Diammonium Glycyrrhizinate_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.318997
TMSB10 thymosin beta 10 0.30588
GPC6 glypican 6 0.188085
B2M beta-2-microglobulin 0.14846
RPL23 ribosomal protein L23 0.143785
FTL ferritin, light polypeptide 0.122369
MT2A metallothionein 2A 0.118286
RPS4X ribosomal protein S4, X-linked 0.11084
RPL26 ribosomal protein L26 0.0992076
EXT1 exostosin glycosyltransferase 1 0.0895584
RPL12 ribosomal protein L12 0.0840174
NDRG1 N-myc downstream regulated 1 0.0797189
RPS19 ribosomal protein S19 0.0754232
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0686129
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0674515
RRBP1 ribosome binding protein 1 0.0662586
TRIO trio Rho guanine nucleotide exchange factor 0.0654433
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0626531
SOD2 superoxide dismutase 2, mitochondrial 0.0590771
RPS17 ribosomal protein S17 0.0571048
NAV2 neuron navigator 2 0.0569532
RACK1 receptor for activated C kinase 1 0.0569482
RPL37 ribosomal protein L37 0.055225
ZFP36L1 ZFP36 ring finger protein-like 1 0.0538938
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0521259
TTC3 tetratricopeptide repeat domain 3 0.0516822
PDE4D phosphodiesterase 4D, cAMP-specific 0.0490979
RPL11 ribosomal protein L11 0.046762
RPL30 ribosomal protein L30 0.046511
ZSWIM6 zinc finger, SWIM-type containing 6 0.0453725
CCL2 chemokine (C-C motif) ligand 2 0.0441942
IRS2 insulin receptor substrate 2 0.0417817
RPL37A ribosomal protein L37a 0.041472
RPL3 ribosomal protein L3 0.0412292
RPS3 ribosomal protein S3 0.0407991
RNF213 ring finger protein 213 0.040684
HLA-A major histocompatibility complex, class I, A 0.0402338
ZBTB20 zinc finger and BTB domain containing 20 0.0401344
TPI1 triosephosphate isomerase 1 0.0399737
ZCCHC7 zinc finger, CCHC domain containing 7 0.0397997
FNDC3B fibronectin type III domain containing 3B 0.0393478
RPL18 ribosomal protein L18 0.0391216
RPL35 ribosomal protein L35 0.0387672
IFITM3 interferon induced transmembrane protein 3 0.0386771
CD63 CD63 molecule 0.0382852
RPS12 ribosomal protein S12 0.0382756
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0372322
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0367657
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.036623
CP ceruloplasmin (ferroxidase) 0.0361086
AKAP9 A kinase (PRKA) anchor protein 9 0.0359036
SON SON DNA binding protein 0.0357684
ELOVL5 ELOVL fatty acid elongase 5 0.0355242
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0354916
COL4A2 collagen, type IV, alpha 2 0.0354137
RPL19 ribosomal protein L19 0.0353603
RAB2A RAB2A, member RAS oncogene family 0.0353384
RPL36 ribosomal protein L36 0.0352231
P3H2 prolyl 3-hydroxylase 2 0.0346904
SPDYA speedy/RINGO cell cycle regulator family member A 0.0335899
RPL31 ribosomal protein L31 0.033159
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0328937
HM13 histocompatibility (minor) 13 0.0320058
RPL34 ribosomal protein L34 0.0317684
CBX3 chromobox homolog 3 0.0316417
TFPI2 tissue factor pathway inhibitor 2 0.031504
RPL27 ribosomal protein L27 0.0313317
LPP LIM domain containing preferred translocation partner in lipoma 0.0313297
S100A11 S100 calcium binding protein A11 0.0313024
ESYT2 extended synaptotagmin-like protein 2 0.0307999
CYBA cytochrome b-245, alpha polypeptide 0.0305438
HLA-C major histocompatibility complex, class I, C 0.0303804
TPT1 tumor protein, translationally-controlled 1 0.0301505
LOC112694756 uncharaterized LOC112694756 0.0300178
RPL9 ribosomal protein L9 0.0297828
CRY1 cryptochrome circadian clock 1 0.0296389
EFNA5 ephrin-A5 0.0295035
PFN1 profilin 1 0.0294772
RPS5 ribosomal protein S5 0.0294768
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0293412
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.029241
KIRREL3 kin of IRRE like 3 (Drosophila) 0.028838
SERF2 small EDRK-rich factor 2 0.028773
COG5 component of oligomeric golgi complex 5 0.0286151
RND3 Rho family GTPase 3 0.0283561
CSDE1 cold shock domain containing E1, RNA-binding 0.0282793
HDLBP high density lipoprotein binding protein 0.0282719
KYNU kynureninase 0.0281626
CALU calumenin 0.0277211
RPS15A ribosomal protein S15a 0.0276057
EGFR epidermal growth factor receptor 0.0274266
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0274098
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0273934
MRPS6 mitochondrial ribosomal protein S6 0.0273014
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0270117
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0269933
RNASET2 ribonuclease T2 0.0269602
EHBP1 EH domain binding protein 1 0.0268676
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0267084
EEF2 eukaryotic translation elongation factor 2 0.0264736

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.0964694
ASPH aspartate beta-hydroxylase -0.0881236
POTEF POTE ankyrin domain family, member F -0.0673848
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0446714
