Diammonium Glycyrrhizinate_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.13304
RPS19 ribosomal protein S19 0.120561
RPL26 ribosomal protein L26 0.10893
MT2A metallothionein 2A 0.105898
RPS3 ribosomal protein S3 0.0983243
RPS12 ribosomal protein S12 0.0871979
RPS17 ribosomal protein S17 0.0855204
RACK1 receptor for activated C kinase 1 0.0726083
TMSB10 thymosin beta 10 0.0712986
NDRG1 N-myc downstream regulated 1 0.0701642
RPL37A ribosomal protein L37a 0.0669378
EEF2 eukaryotic translation elongation factor 2 0.0661638
RPL11 ribosomal protein L11 0.064955
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0587649
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0551759
RPL12 ribosomal protein L12 0.0514415
RPL3 ribosomal protein L3 0.0496813
RPL18 ribosomal protein L18 0.0487623
RPL13A ribosomal protein L13a 0.0469584
RPL7 ribosomal protein L7 0.046906
RPL4 ribosomal protein L4 0.0444343
RPS4X ribosomal protein S4, X-linked 0.0439681
RPL31 ribosomal protein L31 0.0421254
STC1 stanniocalcin 1 0.0410571
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.039308
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0372576
RPL9 ribosomal protein L9 0.0358524
RPS8 ribosomal protein S8 0.0353338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0346552
RPL37 ribosomal protein L37 0.0332092
RPS2 ribosomal protein S2 0.0330019
RPS15A ribosomal protein S15a 0.0322288
FLNA filamin A, alpha 0.0322173
PLEC plectin 0.0314239
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0314084
RPS27A ribosomal protein S27a 0.0299954
SHB Src homology 2 domain containing adaptor protein B 0.0298573
RPL36 ribosomal protein L36 0.0297146
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0291186
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290351
NACA nascent polypeptide-associated complex alpha subunit 0.0289705
SAMD4A sterile alpha motif domain containing 4A 0.028708
MCL1 myeloid cell leukemia 1 0.0286002
RPL27 ribosomal protein L27 0.0285511
EEF1G eukaryotic translation elongation factor 1 gamma 0.0284084
RPS14 ribosomal protein S14 0.0281221
RPS27 ribosomal protein S27 0.0273819
RPL21 ribosomal protein L21 0.0273422
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0262625
SRRM2 serine/arginine repetitive matrix 2 0.0254867
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0254552
INTS6 integrator complex subunit 6 0.0250285
B2M beta-2-microglobulin 0.0248368
BACE2 beta-site APP-cleaving enzyme 2 0.0245301
AHNAK2 AHNAK nucleoprotein 2 0.0244584
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0242509
ANGPTL4 angiopoietin-like 4 0.0238335
CTBP2 C-terminal binding protein 2 0.0237065
CXCL5 chemokine (C-X-C motif) ligand 5 0.0236747
RPL30 ribosomal protein L30 0.0233953
RPL35 ribosomal protein L35 0.0206694
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0206028
LIMCH1 LIM and calponin homology domains 1 0.020601
RPL19 ribosomal protein L19 0.0198516
HSPA8 heat shock 70kDa protein 8 0.019732
IRS2 insulin receptor substrate 2 0.0196835
PDCD5 programmed cell death 5 0.0186267
ZFP36 ZFP36 ring finger protein 0.0185213
RPS27L ribosomal protein S27-like 0.0179863
RPS7 ribosomal protein S7 0.0178108
KLF6 Kruppel-like factor 6 0.0175845
ETNK1 ethanolamine kinase 1 0.0173576
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0172946
FAT1 FAT atypical cadherin 1 0.0171181
AHNAK AHNAK nucleoprotein 0.0170398
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0170192
LOC112694756 uncharaterized LOC112694756 0.0169529
RBBP6 retinoblastoma binding protein 6 0.0168845
SET SET nuclear proto-oncogene 0.0167578
PTPRF protein tyrosine phosphatase, receptor type, F 0.0163997
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0163801
SFPQ splicing factor proline/glutamine-rich 0.0162287
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0157141
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0155558
TUBB4B tubulin, beta 4B class IVb 0.0154856
TPM3 tropomyosin 3 0.0154664
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0154419
GOLGB1 golgin B1 0.0153175
PEAK1 pseudopodium-enriched atypical kinase 1 0.0152752
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.0150495
ENO2 enolase 2 (gamma, neuronal) 0.0150159
NFE2L1 nuclear factor, erythroid 2-like 1 0.0149244
NAP1L1 nucleosome assembly protein 1-like 1 0.0146988
SOX9 SRY (sex determining region Y)-box 9 0.0146489
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.0146159
CHMP5 charged multivesicular body protein 5 0.0145646
AADAC arylacetamide deacetylase 0.0143654
ZMIZ1 zinc finger, MIZ-type containing 1 0.0143509
TPI1 triosephosphate isomerase 1 0.0143488
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0142722

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.260097
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.182783
