Dexmedetomidine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dexmedetomidine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dexmedetomidine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.12891
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.12744
TRIO trio Rho guanine nucleotide exchange factor 0.0507908
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0501613
NAP1L1 nucleosome assembly protein 1-like 1 0.0481784
TMSB10 thymosin beta 10 0.0480742
SDC4 syndecan 4 0.0476473
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0471424
SMYD3 SET and MYND domain containing 3 0.0459861
PTMA prothymosin, alpha 0.0458667
MKI67 marker of proliferation Ki-67 0.0421871
NAV2 neuron navigator 2 0.0391717
AHNAK AHNAK nucleoprotein 0.0383716
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0375074
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0373901
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0352521
GNAS GNAS complex locus 0.0350455
TPT1 tumor protein, translationally-controlled 1 0.034989
RPS3 ribosomal protein S3 0.0342536
EEF2 eukaryotic translation elongation factor 2 0.0336741
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0331745
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0319968
PDE8A phosphodiesterase 8A 0.0309244
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0306693
MBD5 methyl-CpG binding domain protein 5 0.0306464
SMAD3 SMAD family member 3 0.0302913
PHF20 PHD finger protein 20 0.0302551
TPX2 TPX2, microtubule-associated 0.0300828
INTS6 integrator complex subunit 6 0.0290696
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0288776
RPL12 ribosomal protein L12 0.0285576
ANKRD11 ankyrin repeat domain 11 0.028454
RNF213 ring finger protein 213 0.0284058
PRRC2B proline-rich coiled-coil 2B 0.0278412
FTL ferritin, light polypeptide 0.0274412
ECT2 epithelial cell transforming 2 0.0270841
RPL23 ribosomal protein L23 0.0268348
CENPF centromere protein F, 350/400kDa 0.0263378
TBC1D5 TBC1 domain family, member 5 0.0263297
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0260237
VMP1 vacuole membrane protein 1 0.0260001
NACA nascent polypeptide-associated complex alpha subunit 0.0251529
RPLP2 ribosomal protein, large, P2 0.0250746
MED13L mediator complex subunit 13-like 0.0248266
RPL37 ribosomal protein L37 0.0246569
RPLP0 ribosomal protein, large, P0 0.0246283
OSMR oncostatin M receptor 0.0240414
SRRM2 serine/arginine repetitive matrix 2 0.0234968
TNRC18 trinucleotide repeat containing 18 0.0234381
SH3KBP1 SH3-domain kinase binding protein 1 0.022914
RPL4 ribosomal protein L4 0.0228497
BZW1 basic leucine zipper and W2 domains 1 0.0224476
RPS21 ribosomal protein S21 0.022387
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0223293
CXCL8 chemokine (C-X-C motif) ligand 8 0.022232
RPS8 ribosomal protein S8 0.0220931
TUBB4B tubulin, beta 4B class IVb 0.0220595
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0220507
ARHGAP5 Rho GTPase activating protein 5 0.0220271
SKP1 S-phase kinase-associated protein 1 0.0216888
SEPTIN9 septin 9 0.0216846
RPS20 ribosomal protein S20 0.0215458
ATXN2L ataxin 2-like 0.0214378
BICD1 bicaudal D homolog 1 (Drosophila) 0.0213271
HMGA2 high mobility group AT-hook 2 0.0213127
LPP LIM domain containing preferred translocation partner in lipoma 0.0211264
CD59 CD59 molecule, complement regulatory protein 0.0210982
RPS12 ribosomal protein S12 0.0210885
SCAPER S-phase cyclin A-associated protein in the ER 0.0207704
LOC112694756 uncharaterized LOC112694756 0.0207224
RPL32 ribosomal protein L32 0.0206746
TM4SF1 transmembrane 4 L six family member 1 0.0204277
DST dystonin 0.0203616
PRRC2C proline-rich coiled-coil 2C 0.0202061
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0201151
BCAS3 breast carcinoma amplified sequence 3 0.0199981
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0199286
PGK1 phosphoglycerate kinase 1 0.0199244
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0197159
CEP250 centrosomal protein 250kDa 0.0195802
RPS17 ribosomal protein S17 0.0195535
RSF1 remodeling and spacing factor 1 0.0194805
C6ORF62 chromosome 6 open reading frame 62 0.0194472
CLIP1 CAP-GLY domain containing linker protein 1 0.0194176
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0193637
RPL26 ribosomal protein L26 0.0193467
KIAA1328 KIAA1328 0.0193363
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.019322
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0192668
CKAP5 cytoskeleton associated protein 5 0.0192198
SMC4 structural maintenance of chromosomes 4 0.0191322
TNPO1 transportin 1 0.0190726
H3-3B H3.3 histone B 0.0188472
RPLP1 ribosomal protein, large, P1 0.0187588
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0186356
RRBP1 ribosome binding protein 1 0.0184088
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0182215
RACK1 receptor for activated C kinase 1 0.0179374
RPS15 ribosomal protein S15 0.0177362
VCL vinculin 0.0177249

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0639934
