Dexmedetomidine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.193163
FLNB filamin B, beta 0.165663
TIMP3 TIMP metallopeptidase inhibitor 3 0.119389
POTEF POTE ankyrin domain family, member F 0.111317
RPS21 ribosomal protein S21 0.104998
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.100216
TMSB10 thymosin beta 10 0.094917
PTMA prothymosin, alpha 0.0848025
STC1 stanniocalcin 1 0.0822607
B2M beta-2-microglobulin 0.0796134
LMNA lamin A/C 0.077072
TPT1 tumor protein, translationally-controlled 1 0.0722911
RPLP2 ribosomal protein, large, P2 0.0656207
RPS8 ribosomal protein S8 0.0622144
PODXL podocalyxin-like 0.0612233
LDHA lactate dehydrogenase A 0.0598545
PGK1 phosphoglycerate kinase 1 0.0597408
MT2A metallothionein 2A 0.0582841
S100A10 S100 calcium binding protein A10 0.057468
RPS6 ribosomal protein S6 0.0574348
RPL11 ribosomal protein L11 0.0556103
H1-0 H1.0 linker histone 0.0549569
S100A9 S100 calcium binding protein A9 0.0543102
RPS24 ribosomal protein S24 0.0534873
BCL2L1 BCL2-like 1 0.0511352
HSPG2 heparan sulfate proteoglycan 2 0.0507956
CLU clusterin 0.0499019
RPS13 ribosomal protein S13 0.049102
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0490001
HLA-B major histocompatibility complex, class I, B 0.0480381
KRT17 keratin 17, type I 0.0474364
BCAR3 breast cancer anti-estrogen resistance 3 0.0455701
ENO1 enolase 1, (alpha) 0.0449517
TMSB4X thymosin beta 4, X-linked 0.0441413
DPYD dihydropyrimidine dehydrogenase 0.0439009
MKI67 marker of proliferation Ki-67 0.0434038
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0428711
RPS3 ribosomal protein S3 0.0422318
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0420623
IFITM3 interferon induced transmembrane protein 3 0.0419331
ACTN4 actinin, alpha 4 0.0415618
SRRM2 serine/arginine repetitive matrix 2 0.0410648
EGR1 early growth response 1 0.0406648
FLNA filamin A, alpha 0.0405511
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0405381
RPS12 ribosomal protein S12 0.0403437
RPS19 ribosomal protein S19 0.039715
RPLP1 ribosomal protein, large, P1 0.0396878
FOSL1 FOS-like antigen 1 0.0394621
RPL37 ribosomal protein L37 0.0387516
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0379257
PALM2AKAP2 PALM2 and AKAP2 fusion 0.037523
IFITM1 interferon induced transmembrane protein 1 0.037497
ITGA6 integrin, alpha 6 0.0370745
TPX2 TPX2, microtubule-associated 0.0369211
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0368996
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0362653
PFN1 profilin 1 0.0360007
PALLD palladin, cytoskeletal associated protein 0.0359238
MSN moesin 0.035398
ANXA2 annexin A2 0.0353749
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0351836
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0346442
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0343475
ZMYND8 zinc finger, MYND-type containing 8 0.0339455
RALY RALY heterogeneous nuclear ribonucleoprotein 0.033769
RPL5 ribosomal protein L5 0.0336833
RASAL2 RAS protein activator like 2 0.0335751
PKM pyruvate kinase, muscle 0.0335142
IFI6 interferon, alpha-inducible protein 6 0.0332595
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0328305
ACTG1 actin gamma 1 0.031711
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0314879
VCL vinculin 0.0314756
CAV1 caveolin 1, caveolae protein, 22kDa 0.0313332
TAGLN2 transgelin 2 0.0311927
RPL26 ribosomal protein L26 0.0311344
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0308027
FOXO1 forkhead box O1 0.0307575
BLCAP bladder cancer associated protein 0.0306786
WASF2 WAS protein family, member 2 0.0306109
RPL23 ribosomal protein L23 0.0305926
GNAS GNAS complex locus 0.0305825
RPS25 ribosomal protein S25 0.0305519
RPL37A ribosomal protein L37a 0.0303208
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0301008
ZMIZ1 zinc finger, MIZ-type containing 1 0.0300815
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0299359
S100A2 S100 calcium binding protein A2 0.0293338
PRRC2C proline-rich coiled-coil 2C 0.0291585
IFI27 interferon, alpha-inducible protein 27 0.02909
KRT6A keratin 6A, type II 0.0290699
EPHA2 EPH receptor A2 0.0288635
MIDN midnolin 0.0288071
IGF2 insulin-like growth factor 2 0.0285658
RPL7A ribosomal protein L7a 0.0285621
RPS27A ribosomal protein S27a 0.0282941
RPL9 ribosomal protein L9 0.0282389
NEK7 NIMA-related kinase 7 0.0281858
CNRIP1 cannabinoid receptor interacting protein 1 0.0281242

decreased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A -0.0535035
ANXA1 annexin A1 -0.0346295
MYOF myoferlin -0.0316221
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0285047
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0283134
QKI QKI, KH domain containing, RNA binding -0.0272843
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0254475
CANX calnexin -0.0249443