ACTG1 actin gamma 1 -0.121829
FTH1 ferritin, heavy polypeptide 1 -0.116626
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.116373
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.106023
IGFBP4 insulin-like growth factor binding protein 4 -0.105634
FNDC3B fibronectin type III domain containing 3B -0.0962635
IGFBP3 insulin-like growth factor binding protein 3 -0.0921669
ANXA2 annexin A2 -0.0919208
KRT81 keratin 81, type II -0.0912276
PDE4D phosphodiesterase 4D, cAMP-specific -0.0885209
AKR1C2 aldo-keto reductase family 1, member C2 -0.0872475
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0859282
CA12 carbonic anhydrase XII -0.0760523
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0730481
EXT1 exostosin glycosyltransferase 1 -0.0671101
USP3 ubiquitin specific peptidase 3 -0.0659012
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0647132
ARHGAP26 Rho GTPase activating protein 26 -0.0635101
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.06344
DOCK5 dedicator of cytokinesis 5 -0.0625023
OSMR oncostatin M receptor -0.0621936
POTEF POTE ankyrin domain family, member F -0.0611771
S100A10 S100 calcium binding protein A10 -0.0604858
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0602612
NAMPT nicotinamide phosphoribosyltransferase -0.0598332
TXNRD1 thioredoxin reductase 1 -0.05765
KCTD9 potassium channel tetramerization domain containing 9 -0.0569432
SPAG9 sperm associated antigen 9 -0.056595
ASPH aspartate beta-hydroxylase -0.054558
PDE10A phosphodiesterase 10A -0.054182
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0517144
EHBP1 EH domain binding protein 1 -0.050941
RTN4 reticulon 4 -0.0504349
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0500815
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0498803
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0492867
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0491587
RAB1A RAB1A, member RAS oncogene family -0.0476781
KPNB1 karyopherin (importin) beta 1 -0.0469691
TPT1 tumor protein, translationally-controlled 1 -0.0466679
MAP1B microtubule-associated protein 1B -0.0459319
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0456806
MT1X metallothionein 1X -0.0456589
SBF2 SET binding factor 2 -0.0455463
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0454058
CANX calnexin -0.0451634
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0424644
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0403646
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0402015
DENND4C DENN/MADD domain containing 4C -0.0395037
DGKD diacylglycerol kinase, delta 130kDa -0.0393376
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0392291
RASA2 RAS p21 protein activator 2 -0.0392259
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0388325
TOP2A topoisomerase (DNA) II alpha 170kDa -0.038584
MYO1E myosin IE -0.0385705
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0380477
VCL vinculin -0.037665
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0365456
NF1 neurofibromin 1 -0.0361648
CCDC88A coiled-coil domain containing 88A -0.0360777
ADAM17 ADAM metallopeptidase domain 17 -0.0356511
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0353909
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0349991
AGFG1 ArfGAP with FG repeats 1 -0.0348048
VDAC1 voltage-dependent anion channel 1 -0.0348015
UBE2H ubiquitin-conjugating enzyme E2H -0.0347573
UBC ubiquitin C -0.034741
AKAP12 A kinase (PRKA) anchor protein 12 -0.0347227
NRG1 neuregulin 1 -0.0346975
USP34 ubiquitin specific peptidase 34 -0.0345556
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0338133
BMERB1 bMERB domain containing 1 -0.0338062
NRP1 neuropilin 1 -0.0335905
PTBP3 polypyrimidine tract binding protein 3 -0.03337
SSH1 slingshot protein phosphatase 1 -0.0332318
TBK1 TANK-binding kinase 1 -0.0323371
TPM4 tropomyosin 4 -0.0319226
TMOD3 tropomodulin 3 (ubiquitous) -0.0315234
HIP1 huntingtin interacting protein 1 -0.0313289
KCMF1 potassium channel modulatory factor 1 -0.0311036
RIN2 Ras and Rab interactor 2 -0.0309596
ELL2 elongation factor, RNA polymerase II, 2 -0.0306975
TPM1 tropomyosin 1 (alpha) -0.0306496
WDR45B WD repeat domain 45B -0.0304743
CD44 CD44 molecule (Indian blood group) -0.0303809
HELZ helicase with zinc finger -0.0302444
NPEPPS aminopeptidase puromycin sensitive -0.0301858
CDCA2 cell division cycle associated 2 -0.0300418
EPAS1 endothelial PAS domain protein 1 -0.0299324
SCAF11 SR-related CTD-associated factor 11 -0.0296073
KRT7 keratin 7, type II -0.0295023
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0292595
AKAP13 A kinase (PRKA) anchor protein 13 -0.0290811
TFG TRK-fused gene -0.0289806
GCC2 GRIP and coiled-coil domain containing 2 -0.0286208
TM4SF1 transmembrane 4 L six family member 1 -0.028521
NPC1 Niemann-Pick disease, type C1 -0.0284861