| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dexmedetomidine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0998138 |
| NAV2 | neuron navigator 2 | 0.0840899 |
| PDE10A | phosphodiesterase 10A | 0.0734991 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0691719 |
| NRG3 | neuregulin 3 | 0.0679399 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0673674 |
| RAD51B | RAD51 paralog B | 0.0667669 |
| DST | dystonin | 0.0626209 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0607751 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0604322 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0595326 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0572547 |
| BBX | bobby sox homolog (Drosophila) | 0.0560984 |
| RBM25 | RNA binding motif protein 25 | 0.0524882 |
| TMF1 | TATA element modulatory factor 1 | 0.0524387 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0518239 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.050464 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.049354 |
| INHBA | inhibin, beta A | 0.0492688 |
| GOLGA4 | golgin A4 | 0.0492481 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0480593 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0476559 |
| VIM | vimentin | 0.0474493 |
| IGF2 | insulin-like growth factor 2 | 0.0473153 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0469029 |
| YME1L1 | YME1-like 1 ATPase | 0.0463737 |
| UBE3A | ubiquitin protein ligase E3A | 0.0451073 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0444054 |
| CDK19 | cyclin-dependent kinase 19 | 0.0441856 |
| SERTAD2 | SERTA domain containing 2 | 0.0440686 |
| YTHDC1 | YTH domain containing 1 | 0.0435428 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0433644 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0429138 |
| FMNL2 | formin-like 2 | 0.0424927 |
| RNF145 | ring finger protein 145 | 0.0417637 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0415538 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0412545 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0399864 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0397398 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0389993 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0384545 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0383228 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0383192 |
| FOXO3 | forkhead box O3 | 0.0381782 |
| ENO1 | enolase 1, (alpha) | 0.0381523 |
| CDC73 | cell division cycle 73 | 0.0378741 |
| FMN1 | formin 1 | 0.0376424 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0375583 |
| H1-0 | H1.0 linker histone | 0.0372358 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.03667 |
| CENPF | centromere protein F, 350/400kDa | 0.0366552 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0365425 |
| NCKAP1 | NCK-associated protein 1 | 0.0363813 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0355307 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0352809 |
| SNX9 | sorting nexin 9 | 0.0352762 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0351974 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0350587 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0348724 |
| TMSB4X | thymosin beta 4, X-linked | 0.0347572 |
| RPL32 | ribosomal protein L32 | 0.0346563 |
| TMEM131 | transmembrane protein 131 | 0.0343678 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.034309 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0341438 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0340475 |
| DENND1A | DENN/MADD domain containing 1A | 0.0338427 |
| PHF21A | PHD finger protein 21A | 0.033626 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0335143 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0334112 |
| PTMA | prothymosin, alpha | 0.0333886 |
| HELZ | helicase with zinc finger | 0.0333251 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0330471 |
| NEMF | nuclear export mediator factor | 0.0328123 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0327473 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0324232 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0321785 |
| KLC1 | kinesin light chain 1 | 0.0320026 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0317911 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0312331 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0309278 |
| LAMB3 | laminin, beta 3 | 0.0308327 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0304907 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0302472 |
| TLK1 | tousled-like kinase 1 | 0.0302137 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0299269 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0297957 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0297353 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.029699 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0296932 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0296854 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0296064 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0294715 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0292707 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0290079 |
| YEATS2 | YEATS domain containing 2 | 0.0289675 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0287386 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0284154 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0283995 |
| FLNB | filamin B, beta | 0.0282725 |
| SEC24A | SEC24 family member A | 0.0278581 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.14268 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.113177 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107526 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.101081 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0985477 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0972708 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0956028 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0822871 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0783363 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.074722 |
| MYO1E | myosin IE | -0.0695132 |
| MUC16 | mucin 16, cell surface associated | -0.0694423 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0658822 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0586892 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0571746 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0561794 |
| AHNAK | AHNAK nucleoprotein | -0.0550145 |
| PRKCA | protein kinase C, alpha | -0.0545209 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0542868 |
| LAMC2 | laminin, gamma 2 | -0.053238 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0509034 |
| TPM4 | tropomyosin 4 | -0.0508422 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0505368 |
| EGFR | epidermal growth factor receptor | -0.0498875 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0498197 |
| ERBIN | erbb2 interacting protein | -0.0491276 |
| RPLP0 | ribosomal protein, large, P0 | -0.0472121 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0467502 |
| TXNRD1 | thioredoxin reductase 1 | -0.0464124 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0462027 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0457138 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0453677 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0452325 |
| MEF2A | myocyte enhancer factor 2A | -0.0439381 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0432503 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0427435 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0424416 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0424354 |
| RBM47 | RNA binding motif protein 47 | -0.0419834 |
| ATOSA | atos homolog A | -0.0416816 |
| NABP1 | nucleic acid binding protein 1 | -0.0416436 |
| RUNX1 | runt-related transcription factor 1 | -0.0415898 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0414419 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0395122 |
| RPS23 | ribosomal protein S23 | -0.0389077 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0380457 |
| USP34 | ubiquitin specific peptidase 34 | -0.0380056 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0375111 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.037416 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0371528 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0369524 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0363696 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0359816 |
| LMNA | lamin A/C | -0.0359571 |
| RPS8 | ribosomal protein S8 | -0.0353163 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0352951 |
| HLA-B | major histocompatibility complex, class I, B | -0.0352408 |
| CD2AP | CD2-associated protein | -0.0352116 |
| DSPP | dentin sialophosphoprotein | -0.0345473 |
| PARD3 | par-3 family cell polarity regulator | -0.0341289 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0337465 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0336445 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0335334 |
| FTL | ferritin, light polypeptide | -0.0334086 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0333959 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0325779 |
| DOCK4 | dedicator of cytokinesis 4 | -0.032106 |
| RPS20 | ribosomal protein S20 | -0.0320804 |
| TUFT1 | tuftelin 1 | -0.0320455 |
| WASF2 | WAS protein family, member 2 | -0.0319714 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0317701 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0317181 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0302971 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0302233 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0302095 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0299863 |
| TMSB10 | thymosin beta 10 | -0.0298156 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0297395 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0295938 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0292262 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0291457 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0291089 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0289794 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0289743 |
| COL5A1 | collagen, type V, alpha 1 | -0.0285801 |
| INTS6 | integrator complex subunit 6 | -0.0285625 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0283122 |
| OSMR | oncostatin M receptor | -0.0282336 |
| SLC38A1 | solute carrier family 38, member 1 | -0.028169 |
| ASPH | aspartate beta-hydroxylase | -0.0275141 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0273314 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0271105 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0266937 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0265761 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0261772 |
| HOMER1 | homer scaffolding protein 1 | -0.0259264 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0255337 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0251558 |
| ATP13A3 | ATPase type 13A3 | -0.0250453 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0249914 |
