Diammonium Glycyrrhizinate_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.122966
CADM2 cell adhesion molecule 2 0.100255
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0746699
MEOX2 mesenchyme homeobox 2 0.0675173
NFIB nuclear factor I/B 0.0536118
HMGA2 high mobility group AT-hook 2 0.0499685
KAZN kazrin, periplakin interacting protein 0.0498559
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0488598
FNDC3B fibronectin type III domain containing 3B 0.0456572
CDK6 cyclin-dependent kinase 6 0.0423898
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0422682
SRRM2 serine/arginine repetitive matrix 2 0.0414635
RPL23 ribosomal protein L23 0.0407023
SEPTIN11 septin 11 0.0406052
MSRB3 methionine sulfoxide reductase B3 0.0394803
FTL ferritin, light polypeptide 0.0382989
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0379604
QKI QKI, KH domain containing, RNA binding 0.0378054
TMSB10 thymosin beta 10 0.0373335
RPL3 ribosomal protein L3 0.0360728
MED13L mediator complex subunit 13-like 0.0354352
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0345371
WWC2 WW and C2 domain containing 2 0.0343139
AFF4 AF4/FMR2 family, member 4 0.0341685
ZCCHC7 zinc finger, CCHC domain containing 7 0.0340271
MEIS2 Meis homeobox 2 0.03353
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0334988
PCBP2 poly(rC) binding protein 2 0.0332296
ELOVL5 ELOVL fatty acid elongase 5 0.0329054
GPHN gephyrin 0.0328747
CTBP2 C-terminal binding protein 2 0.0326407
RPL11 ribosomal protein L11 0.0323525
PBX3 pre-B-cell leukemia homeobox 3 0.032223
MT2A metallothionein 2A 0.0321835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0318205
RHEB Ras homolog enriched in brain 0.0312063
CRY1 cryptochrome circadian clock 1 0.0310351
NBAS neuroblastoma amplified sequence 0.0306926
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0303716
DLG1 discs, large homolog 1 (Drosophila) 0.0301529
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0297973
KMT2E lysine (K)-specific methyltransferase 2E 0.0297774
CSDE1 cold shock domain containing E1, RNA-binding 0.0295835
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0293812
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.029313
SRPK2 SRSF protein kinase 2 0.0291571
COL5A2 collagen, type V, alpha 2 0.0279123
RBM39 RNA binding motif protein 39 0.0278246
COPA coatomer protein complex, subunit alpha 0.0277556
TPK1 thiamin pyrophosphokinase 1 0.0277043
UTRN utrophin 0.0270789
ADAM17 ADAM metallopeptidase domain 17 0.0267457
RC3H1 ring finger and CCCH-type domains 1 0.0266792
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0265393
TBL1X transducin (beta)-like 1X-linked 0.0264769
NDRG1 N-myc downstream regulated 1 0.0264219
ASPH aspartate beta-hydroxylase 0.0262022
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.026185
NPTN neuroplastin 0.0260181
RPL26 ribosomal protein L26 0.0260018
RPS3 ribosomal protein S3 0.0258925
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0258668
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.025685
ADIPOR2 adiponectin receptor 2 0.0255984
HIPK2 homeodomain interacting protein kinase 2 0.0253703
EXT1 exostosin glycosyltransferase 1 0.0253433
WDR26 WD repeat domain 26 0.0253198
OSBPL9 oxysterol binding protein-like 9 0.0252405
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0252279
PDGFC platelet derived growth factor C 0.0251175
ATXN2 ataxin 2 0.0251157
SCAF8 SR-related CTD-associated factor 8 0.0249153
UST uronyl-2-sulfotransferase 0.0248985
SAMD4A sterile alpha motif domain containing 4A 0.0247863
BIRC6 baculoviral IAP repeat containing 6 0.0247277
JARID2 jumonji, AT rich interactive domain 2 0.0246794
BCAS3 breast carcinoma amplified sequence 3 0.0245883
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.024456
CSNK1A1 casein kinase 1, alpha 1 0.0244028
ALCAM activated leukocyte cell adhesion molecule 0.0243498
CSPP1 centrosome and spindle pole associated protein 1 0.0242368
CALU calumenin 0.0241905
FMNL2 formin-like 2 0.0241476
PDS5B PDS5 cohesin associated factor B 0.023935
FAM13A family with sequence similarity 13, member A 0.0239329
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0238055
NCOR2 nuclear receptor corepressor 2 0.0235551
PRKD1 protein kinase D1 0.0233231
GPBP1 GC-rich promoter binding protein 1 0.0231593
SPPL3 signal peptide peptidase like 3 0.0229876
NALF1 NALCN channel auxiliary factor 1 0.0229712
RPS19 ribosomal protein S19 0.0229269
TMF1 TATA element modulatory factor 1 0.022807
RAD51B RAD51 paralog B 0.0227847
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0226241
AFG2A AFG2 AAA ATPase homolog A 0.0226148
INVS inversin 0.022412
SEM1 SEM1 26S proteasome subunit 0.022343
SON SON DNA binding protein 0.0220973
KMT2C lysine (K)-specific methyltransferase 2C 0.0220328

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.211035
PEG10 paternally expressed 10 -0.151415
