Diammonium Glycyrrhizinate_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.13911
MT2A metallothionein 2A 0.132653
FTL ferritin, light polypeptide 0.113494
RACK1 receptor for activated C kinase 1 0.103786
RPS19 ribosomal protein S19 0.095323
TMSB10 thymosin beta 10 0.0933953
RPL12 ribosomal protein L12 0.0927954
B2M beta-2-microglobulin 0.0921737
RPS12 ribosomal protein S12 0.0918578
RPS3 ribosomal protein S3 0.0789694
RPL3 ribosomal protein L3 0.0777489
RPL26 ribosomal protein L26 0.073451
RPL31 ribosomal protein L31 0.0670267
NDRG1 N-myc downstream regulated 1 0.0669786
EEF2 eukaryotic translation elongation factor 2 0.0662405
RPL18 ribosomal protein L18 0.061178
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0595835
RPS17 ribosomal protein S17 0.0595022
RPL11 ribosomal protein L11 0.0571853
RPS8 ribosomal protein S8 0.0541707
RPS4X ribosomal protein S4, X-linked 0.0528759
TPI1 triosephosphate isomerase 1 0.0523774
RPL9 ribosomal protein L9 0.0517708
RPL37A ribosomal protein L37a 0.0462748
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.045163
IRS2 insulin receptor substrate 2 0.0445056
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0443755
RPS14 ribosomal protein S14 0.0417982
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0414596
RPS5 ribosomal protein S5 0.0401923
ANXA1 annexin A1 0.0401869
FLNA filamin A, alpha 0.0396212
RPL36 ribosomal protein L36 0.0394277
RPL32 ribosomal protein L32 0.0389545
RPL13A ribosomal protein L13a 0.0385523
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0384364
SMAD3 SMAD family member 3 0.0364212
RPL21 ribosomal protein L21 0.0362656
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0349481
RPL19 ribosomal protein L19 0.0349466
RPL35 ribosomal protein L35 0.0348995
RPS27 ribosomal protein S27 0.0345336
HELZ helicase with zinc finger 0.0344206
ANKRD33B ankyrin repeat domain 33B 0.0338265
RPS27A ribosomal protein S27a 0.0337775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0331212
ZNF292 zinc finger protein 292 0.0330159
EZR ezrin 0.0323232
YBX1 Y box binding protein 1 0.0319531
RPL7 ribosomal protein L7 0.031764
INTS6 integrator complex subunit 6 0.0314799
RPS15A ribosomal protein S15a 0.031041
NAP1L1 nucleosome assembly protein 1-like 1 0.0309274
LAMB3 laminin, beta 3 0.0290205
UGCG UDP-glucose ceramide glucosyltransferase 0.0280856
TNIP1 TNFAIP3 interacting protein 1 0.0280213
RPL37 ribosomal protein L37 0.0279337
RPL30 ribosomal protein L30 0.0278212
ZSWIM6 zinc finger, SWIM-type containing 6 0.02742
DDIT4 DNA-damage-inducible transcript 4 0.0269956
RPL27 ribosomal protein L27 0.026818
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.02658
RYBP RING1 and YY1 binding protein 0.0259639
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0255847
CD46 CD46 molecule, complement regulatory protein 0.0252372
TRA2A transformer 2 alpha homolog (Drosophila) 0.0244919
LOC112694756 uncharaterized LOC112694756 0.0240139
ESYT2 extended synaptotagmin-like protein 2 0.0237239
GPX4 glutathione peroxidase 4 0.0236887
RPL4 ribosomal protein L4 0.0234254
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0229319
KRT86 keratin 86, type II 0.0226662
APLP2 amyloid beta (A4) precursor-like protein 2 0.0224763
NACA nascent polypeptide-associated complex alpha subunit 0.0224261
SOX9 SRY (sex determining region Y)-box 9 0.0223042
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0220211
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0217722
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0217603
HSPA8 heat shock 70kDa protein 8 0.0216893
ORC4 origin recognition complex, subunit 4 0.0213576
EEF1G eukaryotic translation elongation factor 1 gamma 0.0212758
SHB Src homology 2 domain containing adaptor protein B 0.0210907
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0210107
YBX3 Y box binding protein 3 0.0207128
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0205439
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.020521
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0204425
EIF4A2 eukaryotic translation initiation factor 4A2 0.0201919
MPRIP myosin phosphatase Rho interacting protein 0.0199337
IRF1 interferon regulatory factor 1 0.0199187
FLNB filamin B, beta 0.0198701
CYSTM1 cysteine-rich transmembrane module containing 1 0.0198347
ICAM1 intercellular adhesion molecule 1 0.0197483
ECT2 epithelial cell transforming 2 0.0197311
TSC22D2 TSC22 domain family, member 2 0.0195435
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0194376
BIRC3 baculoviral IAP repeat containing 3 0.0191778
RPS2 ribosomal protein S2 0.0187918
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0187588
SERINC1 serine incorporator 1 0.0187029

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.152757
TPM4 tropomyosin 4 -0.103307
ACTG1 actin gamma 1 -0.100865
