| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dexmedetomidine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0187938 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.01653 |
| NDRG1 | N-myc downstream regulated 1 | 0.0161473 |
| FLNA | filamin A, alpha | 0.0140763 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0139222 |
| RPS2 | ribosomal protein S2 | 0.0132005 |
| POTEF | POTE ankyrin domain family, member F | 0.013083 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0130633 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0120616 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.011229 |
| FLNB | filamin B, beta | 0.0109545 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0108767 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0105143 |
| MSN | moesin | 0.0104662 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0104327 |
| TPM3 | tropomyosin 3 | 0.0095053 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00897824 |
| PRELID2 | PRELI domain containing 2 | 0.00880272 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0086949 |
| DTNA | dystrobrevin, alpha | 0.00845118 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.00822499 |
| LAMA5 | laminin, alpha 5 | 0.00803825 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00798636 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.00789667 |
| RPL3 | ribosomal protein L3 | 0.00784794 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0075233 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00734111 |
| INTS6 | integrator complex subunit 6 | 0.00720243 |
| CABIN1 | calcineurin binding protein 1 | 0.00716813 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.00708409 |
| PRRC2A | proline-rich coiled-coil 2A | 0.00697289 |
| PER1 | period circadian clock 1 | 0.00687109 |
| FOSL1 | FOS-like antigen 1 | 0.00678984 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0064741 |
| MEF2D | myocyte enhancer factor 2D | 0.00638633 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.00632117 |
| ATXN2L | ataxin 2-like | 0.00627408 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00603717 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.00600483 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.00599477 |
| INTS1 | integrator complex subunit 1 | 0.00598079 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00592283 |
| PCBP2 | poly(rC) binding protein 2 | 0.00586333 |
| RUNX1 | runt-related transcription factor 1 | 0.00581426 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.00571693 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.00549583 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.00549518 |
| MCL1 | myeloid cell leukemia 1 | 0.00546224 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.00546116 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.00544648 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.00543047 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.00540286 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.00532166 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00529647 |
| SEC24A | SEC24 family member A | 0.00527438 |
| EP400 | E1A binding protein p400 | 0.00526595 |
| DSCAM | Down syndrome cell adhesion molecule | 0.00525633 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00522109 |
| BRD2 | bromodomain containing 2 | 0.0052208 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.00519755 |
| CTBP2 | C-terminal binding protein 2 | 0.00514697 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.00510183 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00506062 |
| RPS12 | ribosomal protein S12 | 0.00504556 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00502227 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.00491743 |
| SEC24D | SEC24 family member D | 0.00490221 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.00488561 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.00486123 |
| BRD4 | bromodomain containing 4 | 0.00474803 |
| FOSL2 | FOS-like antigen 2 | 0.00467516 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.00467448 |
| FAM219A | family with sequence similarity 219, member A | 0.00465668 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.00464453 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.00459998 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.00455671 |
| FUS | FUS RNA binding protein | 0.00451533 |
| JUP | junction plakoglobin | 0.00450582 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.00447758 |
| MNT | MAX network transcriptional repressor | 0.00447466 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.00444506 |
| SURF4 | surfeit 4 | 0.00441926 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.00436707 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.00432817 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.00431503 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00430518 |
| RPL27 | ribosomal protein L27 | 0.0043028 |
| RPS18 | ribosomal protein S18 | 0.00429938 |
| BMP6 | bone morphogenetic protein 6 | 0.00429148 |
| KLHL29 | kelch-like family member 29 | 0.00427003 |
| RPL5 | ribosomal protein L5 | 0.00424165 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.00423243 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00421719 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.00421428 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.00420533 |
| NUP58 | nucleoporin 58 | 0.00419013 |
| TUFT1 | tuftelin 1 | 0.00417339 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.00417141 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0041609 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00415561 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.275708 |
| FN1 | fibronectin 1 | -0.202366 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.146155 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.11086 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.104031 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0862851 |
| COL5A2 | collagen, type V, alpha 2 | -0.0843854 |
| EFNA5 | ephrin-A5 | -0.0843198 |
| SMYD3 | SET and MYND domain containing 3 | -0.0757184 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0753314 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0750833 |
| PDE10A | phosphodiesterase 10A | -0.0750135 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0748365 |
| GDA | guanine deaminase | -0.0736118 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0687262 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0671802 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0649909 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0643549 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0582458 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0536976 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0528793 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0495646 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0471267 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0469822 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0456109 |
| ASPH | aspartate beta-hydroxylase | -0.0435962 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0427659 |
| TXNRD1 | thioredoxin reductase 1 | -0.0422679 |
| CDH13 | cadherin 13 | -0.0421754 |
| CANX | calnexin | -0.042076 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0419555 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0407429 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0404612 |
| DST | dystonin | -0.0399624 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0398707 |
| PCBP3 | poly(rC) binding protein 3 | -0.0396849 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0395185 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0391834 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0378417 |
| NRCAM | neuronal cell adhesion molecule | -0.0367117 |
| TMSB10 | thymosin beta 10 | -0.0366811 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0356718 |
| MYOF | myoferlin | -0.0356657 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0355656 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0354484 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0334776 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0330465 |
| VIM | vimentin | -0.0329779 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0328412 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0326701 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0318931 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.031516 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0307239 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0302128 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0293697 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0286537 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0280273 |
| NCKAP5 | NCK-associated protein 5 | -0.027929 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0274834 |
| KIAA0825 | KIAA0825 | -0.0272787 |
| PDE7B | phosphodiesterase 7B | -0.0270461 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0270096 |
| RTN1 | reticulon 1 | -0.0266562 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0258856 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0254332 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0252605 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.025246 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0251141 |
| B2M | beta-2-microglobulin | -0.0248255 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0248158 |
| ANTXR1 | anthrax toxin receptor 1 | -0.024758 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0247526 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0241708 |
| PALLD | palladin, cytoskeletal associated protein | -0.0239585 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0238638 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0236723 |
| PTMA | prothymosin, alpha | -0.0235502 |
| S100A6 | S100 calcium binding protein A6 | -0.0233975 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0233917 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0232366 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.02272 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0224017 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0223737 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0218323 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0212615 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0212221 |
| LAMA1 | laminin, alpha 1 | -0.0211451 |
| DOCK5 | dedicator of cytokinesis 5 | -0.020942 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0208102 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0207543 |
| HLA-B | major histocompatibility complex, class I, B | -0.0204446 |
| PTGR1 | prostaglandin reductase 1 | -0.0200353 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0198962 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0196783 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0196249 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0195377 |
| PDLIM5 | PDZ and LIM domain 5 | -0.019314 |
| NF1 | neurofibromin 1 | -0.0192964 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0191626 |
| OSMR | oncostatin M receptor | -0.0191514 |
