Dexmedetomidine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Dexmedetomidine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152966
PTMA prothymosin, alpha 0.103437
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0978095
FLNB filamin B, beta 0.0695629
POTEF POTE ankyrin domain family, member F 0.0687964
ENO2 enolase 2 (gamma, neuronal) 0.0669853
RPL26 ribosomal protein L26 0.05156
SRRM2 serine/arginine repetitive matrix 2 0.0499883
CCND1 cyclin D1 0.0487016
DUSP4 dual specificity phosphatase 4 0.0484051
PKM pyruvate kinase, muscle 0.0474327
PDE4B phosphodiesterase 4B, cAMP-specific 0.0469263
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0439908
RPL37A ribosomal protein L37a 0.0434438
EEF2 eukaryotic translation elongation factor 2 0.0432833
GSE1 Gse1 coiled-coil protein 0.0425202
GLI2 GLI family zinc finger 2 0.0419511
EGFR epidermal growth factor receptor 0.0415717
NPAS2 neuronal PAS domain protein 2 0.0414874
RPS3 ribosomal protein S3 0.0403796
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0387653
PYGB phosphorylase, glycogen; brain 0.0371402
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0368997
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0366014
PFN1 profilin 1 0.0355492
PTMS parathymosin 0.0339197
RPL11 ribosomal protein L11 0.0334884
RPS12 ribosomal protein S12 0.0334624
S100A9 S100 calcium binding protein A9 0.0329567
S100A4 S100 calcium binding protein A4 0.0323557
MT2A metallothionein 2A 0.0317475
RPS8 ribosomal protein S8 0.0314014
HSPB1 heat shock 27kDa protein 1 0.0295905
RPS2 ribosomal protein S2 0.0293842
RPL36 ribosomal protein L36 0.0292094
RACK1 receptor for activated C kinase 1 0.0288263
BMP10 bone morphogenetic protein 10 0.0278602
ATF4 activating transcription factor 4 0.0270584
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269041
RPLP2 ribosomal protein, large, P2 0.0261263
SMIM44 small integral membrane protein 44 0.0260547
EBNA1BP2 EBNA1 binding protein 2 0.025679
RPL5 ribosomal protein L5 0.0253094
LENG8 leukocyte receptor cluster (LRC) member 8 0.0249822
CSF1 colony stimulating factor 1 (macrophage) 0.024817
S100A10 S100 calcium binding protein A10 0.0247361
RPS21 ribosomal protein S21 0.0246154
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0241806
EFNA5 ephrin-A5 0.0237017
TXNRD1 thioredoxin reductase 1 0.0235769
AMOTL2 angiomotin like 2 0.0230289
RPS13 ribosomal protein S13 0.0228104
NACA nascent polypeptide-associated complex alpha subunit 0.0223924
TMSB10 thymosin beta 10 0.0223617
ARL4C ADP-ribosylation factor-like 4C 0.0221904
GLI3 GLI family zinc finger 3 0.0221564
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0221384
AKAP12 A kinase (PRKA) anchor protein 12 0.0219147
SET SET nuclear proto-oncogene 0.0216865
RPL7A ribosomal protein L7a 0.0213361
RPL28 ribosomal protein L28 0.0207737
RPS24 ribosomal protein S24 0.0200954
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0200577
HDGF hepatoma-derived growth factor 0.019839
RPS17 ribosomal protein S17 0.0197829
RPS29 ribosomal protein S29 0.0196403
KMT2D lysine (K)-specific methyltransferase 2D 0.0194366
PRSS23 protease, serine, 23 0.0194153
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0193434
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0192637
RPL23 ribosomal protein L23 0.0191376
SOX9 SRY (sex determining region Y)-box 9 0.0191299
PRDX2 peroxiredoxin 2 0.0191159
PABPN1 poly(A) binding protein, nuclear 1 0.0190145
RPL32 ribosomal protein L32 0.0189042
TACC2 transforming, acidic coiled-coil containing protein 2 0.0188499
RPL37 ribosomal protein L37 0.0187588
LOXL3 lysyl oxidase-like 3 0.0187295
RPL18 ribosomal protein L18 0.0186879
RPL27 ribosomal protein L27 0.0186715
PTPRF protein tyrosine phosphatase, receptor type, F 0.0184341
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0182735
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0182325
RPL12 ribosomal protein L12 0.0181355
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0181256
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0180988
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.0177148
RPL21 ribosomal protein L21 0.0175145
ZMIZ1 zinc finger, MIZ-type containing 1 0.017441
ATN1 atrophin 1 0.0171747
NCOR2 nuclear receptor corepressor 2 0.017163
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0170408
RPL8 ribosomal protein L8 0.0164381
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.01628
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0162442
TSC22D1 TSC22 domain family, member 1 0.0162316
ITSN1 intersectin 1 (SH3 domain protein) 0.0159177
MYO5A myosin VA (heavy chain 12, myoxin) 0.0158389
S100A11 S100 calcium binding protein A11 0.0158248
CTIF CBP80/20-dependent translation initiation factor 0.0157349

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.230409
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109745
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.103753
SSBP2 single-stranded DNA binding protein 2 -0.100408
ZNF292 zinc finger protein 292 -0.0945846
