Diammonium Glycyrrhizinate_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.215453
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.201286
IGFBP3 insulin-like growth factor binding protein 3 0.184675
MT2A metallothionein 2A 0.123419
VIM vimentin 0.108511
NDRG1 N-myc downstream regulated 1 0.086854
RPL23 ribosomal protein L23 0.082909
FTL ferritin, light polypeptide 0.0760825
TIMP3 TIMP metallopeptidase inhibitor 3 0.0739613
EGFR epidermal growth factor receptor 0.0731287
HLA-A major histocompatibility complex, class I, A 0.0711648
COL6A3 collagen, type VI, alpha 3 0.0704062
IGFBP5 insulin-like growth factor binding protein 5 0.0692233
RACK1 receptor for activated C kinase 1 0.0668755
CALD1 caldesmon 1 0.0634119
RPL37A ribosomal protein L37a 0.0629706
RPS19 ribosomal protein S19 0.0618384
RPL35A ribosomal protein L35a 0.0593188
PDE4D phosphodiesterase 4D, cAMP-specific 0.057191
NALF1 NALCN channel auxiliary factor 1 0.0553462
ZSWIM6 zinc finger, SWIM-type containing 6 0.0551401
CADM1 cell adhesion molecule 1 0.0548249
B2M beta-2-microglobulin 0.0543888
RPL9 ribosomal protein L9 0.0516228
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0508551
EGR1 early growth response 1 0.0507226
RPS8 ribosomal protein S8 0.0502143
VCL vinculin 0.0491689
BACE2 beta-site APP-cleaving enzyme 2 0.0484263
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0483268
TIMP1 TIMP metallopeptidase inhibitor 1 0.0482703
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0466029
TPT1 tumor protein, translationally-controlled 1 0.0455307
TPI1 triosephosphate isomerase 1 0.0453952
HILPDA hypoxia inducible lipid droplet-associated 0.0415655
LGALS1 lectin, galactoside-binding, soluble, 1 0.0412431
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0408235
INTS6 integrator complex subunit 6 0.0401156
RPL12 ribosomal protein L12 0.0397947
RPL11 ribosomal protein L11 0.0367278
GNPDA1 glucosamine-6-phosphate deaminase 1 0.036414
RPS3 ribosomal protein S3 0.0362621
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0359418
SQSTM1 sequestosome 1 0.0358278
ENO2 enolase 2 (gamma, neuronal) 0.0350751
RPS4X ribosomal protein S4, X-linked 0.034922
STC1 stanniocalcin 1 0.0348417
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.032949
CEMIP cell migration inducing protein, hyaluronan binding 0.0312649
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0310875
EEF2 eukaryotic translation elongation factor 2 0.0307759
RPL18 ribosomal protein L18 0.0303268
RPS5 ribosomal protein S5 0.0302562
INSIG2 insulin induced gene 2 0.0302293
RPS12 ribosomal protein S12 0.0299781
RPS27 ribosomal protein S27 0.0293274
TRA2A transformer 2 alpha homolog (Drosophila) 0.0290724
PTMA prothymosin, alpha 0.0290592
RPLP0 ribosomal protein, large, P0 0.0288396
RPS14 ribosomal protein S14 0.0286762
RPL37 ribosomal protein L37 0.0282583
PTPRF protein tyrosine phosphatase, receptor type, F 0.0278226
RPS17 ribosomal protein S17 0.0274961
HMGA2 high mobility group AT-hook 2 0.0274294
HMGA1 high mobility group AT-hook 1 0.0265581
SEC61G Sec61 gamma subunit 0.0260997
FNDC3B fibronectin type III domain containing 3B 0.0260224
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0254697
RPL35 ribosomal protein L35 0.0253876
SEM1 SEM1 26S proteasome subunit 0.0251344
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0251328
RPL34 ribosomal protein L34 0.0251204
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0249305
BSG basigin (Ok blood group) 0.0248227
SON SON DNA binding protein 0.0248032
NAP1L1 nucleosome assembly protein 1-like 1 0.024717
TGFBI transforming growth factor, beta-induced, 68kDa 0.024702
LOX lysyl oxidase 0.0244777
AEBP2 AE binding protein 2 0.0242398
KDM4B lysine (K)-specific demethylase 4B 0.0237266
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0235826
PICALM phosphatidylinositol binding clathrin assembly protein 0.0235512
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0230233
RPL36 ribosomal protein L36 0.0230038
RPLP1 ribosomal protein, large, P1 0.022916
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0227961
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0227503
SCFD1 sec1 family domain containing 1 0.0225206
FAM162A family with sequence similarity 162, member A 0.0223105
FSCN1 fascin actin-bundling protein 1 0.0220294
PFKP phosphofructokinase, platelet 0.0217952
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0217826
RPL4 ribosomal protein L4 0.0216374
EEF1G eukaryotic translation elongation factor 1 gamma 0.0215549
HDLBP high density lipoprotein binding protein 0.021518
ARHGAP22 Rho GTPase activating protein 22 0.0215094
CLEC1B C-type lectin domain family 1, member B 0.0214652
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0212521
RPS27A ribosomal protein S27a 0.0208484
CBX3 chromobox homolog 3 0.020555

decreased expression

Symbol Name Standardized Value
