Diammonium Glycyrrhizinate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.177969
RPS3 ribosomal protein S3 0.0853425
ZNF608 zinc finger protein 608 0.0815328
RPS12 ribosomal protein S12 0.0789277
RPL11 ribosomal protein L11 0.0784249
RACK1 receptor for activated C kinase 1 0.0672023
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0641529
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0638709
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0631991
RPL26 ribosomal protein L26 0.0596657
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0561127
TMSB10 thymosin beta 10 0.0537255
RPL3 ribosomal protein L3 0.0519769
EEF2 eukaryotic translation elongation factor 2 0.0478381
RPS4X ribosomal protein S4, X-linked 0.0417951
TPI1 triosephosphate isomerase 1 0.0386567
IFI6 interferon, alpha-inducible protein 6 0.03791
RPL9 ribosomal protein L9 0.0376084
RPL13A ribosomal protein L13a 0.0366747
RPL7 ribosomal protein L7 0.0365243
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0348587
RPL37A ribosomal protein L37a 0.0319674
RPL18 ribosomal protein L18 0.031601
RPL4 ribosomal protein L4 0.0315125
VCL vinculin 0.0314822
RCC1 regulator of chromosome condensation 1 0.0307408
RPS17 ribosomal protein S17 0.0298886
ENO1 enolase 1, (alpha) 0.0297518
ISG15 ISG15 ubiquitin-like modifier 0.0295518
RPS19 ribosomal protein S19 0.0295014
HSPA8 heat shock 70kDa protein 8 0.0294809
LOC112694756 uncharaterized LOC112694756 0.0294535
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0276355
B2M beta-2-microglobulin 0.0272757
RPS2 ribosomal protein S2 0.0270341
NACA nascent polypeptide-associated complex alpha subunit 0.0267465
RPL12 ribosomal protein L12 0.0256761
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0254894
RPL23 ribosomal protein L23 0.025291
RPS15A ribosomal protein S15a 0.0252393
SHISA5 shisa family member 5 0.0223202
JUN jun proto-oncogene 0.0221136
YBX1 Y box binding protein 1 0.0213093
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0210211
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0205866
ADGRG6 adhesion G protein-coupled receptor G6 0.0203934
RPS8 ribosomal protein S8 0.0200763
PDAP1 PDGFA associated protein 1 0.0198225
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0195914
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0193822
SMC1A structural maintenance of chromosomes 1A 0.0192597
RPL37 ribosomal protein L37 0.0192299
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0185575
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0185365
SRRM2 serine/arginine repetitive matrix 2 0.0183344
RPL21 ribosomal protein L21 0.0181252
RPLP0 ribosomal protein, large, P0 0.0179867
EGFR epidermal growth factor receptor 0.0172475
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0171951
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0171008
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0170735
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0170466
NEBL nebulette 0.0170337
TUBB4B tubulin, beta 4B class IVb 0.0154674
SRRM1 serine/arginine repetitive matrix 1 0.0154024
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0153718
ATF4 activating transcription factor 4 0.0151798
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0151558
COX6C cytochrome c oxidase subunit VIc 0.0151398
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.014954
TMED2 transmembrane emp24 domain trafficking protein 2 0.0148943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0148894
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.0146955
ZNF248 zinc finger protein 248 0.0146425
GPATCH2L G patch domain containing 2-like 0.0145442
MSH4 mutS homolog 4 0.0144169
SSB Sjogren syndrome antigen B (autoantigen La) 0.0144066
TMEM259 transmembrane protein 259 0.014363
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 0.014217
NDUFA4 NDUFA4, mitochondrial complex associated 0.0140778
SPDYA speedy/RINGO cell cycle regulator family member A 0.0139608
TPM3 tropomyosin 3 0.0137744
GPBP1 GC-rich promoter binding protein 1 0.0137571
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0135769
MLIP muscular LMNA-interacting protein 0.0135466
LOC102724023 ES1 protein homolog, mitochondrial 0.0135422
RPL27 ribosomal protein L27 0.0135315
DDIT3 DNA-damage-inducible transcript 3 0.0135181
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0134771
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0133666
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0132171
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0131667
WAPL WAPL cohesin release factor 0.0131175
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0130708
KIAA1549 KIAA1549 0.0129883
SNX14 sorting nexin 14 0.0127755
STAU2 staufen double-stranded RNA binding protein 2 0.0127653
RBBP6 retinoblastoma binding protein 6 0.0126352
PSEN1 presenilin 1 0.0126335
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0126222

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.132011
