Diammonium Glycyrrhizinate_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0936343
ZSWIM6 zinc finger, SWIM-type containing 6 0.0792216
MT2A metallothionein 2A 0.0697564
GRB10 growth factor receptor-bound protein 10 0.0634729
DTNA dystrobrevin, alpha 0.0615714
RPL23 ribosomal protein L23 0.0602651
FAM13A family with sequence similarity 13, member A 0.056119
SAMD4A sterile alpha motif domain containing 4A 0.0527485
SMAD3 SMAD family member 3 0.0421876
FAM107B family with sequence similarity 107, member B 0.03808
ESYT2 extended synaptotagmin-like protein 2 0.0360725
INTS6 integrator complex subunit 6 0.0359812
ZMIZ1 zinc finger, MIZ-type containing 1 0.0355074
S100P S100 calcium binding protein P 0.0343267
ANKRD11 ankyrin repeat domain 11 0.0324698
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0324604
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.032132
MT1E metallothionein 1E 0.0318989
EPAS1 endothelial PAS domain protein 1 0.0314896
STC1 stanniocalcin 1 0.0312446
PPARD peroxisome proliferator-activated receptor delta 0.0300216
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0298868
RIMKLB ribosomal modification protein rimK-like family member B 0.0292723
GLS2 glutaminase 2 (liver, mitochondrial) 0.0292414
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0290877
SPTBN1 spectrin, beta, non-erythrocytic 1 0.028939
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0283109
ARRDC3 arrestin domain containing 3 0.0282403
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.028046
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0273822
IFRD1 interferon-related developmental regulator 1 0.0266299
ATF3 activating transcription factor 3 0.0265535
EZR ezrin 0.026367
SEC31A SEC31 homolog A (S. cerevisiae) 0.0257944
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0255333
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0253785
FLNB filamin B, beta 0.0252387
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0242405
PRSS8 protease, serine, 8 0.0234757
CCNY cyclin Y 0.0234644
ELL2 elongation factor, RNA polymerase II, 2 0.0232565
KDM5B lysine (K)-specific demethylase 5B 0.0230076
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0228759
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0228621
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0226032
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0225657
LMO7 LIM domain 7 0.022368
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0221392
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220463
FGFR1 fibroblast growth factor receptor 1 0.0218547
RBM39 RNA binding motif protein 39 0.0216067
FOXO3 forkhead box O3 0.0215735
RPL11 ribosomal protein L11 0.0215628
RPL3 ribosomal protein L3 0.0214873
SHB Src homology 2 domain containing adaptor protein B 0.0203557
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0197443
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.0195402
CEMIP cell migration inducing protein, hyaluronan binding 0.0194497
CTBP2 C-terminal binding protein 2 0.0194286
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0194065
MT1G metallothionein 1G 0.0193901
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.019269
MORF4L2 mortality factor 4 like 2 0.0190299
SRP54 signal recognition particle 54kDa 0.0190264
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0186938
JUN jun proto-oncogene 0.0186743
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0182649
KYNU kynureninase 0.0181486
IRS2 insulin receptor substrate 2 0.0180359
SKP1 S-phase kinase-associated protein 1 0.0178217
EIF1 eukaryotic translation initiation factor 1 0.0177467
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0177208
CEP44 centrosomal protein 44kDa 0.0177062
TIMP2 TIMP metallopeptidase inhibitor 2 0.0174382
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.017426
AKAP9 A kinase (PRKA) anchor protein 9 0.0174122
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0171092
MT1M metallothionein 1M 0.0170275
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0167526
FNBP1L formin binding protein 1-like 0.0167398
FA2H fatty acid 2-hydroxylase 0.0165537
RPS17 ribosomal protein S17 0.016457
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0164132
MLF1 myeloid leukemia factor 1 0.0162538
MXD1 MAX dimerization protein 1 0.016199
DDIT4 DNA-damage-inducible transcript 4 0.0160947
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0159606
EEF2 eukaryotic translation elongation factor 2 0.015773
HILPDA hypoxia inducible lipid droplet-associated 0.0156829
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0156084
FAM53C family with sequence similarity 53, member C 0.0154994
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0154346
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0154166
BZW2 basic leucine zipper and W2 domains 2 0.0153899
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0153633
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0153194
ANO6 anoctamin 6 0.0152784
