Dexmedetomidine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.107799
AKAP12 A kinase (PRKA) anchor protein 12 0.0814074
VIM vimentin 0.0743012
PTMA prothymosin, alpha 0.0642976
EEF2 eukaryotic translation elongation factor 2 0.0604198
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0561826
TPI1 triosephosphate isomerase 1 0.0528666
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0514487
TFPI2 tissue factor pathway inhibitor 2 0.0510779
MKI67 marker of proliferation Ki-67 0.0505156
RPL26 ribosomal protein L26 0.0474782
RPS3 ribosomal protein S3 0.0452304
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0419813
PFN1 profilin 1 0.0406937
MT2A metallothionein 2A 0.0405538
RPL12 ribosomal protein L12 0.0388124
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0376528
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0348782
POTEF POTE ankyrin domain family, member F 0.0348556
RPL5 ribosomal protein L5 0.0347113
PRRC2C proline-rich coiled-coil 2C 0.0345229
RPLP1 ribosomal protein, large, P1 0.0341478
RPS8 ribosomal protein S8 0.0332116
TM4SF1 transmembrane 4 L six family member 1 0.0328514
H1-0 H1.0 linker histone 0.0326807
RPL37A ribosomal protein L37a 0.0321537
NAP1L1 nucleosome assembly protein 1-like 1 0.0317639
RPS12 ribosomal protein S12 0.0315835
RPL18 ribosomal protein L18 0.0310659
RBM25 RNA binding motif protein 25 0.0298989
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0295018
PGK1 phosphoglycerate kinase 1 0.0294941
PRRC2A proline-rich coiled-coil 2A 0.0293931
RPLP2 ribosomal protein, large, P2 0.0280605
EGR1 early growth response 1 0.0274166
GRAMD1B GRAM domain containing 1B 0.0271253
YBX1 Y box binding protein 1 0.0267701
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0267617
KRT18 keratin 18, type I 0.0249793
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.024523
PTMS parathymosin 0.0243015
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0242242
PER1 period circadian clock 1 0.0242153
NACA nascent polypeptide-associated complex alpha subunit 0.0239638
RPS20 ribosomal protein S20 0.0239514
TMSB10 thymosin beta 10 0.0237238
RPL32 ribosomal protein L32 0.0235665
RPL11 ribosomal protein L11 0.0231729
SRP72 signal recognition particle 72kDa 0.023155
RPS21 ribosomal protein S21 0.0230018
SRRM2 serine/arginine repetitive matrix 2 0.0228088
SRRM1 serine/arginine repetitive matrix 1 0.0223773
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218636
FLNA filamin A, alpha 0.0213209
RPS27 ribosomal protein S27 0.0204567
MYL12B myosin, light chain 12B, regulatory 0.0203937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.019774
TLN1 talin 1 0.0195639
TPM3 tropomyosin 3 0.0188903
BRD4 bromodomain containing 4 0.0187869
RPL19 ribosomal protein L19 0.0184741
ATXN2L ataxin 2-like 0.0184173
RPL36 ribosomal protein L36 0.0181869
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0181707
WASF2 WAS protein family, member 2 0.0180564
NCAPD2 non-SMC condensin I complex, subunit D2 0.017867
SET SET nuclear proto-oncogene 0.0178383
RPS4X ribosomal protein S4, X-linked 0.0177451
SEPTIN7 septin 7 0.0176232
RACK1 receptor for activated C kinase 1 0.01762
RPS24 ribosomal protein S24 0.0176085
NCOR2 nuclear receptor corepressor 2 0.0176028
ACTG1 actin gamma 1 0.0175678
ANKRD12 ankyrin repeat domain 12 0.0174503
EIF1 eukaryotic translation initiation factor 1 0.0169502
ASXL2 additional sex combs like transcriptional regulator 2 0.016896
RPS29 ribosomal protein S29 0.0168298
RPS2 ribosomal protein S2 0.0167645
HMGA1 high mobility group AT-hook 1 0.0166265
LENG8 leukocyte receptor cluster (LRC) member 8 0.0166003
RPL37 ribosomal protein L37 0.0164659
FAM162A family with sequence similarity 162, member A 0.0162871
KDM3A lysine (K)-specific demethylase 3A 0.0162545
WDR45B WD repeat domain 45B 0.0162241
RPL23 ribosomal protein L23 0.0157273
LOC112694756 uncharaterized LOC112694756 0.0154636
RPL23A ribosomal protein L23a 0.0153904
RPL13A ribosomal protein L13a 0.0153861
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0152438
GOLT1B golgi transport 1B 0.0147383
SON SON DNA binding protein 0.0146098
TAGLN2 transgelin 2 0.0146055
YBX3 Y box binding protein 3 0.014599
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0145538
S100A6 S100 calcium binding protein A6 0.0144643
UBE2K ubiquitin-conjugating enzyme E2K 0.0143357
PXDN peroxidasin 0.0143069
RPL35 ribosomal protein L35 0.0142307
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0141107
PFDN2 prefoldin subunit 2 0.0140755

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.082336
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0725438
RAD51B RAD51 paralog B -0.0620551
THSD4 thrombospondin, type I, domain containing 4 -0.0517267
MCL1 myeloid cell leukemia 1 -0.0478817
FBXO11 F-box protein 11 -0.0467888
OSMR oncostatin M receptor -0.0460226
VCL vinculin -0.0453222