QKI QKI, KH domain containing, RNA binding -0.0827125
NAMPT nicotinamide phosphoribosyltransferase -0.0813662
EML4 echinoderm microtubule associated protein like 4 -0.0795115
RBM39 RNA binding motif protein 39 -0.0721873
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.066175
ZFAND3 zinc finger, AN1-type domain 3 -0.0649917
KDM3A lysine (K)-specific demethylase 3A -0.0637322
TFG TRK-fused gene -0.0587866
TMSB4X thymosin beta 4, X-linked -0.0570748
CAMTA1 calmodulin binding transcription activator 1 -0.0563931
CDC73 cell division cycle 73 -0.0552782
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0536649
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0522083
KMT2E lysine (K)-specific methyltransferase 2E -0.0520502
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0517735
WAC WW domain containing adaptor with coiled-coil -0.050293
RAB1A RAB1A, member RAS oncogene family -0.050127
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0496089
TRA2A transformer 2 alpha homolog (Drosophila) -0.0489135
ECT2 epithelial cell transforming 2 -0.0475249
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0472058
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0444961
USP9X ubiquitin specific peptidase 9, X-linked -0.0434675
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0426656
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0425935
GOLGA4 golgin A4 -0.0421379
ELOVL5 ELOVL fatty acid elongase 5 -0.0420159
RLF rearranged L-myc fusion -0.0415584
PTBP2 polypyrimidine tract binding protein 2 -0.0413949
SPAG9 sperm associated antigen 9 -0.0413768
FBXO11 F-box protein 11 -0.0409055
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0404853
PHIP pleckstrin homology domain interacting protein -0.0402377
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0401691
MON2 MON2 homolog (S. cerevisiae) -0.039797
HELZ helicase with zinc finger -0.039706
ABI1 abl-interactor 1 -0.0395787
ADAM10 ADAM metallopeptidase domain 10 -0.0393378
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0391635
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0390403
KMT2C lysine (K)-specific methyltransferase 2C -0.0379939
EVI5 ecotropic viral integration site 5 -0.0379484
NCKAP1 NCK-associated protein 1 -0.0378275
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0377507
COG5 component of oligomeric golgi complex 5 -0.0368691
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0366152
CANX calnexin -0.0363729
PUM2 pumilio RNA-binding family member 2 -0.0361878
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0356453
PDIA6 protein disulfide isomerase family A, member 6 -0.0352901
PDGFC platelet derived growth factor C -0.0350165
RHEB Ras homolog enriched in brain -0.034924
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0347471
ZEB1 zinc finger E-box binding homeobox 1 -0.0346133
HDLBP high density lipoprotein binding protein -0.034408
MIS18BP1 MIS18 binding protein 1 -0.0337198
GARS1 glycyl-tRNA synthetase 1 -0.0333548
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0333334
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.033031
SENP6 SUMO1/sentrin specific peptidase 6 -0.032837
TNRC6B trinucleotide repeat containing 6B -0.0326311
BRWD1 bromodomain and WD repeat domain containing 1 -0.0325858
LCORL ligand dependent nuclear receptor corepressor-like -0.0325376
ADAM9 ADAM metallopeptidase domain 9 -0.0324875
PIAS1 protein inhibitor of activated STAT, 1 -0.0324614
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0323968
AHNAK AHNAK nucleoprotein -0.0322242
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0322225
LDHA lactate dehydrogenase A -0.0320999
RTN4 reticulon 4 -0.0320567
WSB1 WD repeat and SOCS box containing 1 -0.0319394
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0319329
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0314679
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0313288
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0310442
ZNF644 zinc finger protein 644 -0.0310237
ANKRD10 ankyrin repeat domain 10 -0.0306922
NCOR1 nuclear receptor corepressor 1 -0.0306429
FNDC3B fibronectin type III domain containing 3B -0.0305789
IARS1 isoleucyl-tRNA synthetase 1 -0.0304545
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0304395
RYBP RING1 and YY1 binding protein -0.0298812
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0298789
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.029644
USP3 ubiquitin specific peptidase 3 -0.0295922
NUP58 nucleoporin 58 -0.0295753
PTK2 protein tyrosine kinase 2 -0.029439
PNISR PNN-interacting serine/arginine-rich protein -0.029153
PUM1 pumilio RNA-binding family member 1 -0.0290898
YME1L1 YME1-like 1 ATPase -0.0289233
TOP2B topoisomerase (DNA) II beta 180kDa -0.0288661
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0287227
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0287022
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0286988
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0286855