| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dexmedetomidine perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dexmedetomidine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.185478 |
| VIM | vimentin | 0.147544 |
| TMSB10 | thymosin beta 10 | 0.131591 |
| PTMA | prothymosin, alpha | 0.0954801 |
| RPS16 | ribosomal protein S16 | 0.0942961 |
| CADM2 | cell adhesion molecule 2 | 0.0897994 |
| LRRC4C | leucine rich repeat containing 4C | 0.0842774 |
| RPS8 | ribosomal protein S8 | 0.0842009 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0818788 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0743679 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0693829 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0670944 |
| COL1A2 | collagen, type I, alpha 2 | 0.0660559 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0615509 |
| SNX6 | sorting nexin 6 | 0.0595348 |
| SMYD3 | SET and MYND domain containing 3 | 0.0578114 |
| MAP4 | microtubule-associated protein 4 | 0.0574943 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0558615 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0552295 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0548391 |
| CALR | calreticulin | 0.0533351 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0525291 |
| MKI67 | marker of proliferation Ki-67 | 0.0513479 |
| UPP1 | uridine phosphorylase 1 | 0.0499388 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0497156 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0496187 |
| RPL5 | ribosomal protein L5 | 0.0493847 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0483775 |
| GPC3 | glypican 3 | 0.0481979 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0476868 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0473071 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0459195 |
| RPL36A | ribosomal protein L36a | 0.0442079 |
| H1-0 | H1.0 linker histone | 0.0440956 |
| RPS2 | ribosomal protein S2 | 0.0438225 |
| S100A10 | S100 calcium binding protein A10 | 0.0428344 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0425887 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0412815 |
| HMCN1 | hemicentin 1 | 0.0401162 |
| TMSB4X | thymosin beta 4, X-linked | 0.0399793 |
| RPS25 | ribosomal protein S25 | 0.0392945 |
| RPL23 | ribosomal protein L23 | 0.0388902 |
| RPS12 | ribosomal protein S12 | 0.038604 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0377022 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0371774 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0371417 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0369937 |
| BRD4 | bromodomain containing 4 | 0.0365823 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0361526 |
| PGK1 | phosphoglycerate kinase 1 | 0.0358213 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0355133 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0351414 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0349907 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0346824 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0346292 |
| RAD51B | RAD51 paralog B | 0.0345329 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0340268 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0332704 |
| FBXO27 | F-box protein 27 | 0.0332429 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0331803 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0326892 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0326798 |
| RPS6 | ribosomal protein S6 | 0.0324209 |
| RPL26 | ribosomal protein L26 | 0.0321413 |
| FOXP2 | forkhead box P2 | 0.0320299 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.031962 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0316676 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0316544 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0315898 |
| NTM | neurotrimin | 0.031351 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0313262 |
| SOX2 | SRY (sex determining region Y)-box 2 | 0.0309658 |
| SERF2 | small EDRK-rich factor 2 | 0.0308558 |
| CEP350 | centrosomal protein 350kDa | 0.0307918 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0306598 |
| S100A9 | S100 calcium binding protein A9 | 0.0305106 |
| RPL31 | ribosomal protein L31 | 0.0303899 |
| RBM20 | RNA binding motif protein 20 | 0.0303604 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0301658 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0301639 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0298525 |
| RPS13 | ribosomal protein S13 | 0.0298132 |
| CAVIN1 | caveolae associated protein 1 | 0.0297245 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.0296994 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0293879 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0286483 |
| WASF2 | WAS protein family, member 2 | 0.0286416 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0283603 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | 0.0282349 |
| RPL37A | ribosomal protein L37a | 0.0280606 |
| FUS | FUS RNA binding protein | 0.027891 |
| ABI2 | abl-interactor 2 | 0.0278227 |
| NCOA6 | nuclear receptor coactivator 6 | 0.0277688 |
| ENO1 | enolase 1, (alpha) | 0.0275405 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.026978 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0269493 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.026724 |
| RPL35A | ribosomal protein L35a | 0.0265782 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0265733 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0261213 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC22D2 | TSC22 domain family, member 2 | -0.0991167 |
