Dexmedetomidine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Dexmedetomidine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.387299
AKAP12 A kinase (PRKA) anchor protein 12 0.136265
MT2A metallothionein 2A 0.129703
GPC3 glypican 3 0.121579
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.105024
APOA2 apolipoprotein A-II 0.096344
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0940821
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0857745
TPT1 tumor protein, translationally-controlled 1 0.0751939
RPS12 ribosomal protein S12 0.0730289
RPL11 ribosomal protein L11 0.0630634
RPS6 ribosomal protein S6 0.0608377
RPL37A ribosomal protein L37a 0.056282
RPS8 ribosomal protein S8 0.0558768
RPLP1 ribosomal protein, large, P1 0.0540743
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0536224
C3 complement component 3 0.0518698
TMSB10 thymosin beta 10 0.0516037
RPS24 ribosomal protein S24 0.050978
RPS19 ribosomal protein S19 0.0485571
RPL23 ribosomal protein L23 0.0471824
RPL12 ribosomal protein L12 0.0399421
RPS27A ribosomal protein S27a 0.0397555
APOE apolipoprotein E 0.0389101
FTL ferritin, light polypeptide 0.0386792
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0386609
RPS29 ribosomal protein S29 0.0382091
RPLP2 ribosomal protein, large, P2 0.0363135
TM4SF1 transmembrane 4 L six family member 1 0.0359911
RPL26 ribosomal protein L26 0.0351779
RPS25 ribosomal protein S25 0.0351739
TF transferrin 0.0344438
HMGA1 high mobility group AT-hook 1 0.0335998
RPL31 ribosomal protein L31 0.0335046
RPS21 ribosomal protein S21 0.0334597
SLC38A2 solute carrier family 38, member 2 0.0333588
RPL5 ribosomal protein L5 0.0332977
ISG15 ISG15 ubiquitin-like modifier 0.0321399
RPS3 ribosomal protein S3 0.0321355
ENO1 enolase 1, (alpha) 0.0315544
RACK1 receptor for activated C kinase 1 0.0314599
RPS23 ribosomal protein S23 0.0311304
SDC4 syndecan 4 0.0299381
PDGFB platelet-derived growth factor beta polypeptide 0.0299247
PTMA prothymosin, alpha 0.0298818
RPL9 ribosomal protein L9 0.0298712
RPL32 ribosomal protein L32 0.0292432
AMBP alpha-1-microglobulin/bikunin precursor 0.0281426
APOA1 apolipoprotein A-I 0.0279987
MARCKS myristoylated alanine-rich protein kinase C substrate 0.02792
RPL19 ribosomal protein L19 0.027793
RPL34 ribosomal protein L34 0.0269785
AHSG alpha-2-HS-glycoprotein 0.0268779
RPL37 ribosomal protein L37 0.0256376
RNASET2 ribonuclease T2 0.0253649
TIMP1 TIMP metallopeptidase inhibitor 1 0.0250871
RPS14 ribosomal protein S14 0.0249619
RPL13A ribosomal protein L13a 0.0247989
S100A9 S100 calcium binding protein A9 0.0240464
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0229806
RPS13 ribosomal protein S13 0.0227523
RPL28 ribosomal protein L28 0.0227056
IFI6 interferon, alpha-inducible protein 6 0.0224324
PGK1 phosphoglycerate kinase 1 0.0222884
FRMD5 FERM domain containing 5 0.0222416
DDIT4 DNA-damage-inducible transcript 4 0.0222195
LOC112694756 uncharaterized LOC112694756 0.0220867
GNAS GNAS complex locus 0.0217777
RPS17 ribosomal protein S17 0.0211806
RPL35A ribosomal protein L35a 0.0209918
RPL10A ribosomal protein L10a 0.0207399
EEF2 eukaryotic translation elongation factor 2 0.0206595
PKM pyruvate kinase, muscle 0.0204939
B2M beta-2-microglobulin 0.0204354
PRRC2C proline-rich coiled-coil 2C 0.0199223
RPL36 ribosomal protein L36 0.0198713
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0196978
RPS5 ribosomal protein S5 0.0195421
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0194867
RPLP0 ribosomal protein, large, P0 0.0193037
TPM4 tropomyosin 4 0.0191368
LYZ lysozyme 0.0190816
RPL38 ribosomal protein L38 0.0189225
RPL18 ribosomal protein L18 0.0187599
PERP PERP, TP53 apoptosis effector 0.0182353
PTPRF protein tyrosine phosphatase, receptor type, F 0.0180493
RPS10 ribosomal protein S10 0.0179286
RPS16 ribosomal protein S16 0.0178972
RPL7A ribosomal protein L7a 0.0178652
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0177807
NPR2 natriuretic peptide receptor 2 0.0177647
ACTG1 actin gamma 1 0.0175786
RPL8 ribosomal protein L8 0.0175066
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0172386
ANGPTL8 angiopoietin like 8 0.0171347
RPL7 ribosomal protein L7 0.0169911
NACA nascent polypeptide-associated complex alpha subunit 0.0169475
HLA-A major histocompatibility complex, class I, A 0.0169422
RPL36A ribosomal protein L36a 0.0168817
IFITM1 interferon induced transmembrane protein 1 0.0167437

decreased expression

Symbol Name Standardized Value
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.091633
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0782837
SAMD4A sterile alpha motif domain containing 4A -0.0644899
FNDC3B fibronectin type III domain containing 3B -0.0609599
GPC6 glypican 6 -0.0606043
LRMDA leucine rich melanocyte differentiation associated -0.0414063
APOB apolipoprotein B -0.0405872
