| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dexmedetomidine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.146945 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.116353 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.114468 |
| TXNRD1 | thioredoxin reductase 1 | 0.104007 |
| NDRG1 | N-myc downstream regulated 1 | 0.095954 |
| RPS3 | ribosomal protein S3 | 0.0807238 |
| OSMR | oncostatin M receptor | 0.0671998 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0658057 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0640292 |
| TMSB10 | thymosin beta 10 | 0.062781 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0622651 |
| FTL | ferritin, light polypeptide | 0.0617806 |
| LAMA4 | laminin, alpha 4 | 0.0613955 |
| H1-0 | H1.0 linker histone | 0.0601218 |
| SMAD3 | SMAD family member 3 | 0.0588007 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0574117 |
| FAM13A | family with sequence similarity 13, member A | 0.0558732 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0513983 |
| RPS12 | ribosomal protein S12 | 0.0492754 |
| PRRC2C | proline-rich coiled-coil 2C | 0.048908 |
| MT1X | metallothionein 1X | 0.0479025 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0453779 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0443429 |
| MKI67 | marker of proliferation Ki-67 | 0.0430372 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0421589 |
| RPL37A | ribosomal protein L37a | 0.0407079 |
| RPLP1 | ribosomal protein, large, P1 | 0.0406131 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0402569 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0392431 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0363898 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0350132 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0349638 |
| EFNA5 | ephrin-A5 | 0.0349602 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0345654 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0338006 |
| RNF213 | ring finger protein 213 | 0.0337813 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.033289 |
| RBM25 | RNA binding motif protein 25 | 0.0328121 |
| CSNK1E | casein kinase 1, epsilon | 0.0325843 |
| PGK1 | phosphoglycerate kinase 1 | 0.0325467 |
| LAMB3 | laminin, beta 3 | 0.0320838 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0317964 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0313123 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0303154 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0289982 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0289269 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0288698 |
| RBM39 | RNA binding motif protein 39 | 0.0286478 |
| RNF149 | ring finger protein 149 | 0.0278547 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0269676 |
| RUNX1 | runt-related transcription factor 1 | 0.0269084 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0267309 |
| FOSL1 | FOS-like antigen 1 | 0.0258299 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0252046 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0250228 |
| CES1 | carboxylesterase 1 | 0.0249599 |
| RPS29 | ribosomal protein S29 | 0.024935 |
| WASF2 | WAS protein family, member 2 | 0.0243956 |
| RPS24 | ribosomal protein S24 | 0.0243067 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0242679 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0241026 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0240942 |
| NGLY1 | N-glycanase 1 | 0.0237393 |
| RPL36 | ribosomal protein L36 | 0.0236328 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0235401 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0234491 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.023429 |
| TMEM165 | transmembrane protein 165 | 0.0230038 |
| CCNL1 | cyclin L1 | 0.0229489 |
| RPS23 | ribosomal protein S23 | 0.0229149 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0225369 |
| USP34 | ubiquitin specific peptidase 34 | 0.0223304 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0220604 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0216947 |
| WDR45B | WD repeat domain 45B | 0.0215671 |
| RPL26 | ribosomal protein L26 | 0.0214791 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0211973 |
| STC1 | stanniocalcin 1 | 0.0211063 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0208159 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0205714 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0205401 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0205247 |
| RPLP2 | ribosomal protein, large, P2 | 0.0201494 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0201343 |
| ADAR | adenosine deaminase, RNA-specific | 0.0200417 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0198806 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0198549 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0197614 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.019715 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0196375 |
| RPS25 | ribosomal protein S25 | 0.0196252 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0193398 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0192009 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0190899 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0190447 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0189597 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.0186578 |
| YBX3 | Y box binding protein 3 | 0.0186304 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.018551 |
| CAB39 | calcium binding protein 39 | 0.0185462 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.272353 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.177238 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.121867 |
| ASPH | aspartate beta-hydroxylase | -0.0923025 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0898604 |
| INTS6 | integrator complex subunit 6 | -0.0723333 |
| CANX | calnexin | -0.0653833 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0594278 |
| LDHA | lactate dehydrogenase A | -0.0574216 |
| GOLGB1 | golgin B1 | -0.0566813 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0537397 |
| KRT18 | keratin 18, type I | -0.0527574 |
| ACTG1 | actin gamma 1 | -0.0491912 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0478547 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0476589 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0469614 |
| HDLBP | high density lipoprotein binding protein | -0.0428743 |
| ENO1 | enolase 1, (alpha) | -0.0427309 |
| HOMER1 | homer scaffolding protein 1 | -0.0416549 |
| AGR2 | anterior gradient 2 | -0.040674 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.038004 |
| KRT7 | keratin 7, type II | -0.0359789 |
| MYOF | myoferlin | -0.0359694 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0350543 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0337675 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0330923 |
| MORF4L2 | mortality factor 4 like 2 | -0.0322678 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0319582 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.030199 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0288258 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0285247 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0283698 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0281899 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0279435 |
| LMO7 | LIM domain 7 | -0.027357 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0273421 |
| HYOU1 | hypoxia up-regulated 1 | -0.0273284 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0271011 |
| SCEL | sciellin | -0.0270168 |
| MAGT1 | magnesium transporter 1 | -0.0269281 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0267729 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0267478 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0266236 |
| ARCN1 | archain 1 | -0.0260693 |
| USP53 | ubiquitin specific peptidase 53 | -0.0255152 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0251948 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0251358 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0250866 |
| DSPP | dentin sialophosphoprotein | -0.0249192 |
| MYO1E | myosin IE | -0.0248203 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0248075 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0246549 |
| CAV2 | caveolin 2 | -0.0241006 |
| S100A10 | S100 calcium binding protein A10 | -0.0235126 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0234947 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0228919 |
| TPM4 | tropomyosin 4 | -0.0228174 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0228034 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0227775 |
| TRAM1 | translocation associated membrane protein 1 | -0.0227408 |
| SEC24D | SEC24 family member D | -0.0220761 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0220377 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.02173 |
| PMM2 | phosphomannomutase 2 | -0.0216322 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0214778 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0208998 |
| ATF6 | activating transcription factor 6 | -0.0208448 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0207183 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0202881 |
| HM13 | histocompatibility (minor) 13 | -0.0202881 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0200513 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0200308 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0198579 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0197895 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0191276 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0190577 |
| USO1 | USO1 vesicle transport factor | -0.0190486 |
| TES | testin LIM domain protein | -0.0188424 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0188262 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0188118 |
| ARF1 | ADP-ribosylation factor 1 | -0.0185463 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0183761 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0183694 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0182362 |
| DSG2 | desmoglein 2 | -0.0180848 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0178842 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0178178 |
| MYO5B | myosin VB | -0.0175323 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | -0.0174898 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0173674 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0173086 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0172132 |
| ERI2 | ERI1 exoribonuclease family member 2 | -0.017152 |
| CLTC | clathrin, heavy chain (Hc) | -0.0170636 |
| FBXO11 | F-box protein 11 | -0.0167787 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0166265 |
| SCFD1 | sec1 family domain containing 1 | -0.0166178 |
| HSPA13 | heat shock protein 70kDa family, member 13 | -0.0164803 |
| COPA | coatomer protein complex, subunit alpha | -0.0163805 |
| PGM3 | phosphoglucomutase 3 | -0.0162409 |