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0518499
FNDC3B fibronectin type III domain containing 3B -0.0454345
ESYT2 extended synaptotagmin-like protein 2 -0.0402094
IGFBP3 insulin-like growth factor binding protein 3 -0.0366023
NDRG1 N-myc downstream regulated 1 -0.0349235
HILPDA hypoxia inducible lipid droplet-associated -0.0344994
RBM25 RNA binding motif protein 25 -0.0325737
ATXN1 ataxin 1 -0.0297874
ADM adrenomedullin -0.029463
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0275628
RAB2A RAB2A, member RAS oncogene family -0.026519
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.02596
GPC6 glypican 6 -0.0248416
FTH1 ferritin, heavy polypeptide 1 -0.0246328
AHCTF1 AT hook containing transcription factor 1 -0.0243893
DTNA dystrobrevin, alpha -0.0237326
TENT2 terminal nucleotidyltransferase 2 -0.0236736
SETD5 SET domain containing 5 -0.0236493
FAM13A family with sequence similarity 13, member A -0.0236046
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0234316
ERBIN erbb2 interacting protein -0.0230929
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0230314
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0229269
FNDC3A fibronectin type III domain containing 3A -0.0228293
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0225624
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.022501
RASA2 RAS p21 protein activator 2 -0.022295
SASH1 SAM and SH3 domain containing 1 -0.0220753
TBC1D23 TBC1 domain family, member 23 -0.0217293
YY1 YY1 transcription factor -0.0216254
FNIP1 folliculin interacting protein 1 -0.0215476
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0214488
USP3 ubiquitin specific peptidase 3 -0.0210545
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0208842
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0204703
EFNA5 ephrin-A5 -0.0202909
LDHA lactate dehydrogenase A -0.0202541
ATP13A3 ATPase type 13A3 -0.0202159
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0200693
COLEC11 collectin sub-family member 11 -0.0199971
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.019968
FLNB filamin B, beta -0.0199668
ANXA2 annexin A2 -0.0199407
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0198628
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0197632
PBX3 pre-B-cell leukemia homeobox 3 -0.0196148
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0195723
KCMF1 potassium channel modulatory factor 1 -0.0193991
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0190545
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0189009
JMJD1C jumonji domain containing 1C -0.0187174
NHSL1 NHS-like 1 -0.0186107
SPAG9 sperm associated antigen 9 -0.0183294
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0180599
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0179557
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0179343
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0178671
NGLY1 N-glycanase 1 -0.0178186
GOLGA2 golgin A2 -0.0175714
QKI QKI, KH domain containing, RNA binding -0.0175711
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0173411
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0172922
CCNL1 cyclin L1 -0.0172168
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0171324
SLC35F2 solute carrier family 35, member F2 -0.0168101
MYADM myeloid-associated differentiation marker -0.0167935
CEMIP2 cell migration inducing hyaluronidase 2 -0.0167923
MTCH1 mitochondrial carrier 1 -0.0167847
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0167709
C1D C1D nuclear receptor corepressor -0.0167692
RNF24 ring finger protein 24 -0.0166836
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0166016
SMAP1 small ArfGAP 1 -0.0165961
MEIS2 Meis homeobox 2 -0.016443
B2M beta-2-microglobulin -0.0164094
PDE10A phosphodiesterase 10A -0.0163141
CD2AP CD2-associated protein -0.0162714
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0162461
RYBP RING1 and YY1 binding protein -0.016216
CAPRIN2 caprin family member 2 -0.0161161
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0160847
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0159198
PCNX1 pecanex 1 -0.0158665
BRWD1 bromodomain and WD repeat domain containing 1 -0.0158466
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.01584
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0158203
ADAM17 ADAM metallopeptidase domain 17 -0.0157641
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0156702
MAP1B microtubule-associated protein 1B -0.0156649
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0155162
ZNF207 zinc finger protein 207 -0.0154675
UBP1 upstream binding protein 1 (LBP-1a) -0.0153692
TSC22D2 TSC22 domain family, member 2 -0.0152488
FN1 fibronectin 1 -0.0152478
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0152372
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0151177
GRK5 G protein-coupled receptor kinase 5 -0.0150281
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -0.0149847
TRRAP transformation/transcription domain-associated protein -0.0149142