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0361314
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0360237
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0358728
FN1 fibronectin 1 -0.0336908
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0326858
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0318596
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0311803
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0305848
DOCK4 dedicator of cytokinesis 4 -0.0305489
DST dystonin -0.0288109
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0276435
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.026901
DTNA dystrobrevin, alpha -0.0257639
EXT1 exostosin glycosyltransferase 1 -0.0254446
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0248996
PDLIM5 PDZ and LIM domain 5 -0.0239561
VCL vinculin -0.023018
AHR aryl hydrocarbon receptor -0.0229194
NRIP1 nuclear receptor interacting protein 1 -0.0228331
ATXN1 ataxin 1 -0.0225046
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0219932
ITGAV integrin, alpha V -0.0215811
BIRC6 baculoviral IAP repeat containing 6 -0.0207699
SOX5 SRY (sex determining region Y)-box 5 -0.0205779
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.019876
KIF21A kinesin family member 21A -0.0197945
LCOR ligand dependent nuclear receptor corepressor -0.0194518
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0193659
PTPRK protein tyrosine phosphatase, receptor type, K -0.0190741
PKP4 plakophilin 4 -0.0189758
ELL2 elongation factor, RNA polymerase II, 2 -0.0185678
GLS2 glutaminase 2 (liver, mitochondrial) -0.0185636
AFDN afadin, adherens junction formation factor -0.018513
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0181079
PTPRM protein tyrosine phosphatase, receptor type, M -0.0180505
MED13L mediator complex subunit 13-like -0.017984
FAM135A family with sequence similarity 135, member A -0.0178154
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0174562
RERE arginine-glutamic acid dipeptide (RE) repeats -0.017379
ITGA1 integrin, alpha 1 -0.0173291
KDM4C lysine (K)-specific demethylase 4C -0.017004
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0168765
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0168667
MYO1B myosin IB -0.0168436
MAML2 mastermind-like 2 (Drosophila) -0.0168233
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0167962
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0167283
ZFAND3 zinc finger, AN1-type domain 3 -0.016657
RYBP RING1 and YY1 binding protein -0.0164719
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.016408
LPP LIM domain containing preferred translocation partner in lipoma -0.016195
WWC2 WW and C2 domain containing 2 -0.0158644
INTS6 integrator complex subunit 6 -0.0157862
STK17A serine/threonine kinase 17a -0.0155778
RB1CC1 RB1-inducible coiled-coil 1 -0.015529
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0155114
KDM6A lysine (K)-specific demethylase 6A -0.0154766
QKI QKI, KH domain containing, RNA binding -0.0151368
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.014714
LMCD1 LIM and cysteine-rich domains 1 -0.0145474
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0144181
SOD2 superoxide dismutase 2, mitochondrial -0.0143598
ADGRG6 adhesion G protein-coupled receptor G6 -0.0143272
SVIL supervillin -0.0142929
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0142523
VMP1 vacuole membrane protein 1 -0.0141218
DSPP dentin sialophosphoprotein -0.0140894
IL6ST interleukin 6 signal transducer -0.0140857
SKIL SKI-like proto-oncogene -0.0139777
ASXL1 additional sex combs like transcriptional regulator 1 -0.0139308
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0138848
RAD51B RAD51 paralog B -0.0137896
FAT1 FAT atypical cadherin 1 -0.013745
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0136783
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0136566
GMDS GDP-mannose 4,6-dehydratase -0.0135384
JMJD1C jumonji domain containing 1C -0.0132568
PICALM phosphatidylinositol binding clathrin assembly protein -0.0131095
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0129084
SMAD3 SMAD family member 3 -0.012862
MBNL3 muscleblind-like splicing regulator 3 -0.0128414
SPDYA speedy/RINGO cell cycle regulator family member A -0.0128255
ZHX2 zinc fingers and homeoboxes 2 -0.0127549
TAS2R14 taste receptor, type 2, member 14 -0.0127312
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0126892
NABP1 nucleic acid binding protein 1 -0.0126599
MYO6 myosin VI -0.0126375
PATJ PATJ crumbs cell polarity complex component -0.0125379
FOXO3 forkhead box O3 -0.0124954
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0124221
SIK3 SIK family kinase 3 -0.012394
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0123127
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0122352