Diabetic Neuropathies Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D003929
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Genes

180 genes/proteins associated with the disease Diabetic Neuropathies from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
INSR insulin receptor 2.88009
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.88009
NTF3 neurotrophin 3 2.88009
TGFB1 transforming growth factor, beta 1 2.88009
CAT catalase 2.88009
INS insulin 2.88009
MME membrane metallo-endopeptidase 2.88009
SGK1 serum/glucocorticoid regulated kinase 1 2.88009
TLR4 toll-like receptor 4 2.88009
GRM5 glutamate receptor, metabotropic 5 2.88009
CHRM2 cholinergic receptor, muscarinic 2 2.88009
MMP9 matrix metallopeptidase 9 2.88009
MMP2 matrix metallopeptidase 2 2.88009
CCL2 chemokine (C-C motif) ligand 2 1.63832
TNF tumor necrosis factor 1.62893
SOD2 superoxide dismutase 2, mitochondrial 1.61851
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.57546
NOS2 nitric oxide synthase 2, inducible 1.56288
GSK3B glycogen synthase kinase 3 beta 1.52667
COL3A1 collagen, type III, alpha 1 1.51936
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.45458
VEGFA vascular endothelial growth factor A 1.45431
MAPK1 mitogen-activated protein kinase 1 1.45168
SIRT1 sirtuin 1 1.4479
IL6 interleukin 6 1.44735
CYBA cytochrome b-245, alpha polypeptide 1.42374
PPARA peroxisome proliferator-activated receptor alpha 1.42347
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.42266
SREBF1 sterol regulatory element binding transcription factor 1 1.40148
IL1B interleukin 1, beta 1.40148
NCF1 neutrophil cytosolic factor 1 1.38807
VCAM1 vascular cell adhesion molecule 1 1.37789
MAPK3 mitogen-activated protein kinase 3 1.37733
ACTA2 actin, alpha 2, smooth muscle, aorta 1.36933
APP amyloid beta (A4) precursor protein 1.35991
SOD1 superoxide dismutase 1, soluble 1.35705
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.35647
BCL2 B-cell CLL/lymphoma 2 1.33791
EDN1 endothelin 1 1.33553
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.32993
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.32607
ALB albumin 1.30788
LEP leptin 1.30696
CTGF connective tissue growth factor 1.30574
NOS3 nitric oxide synthase 3 (endothelial cell) 1.30543
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.30482
BAX BCL2-associated X protein 1.30147
TIMP1 TIMP metallopeptidase inhibitor 1 1.30087
NQO1 NAD(P)H dehydrogenase, quinone 1 1.29843
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.29256
NPPA natriuretic peptide A 1.2895
IRS1 insulin receptor substrate 1 1.27966
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.27533
MMP7 matrix metallopeptidase 7 1.27533
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.27132
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.26856
HSPB1 heat shock 27kDa protein 1 1.26052
MMP13 matrix metallopeptidase 13 1.25525
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.25525
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.24338
CAV1 caveolin 1, caveolae protein, 22kDa 1.23899
ICAM1 intercellular adhesion molecule 1 1.23488
MMP3 matrix metallopeptidase 3 1.23106
SMAD2 SMAD family member 2 1.22758
ERCC5 excision repair cross-complementation group 5 1.22339
HMOX1 heme oxygenase 1 1.22145
IGF1 insulin-like growth factor 1 (somatomedin C) 1.21631
IFNG interferon, gamma 1.21631
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.21108
DDIT3 DNA-damage-inducible transcript 3 1.20881
CREB1 cAMP responsive element binding protein 1 1.20848
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 1.2013
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.19312
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.19047
TP53 tumor protein p53 1.18359
G6PC glucose-6-phosphatase, catalytic subunit 1.18193
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.18193
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.18126
LIPE lipase, hormone-sensitive 1.18093
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 1.18059
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.17794
RPS6 ribosomal protein S6 1.17629
MAPK8 mitogen-activated protein kinase 8 1.17563
ADIPOR2 adiponectin receptor 2 1.165
TIMP3 TIMP metallopeptidase inhibitor 3 1.16269
FGF21 fibroblast growth factor 21 1.16203
VIM vimentin 1.16137
XDH xanthine dehydrogenase 1.16137
SMAD3 SMAD family member 3 1.15899