RTN4 reticulon 4 -0.0903739
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0786347
NAMPT nicotinamide phosphoribosyltransferase -0.0773416
CENPF centromere protein F, 350/400kDa -0.0743
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0669708
MKI67 marker of proliferation Ki-67 -0.0661521
MAP1B microtubule-associated protein 1B -0.0632343
NLGN1 neuroligin 1 -0.0597271
DST dystonin -0.059074
CANX calnexin -0.0582433
MSN moesin -0.0561139
DGKD diacylglycerol kinase, delta 130kDa -0.0544474
TXNIP thioredoxin interacting protein -0.0526846
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0524266
RPS2 ribosomal protein S2 -0.0524096
CENPE centromere protein E, 312kDa -0.0521703
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0476991
CD44 CD44 molecule (Indian blood group) -0.047417
TPM4 tropomyosin 4 -0.0462939
NAV2 neuron navigator 2 -0.0459134
TXNRD1 thioredoxin reductase 1 -0.0449748
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0443511
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0439409
NAV3 neuron navigator 3 -0.0433788
NPC1 Niemann-Pick disease, type C1 -0.0432903
RNF216 ring finger protein 216 -0.0431824
APP amyloid beta (A4) precursor protein -0.0407862
TPX2 TPX2, microtubule-associated -0.040098
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0383761
ANKRD11 ankyrin repeat domain 11 -0.0381174
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0379343
SMC4 structural maintenance of chromosomes 4 -0.0375914
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0375531
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0368178
ANKRD28 ankyrin repeat domain 28 -0.0367062
GSK3B glycogen synthase kinase 3 beta -0.0364855
KPNB1 karyopherin (importin) beta 1 -0.0359623
ZNF148 zinc finger protein 148 -0.0351377
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0351276
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0342831
EXT1 exostosin glycosyltransferase 1 -0.0339996
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0336474
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0334878
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0330786
NF1 neurofibromin 1 -0.0329011
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0328094
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.032714
XPO1 exportin 1 -0.0322145
ANLN anillin, actin binding protein -0.0319864
DARS1 aspartyl-tRNA synthetase 1 -0.0313044
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0311022
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0309192
MYH9 myosin, heavy chain 9, non-muscle -0.0307966
NIPBL Nipped-B homolog (Drosophila) -0.0305373
ANKRD17 ankyrin repeat domain 17 -0.0305205
CCDC88A coiled-coil domain containing 88A -0.0303134
PTPRG protein tyrosine phosphatase, receptor type, G -0.0298426
GCC2 GRIP and coiled-coil domain containing 2 -0.0292944
NUMB numb homolog (Drosophila) -0.0292779
NRDC nardilysin convertase -0.0292601
SEPTIN7 septin 7 -0.0289841
TENM3 teneurin transmembrane protein 3 -0.0287231
ATP13A3 ATPase type 13A3 -0.0286084
GLG1 golgi glycoprotein 1 -0.0285642
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0285111
UBE2H ubiquitin-conjugating enzyme E2H -0.0284678
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0283862
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0283716
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0282684
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0280196
ANTXR2 anthrax toxin receptor 2 -0.0278876
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0275837
COPB1 coatomer protein complex, subunit beta 1 -0.0274335
CKAP5 cytoskeleton associated protein 5 -0.0272723
SNX13 sorting nexin 13 -0.0272254
USP34 ubiquitin specific peptidase 34 -0.0272103
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0270315
PHF14 PHD finger protein 14 -0.0269251
AKAP13 A kinase (PRKA) anchor protein 13 -0.0268743
PTK2 protein tyrosine kinase 2 -0.0265302
KIF2C kinesin family member 2C -0.0265181
TLN1 talin 1 -0.0264359
SCAF11 SR-related CTD-associated factor 11 -0.0262699
MCTP2 multiple C2 domains, transmembrane 2 -0.0261528
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.026063
ARHGAP11A Rho GTPase activating protein 11A -0.0254394
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0253085
CDC27 cell division cycle 27 -0.0249781
BTBD10 BTB (POZ) domain containing 10 -0.0247623
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0247223
TACC3 transforming, acidic coiled-coil containing protein 3 -0.0246602
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0245355
SMAD3 SMAD family member 3 -0.0243903
ELMO1 engulfment and cell motility 1 -0.0242932
GOLGA4 golgin A4 -0.0241911
PRR11 proline rich 11 -0.0240832
ADAM9 ADAM metallopeptidase domain 9 -0.0239102
RAD21 RAD21 homolog (S. pombe) -0.0237884
KIF14 kinesin family member 14 -0.0237208
STK17A serine/threonine kinase 17a -0.0236482