LGMN legumain 0.0152596
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0152215
GPBP1 GC-rich promoter binding protein 1 0.0151626

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.185186
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144944
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.130482
MMP7 matrix metallopeptidase 7 -0.129464
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.116004
VIM vimentin -0.102699
DST dystonin -0.098959
RTN4 reticulon 4 -0.0938356
LAMA4 laminin, alpha 4 -0.0878587
IGFBP3 insulin-like growth factor binding protein 3 -0.0875973
ENO1 enolase 1, (alpha) -0.0852774
LAMC2 laminin, gamma 2 -0.0852606
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.084553
TMSB4X thymosin beta 4, X-linked -0.083862
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0837987
ITGA6 integrin, alpha 6 -0.0822281
ACTG1 actin gamma 1 -0.0793381
KRT19 keratin 19, type I -0.0790574
ANXA2 annexin A2 -0.0769701
POTEF POTE ankyrin domain family, member F -0.0745599
PTMA prothymosin, alpha -0.0728465
S100A6 S100 calcium binding protein A6 -0.0718943
EFNA5 ephrin-A5 -0.0698601
IFI27 interferon, alpha-inducible protein 27 -0.0658322
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0638456
CD2AP CD2-associated protein -0.0637231
S100A10 S100 calcium binding protein A10 -0.0631835
MAP1B microtubule-associated protein 1B -0.0609467
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0591618
MAML2 mastermind-like 2 (Drosophila) -0.0579473
APOL1 apolipoprotein L, 1 -0.0570423
ALCAM activated leukocyte cell adhesion molecule -0.0570319
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0555229
NPEPPS aminopeptidase puromycin sensitive -0.0552131
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.054191
NAMPT nicotinamide phosphoribosyltransferase -0.0527227
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0521339
TPM4 tropomyosin 4 -0.0520159
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0518474
OSMR oncostatin M receptor -0.0515326
AKAP13 A kinase (PRKA) anchor protein 13 -0.0501489
PLAT plasminogen activator, tissue -0.0500389
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0493034
ACTN4 actinin, alpha 4 -0.048364
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0480258
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0476377
VCL vinculin -0.0476219
FNDC3B fibronectin type III domain containing 3B -0.0473526
EHBP1 EH domain binding protein 1 -0.04698
PKM pyruvate kinase, muscle -0.0469742
TPM1 tropomyosin 1 (alpha) -0.0467633
RASAL2 RAS protein activator like 2 -0.0461949
BCL2L1 BCL2-like 1 -0.0460622
TM4SF1 transmembrane 4 L six family member 1 -0.0449454
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0445096
PDZD8 PDZ domain containing 8 -0.0444754
DSG2 desmoglein 2 -0.0442043
PDLIM5 PDZ and LIM domain 5 -0.0433617
CDCP1 CUB domain containing protein 1 -0.0433028
NRG3 neuregulin 3 -0.0425986
ADAM9 ADAM metallopeptidase domain 9 -0.0422314
BICC1 BicC family RNA binding protein 1 -0.0422089
NRP1 neuropilin 1 -0.0418995
NT5C2 5'-nucleotidase, cytosolic II -0.0418953
MKI67 marker of proliferation Ki-67 -0.0416564
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0416512
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0414184
FAM3C family with sequence similarity 3, member C -0.0406349
KPNB1 karyopherin (importin) beta 1 -0.0405612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0403613
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0393786
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0387514
SLC38A1 solute carrier family 38, member 1 -0.0386945
BPTF bromodomain PHD finger transcription factor -0.0382563
WWTR1 WW domain containing transcription regulator 1 -0.0379796
STRN3 striatin, calmodulin binding protein 3 -0.0373364
PGK1 phosphoglycerate kinase 1 -0.037161
SVIL supervillin -0.0369298
UBC ubiquitin C -0.0368985
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0366976
ITPRID2 ITPR interacting domain containing 2 -0.0362403
HMGA2 high mobility group AT-hook 2 -0.0360394
KTN1 kinectin 1 (kinesin receptor) -0.0356663
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0350543
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0342573
CDK6 cyclin-dependent kinase 6 -0.0341038
FRMD5 FERM domain containing 5 -0.0340782
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0334033
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0331671
SAMD9 sterile alpha motif domain containing 9 -0.0331032
ARHGAP5 Rho GTPase activating protein 5 -0.0329851
DPYD dihydropyrimidine dehydrogenase -0.0323217
RAD51B RAD51 paralog B -0.0321451
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.03212
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0320519
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0319647
IFI16 interferon, gamma-inducible protein 16 -0.0319551
MYH9 myosin, heavy chain 9, non-muscle -0.0317491
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0316936
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0313297