TENM3 teneurin transmembrane protein 3 -0.0959718
RPS21 ribosomal protein S21 -0.0790946
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0742249
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0741474
RAD51B RAD51 paralog B -0.0707051
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0706946
ACTG1 actin gamma 1 -0.0684106
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0677767
RPS6 ribosomal protein S6 -0.0672714
SLIT2 slit homolog 2 (Drosophila) -0.0655168
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0632406
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0595384
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0586994
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0572624
ZNF292 zinc finger protein 292 -0.0559392
COL5A2 collagen, type V, alpha 2 -0.0557374
CADM2 cell adhesion molecule 2 -0.054537
PARD3 par-3 family cell polarity regulator -0.052567
RPLP2 ribosomal protein, large, P2 -0.0525101
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0520342
OSBPL10 oxysterol binding protein-like 10 -0.0516531
NF1 neurofibromin 1 -0.0509217
RPLP1 ribosomal protein, large, P1 -0.0506287
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0491361
ACACA acetyl-CoA carboxylase alpha -0.0480614
WDR45B WD repeat domain 45B -0.048061
PTK2 protein tyrosine kinase 2 -0.047428
PHIP pleckstrin homology domain interacting protein -0.0474179
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0462932
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0461159
RPL28 ribosomal protein L28 -0.0448578
KTN1 kinectin 1 (kinesin receptor) -0.0448515
NUP58 nucleoporin 58 -0.0447392
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0440256
SMYD3 SET and MYND domain containing 3 -0.0429054
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0421494
PTMA prothymosin, alpha -0.0421036
XPO1 exportin 1 -0.0417836
PRICKLE1 prickle homolog 1 (Drosophila) -0.0415153
PDS5A PDS5 cohesin associated factor A -0.041465
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.041277
TPD52 tumor protein D52 -0.0412236
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.041091
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0410534
CELF2 CUGBP, Elav-like family member 2 -0.0407181
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0403881
OGA O-GlcNAcase -0.0402992
SRPK2 SRSF protein kinase 2 -0.0401898
ADNP activity-dependent neuroprotector homeobox -0.040071
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0400489
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0400447
KPNB1 karyopherin (importin) beta 1 -0.0398474
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0395228
ZFAND3 zinc finger, AN1-type domain 3 -0.0392835
MED13 mediator complex subunit 13 -0.0380886
TCF12 transcription factor 12 -0.0377178
NCOR1 nuclear receptor corepressor 1 -0.0371334
CENPF centromere protein F, 350/400kDa -0.0370247
CELF1 CUGBP, Elav-like family member 1 -0.036784
KDM3A lysine (K)-specific demethylase 3A -0.0365841
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0363759
ENAH enabled homolog (Drosophila) -0.0358344
FBXO11 F-box protein 11 -0.0357608
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0356016
NFIA nuclear factor I/A -0.0355709
RLF rearranged L-myc fusion -0.0355117
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.035454
RPS15 ribosomal protein S15 -0.0351964
ZMYND8 zinc finger, MYND-type containing 8 -0.0351414
USP34 ubiquitin specific peptidase 34 -0.0350274
SETD5 SET domain containing 5 -0.0348203
JMJD1C jumonji domain containing 1C -0.0347568
PTPRG protein tyrosine phosphatase, receptor type, G -0.0346142
SOX4 SRY (sex determining region Y)-box 4 -0.0345381
UBE2K ubiquitin-conjugating enzyme E2K -0.0343789
RPS11 ribosomal protein S11 -0.0340978
TRIO trio Rho guanine nucleotide exchange factor -0.0339371
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0338707
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0338143
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0336932
AUTS2 autism susceptibility candidate 2 -0.0335639
SRSF4 serine/arginine-rich splicing factor 4 -0.0332616
IPO7 importin 7 -0.0332385
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0331449
ZNF638 zinc finger protein 638 -0.0329787
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0329435
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.032907
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0322173
TTC28 tetratricopeptide repeat domain 28 -0.0322032
HELZ helicase with zinc finger -0.0321638
MKI67 marker of proliferation Ki-67 -0.0321114
TNPO3 transportin 3 -0.0320367
GLG1 golgi glycoprotein 1 -0.0318943
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0315232
ATXN2 ataxin 2 -0.0314604
CHD7 chromodomain helicase DNA binding protein 7 -0.0314338
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0313886
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.0312513
TXNRD1 thioredoxin reductase 1 -0.0311936