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0940385
BICD1 bicaudal D homolog 1 (Drosophila) -0.0693743
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0674261
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0660805
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0659211
IGFBP3 insulin-like growth factor binding protein 3 -0.0658138
VCL vinculin -0.0644553
BPTF bromodomain PHD finger transcription factor -0.0644137
RAD51B RAD51 paralog B -0.0619418
MKI67 marker of proliferation Ki-67 -0.0616333
CCND1 cyclin D1 -0.0593971
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0566562
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0563146
DLC1 DLC1 Rho GTPase activating protein -0.0557056
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0542776
ZBTB20 zinc finger and BTB domain containing 20 -0.0541817
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0534728
TBC1D5 TBC1 domain family, member 5 -0.0532022
KPNB1 karyopherin (importin) beta 1 -0.052943
CD44 CD44 molecule (Indian blood group) -0.0518196
HMGA2 high mobility group AT-hook 2 -0.0513889
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0458493
OSBPL10 oxysterol binding protein-like 10 -0.0457169
PATJ PATJ crumbs cell polarity complex component -0.0451431
AHNAK AHNAK nucleoprotein -0.0449172
PRELID2 PRELI domain containing 2 -0.0445619
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.044124
SVIL supervillin -0.0432761
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0430613
S100A10 S100 calcium binding protein A10 -0.0412881
LPP LIM domain containing preferred translocation partner in lipoma -0.0407142
LAMC2 laminin, gamma 2 -0.0406941
ATG7 autophagy related 7 -0.0404834
DIAPH3 diaphanous-related formin 3 -0.040226
DARS1 aspartyl-tRNA synthetase 1 -0.0396789
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.039196
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.039169
SMYD3 SET and MYND domain containing 3 -0.0388671
PSD3 pleckstrin and Sec7 domain containing 3 -0.0385667
PDIA3 protein disulfide isomerase family A, member 3 -0.0381249
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0378381
HMGB1 high mobility group box 1 -0.0371101
CAPN2 calpain 2, (m/II) large subunit -0.0363041
TUBA1B tubulin, alpha 1b -0.035957
VDAC1 voltage-dependent anion channel 1 -0.0355062
CENPF centromere protein F, 350/400kDa -0.0354876
FHIT fragile histidine triad -0.0353466
DEK DEK proto-oncogene -0.0349593
ZMYND8 zinc finger, MYND-type containing 8 -0.0346533
MAP4 microtubule-associated protein 4 -0.0343021
KRT7 keratin 7, type II -0.0341378
SH3KBP1 SH3-domain kinase binding protein 1 -0.0339256
CDCP1 CUB domain containing protein 1 -0.0338726
CANX calnexin -0.033711
ITGA6 integrin, alpha 6 -0.0334052
APOLD1 apolipoprotein L domain containing 1 -0.0332499
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.033221
POTEF POTE ankyrin domain family, member F -0.0329055
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.032297
SEPTIN10 septin 10 -0.0322409
TAOK1 TAO kinase 1 -0.0317247
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0316828
WWOX WW domain containing oxidoreductase -0.0313594
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0309786
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.030322
PTMA prothymosin, alpha -0.0301753
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0299155
MACROD2 MACRO domain containing 2 -0.0299098
FAF1 Fas (TNFRSF6) associated factor 1 -0.0297153
PTK2 protein tyrosine kinase 2 -0.0296639
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0295817
RHOA ras homolog family member A -0.0291918
CD2AP CD2-associated protein -0.0287601
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0286419
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0285913
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0281812
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0281775
OXR1 oxidation resistance 1 -0.0280041
NSD2 nuclear receptor binding SET domain protein 2 -0.0277315
DOCK1 dedicator of cytokinesis 1 -0.0274765
GPATCH8 G patch domain containing 8 -0.0274392
PCED1B PC-esterase domain containing 1B -0.0273668
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0270806
GPR39 G protein-coupled receptor 39 -0.0268957
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0266159
PRR11 proline rich 11 -0.0265657
NF1 neurofibromin 1 -0.0264641
EHBP1 EH domain binding protein 1 -0.0263101
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0262011
TMCC1 transmembrane and coiled-coil domain family 1 -0.0259382
SEPTIN9 septin 9 -0.0256625
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0255115
KIF18B kinesin family member 18B -0.0254549
GLIS3 GLIS family zinc finger 3 -0.0254321
EXOC4 exocyst complex component 4 -0.0253658
DSG2 desmoglein 2 -0.025305
POU5F1 POU class 5 homeobox 1 -0.0249824