| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dexmedetomidine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.145179 |
| POTEF | POTE ankyrin domain family, member F | 0.106036 |
| MT2A | metallothionein 2A | 0.0984364 |
| MT1X | metallothionein 1X | 0.0693572 |
| TXNRD1 | thioredoxin reductase 1 | 0.0681922 |
| TMSB10 | thymosin beta 10 | 0.0663391 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0597306 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0583832 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0574911 |
| MKI67 | marker of proliferation Ki-67 | 0.0573108 |
| RTN4 | reticulon 4 | 0.0519808 |
| CENPF | centromere protein F, 350/400kDa | 0.050807 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0491307 |
| RAI1 | retinoic acid induced 1 | 0.0487662 |
| FOSL1 | FOS-like antigen 1 | 0.0483718 |
| RBM25 | RNA binding motif protein 25 | 0.0472955 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0446724 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.044607 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0380879 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0376971 |
| KLF6 | Kruppel-like factor 6 | 0.0376632 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0371832 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0370857 |
| PTMA | prothymosin, alpha | 0.0364383 |
| TMEM41B | transmembrane protein 41B | 0.0362341 |
| YBX3 | Y box binding protein 3 | 0.0359553 |
| EZR | ezrin | 0.0358798 |
| RPL5 | ribosomal protein L5 | 0.0353096 |
| RBM39 | RNA binding motif protein 39 | 0.0351756 |
| BRD4 | bromodomain containing 4 | 0.0351548 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0346262 |
| TOP1 | topoisomerase (DNA) I | 0.0336174 |
| XPO1 | exportin 1 | 0.0328545 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0326134 |
| FLNB | filamin B, beta | 0.0315929 |
| MATR3 | matrin 3 | 0.0312059 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0311122 |
| POM121 | POM121 transmembrane nucleoporin | 0.0303116 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0302988 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0297431 |
| WDR26 | WD repeat domain 26 | 0.0289476 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0281729 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0280036 |
| SRPK2 | SRSF protein kinase 2 | 0.0275837 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0274127 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0270481 |
| RPL13A | ribosomal protein L13a | 0.0270206 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0267333 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0265649 |
| PRDX1 | peroxiredoxin 1 | 0.0264955 |
| DIAPH3 | diaphanous-related formin 3 | 0.0264682 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0261405 |
| PER1 | period circadian clock 1 | 0.0260993 |
| ACTG1 | actin gamma 1 | 0.0260351 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0260119 |
| FOXJ3 | forkhead box J3 | 0.0257856 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0254174 |
| TPX2 | TPX2, microtubule-associated | 0.0253507 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0250777 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0248381 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0247428 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0246865 |
| NOP58 | NOP58 ribonucleoprotein | 0.0244651 |
| FMNL2 | formin-like 2 | 0.0242106 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0241527 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0240581 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0237823 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0236553 |
| TCERG1 | transcription elongation regulator 1 | 0.0235785 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0232038 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0231519 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.022946 |
| CKAP5 | cytoskeleton associated protein 5 | 0.022841 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0227079 |
| RLF | rearranged L-myc fusion | 0.0225026 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.022318 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0222532 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0221092 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.0217525 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0215507 |
| SON | SON DNA binding protein | 0.0214498 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0214398 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0214249 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0212319 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0211673 |
| ATP13A3 | ATPase type 13A3 | 0.0210567 |
| GTF2I | general transcription factor IIi | 0.0210413 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0208499 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0207323 |
| POM121C | POM121 transmembrane nucleoporin C | 0.0206618 |
| HJURP | Holliday junction recognition protein | 0.0204928 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0204048 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0203403 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0202879 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0201334 |
| ATXN2L | ataxin 2-like | 0.0200942 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0200098 |
| OGA | O-GlcNAcase | 0.0199932 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0198492 |
| PCBP2 | poly(rC) binding protein 2 | 0.0197844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | -0.186389 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.177913 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.164748 |
| CD44 | CD44 molecule (Indian blood group) | -0.144152 |
| TP63 | tumor protein p63 | -0.140673 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125482 |
| CADM2 | cell adhesion molecule 2 | -0.118134 |
| HLA-B | major histocompatibility complex, class I, B | -0.107675 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0965068 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0895934 |
| CANX | calnexin | -0.0877328 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0847858 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0814137 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0736046 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0708646 |
| EFNA5 | ephrin-A5 | -0.0689894 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0678906 |
| EPHA4 | EPH receptor A4 | -0.0644627 |
| MYOF | myoferlin | -0.0628621 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0585401 |
| PRELID2 | PRELI domain containing 2 | -0.0566371 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0566343 |
| VCL | vinculin | -0.0547023 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0543412 |
| ENO1 | enolase 1, (alpha) | -0.0541599 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0538451 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0532458 |
| EHBP1 | EH domain binding protein 1 | -0.0511343 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0494607 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0493368 |
| TNS3 | tensin 3 | -0.0475627 |
| RPS6 | ribosomal protein S6 | -0.0455714 |
| INTS6 | integrator complex subunit 6 | -0.0454805 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0450576 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0446663 |
| TMEM123 | transmembrane protein 123 | -0.0441279 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0427154 |
| RPL35A | ribosomal protein L35a | -0.0425001 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.042367 |
| SP100 | SP100 nuclear antigen | -0.0420759 |
| LDHA | lactate dehydrogenase A | -0.0417502 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0412075 |
| HDLBP | high density lipoprotein binding protein | -0.0410339 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0404096 |
| EGFR | epidermal growth factor receptor | -0.0401805 |
| RAB7A | RAB7A, member RAS oncogene family | -0.039944 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0396875 |
| LYST | lysosomal trafficking regulator | -0.0393287 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0387414 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0387061 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0382848 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0377045 |
| LOXL2 | lysyl oxidase-like 2 | -0.0373764 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.036655 |
| GOLGB1 | golgin B1 | -0.0362718 |
| RPS8 | ribosomal protein S8 | -0.0346798 |
| B2M | beta-2-microglobulin | -0.0346522 |
| EXOC4 | exocyst complex component 4 | -0.034316 |
| PLIN2 | perilipin 2 | -0.034115 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0335884 |
| HOMER1 | homer scaffolding protein 1 | -0.0335066 |
| HDAC9 | histone deacetylase 9 | -0.0332984 |
| ZNF217 | zinc finger protein 217 | -0.0331433 |
| UBC | ubiquitin C | -0.0328075 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0325389 |
| RNF213 | ring finger protein 213 | -0.0323407 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0322283 |
| NEK10 | NIMA-related kinase 10 | -0.0321927 |
| DENND1A | DENN/MADD domain containing 1A | -0.0317617 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0311222 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0311056 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0307774 |
| PDE10A | phosphodiesterase 10A | -0.0306377 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0303276 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0302811 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0302428 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0298583 |
| CUX1 | cut-like homeobox 1 | -0.0294928 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0293528 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0290781 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.029067 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0285231 |
| FNIP1 | folliculin interacting protein 1 | -0.0284935 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0283637 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0283385 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.028148 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0276867 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0274903 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.027067 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0268335 |
| SQSTM1 | sequestosome 1 | -0.0266085 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0266018 |
| RAD51B | RAD51 paralog B | -0.0264924 |
| GLG1 | golgi glycoprotein 1 | -0.0260081 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0256704 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0255662 |
| CALR | calreticulin | -0.0253283 |
| AEBP2 | AE binding protein 2 | -0.0252867 |
| COL5A2 | collagen, type V, alpha 2 | -0.0251509 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0250411 |