CENPF centromere protein F, 350/400kDa -0.0965748
IER3 immediate early response 3 -0.0694532
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0572879
RPLP0 ribosomal protein, large, P0 -0.0547353
ACTG1 actin gamma 1 -0.0501461
RPS6 ribosomal protein S6 -0.049489
RPLP1 ribosomal protein, large, P1 -0.0494328
BCOR BCL6 corepressor -0.0464045
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0413993
MGP matrix Gla protein -0.0412953
RPS8 ribosomal protein S8 -0.0412735
TPT1 tumor protein, translationally-controlled 1 -0.0409118
KPNB1 karyopherin (importin) beta 1 -0.0403661
RPS24 ribosomal protein S24 -0.0399147
LDHA lactate dehydrogenase A -0.0385706
PDE4D phosphodiesterase 4D, cAMP-specific -0.0371976
DEK DEK proto-oncogene -0.0357555
MKI67 marker of proliferation Ki-67 -0.0357181
FTH1 ferritin, heavy polypeptide 1 -0.0338281
RPL35A ribosomal protein L35a -0.0329657
SOX4 SRY (sex determining region Y)-box 4 -0.0325524
HMGB2 high mobility group box 2 -0.0325195
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0322947
TPR translocated promoter region, nuclear basket protein -0.0319957
SMC3 structural maintenance of chromosomes 3 -0.0317963
XPO1 exportin 1 -0.0317822
RAD21 RAD21 homolog (S. pombe) -0.03139
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0306209
RPL38 ribosomal protein L38 -0.0304758
KIF11 kinesin family member 11 -0.0298784
COL1A2 collagen, type I, alpha 2 -0.0295774
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0294788
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0291765
RPS2 ribosomal protein S2 -0.0286505
WWOX WW domain containing oxidoreductase -0.0285276
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0275085
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0269931
ZMYND8 zinc finger, MYND-type containing 8 -0.0268281
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0265673
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0264674
RPL37 ribosomal protein L37 -0.0260475
BUB3 BUB3 mitotic checkpoint protein -0.0255042
RPL34 ribosomal protein L34 -0.025317
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253024
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0252224
MIS18BP1 MIS18 binding protein 1 -0.0251623
WAC WW domain containing adaptor with coiled-coil -0.0249779
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0247302
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0246924
JMJD1C jumonji domain containing 1C -0.0244183
PDIA3 protein disulfide isomerase family A, member 3 -0.0243543
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0242025
NCAPG non-SMC condensin I complex, subunit G -0.0241009
RPS11 ribosomal protein S11 -0.0239772
PHIP pleckstrin homology domain interacting protein -0.0236111
CKAP2 cytoskeleton associated protein 2 -0.0235736
FNIP1 folliculin interacting protein 1 -0.0232438
GTF2IRD1 GTF2I repeat domain containing 1 -0.0229041
TRIO trio Rho guanine nucleotide exchange factor -0.0227986
RPS15 ribosomal protein S15 -0.0224285
KLHL24 kelch-like family member 24 -0.0223403
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0222307
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.0219799
DOCK3 dedicator of cytokinesis 3 -0.0219431
RSL1D1 ribosomal L1 domain containing 1 -0.0218371
PPME1 protein phosphatase methylesterase 1 -0.0218029
RAI1 retinoic acid induced 1 -0.0215949
SF1 splicing factor 1 -0.0215565
KIF13B kinesin family member 13B -0.0215318
KDM5B lysine (K)-specific demethylase 5B -0.0213674
GOLM2 golgi membrane protein 2 -0.0211962
LOC112694756 uncharaterized LOC112694756 -0.0211945
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0209001
MTUS1 microtubule associated tumor suppressor 1 -0.0206264
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0204401
CFAP97 cilia and flagella associated protein 97 -0.0203892
XPO7 exportin 7 -0.0203334
WSB1 WD repeat and SOCS box containing 1 -0.0201709
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0200516
SRP72 signal recognition particle 72kDa -0.0200105
KIF18B kinesin family member 18B -0.0199065
PDS5A PDS5 cohesin associated factor A -0.0198434
TMSB4X thymosin beta 4, X-linked -0.019621
TENT4A terminal nucleotidyltransferase 4A -0.0195046
ZNF292 zinc finger protein 292 -0.0194571
ECT2 epithelial cell transforming 2 -0.019335
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0193112
ANXA2 annexin A2 -0.0193009
CKAP5 cytoskeleton associated protein 5 -0.0191803
HDLBP high density lipoprotein binding protein -0.0188989
ZNF93 zinc finger protein 93 -0.0187722
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0187627
TOP2B topoisomerase (DNA) II beta 180kDa -0.0187625
TM9SF3 transmembrane 9 superfamily member 3 -0.0187222
TLK1 tousled-like kinase 1 -0.0186581
RAN RAN, member RAS oncogene family -0.0186423
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -0.0183688
TASOR2 transcription activation suppressor family member 2 -0.0182846