TPM4 tropomyosin 4 -0.0439957
TXNRD1 thioredoxin reductase 1 -0.0426556
PDIA3 protein disulfide isomerase family A, member 3 -0.0420607
CENPF centromere protein F, 350/400kDa -0.0412827
RTN4 reticulon 4 -0.0410239
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0403938
NAMPT nicotinamide phosphoribosyltransferase -0.038719
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0364785
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0320763
WAC WW domain containing adaptor with coiled-coil -0.0316685
ANLN anillin, actin binding protein -0.0313572
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.02943
MSN moesin -0.0293736
KTN1 kinectin 1 (kinesin receptor) -0.0289701
UBE2H ubiquitin-conjugating enzyme E2H -0.0287722
RBM39 RNA binding motif protein 39 -0.0265697
RHEB Ras homolog enriched in brain -0.0257486
DIAPH3 diaphanous-related formin 3 -0.0254428
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0251085
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.024809
RPS6 ribosomal protein S6 -0.0247874
KPNB1 karyopherin (importin) beta 1 -0.0246699
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0241955
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0238837
KMT2E lysine (K)-specific methyltransferase 2E -0.0236795
RRM2 ribonucleotide reductase M2 -0.0233986
NRP2 neuropilin 2 -0.0232159
TPR translocated promoter region, nuclear basket protein -0.0231817
CSF1 colony stimulating factor 1 (macrophage) -0.0231583
GCLM glutamate-cysteine ligase, modifier subunit -0.0229031
ITGAV integrin, alpha V -0.0227306
MKI67 marker of proliferation Ki-67 -0.0224802
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0223527
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0221511
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0216
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0214665
IPO7 importin 7 -0.0213454
ADAM9 ADAM metallopeptidase domain 9 -0.0212819
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0211029
VCAM1 vascular cell adhesion molecule 1 -0.0202331
PTBP3 polypyrimidine tract binding protein 3 -0.0200899
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0198729
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0198209
NIBAN1 niban apoptosis regulator 1 -0.0194825
SMC4 structural maintenance of chromosomes 4 -0.0191429
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0189551
QKI QKI, KH domain containing, RNA binding -0.0189421
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0187312
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0186799
TUBA1B tubulin, alpha 1b -0.0186156
MYH9 myosin, heavy chain 9, non-muscle -0.0184809
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0183717
SQSTM1 sequestosome 1 -0.0183509
RPL38 ribosomal protein L38 -0.0181196
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0181188
AGFG1 ArfGAP with FG repeats 1 -0.0181092
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0179928
ANKRD11 ankyrin repeat domain 11 -0.0179343
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0178044
KCTD9 potassium channel tetramerization domain containing 9 -0.0177878
ANXA5 annexin A5 -0.0177546
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0175617
RPS2 ribosomal protein S2 -0.0175418
PDIA6 protein disulfide isomerase family A, member 6 -0.0175011
WTAP Wilms tumor 1 associated protein -0.0174293
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.0173454
NPEPPS aminopeptidase puromycin sensitive -0.0172247
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0171651
RAB10 RAB10, member RAS oncogene family -0.0167793
SETD5 SET domain containing 5 -0.0167382
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0167274
SRPK2 SRSF protein kinase 2 -0.0166975
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0166709
CANX calnexin -0.0165989
HMGB1 high mobility group box 1 -0.0165666
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0164508
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.016405
SET SET nuclear proto-oncogene -0.0163834
SCAF11 SR-related CTD-associated factor 11 -0.0162555
SEPTIN7 septin 7 -0.0160579
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0160439
MATR3 matrin 3 -0.0158839
NRIP1 nuclear receptor interacting protein 1 -0.0158545
CAND1 cullin-associated and neddylation-dissociated 1 -0.0157734
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0157553
PKM pyruvate kinase, muscle -0.0156569
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0156511
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0155668
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0155627
CXXC1 CXXC finger protein 1 -0.0155126
CYB5R3 cytochrome b5 reductase 3 -0.0154914
COPA coatomer protein complex, subunit alpha -0.0153403
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0153217
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0152595
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0152314
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0152002