Diammonium Glycyrrhizinate_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.145737
B2M beta-2-microglobulin 0.11844
EGR1 early growth response 1 0.108328
AREG amphiregulin 0.0892684
LYZ lysozyme 0.0891899
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0767764
STS steroid sulfatase (microsomal), isozyme S 0.0736963
INTS6 integrator complex subunit 6 0.0668769
FTL ferritin, light polypeptide 0.0662906
RAB7A RAB7A, member RAS oncogene family 0.0626277
IGFBP3 insulin-like growth factor binding protein 3 0.0625533
ZSWIM6 zinc finger, SWIM-type containing 6 0.0586923
ERBIN erbb2 interacting protein 0.052231
FOS FBJ murine osteosarcoma viral oncogene homolog 0.051766
LCN2 lipocalin 2 0.0492912
MCL1 myeloid cell leukemia 1 0.0479526
TMC5 transmembrane channel-like 5 0.0477731
BAIAP2L1 BAI1-associated protein 2-like 1 0.0460073
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0450962
FTH1 ferritin, heavy polypeptide 1 0.0435428
ANXA2 annexin A2 0.042506
IFI27 interferon, alpha-inducible protein 27 0.0410539
AKAP13 A kinase (PRKA) anchor protein 13 0.0408495
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0404076
RPL23 ribosomal protein L23 0.040183
EZR ezrin 0.0401814
SMAD3 SMAD family member 3 0.0400865
LAMA4 laminin, alpha 4 0.0389678
TJP1 tight junction protein 1 0.0369582
TM4SF19 transmembrane 4 L six family member 19 0.0367797
LOC102724023 ES1 protein homolog, mitochondrial 0.0362845
MT2A metallothionein 2A 0.0362047
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.035439
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0341066
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0324952
MCTP1 multiple C2 domains, transmembrane 1 0.0320681
KRT19 keratin 19, type I 0.0319672
HKDC1 hexokinase domain containing 1 0.0307481
DIAPH1 diaphanous-related formin 1 0.0303942
IFITM3 interferon induced transmembrane protein 3 0.0295923
ISG15 ISG15 ubiquitin-like modifier 0.0295336
KYNU kynureninase 0.0294961
TACSTD2 tumor-associated calcium signal transducer 2 0.0294692
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0289604
TPI1 triosephosphate isomerase 1 0.028739
NPSR1 neuropeptide S receptor 1 0.0286274
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0284294
PLSCR2 phospholipid scramblase 2 0.0283935
NDRG1 N-myc downstream regulated 1 0.0283857
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.028253
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0282035
GK glycerol kinase 0.027919
S100P S100 calcium binding protein P 0.027757
CYSTM1 cysteine-rich transmembrane module containing 1 0.0273449
KIF16B kinesin family member 16B 0.0269074
HLA-A major histocompatibility complex, class I, A 0.0265924
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0264239
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0260036
UBAP2 ubiquitin associated protein 2 0.0257841
SLC38A1 solute carrier family 38, member 1 0.0257053
VEGFA vascular endothelial growth factor A 0.0256647
MX1 MX dynamin-like GTPase 1 0.0256312
TMSB10 thymosin beta 10 0.0255351
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0253427
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.025288
SEPTIN9 septin 9 0.0252307
DUSP10 dual specificity phosphatase 10 0.0251682
TRIB1 tribbles pseudokinase 1 0.0251365
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0251132
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0248184
NCEH1 neutral cholesterol ester hydrolase 1 0.0246347
POU2F2 POU class 2 homeobox 2 0.02454
NABP1 nucleic acid binding protein 1 0.024221
BCL2L1 BCL2-like 1 0.0241553
CLDN4 claudin 4 0.0241335
DDIT3 DNA-damage-inducible transcript 3 0.0240753
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0238585
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0238304
S100A11 S100 calcium binding protein A11 0.0238084
MAML2 mastermind-like 2 (Drosophila) 0.0237217
CST3 cystatin C 0.023704
EXT1 exostosin glycosyltransferase 1 0.0234569
EFNB2 ephrin-B2 0.0232562
ZFP36L1 ZFP36 ring finger protein-like 1 0.023224
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0230764
ATF4 activating transcription factor 4 0.0228581
POF1B premature ovarian failure, 1B 0.0227417
MYH14 myosin, heavy chain 14, non-muscle 0.0226397
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0223821
RPS12 ribosomal protein S12 0.0217889
EPHA2 EPH receptor A2 0.0214953
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0209806
RPL21 ribosomal protein L21 0.0209181
CRY1 cryptochrome circadian clock 1 0.0201804
POMP proteasome maturation protein 0.0200086
IFI6 interferon, alpha-inducible protein 6 0.0199863
KRT23 keratin 23, type I 0.0199812
KLF6 Kruppel-like factor 6 0.0198564
LIMA1 LIM domain and actin binding 1 0.0195469
RACK1 receptor for activated C kinase 1 0.0194589

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.255993
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.168955
BTBD9 BTB (POZ) domain containing 9 -0.11928
RUNX1 runt-related transcription factor 1 -0.113582
