Diammonium Glycyrrhizinate_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.234763
AHNAK AHNAK nucleoprotein 0.115183
IGFBP3 insulin-like growth factor binding protein 3 0.0895623
PLEC plectin 0.067832
BAIAP2L1 BAI1-associated protein 2-like 1 0.0598521
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0567933
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0531844
EZR ezrin 0.050083
PTMA prothymosin, alpha 0.0416774
DSPP dentin sialophosphoprotein 0.0404465
RPS3 ribosomal protein S3 0.0383534
TPM3 tropomyosin 3 0.0364441
EEF2 eukaryotic translation elongation factor 2 0.0356234
MYH9 myosin, heavy chain 9, non-muscle 0.035429
EMP1 epithelial membrane protein 1 0.0333575
FLNB filamin B, beta 0.0328163
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.032408
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0303215
LOC112694756 uncharaterized LOC112694756 0.0290668
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0283776
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0281401
ARRDC3 arrestin domain containing 3 0.0279456
APLP2 amyloid beta (A4) precursor-like protein 2 0.0273458
RACK1 receptor for activated C kinase 1 0.0253299
SRRM2 serine/arginine repetitive matrix 2 0.0248452
NDRG1 N-myc downstream regulated 1 0.0248072
HSPA8 heat shock 70kDa protein 8 0.0241583
ITGA6 integrin, alpha 6 0.0239498
EGFR epidermal growth factor receptor 0.0236804
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0235242
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0235228
SLK STE20-like kinase 0.0233146
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0231929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0226241
EPCAM epithelial cell adhesion molecule 0.0213536
PGK1 phosphoglycerate kinase 1 0.0211699
SERINC1 serine incorporator 1 0.0210997
GARS1 glycyl-tRNA synthetase 1 0.0210294
ESYT2 extended synaptotagmin-like protein 2 0.0204774
KIF5B kinesin family member 5B 0.0204398
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0203487
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.01997
LDHA lactate dehydrogenase A 0.0198286
RPS12 ribosomal protein S12 0.0190134
FAM13A family with sequence similarity 13, member A 0.0188524
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0187281
TNIP1 TNFAIP3 interacting protein 1 0.0185458
RPL4 ribosomal protein L4 0.0184506
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0183766
PPARG peroxisome proliferator-activated receptor gamma 0.0183763
RPL7 ribosomal protein L7 0.0177557
CD9 CD9 molecule 0.0177349
ANLN anillin, actin binding protein 0.0176392
INSIG2 insulin induced gene 2 0.0167734
ARHGAP42 Rho GTPase activating protein 42 0.0167188
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0166175
MKI67 marker of proliferation Ki-67 0.0164888
SMAD3 SMAD family member 3 0.0164212
FAT1 FAT atypical cadherin 1 0.0163678
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0160407
PLAC8 placenta-specific 8 0.0159242
RPL3 ribosomal protein L3 0.0157695
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.0156667
PKM pyruvate kinase, muscle 0.0156242
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0155994
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0155804
CANX calnexin 0.0154856
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0154066
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0152966
STK39 serine threonine kinase 39 0.0151455
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0149816
OSBPL3 oxysterol binding protein-like 3 0.014946
DDIT4 DNA-damage-inducible transcript 4 0.0148168
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0146132
VCAN versican 0.0145309
TPI1 triosephosphate isomerase 1 0.0144945
EIF4A2 eukaryotic translation initiation factor 4A2 0.0144627
ITGB4 integrin, beta 4 0.0144465
PTPRF protein tyrosine phosphatase, receptor type, F 0.0144268
TMEM41B transmembrane protein 41B 0.0144169
MBNL2 muscleblind-like splicing regulator 2 0.0144034
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0144004
BHLHE40 basic helix-loop-helix family, member e40 0.0143675
RPL23 ribosomal protein L23 0.014302
LYZ lysozyme 0.0143019
KTN1 kinectin 1 (kinesin receptor) 0.0142035
KRT18 keratin 18, type I 0.0141819
PON2 paraoxonase 2 0.0140901
NCKAP1 NCK-associated protein 1 0.0140532
MYOF myoferlin 0.0138974
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0137015
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0136634
HMGB2 high mobility group box 2 0.0135454
MMP7 matrix metallopeptidase 7 0.0135425
RPS27 ribosomal protein S27 0.0135423
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.013458
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0134164
EPHA2 EPH receptor A2 0.0133718
MKRN1 makorin ring finger protein 1 0.0133221
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0132107

decreased expression

Symbol Name Standardized Value
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.224942
TPT1 tumor protein, translationally-controlled 1 -0.13385
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.125126