ESYT2 extended synaptotagmin-like protein 2 -0.0248725
SUCO SUN domain containing ossification factor -0.0223936
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.022333
LMAN1 lectin, mannose-binding, 1 -0.0222139
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0220571
NRIP1 nuclear receptor interacting protein 1 -0.0218001
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0217394
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.021622
IARS1 isoleucyl-tRNA synthetase 1 -0.0214576
NAMPT nicotinamide phosphoribosyltransferase -0.0211522
SRP54 signal recognition particle 54kDa -0.0206319
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0203249
PPARG peroxisome proliferator-activated receptor gamma -0.0202892
FRMD6 FERM domain containing 6 -0.0197589
ITCH itchy E3 ubiquitin protein ligase -0.0193902
GRB10 growth factor receptor-bound protein 10 -0.0189135
ABI3BP ABI family, member 3 (NESH) binding protein -0.0187567
RAI14 retinoic acid induced 14 -0.0185446
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.01822
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0180924
VEGFA vascular endothelial growth factor A -0.0178652
TTC3 tetratricopeptide repeat domain 3 -0.0174546
COG6 component of oligomeric golgi complex 6 -0.0171002
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0170004
FNIP1 folliculin interacting protein 1 -0.016703
RASA3 RAS p21 protein activator 3 -0.0162932
DLG1 discs, large homolog 1 (Drosophila) -0.0161197
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0160661
KIF16B kinesin family member 16B -0.0160467
IL1RAP interleukin 1 receptor accessory protein -0.0158372
ERBIN erbb2 interacting protein -0.0156066
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0155803
EZR ezrin -0.0155562
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.0155365
MORF4L2 mortality factor 4 like 2 -0.0153372
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0144695
COPA coatomer protein complex, subunit alpha -0.01397
ZEB1 zinc finger E-box binding homeobox 1 -0.013959
LOXL2 lysyl oxidase-like 2 -0.0137884
GARS1 glycyl-tRNA synthetase 1 -0.0137573
FNBP4 formin binding protein 4 -0.0137132
PIAS2 protein inhibitor of activated STAT, 2 -0.0136608
KDM7A lysine (K)-specific demethylase 7A -0.0135424
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0132678
TRAM1 translocation associated membrane protein 1 -0.013205
DOK5 docking protein 5 -0.0130539
MARCHF6 membrane associated ring-CH-type finger 6 -0.0129474
COPB1 coatomer protein complex, subunit beta 1 -0.0129307
PRRC1 proline-rich coiled-coil 1 -0.01269
CHKA choline kinase alpha -0.0124763
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -0.0122924
RUNX1 runt-related transcription factor 1 -0.0122346
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0121378
ATP9A ATPase, class II, type 9A -0.0121087
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.012085
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0119979
COG5 component of oligomeric golgi complex 5 -0.0119919
RNF145 ring finger protein 145 -0.0119288
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0119214
DENND4C DENN/MADD domain containing 4C -0.0118393
MANBA mannosidase, beta A, lysosomal -0.0117583
SPIRE1 spire-type actin nucleation factor 1 -0.0117244
NPEPPS aminopeptidase puromycin sensitive -0.0117063
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0116343
ATP13A3 ATPase type 13A3 -0.0115997
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -0.0115712
RNF220 ring finger protein 220 -0.0115102
BIRC3 baculoviral IAP repeat containing 3 -0.0114328
NFIA nuclear factor I/A -0.0113403
OSBPL2 oxysterol binding protein-like 2 -0.0113246
USP24 ubiquitin specific peptidase 24 -0.0112685
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0112638
ARF4 ADP-ribosylation factor 4 -0.0112526
ZNF638 zinc finger protein 638 -0.011221
RLIM ring finger protein, LIM domain interacting -0.0112206
USP3 ubiquitin specific peptidase 3 -0.0112005
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0111764
TMF1 TATA element modulatory factor 1 -0.011157
RC3H1 ring finger and CCCH-type domains 1 -0.0110888
AKAP9 A kinase (PRKA) anchor protein 9 -0.0110667
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.011046
FAM107B family with sequence similarity 107, member B -0.0109959
EPB41 erythrocyte membrane protein band 4.1 -0.0109949
SNX13 sorting nexin 13 -0.0107822
PER3 period circadian clock 3 -0.0107783
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0107547
SENP6 SUMO1/sentrin specific peptidase 6 -0.0105769
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0105015
IFRD1 interferon-related developmental regulator 1 -0.0102945
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0102665
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0102559
ZMYM2 zinc finger, MYM-type 2 -0.0102127