PDE10A phosphodiesterase 10A -0.0446991
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0446656
NABP1 nucleic acid binding protein 1 -0.0444179
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0436695
RAB7A RAB7A, member RAS oncogene family -0.0430919
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0427961
IGF1R insulin-like growth factor 1 receptor -0.0426515
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0387643
TAS2R14 taste receptor, type 2, member 14 -0.0387265
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0377747
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0365867
EXT1 exostosin glycosyltransferase 1 -0.0360825
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0354424
EXOC4 exocyst complex component 4 -0.0344744
RPL35A ribosomal protein L35a -0.0329536
ATXN1 ataxin 1 -0.0328865
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.032138
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.030824
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0306193
PRH1 proline-rich protein HaeIII subfamily 1 -0.0304766
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0303984
AFF3 AF4/FMR2 family, member 3 -0.0303671
DENND5B DENN/MADD domain containing 5B -0.0302256
TXNRD1 thioredoxin reductase 1 -0.0301005
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029977
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0299299
TRIP12 thyroid hormone receptor interactor 12 -0.0290586
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0288009
NCOA7 nuclear receptor coactivator 7 -0.0287962
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0284497
FMNL2 formin-like 2 -0.0282267
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0282028
YAP1 Yes-associated protein 1 -0.0280953
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0277756
ZFAND3 zinc finger, AN1-type domain 3 -0.027717
USP34 ubiquitin specific peptidase 34 -0.0268259
INTS6 integrator complex subunit 6 -0.0265977
VMP1 vacuole membrane protein 1 -0.0264553
BIRC6 baculoviral IAP repeat containing 6 -0.0263656
SETX senataxin -0.0261253
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0259197
MED13L mediator complex subunit 13-like -0.0255894
RIMS2 regulating synaptic membrane exocytosis 2 -0.0255553
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0253553
FNDC3B fibronectin type III domain containing 3B -0.0251897
CCNL1 cyclin L1 -0.0251223
WWOX WW domain containing oxidoreductase -0.0250917
EML4 echinoderm microtubule associated protein like 4 -0.0247115
SETD5 SET domain containing 5 -0.024359
HLA-B major histocompatibility complex, class I, B -0.0239121
PTK2 protein tyrosine kinase 2 -0.0239023
AEBP2 AE binding protein 2 -0.023736
CAMKMT calmodulin-lysine N-methyltransferase -0.0235641
NIPBL Nipped-B homolog (Drosophila) -0.0230582
SENP6 SUMO1/sentrin specific peptidase 6 -0.0230191
TPM4 tropomyosin 4 -0.0226698
ZBTB20 zinc finger and BTB domain containing 20 -0.0226106
RSF1 remodeling and spacing factor 1 -0.0223499
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0223117
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0222416
CDK13 cyclin-dependent kinase 13 -0.0222227
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0219937
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0218999
UBE2H ubiquitin-conjugating enzyme E2H -0.0217833
DOCK5 dedicator of cytokinesis 5 -0.0216655
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0213582
BABAM2 BRISC and BRCA1 A complex member 2 -0.0212552
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.021243
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0211611
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0210098
TBC1D5 TBC1 domain family, member 5 -0.0208406
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0207171
SSH2 slingshot protein phosphatase 2 -0.0204452
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0203687
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0203497
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0201241
IFI6 interferon, alpha-inducible protein 6 -0.0200994
MACF1 microtubule-actin crosslinking factor 1 -0.0200846
HMGA2 high mobility group AT-hook 2 -0.0199421
ADIPOR2 adiponectin receptor 2 -0.0199142
RYR3 ryanodine receptor 3 -0.0197749
WNT2B wingless-type MMTV integration site family, member 2B -0.0197213
PATJ PATJ crumbs cell polarity complex component -0.0196949
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0195688
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0194765
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0191852
CCDC91 coiled-coil domain containing 91 -0.0191623
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0191261
PARD3 par-3 family cell polarity regulator -0.0190779
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.019038
KDM2A lysine (K)-specific demethylase 2A -0.0189201
LOC102724023 ES1 protein homolog, mitochondrial -0.0188035