Diammonium Glycyrrhizinate_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.163584
RPL23 ribosomal protein L23 0.0867028
PRRC2C proline-rich coiled-coil 2C 0.0673283
DSCAM Down syndrome cell adhesion molecule 0.0656391
RPS19 ribosomal protein S19 0.0599662
CSDE1 cold shock domain containing E1, RNA-binding 0.0564011
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0561517
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0517206
TLE4 transducin-like enhancer of split 4 0.0514701
RPS3 ribosomal protein S3 0.0487379
MT2A metallothionein 2A 0.0453118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0446847
TPR translocated promoter region, nuclear basket protein 0.0441321
RPL26 ribosomal protein L26 0.04216
RAD51B RAD51 paralog B 0.0420388
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.040987
PTMA prothymosin, alpha 0.0391429
ZSWIM6 zinc finger, SWIM-type containing 6 0.0381098
RPL19 ribosomal protein L19 0.037824
TPI1 triosephosphate isomerase 1 0.037267
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0371457
MBD5 methyl-CpG binding domain protein 5 0.0366749
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0361744
EEF2 eukaryotic translation elongation factor 2 0.0360047
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0351733
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0350265
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.034419
RPL34 ribosomal protein L34 0.0333241
RACK1 receptor for activated C kinase 1 0.0332872
RPL18 ribosomal protein L18 0.0320846
LDHB lactate dehydrogenase B 0.0311221
EEF1G eukaryotic translation elongation factor 1 gamma 0.0310256
RPTOR regulatory associated protein of MTOR, complex 1 0.0309743
RPL37 ribosomal protein L37 0.0292571
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0292369
AKAP12 A kinase (PRKA) anchor protein 12 0.0291655
EIF1 eukaryotic translation initiation factor 1 0.0291436
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0285889
RPL4 ribosomal protein L4 0.0284821
AKAP9 A kinase (PRKA) anchor protein 9 0.0284669
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0266473
DIAPH1 diaphanous-related formin 1 0.0265192
RPL36 ribosomal protein L36 0.0263083
OGA O-GlcNAcase 0.026194
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0261776
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0258224
EGR1 early growth response 1 0.0256007
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0254529
S100A9 S100 calcium binding protein A9 0.0252474
CDK6 cyclin-dependent kinase 6 0.0251008
AFF4 AF4/FMR2 family, member 4 0.0247441
HILPDA hypoxia inducible lipid droplet-associated 0.0245113
IFI6 interferon, alpha-inducible protein 6 0.0242585
ARHGAP26 Rho GTPase activating protein 26 0.0242215
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0241977
RPL3 ribosomal protein L3 0.0240879
MAP1B microtubule-associated protein 1B 0.0240298
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.023991
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0238044
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0237829
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0236659
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0233542
SEM1 SEM1 26S proteasome subunit 0.0233118
GOLGA4 golgin A4 0.0231867
TMCO1 transmembrane and coiled-coil domains 1 0.0231377
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0230687
RPS17 ribosomal protein S17 0.0229721
CSNK1A1 casein kinase 1, alpha 1 0.0229641
AFMID arylformamidase 0.0229291
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0229261
PDE4D phosphodiesterase 4D, cAMP-specific 0.022848
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0225184
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0223549
ZNF292 zinc finger protein 292 0.0222459
RGS4 regulator of G-protein signaling 4 0.0221772
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0219818
ZNF148 zinc finger protein 148 0.0217266
KIF5B kinesin family member 5B 0.0216888
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0216764
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0216437
FOXP1 forkhead box P1 0.0216007
SRP54 signal recognition particle 54kDa 0.021519
FNBP1 formin binding protein 1 0.0214965
TBC1D5 TBC1 domain family, member 5 0.0214771
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0213644
RPL30 ribosomal protein L30 0.0213012
FN1 fibronectin 1 0.0212581
HLA-A major histocompatibility complex, class I, A 0.0210585
ZNF644 zinc finger protein 644 0.0209225
IFI16 interferon, gamma-inducible protein 16 0.0206937
ARRDC3 arrestin domain containing 3 0.0206588
ANTXR1 anthrax toxin receptor 1 0.0206382
STK38L serine/threonine kinase 38 like 0.0206036
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0205338
DYM dymeclin 0.0204821
CENPE centromere protein E, 312kDa 0.020404
RPL7L1 ribosomal protein L7-like 1 0.0202801
RHOB ras homolog family member B 0.0202334
FTL ferritin, light polypeptide 0.0201926
RPL27 ribosomal protein L27 0.0200811

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.0981962
NALF1 NALCN channel auxiliary factor 1 -0.0953383
