Dexmedetomidine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.196252
PTMA prothymosin, alpha 0.128177
TM4SF1 transmembrane 4 L six family member 1 0.12541
AKAP12 A kinase (PRKA) anchor protein 12 0.124415
GRAMD1B GRAM domain containing 1B 0.123375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112439
RPS27A ribosomal protein S27a 0.0930861
RPL23 ribosomal protein L23 0.0757574
EEF2 eukaryotic translation elongation factor 2 0.0690935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0678023
TPM3 tropomyosin 3 0.0651006
HSPA8 heat shock 70kDa protein 8 0.0631671
MKI67 marker of proliferation Ki-67 0.0581106
RPS3 ribosomal protein S3 0.0575516
UBC ubiquitin C 0.0571532
RPL4 ribosomal protein L4 0.0569422
TMSB10 thymosin beta 10 0.0549797
IER3 immediate early response 3 0.0542584
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0527446
RPL26 ribosomal protein L26 0.0510922
NAP1L1 nucleosome assembly protein 1-like 1 0.0497445
AHNAK AHNAK nucleoprotein 0.0477384
POTEF POTE ankyrin domain family, member F 0.0476632
ENO1 enolase 1, (alpha) 0.0466782
RPL37A ribosomal protein L37a 0.0464138
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0457407
HDGF hepatoma-derived growth factor 0.0445032
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0444018
ASPH aspartate beta-hydroxylase 0.0432677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0430877
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0425599
TFPI2 tissue factor pathway inhibitor 2 0.0398842
RPS8 ribosomal protein S8 0.0396291
S100A6 S100 calcium binding protein A6 0.0395437
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0384959
RPS25 ribosomal protein S25 0.0378095
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0366101
RPS12 ribosomal protein S12 0.035504
ACTG1 actin gamma 1 0.0349247
RACK1 receptor for activated C kinase 1 0.0333971
YBX1 Y box binding protein 1 0.0333817
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0323239
LMNA lamin A/C 0.0320945
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0318607
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0318575
PRRC2A proline-rich coiled-coil 2A 0.0314782
SRRM2 serine/arginine repetitive matrix 2 0.0314425
EIF4A1 eukaryotic translation initiation factor 4A1 0.0308899
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0308577
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0306522
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0305637
RPS24 ribosomal protein S24 0.0304468
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0291753
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0291005
SET SET nuclear proto-oncogene 0.028094
RPL5 ribosomal protein L5 0.027837
PTPRF protein tyrosine phosphatase, receptor type, F 0.0270425
STC1 stanniocalcin 1 0.0262522
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0261945
CFLAR CASP8 and FADD-like apoptosis regulator 0.0260989
FAM107B family with sequence similarity 107, member B 0.0256565
RPS2 ribosomal protein S2 0.025656
RPL19 ribosomal protein L19 0.0254796
FLNA filamin A, alpha 0.0250234
TUBB tubulin, beta class I 0.0249987
EEF1G eukaryotic translation elongation factor 1 gamma 0.0249674
RPL18 ribosomal protein L18 0.0245199
RPL36A ribosomal protein L36a 0.0245027
SFTPA2 surfactant protein A2 0.023713
NPR2 natriuretic peptide receptor 2 0.02351
UPP1 uridine phosphorylase 1 0.0234627
RPS17 ribosomal protein S17 0.023337
DGKD diacylglycerol kinase, delta 130kDa 0.0232323
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0230692
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0229518
SLC38A2 solute carrier family 38, member 2 0.0228287
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0226469
RSL1D1 ribosomal L1 domain containing 1 0.0225646
RPL31 ribosomal protein L31 0.0223597
S100A10 S100 calcium binding protein A10 0.0222182
RHOA ras homolog family member A 0.0219837
EIF4A2 eukaryotic translation initiation factor 4A2 0.0217285
S100A9 S100 calcium binding protein A9 0.0212
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0210015
SRGN serglycin 0.0207673
AXL AXL receptor tyrosine kinase 0.0206172
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0205594
CAVIN1 caveolae associated protein 1 0.0204989
PDIA4 protein disulfide isomerase family A, member 4 0.020416
PM20D1 peptidase M20 domain containing 1 0.0203881
APP amyloid beta (A4) precursor protein 0.0202682
PKM pyruvate kinase, muscle 0.020267
PFDN2 prefoldin subunit 2 0.0202601
NACA nascent polypeptide-associated complex alpha subunit 0.0201305
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0200444
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.0198725
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0196164
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0195053
RAI1 retinoic acid induced 1 0.0191085
XPO1 exportin 1 0.0190353

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.216954
PDE4D phosphodiesterase 4D, cAMP-specific -0.096122
PARD3 par-3 family cell polarity regulator -0.0667173