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.125033
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.123539
KLK10 kallikrein-related peptidase 10 -0.106008
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0927786
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0899491
F3 coagulation factor III (thromboplastin, tissue factor) -0.0858058
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0838466
TM4SF1 transmembrane 4 L six family member 1 -0.0765079
SP100 SP100 nuclear antigen -0.0680981
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0664631
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0635717
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0632347
RASAL2 RAS protein activator like 2 -0.060303
SACK1A scaffolding CK1 anchoring protein A -0.0576697
RAB7A RAB7A, member RAS oncogene family -0.0548669
BLZF1 basic leucine zipper nuclear factor 1 -0.0525684
FBXO11 F-box protein 11 -0.0518513
SEC31A SEC31 homolog A (S. cerevisiae) -0.0498534
RPS21 ribosomal protein S21 -0.0496564
EGR1 early growth response 1 -0.047535
CLMP CXADR-like membrane protein -0.0470027
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0469212
EXT1 exostosin glycosyltransferase 1 -0.0467057
DIAPH2 diaphanous-related formin 2 -0.0461628
TXNIP thioredoxin interacting protein -0.0460822
HDAC9 histone deacetylase 9 -0.0459485
LAMB3 laminin, beta 3 -0.045344
DOCK5 dedicator of cytokinesis 5 -0.0448064
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0447939
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0447105
POTEF POTE ankyrin domain family, member F -0.0445868
AK1 adenylate kinase 1 -0.043739
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0409707
RPL35A ribosomal protein L35a -0.040728
PDLIM5 PDZ and LIM domain 5 -0.0397121
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0396281
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.039368
RPS24 ribosomal protein S24 -0.0381325
PMM2 phosphomannomutase 2 -0.0357609
GREB1L growth regulation by estrogen in breast cancer-like -0.0353852
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.03501
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0349137
THSD4 thrombospondin, type I, domain containing 4 -0.0345641
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0342517
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0337383
MXD1 MAX dimerization protein 1 -0.0337352
TXNRD1 thioredoxin reductase 1 -0.0337325
INTS6 integrator complex subunit 6 -0.0337224
FTH1 ferritin, heavy polypeptide 1 -0.0336481
PARD3 par-3 family cell polarity regulator -0.0334251
TMEM263 transmembrane protein 263 -0.0329378
CDK13 cyclin-dependent kinase 13 -0.0327843
RPLP2 ribosomal protein, large, P2 -0.0322389
SEPTIN10 septin 10 -0.0318756
DENND2C DENN/MADD domain containing 2C -0.0317505
HMGA1 high mobility group AT-hook 1 -0.0311559
USP34 ubiquitin specific peptidase 34 -0.0307243
NUP98 nucleoporin 98kDa -0.0306892
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0306291
UBE2H ubiquitin-conjugating enzyme E2H -0.0306252
RAB2A RAB2A, member RAS oncogene family -0.0303877
HMGA2 high mobility group AT-hook 2 -0.0303494
RAB1A RAB1A, member RAS oncogene family -0.0300373
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0299336
FUS FUS RNA binding protein -0.0298809
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0298649
MCL1 myeloid cell leukemia 1 -0.0296689
IFI16 interferon, gamma-inducible protein 16 -0.0296189
RPL34 ribosomal protein L34 -0.0295924
SLC38A2 solute carrier family 38, member 2 -0.029572
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0293639
S100A10 S100 calcium binding protein A10 -0.0292814
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0290594
GLS2 glutaminase 2 (liver, mitochondrial) -0.0287944
USP53 ubiquitin specific peptidase 53 -0.0287363
LY6E lymphocyte antigen 6 complex, locus E -0.0283561
ZFAND3 zinc finger, AN1-type domain 3 -0.0283368
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0281542
AKAP13 A kinase (PRKA) anchor protein 13 -0.0280588
USP15 ubiquitin specific peptidase 15 -0.0278249
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0276976
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0275983
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0273725
PPARD peroxisome proliferator-activated receptor delta -0.0268255
MAPK8 mitogen-activated protein kinase 8 -0.0267069
MIDN midnolin -0.0265418
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0264475
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.026296
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0259101
TJP1 tight junction protein 1 -0.0258096
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0257907
COG5 component of oligomeric golgi complex 5 -0.0257261
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0254498
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0252828
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0252441
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0252208
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0250759