RHOA ras homolog family member A 1.15695
THBS1 thrombospondin 1 1.15695
JUN jun proto-oncogene 1.15324
TGFA transforming growth factor, alpha 1.15156
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.14954
COL1A1 collagen, type I, alpha 1 1.14919
NPPB natriuretic peptide B 1.14781
TLR2 toll-like receptor 2 1.14781
NRF1 nuclear respiratory factor 1 1.14678
ADIPOQ adiponectin, C1Q and collagen domain containing 1.1461
CHAT choline O-acetyltransferase 1.14132
TXNIP thioredoxin interacting protein 1.13895
GSTM1 glutathione S-transferase mu 1 1.13552
MPZ myelin protein zero 1.13552
LPL lipoprotein lipase 1.13415
IL10 interleukin 10 1.13313
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.13177
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.13007
TGFB2 transforming growth factor, beta 2 1.12838
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.1253
PECAM1 platelet/endothelial cell adhesion molecule 1 1.12461
SOCS3 suppressor of cytokine signaling 3 1.12323
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.11945
ADRB3 adrenoceptor beta 3 1.11945
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.11707
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.11673
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.11571
XBP1 X-box binding protein 1 1.1136
GSTA2 glutathione S-transferase alpha 2 1.1122
IRS2 insulin receptor substrate 2 1.10907
LDHB lactate dehydrogenase B 1.10907
COL4A1 collagen, type IV, alpha 1 1.10907
ATF4 activating transcription factor 4 1.10562
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.10424
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.10388
CPT1A carnitine palmitoyltransferase 1A (liver) 1.10246
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.09892
MAPK14 mitogen-activated protein kinase 14 1.09751
ACE angiotensin I converting enzyme 1.09471
TIMP2 TIMP metallopeptidase inhibitor 2 1.09471
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.09436
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.09436
FOS FBJ murine osteosarcoma viral oncogene homolog 1.08762
COL1A2 collagen, type I, alpha 2 1.0869
CXCL12 chemokine (C-X-C motif) ligand 12 1.08549
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.08442
PRKCD protein kinase C, delta 1.08231
PPARG peroxisome proliferator-activated receptor gamma 1.08161
HBA1 hemoglobin, alpha 1 1.08019
GFAP glial fibrillary acidic protein 1.07804
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.07625
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 1.07589
HNF4A hepatocyte nuclear factor 4, alpha 1.07553
ELOVL6 ELOVL fatty acid elongase 6 1.07305
ERO1L ERO1-like (S. cerevisiae) 1.06771
NOX4 NADPH oxidase 4 1.06442
APLN apelin 1.06406
RXRA retinoid X receptor, alpha 1.0637
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.0637
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.06333
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.0608
SPP1 secreted phosphoprotein 1 1.05648
PRKCA protein kinase C, alpha 1.05386
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.04941
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 1.04904
TMSB4X thymosin beta 4, X-linked 1.04904
TAGLN transgelin 1.04757
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.04126
SOD3 superoxide dismutase 3, extracellular 1.04126
CCND1 cyclin D1 1.03752
CD36 CD36 molecule (thrombospondin receptor) 1.03604
DLD dihydrolipoamide dehydrogenase 1.03493
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.03493
PLAT plasminogen activator, tissue 1.03345
BAD BCL2-associated agonist of cell death 1.03235
G6PD glucose-6-phosphate dehydrogenase 1.03235
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.03122
APOE apolipoprotein E 1.02971
GJA1 gap junction protein, alpha 1, 43kDa 1.02708
PPARD peroxisome proliferator-activated receptor delta 1.02708
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.02559
BCL2L1 BCL2-like 1 1.02485
PC pyruvate carboxylase 1.02485
CLU clusterin 1.02447
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.02151
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.0204
TFRC transferrin receptor 1.01966
C1QA complement component 1, q subcomponent, A chain 1.01814
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.01739
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.01701
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.01137