| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dexmedetomidine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.135476 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.123903 |
| LOC112694756 | uncharaterized LOC112694756 | 0.107768 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0903698 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.090007 |
| LMO7 | LIM domain 7 | 0.0888254 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0869255 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0861954 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0848054 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0787131 |
| TMSB4X | thymosin beta 4, X-linked | 0.0781257 |
| MYO6 | myosin VI | 0.0780124 |
| RBM39 | RNA binding motif protein 39 | 0.0740582 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0676127 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0662304 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0652219 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0652069 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0651922 |
| AHNAK | AHNAK nucleoprotein | 0.0627129 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0613775 |
| RPL12 | ribosomal protein L12 | 0.0613404 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0607971 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0562097 |
| ANXA2 | annexin A2 | 0.0548265 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0543132 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0541588 |
| CCNI | cyclin I | 0.0539351 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0536639 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0533296 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0533183 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0525669 |
| LDHA | lactate dehydrogenase A | 0.0525234 |
| FLNB | filamin B, beta | 0.051837 |
| MYOF | myoferlin | 0.0509784 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0493685 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0480775 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0474647 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0469514 |
| NDRG1 | N-myc downstream regulated 1 | 0.0463492 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0454619 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0444268 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0441893 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0439175 |
| FMN1 | formin 1 | 0.0431806 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0428028 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0423002 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0414897 |
| RPL11 | ribosomal protein L11 | 0.0414824 |
| ACTG1 | actin gamma 1 | 0.0413941 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0409578 |
| RPS3 | ribosomal protein S3 | 0.0405836 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0404545 |
| RYBP | RING1 and YY1 binding protein | 0.0399818 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0394281 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0388405 |
| GOLGA4 | golgin A4 | 0.0370391 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0363507 |
| OGA | O-GlcNAcase | 0.0334123 |
| RNF213 | ring finger protein 213 | 0.0332362 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0328948 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0308339 |
| KAZN | kazrin, periplakin interacting protein | 0.0300451 |
| CTBP2 | C-terminal binding protein 2 | 0.0287937 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0286515 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0284968 |
| NUP58 | nucleoporin 58 | 0.0280463 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0270263 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0263622 |
| GPATCH2L | G patch domain containing 2-like | 0.026058 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0260215 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0259041 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0255331 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0254892 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0253317 |
| ZFR | zinc finger RNA binding protein | 0.0252548 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0251622 |
| SPAG9 | sperm associated antigen 9 | 0.0250519 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0249355 |
| NF1 | neurofibromin 1 | 0.0242452 |
| SMAD3 | SMAD family member 3 | 0.0239921 |
| ACTN4 | actinin, alpha 4 | 0.0238241 |
| RB1 | retinoblastoma 1 | 0.022478 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0196271 |
| MED13L | mediator complex subunit 13-like | 0.0195838 |
| TMSB10 | thymosin beta 10 | 0.0188312 |
| SLTM | SAFB-like, transcription modulator | 0.018497 |
| RPS12 | ribosomal protein S12 | 0.0168989 |
| RBM25 | RNA binding motif protein 25 | 0.0166048 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0164038 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0164034 |
| CD44 | CD44 molecule (Indian blood group) | 0.0163783 |
| RPLP2 | ribosomal protein, large, P2 | 0.0159444 |
| CUL5 | cullin 5 | 0.0158792 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0157324 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.015373 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0153105 |
| RPL5 | ribosomal protein L5 | 0.0152736 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0151413 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.014614 |
| PKM | pyruvate kinase, muscle | 0.0144629 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.21133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114893 |
| FN1 | fibronectin 1 | -0.106474 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0996965 |
| APP | amyloid beta (A4) precursor protein | -0.0907016 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0868804 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0819896 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0805661 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0793489 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0790556 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.074106 |
| CDH13 | cadherin 13 | -0.0713742 |
| MYO1E | myosin IE | -0.0704936 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0701749 |
| RORA | RAR-related orphan receptor A | -0.0668695 |
| VIM | vimentin | -0.0658869 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0645554 |
| JMJD1C | jumonji domain containing 1C | -0.0634655 |
| PGK1 | phosphoglycerate kinase 1 | -0.0611582 |
| PARD3 | par-3 family cell polarity regulator | -0.0609095 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0605206 |
| BBX | bobby sox homolog (Drosophila) | -0.0574065 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0571856 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0566314 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0563166 |
| MT2A | metallothionein 2A | -0.0552378 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0550156 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0548016 |
| RPS6 | ribosomal protein S6 | -0.054662 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0531108 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0526082 |
| INTS6 | integrator complex subunit 6 | -0.052399 |
| PTK2 | protein tyrosine kinase 2 | -0.0520792 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0520429 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0519835 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0499819 |
| RIGI | RNA sensor RIG-I | -0.0496812 |
| PDE10A | phosphodiesterase 10A | -0.0496068 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0495927 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.049561 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0485851 |
| PTMA | prothymosin, alpha | -0.0476377 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0473847 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0466369 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0443878 |
| NBEAL1 | neurobeachin-like 1 | -0.0435519 |
| RPL26 | ribosomal protein L26 | -0.042022 |
| TCF12 | transcription factor 12 | -0.041982 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0406912 |
| ADIPOR2 | adiponectin receptor 2 | -0.040628 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0399094 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0397892 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0389994 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0386402 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0376018 |
| ASPH | aspartate beta-hydroxylase | -0.0372829 |
| SMYD3 | SET and MYND domain containing 3 | -0.0366224 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0365379 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.036047 |
| AOPEP | aminopeptidase O (putative) | -0.035541 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0351844 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0351256 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0342605 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.033956 |
| MAP4 | microtubule-associated protein 4 | -0.0338533 |
| RPL35A | ribosomal protein L35a | -0.0336769 |
| RAD51B | RAD51 paralog B | -0.0331044 |
| GPC6 | glypican 6 | -0.0330744 |
| TLK1 | tousled-like kinase 1 | -0.0328994 |
| SETD5 | SET domain containing 5 | -0.0323751 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | -0.031029 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0305822 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.028531 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0278923 |
| ZNF292 | zinc finger protein 292 | -0.0272064 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0271778 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0269352 |
| MCL1 | myeloid cell leukemia 1 | -0.0267364 |
| CERS6 | ceramide synthase 6 | -0.0260441 |
| RAB10 | RAB10, member RAS oncogene family | -0.0253068 |
| GPHN | gephyrin | -0.0251672 |
| H3-3B | H3.3 histone B | -0.0246019 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0240665 |
| UBC | ubiquitin C | -0.0235232 |
| SRPK2 | SRSF protein kinase 2 | -0.0228383 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0228165 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0226542 |
| FTL | ferritin, light polypeptide | -0.022357 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0214738 |
| RPL23 | ribosomal protein L23 | -0.0214215 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.020549 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0199543 |
| SQSTM1 | sequestosome 1 | -0.0196901 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0192838 |
| STIP1 | stress-induced phosphoprotein 1 | -0.0192249 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0187991 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0187403 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0183115 |
| RPL37A | ribosomal protein L37a | -0.0181645 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0180991 |