FMN1 formin 1 -0.0848135
IGFBP3 insulin-like growth factor binding protein 3 -0.0762377
IGF2 insulin-like growth factor 2 -0.0649473
BICD1 bicaudal D homolog 1 (Drosophila) -0.0628683
ACTG1 actin gamma 1 -0.0582961
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0546113
ZBTB20 zinc finger and BTB domain containing 20 -0.0524204
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0522581
CHD9 chromodomain helicase DNA binding protein 9 -0.0516132
THSD4 thrombospondin, type I, domain containing 4 -0.0508661
PRKCA protein kinase C, alpha -0.0469343
FRMD4A FERM domain containing 4A -0.0463382
COL1A1 collagen, type I, alpha 1 -0.0457477
EXT1 exostosin glycosyltransferase 1 -0.0449618
COL3A1 collagen, type III, alpha 1 -0.0392895
JMJD1C jumonji domain containing 1C -0.0389932
KLHL13 kelch-like family member 13 -0.0382382
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0376876
VIM vimentin -0.0364574
PTPRK protein tyrosine phosphatase, receptor type, K -0.0360387
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.035835
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0353838
CEMIP cell migration inducing protein, hyaluronan binding -0.0351821
VDAC1 voltage-dependent anion channel 1 -0.0351529
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0348469
NPAS2 neuronal PAS domain protein 2 -0.034257
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0337603
TRIO trio Rho guanine nucleotide exchange factor -0.0333065
ZFAND3 zinc finger, AN1-type domain 3 -0.0331442
TPT1 tumor protein, translationally-controlled 1 -0.0327546
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0323122
NF1 neurofibromin 1 -0.0309555
DNM3 dynamin 3 -0.0307952
CUX1 cut-like homeobox 1 -0.0305884
FNDC3A fibronectin type III domain containing 3A -0.0304602
DTNA dystrobrevin, alpha -0.0304194
PKM pyruvate kinase, muscle -0.0300334
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0292542
SYT1 synaptotagmin I -0.0283488
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0283249
CANX calnexin -0.0282934
ADGRB3 adhesion G protein-coupled receptor B3 -0.0281414
FRMD5 FERM domain containing 5 -0.0276372
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0275869
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0274407
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0273315
FLT1 fms-related tyrosine kinase 1 -0.0271267
MAML2 mastermind-like 2 (Drosophila) -0.0271217
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0266405
SLC39A11 solute carrier family 39, member 11 -0.0264334
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0262852
AKAP13 A kinase (PRKA) anchor protein 13 -0.026094
RPS15 ribosomal protein S15 -0.0253066
NRG1 neuregulin 1 -0.0252211
PDIA3 protein disulfide isomerase family A, member 3 -0.0251591
MDM4 MDM4, p53 regulator -0.0247898
RPS13 ribosomal protein S13 -0.0246769
PTPRM protein tyrosine phosphatase, receptor type, M -0.0245017
C1ORF21 chromosome 1 open reading frame 21 -0.0244315
ARHGAP32 Rho GTPase activating protein 32 -0.024416
PRKCE protein kinase C, epsilon -0.0243596
HIP1 huntingtin interacting protein 1 -0.0241866
GLI3 GLI family zinc finger 3 -0.0237239
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0236723
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0233589
MACF1 microtubule-actin crosslinking factor 1 -0.0231021
FUS FUS RNA binding protein -0.0230392
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.022941
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0228373
PDS5A PDS5 cohesin associated factor A -0.0227419
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0225557
UBE2H ubiquitin-conjugating enzyme E2H -0.0225444
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0224843
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.022481
KTN1 kinectin 1 (kinesin receptor) -0.0224748
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0224298
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0224263
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0223332
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0223194
DPH6 diphthamine biosynthesis 6 -0.0221758
PRMT2 protein arginine methyltransferase 2 -0.0220019
NPAS3 neuronal PAS domain protein 3 -0.0218888
KCNIP4 Kv channel interacting protein 4 -0.0216519
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0216018
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0215603
RBM6 RNA binding motif protein 6 -0.0214447
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0212811
TRIM24 tripartite motif containing 24 -0.021257
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0212204
PARD3 par-3 family cell polarity regulator -0.0211094
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0209521
COL4A1 collagen, type IV, alpha 1 -0.0209057
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0208351
AHR aryl hydrocarbon receptor -0.0208196
CCDC93 coiled-coil domain containing 93 -0.0208193
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0207659
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0205884
UNC5C unc-5 homolog C (C. elegans) -0.0205802