| ZNF292 | zinc finger protein 292 | -0.0829214 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0672405 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0487624 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0472655 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.046179 |
| USP3 | ubiquitin specific peptidase 3 | -0.045716 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0438605 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0407128 |
| QKI | QKI, KH domain containing, RNA binding | -0.038542 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0349867 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0341552 |
| EMP1 | epithelial membrane protein 1 | -0.0339053 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0338967 |
| RYBP | RING1 and YY1 binding protein | -0.0333625 |
| PRR16 | proline rich 16 | -0.0327697 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0322932 |
| PLPP1 | phospholipid phosphatase 1 | -0.0316091 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0308709 |
| HDAC9 | histone deacetylase 9 | -0.0306446 |
| PDS5B | PDS5 cohesin associated factor B | -0.0303354 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0298226 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0297561 |
| HBS1L | HBS1-like translational GTPase | -0.0295239 |
| NUP58 | nucleoporin 58 | -0.0293277 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0291598 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.029125 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0290975 |
| FAM171B | family with sequence similarity 171, member B | -0.0286966 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0286731 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0286185 |
| WDR43 | WD repeat domain 43 | -0.0286181 |
| ZNF217 | zinc finger protein 217 | -0.0283234 |
| DENND4C | DENN/MADD domain containing 4C | -0.0281552 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0279458 |
| IPO7 | importin 7 | -0.0278698 |
| ANXA5 | annexin A5 | -0.0274206 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0269013 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.026627 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0263147 |
| CRY1 | cryptochrome circadian clock 1 | -0.0259814 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0257989 |
| RPS4X | ribosomal protein S4, X-linked | -0.025775 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0252646 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0243803 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0242541 |
| NOP58 | NOP58 ribonucleoprotein | -0.0239746 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0238343 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.023625 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0235414 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0231711 |
| PCM1 | pericentriolar material 1 | -0.0226735 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0224694 |
| RTN3 | reticulon 3 | -0.0224267 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0224206 |
| MTREX | Mtr4 exosome RNA helicase | -0.0223523 |
| RPS23 | ribosomal protein S23 | -0.0222888 |
| RBM25 | RNA binding motif protein 25 | -0.0220561 |
| PDGFC | platelet derived growth factor C | -0.0218023 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0216909 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0214063 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.021382 |
| THBS1 | thrombospondin 1 | -0.021327 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0211977 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0211536 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0211147 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0211027 |
| SFRP4 | secreted frizzled-related protein 4 | -0.021081 |
| VCL | vinculin | -0.0206918 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0206382 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0205849 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.0205492 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0203969 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0203809 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0203682 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0202091 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0201526 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0201504 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0200215 |
| RAB1A | RAB1A, member RAS oncogene family | -0.019918 |
| ZNF608 | zinc finger protein 608 | -0.0198811 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0198322 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0197097 |
| TJP1 | tight junction protein 1 | -0.0196364 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0195168 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0194637 |
| PCBP2 | poly(rC) binding protein 2 | -0.0194364 |
| COASY | CoA synthase | -0.0194147 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0194116 |
| ANKRD17 | ankyrin repeat domain 17 | -0.019389 |
| RANBP2 | RAN binding protein 2 | -0.0192876 |
| KAT6A | K(lysine) acetyltransferase 6A | -0.0192811 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0192172 |
| MEF2C | myocyte enhancer factor 2C | -0.0192006 |
| RHOH | ras homolog family member H | -0.0191726 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0191674 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0191423 |
| NCOA2 | nuclear receptor coactivator 2 | -0.019102 |
| LDHB | lactate dehydrogenase B | -0.0188783 |
| GNAS | GNAS complex locus | -0.0188164 |
