 0.0196884
COL6A1 collagen, type VI, alpha 1 0.0196426
ATXN1 ataxin 1 0.0194001
PTPRF protein tyrosine phosphatase, receptor type, F 0.0193608
ANKRD12 ankyrin repeat domain 12 0.0193564
SORBS2 sorbin and SH3 domain containing 2 0.0193068
ARL4C ADP-ribosylation factor-like 4C 0.0192798
CMIP c-Maf inducing protein 0.019187
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0190716
S100A6 S100 calcium binding protein A6 0.0190436
VCAN versican 0.0188858
COL7A1 collagen, type VII, alpha 1 0.0187899
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0185031
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.018197
RPS8 ribosomal protein S8 0.0181924
PDLIM5 PDZ and LIM domain 5 0.0180734
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0179032
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0177747
IGFBP7 insulin-like growth factor binding protein 7 0.0175665
PDE4D phosphodiesterase 4D, cAMP-specific 0.0174742
PRSS23 protease, serine, 23 0.0174694
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0172353
PTPRG protein tyrosine phosphatase, receptor type, G 0.0169528
GOLGB1 golgin B1 0.0168464
PLEC plectin 0.0161933
ZBTB38 zinc finger and BTB domain containing 38 0.0161033
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0160428
H1-0 H1.0 linker histone 0.0158735
ABI3BP ABI family, member 3 (NESH) binding protein 0.0157963
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0157116
HAS2 hyaluronan synthase 2 0.0154309
SMYD3 SET and MYND domain containing 3 0.0153917
SETBP1 SET binding protein 1 0.0153245
CD59 CD59 molecule, complement regulatory protein 0.0150779
ARHGAP22 Rho GTPase activating protein 22 0.0149289
RPS21 ribosomal protein S21 0.0148383
IFI6 interferon, alpha-inducible protein 6 0.0148042

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.0906774
CXCL8 chemokine (C-X-C motif) ligand 8 -0.082738
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0781615
CADM1 cell adhesion molecule 1 -0.0778758
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0728438
IGFBP3 insulin-like growth factor binding protein 3 -0.0698726
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0466775
SOD2 superoxide dismutase 2, mitochondrial -0.0463058
NAMPT nicotinamide phosphoribosyltransferase -0.0458823
SPAG9 sperm associated antigen 9 -0.0456337
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0432804
ARRDC3 arrestin domain containing 3 -0.0413302
ZNF292 zinc finger protein 292 -0.04039
FNDC3B fibronectin type III domain containing 3B -0.0397973
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0389435
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0374531
TRIO trio Rho guanine nucleotide exchange factor -0.0351815
QKI QKI, KH domain containing, RNA binding -0.0349184
LDHA lactate dehydrogenase A -0.0334562
TRAM1 translocation associated membrane protein 1 -0.0324624
USP3 ubiquitin specific peptidase 3 -0.0311979
HILPDA hypoxia inducible lipid droplet-associated -0.0297012
TFG TRK-fused gene -0.0296924
PDIA6 protein disulfide isomerase family A, member 6 -0.0296231
PDIA3 protein disulfide isomerase family A, member 3 -0.0295931
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0292487
ADAM17 ADAM metallopeptidase domain 17 -0.0292389
KMT2E lysine (K)-specific methyltransferase 2E -0.02877
SQLE squalene epoxidase -0.028357
B2M beta-2-microglobulin -0.0281069
ADAM9 ADAM metallopeptidase domain 9 -0.0279011
FXR1 fragile X mental retardation, autosomal homolog 1 -0.027224
FTH1 ferritin, heavy polypeptide 1 -0.0269545
ATP13A3 ATPase type 13A3 -0.0262396
RYBP RING1 and YY1 binding protein -0.0260062
ALCAM activated leukocyte cell adhesion molecule -0.0257333
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0256401
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0256323
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255804
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0254924
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0254049
DLG1 discs, large homolog 1 (Drosophila) -0.0252011
TSC22D2 TSC22 domain family, member 2 -0.0250801
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0250361
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0244969
RLF rearranged L-myc fusion -0.0238144
CYB5R3 cytochrome b5 reductase 3 -0.023758
CANX calnexin -0.0236409
PKM pyruvate kinase, muscle -0.0234214
RNF145 ring finger protein 145 -0.0233284
POSTN periostin, osteoblast specific factor -0.0221083
DSTN destrin (actin depolymerizing factor) -0.0218222
CLINT1 clathrin interactor 1 -0.0218007
ICAM1 intercellular adhesion molecule 1 -0.021755
CCNL1 cyclin L1 -0.0217245
UBC ubiquitin C -0.0214758
ZFAND3 zinc finger, AN1-type domain 3 -0.0212624
UGCG UDP-glucose ceramide glucosyltransferase -0.0210752
GOLGA4 golgin A4 -0.0209627
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0205357
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0204906
CAMTA1 calmodulin binding transcription activator 1 -0.0200823
SETD5 SET domain containing 5 -0.019992
CD44 CD44 molecule (Indian blood group) -0.0198254
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0193091
HYOU1 hypoxia up-regulated 1 -0.0189252
KIF1B kinesin family member 1B -0.0187861
IL6ST interleukin 6 signal transducer -0.0187669
CLIC4 chloride intracellular channel 4 -0.0182651
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0181921
MRTFA myocardin related transcription factor A -0.0181043
YBX1 Y box binding protein 1 -0.0180698
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0179902
PTK2 protein tyrosine kinase 2 -0.0178873
ESYT2 extended synaptotagmin-like protein 2 -0.0178483
NDRG1 N-myc downstream regulated 1 -0.0177172
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0175943
HELZ helicase with zinc finger -0.0175737
TAPBP TAP binding protein (tapasin) -0.0174603
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0173343
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0171863
RIOK3 RIO kinase 3 -0.0170891
PCBP2 poly(rC) binding protein 2 -0.0170423
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0170312
COG5 component of oligomeric golgi complex 5 -0.0168249
PRRC1 proline-rich coiled-coil 1 -0.0167783
RASA2 RAS p21 protein activator 2 -0.016748
RHEB Ras homolog enriched in brain -0.016718
MYO1B myosin IB -0.0166415
ELL2 elongation factor, RNA polymerase II, 2 -0.016628
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0165829
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0163421
RNF24 ring finger protein 24 -0.0163253
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0161436
NUP58 nucleoporin 58 -0.0161297
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0160444
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0160103
ATP11B ATPase, class VI, type 11B -0.0159743
PDE8A phosphodiesterase 8A -0.0158148
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -0.0158045