FNDC3B fibronectin type III domain containing 3B -0.0652268
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0637823
THSD4 thrombospondin, type I, domain containing 4 -0.0608678
FTL ferritin, light polypeptide -0.0592163
DOCK4 dedicator of cytokinesis 4 -0.0578832
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0571363
MT2A metallothionein 2A -0.0548825
IGFBP3 insulin-like growth factor binding protein 3 -0.051423
PTK2 protein tyrosine kinase 2 -0.048639
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0457041
FTH1 ferritin, heavy polypeptide 1 -0.0450245
ARHGAP26 Rho GTPase activating protein 26 -0.0448011
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0392193
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0388994
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0378909
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0367113
ERBIN erbb2 interacting protein -0.036396
RASAL2 RAS protein activator like 2 -0.0361489
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0355216
GLS2 glutaminase 2 (liver, mitochondrial) -0.0352447
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0351555
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0346237
RPL35A ribosomal protein L35a -0.0339372
EXT1 exostosin glycosyltransferase 1 -0.032673
WAC WW domain containing adaptor with coiled-coil -0.032302
IGF2 insulin-like growth factor 2 -0.0311521
LPP LIM domain containing preferred translocation partner in lipoma -0.0307456
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0306637
MAP1B microtubule-associated protein 1B -0.0302821
RAB7A RAB7A, member RAS oncogene family -0.0299119
FMNL2 formin-like 2 -0.0294878
NEGR1 neuronal growth regulator 1 -0.028676
EGFR epidermal growth factor receptor -0.0285618
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0285036
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0283254
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0281423
TTC28 tetratricopeptide repeat domain 28 -0.0280892
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0277935
ELL2 elongation factor, RNA polymerase II, 2 -0.0273282
UTRN utrophin -0.0268053
STRN3 striatin, calmodulin binding protein 3 -0.0255336
ARMH4 armadillo like helical domain containing 4 -0.0253814
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0251162
PTPRM protein tyrosine phosphatase, receptor type, M -0.0247875
SMOC1 SPARC related modular calcium binding 1 -0.0244505
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0239157
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0236895
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0233431
NF1 neurofibromin 1 -0.0233421
GDNF glial cell derived neurotrophic factor -0.0231589
SAMD4A sterile alpha motif domain containing 4A -0.022921
SLC35F3 solute carrier family 35, member F3 -0.0227472
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0226431
BICC1 BicC family RNA binding protein 1 -0.0226361
PDLIM5 PDZ and LIM domain 5 -0.0226232
TBC1D5 TBC1 domain family, member 5 -0.0225428
ZFAND3 zinc finger, AN1-type domain 3 -0.0223917
ATP5F1B ATP synthase F1 subunit beta -0.0223852
RAD51B RAD51 paralog B -0.0219951
PTPRG protein tyrosine phosphatase, receptor type, G -0.0219696
RBM39 RNA binding motif protein 39 -0.0218531
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.021797
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0213083
KTN1 kinectin 1 (kinesin receptor) -0.0210377
TFG TRK-fused gene -0.0209642
KMT2C lysine (K)-specific methyltransferase 2C -0.0208677
BASP1 brain abundant, membrane attached signal protein 1 -0.0207338
COG5 component of oligomeric golgi complex 5 -0.0207064
ZBTB20 zinc finger and BTB domain containing 20 -0.0203625
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0202824
NDRG1 N-myc downstream regulated 1 -0.0202489
NRG1 neuregulin 1 -0.0201601
BRD2 bromodomain containing 2 -0.0200786
SRBD1 S1 RNA binding domain 1 -0.0199609
BZW2 basic leucine zipper and W2 domains 2 -0.0197772
KMT2E lysine (K)-specific methyltransferase 2E -0.0196693
VEZT vezatin, adherens junctions transmembrane protein -0.0196496
DST dystonin -0.0194156
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0193284
PYGL phosphorylase, glycogen, liver -0.0191913
ALCAM activated leukocyte cell adhesion molecule -0.0191596
PDIA3 protein disulfide isomerase family A, member 3 -0.0191444
NUP58 nucleoporin 58 -0.0191136
MORF4L2 mortality factor 4 like 2 -0.0190909
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0188657
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0188284
CCNL1 cyclin L1 -0.0187953
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0186873
EGR1 early growth response 1 -0.0186603
HMGA1 high mobility group AT-hook 1 -0.0185838
TJP1 tight junction protein 1 -0.0184099
FAM135A family with sequence similarity 135, member A -0.0183376
B2M beta-2-microglobulin -0.0183218
NHSL1 NHS-like 1 -0.018246
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0181678
TSC22D2 TSC22 domain family, member 2 -0.0180505
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0180218