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0906289
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0867007
RNF43 ring finger protein 43 -0.081518
UBC ubiquitin C -0.080349
CANX calnexin -0.0767993
MBNL2 muscleblind-like splicing regulator 2 -0.0746202
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0662844
PDIA3 protein disulfide isomerase family A, member 3 -0.0660676
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0616348
RHOBTB3 Rho-related BTB domain containing 3 -0.0594078
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0586747
NRIP1 nuclear receptor interacting protein 1 -0.0557313
FNDC3A fibronectin type III domain containing 3A -0.0544694
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0536298
CALR calreticulin -0.0530443
PDIA4 protein disulfide isomerase family A, member 4 -0.0525575
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0516642
PTBP3 polypyrimidine tract binding protein 3 -0.0513544
PRELID2 PRELI domain containing 2 -0.0459037
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0453806
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0453014
ZMYM2 zinc finger, MYM-type 2 -0.0447595
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0444437
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0440729
DSCAM Down syndrome cell adhesion molecule -0.043709
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0429134
OGA O-GlcNAcase -0.0426731
AHI1 Abelson helper integration site 1 -0.0426452
EHF ets homologous factor -0.0424676
ZMYND8 zinc finger, MYND-type containing 8 -0.0423132
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0422764
FOXP1 forkhead box P1 -0.0417828
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0407861
AHNAK AHNAK nucleoprotein -0.0406032
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0405061
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.040395
NF1 neurofibromin 1 -0.0403637
UBAC2 UBA domain containing 2 -0.0402021
MEIS2 Meis homeobox 2 -0.0395057
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0394379
TXNIP thioredoxin interacting protein -0.0380068
STK24 serine/threonine kinase 24 -0.0379145
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0375434
DIAPH3 diaphanous-related formin 3 -0.0371685
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0370973
SBF2 SET binding factor 2 -0.0366193
IFNGR1 interferon gamma receptor 1 -0.0365055
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.036223
TM9SF2 transmembrane 9 superfamily member 2 -0.0353067
RBM39 RNA binding motif protein 39 -0.0350245
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0345991
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0342881
MCTP2 multiple C2 domains, transmembrane 2 -0.0341618
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0341025
TNRC6B trinucleotide repeat containing 6B -0.0338903
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0338599
TMEM62 transmembrane protein 62 -0.0336448
SREBF2 sterol regulatory element binding transcription factor 2 -0.0335733
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0331596
USP3 ubiquitin specific peptidase 3 -0.0325808
RABGAP1 RAB GTPase activating protein 1 -0.0323578
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0321816
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0321355
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.031473
ACTN4 actinin, alpha 4 -0.0313696
IL20RA interleukin 20 receptor, alpha -0.0312659
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.030737
HDLBP high density lipoprotein binding protein -0.03039
ARGLU1 arginine and glutamate rich 1 -0.0300476
RNF149 ring finger protein 149 -0.0294696
H1-0 H1.0 linker histone -0.029377
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.029275
ZBTB20 zinc finger and BTB domain containing 20 -0.0290976
PATJ PATJ crumbs cell polarity complex component -0.0289141
RRBP1 ribosome binding protein 1 -0.0287951
DENND4C DENN/MADD domain containing 4C -0.0286574
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0286186
SEC24D SEC24 family member D -0.0283364
BIRC6 baculoviral IAP repeat containing 6 -0.0282927
SMC4 structural maintenance of chromosomes 4 -0.0281122
UBL3 ubiquitin-like 3 -0.0280323
ATXN1 ataxin 1 -0.0279418
HBS1L HBS1-like translational GTPase -0.0276825
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0276415
NCKAP5 NCK-associated protein 5 -0.0276186
WDR26 WD repeat domain 26 -0.0274359
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0273963
PTEN phosphatase and tensin homolog -0.0273532
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0271734
XPO1 exportin 1 -0.0271251
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0270411
NCOR1 nuclear receptor corepressor 1 -0.0269409
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0268523
SERINC5 serine incorporator 5 -0.0267968
PDIA5 protein disulfide isomerase family A, member 5 -0.0267678
TC2N tandem C2 domains, nuclear -0.0263381