Diammonium Glycyrrhizinate_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.111113
MT2A metallothionein 2A 0.102303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0939786
RPL23 ribosomal protein L23 0.0650941
TMSB10 thymosin beta 10 0.051677
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0492025
RPL12 ribosomal protein L12 0.0463545
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0461971
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0410374
TPI1 triosephosphate isomerase 1 0.0404706
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0379735
RPS17 ribosomal protein S17 0.0378968
RPL11 ribosomal protein L11 0.0367675
PKM pyruvate kinase, muscle 0.0366599
RPS12 ribosomal protein S12 0.0365151
RPL3 ribosomal protein L3 0.0339306
RPS19 ribosomal protein S19 0.0336528
RPS8 ribosomal protein S8 0.0335015
RPS3 ribosomal protein S3 0.032966
EEF2 eukaryotic translation elongation factor 2 0.0328279
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0327372
NDRG1 N-myc downstream regulated 1 0.0324145
RACK1 receptor for activated C kinase 1 0.0313905
MCL1 myeloid cell leukemia 1 0.0306376
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0298318
INTS6 integrator complex subunit 6 0.0296586
RPL7 ribosomal protein L7 0.0293769
SEPTIN9 septin 9 0.0288688
LDHA lactate dehydrogenase A 0.0276219
WWOX WW domain containing oxidoreductase 0.0275088
CENPF centromere protein F, 350/400kDa 0.0272268
MAP1B microtubule-associated protein 1B 0.0268459
B2M beta-2-microglobulin 0.025985
YBX1 Y box binding protein 1 0.0259188
RPL37A ribosomal protein L37a 0.0259157
ENO1 enolase 1, (alpha) 0.0258747
TIMP1 TIMP metallopeptidase inhibitor 1 0.0253717
HSPA8 heat shock 70kDa protein 8 0.0253517
RPL9 ribosomal protein L9 0.0249798
RCOR1 REST corepressor 1 0.024965
RPS4X ribosomal protein S4, X-linked 0.0241821
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.023778
ANGPTL4 angiopoietin-like 4 0.0236634
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0235401
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0234573
STC1 stanniocalcin 1 0.0230843
ZBTB38 zinc finger and BTB domain containing 38 0.0225559
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0218606
RPL21 ribosomal protein L21 0.0218069
LGALS1 lectin, galactoside-binding, soluble, 1 0.0216137
TPM3 tropomyosin 3 0.0214118
SFPQ splicing factor proline/glutamine-rich 0.0210649
FTL ferritin, light polypeptide 0.0209314
NALF1 NALCN channel auxiliary factor 1 0.0208783
RPS6 ribosomal protein S6 0.0208088
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0204604
EEF1G eukaryotic translation elongation factor 1 gamma 0.0203424
ZSWIM6 zinc finger, SWIM-type containing 6 0.0198381
AXL AXL receptor tyrosine kinase 0.0196739
RPL26 ribosomal protein L26 0.0195976
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0194066
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193657
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.019054
RPL31 ribosomal protein L31 0.0188187
FLNA filamin A, alpha 0.0184349
RPL4 ribosomal protein L4 0.0181961
NAV2 neuron navigator 2 0.0180368
PCBP2 poly(rC) binding protein 2 0.0180221
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0177503
TNS1 tensin 1 0.0176763
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0171524
RRM2 ribonucleotide reductase M2 0.0171179
POTEF POTE ankyrin domain family, member F 0.0170677
RPL30 ribosomal protein L30 0.0167077
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0166894
HMGA1 high mobility group AT-hook 1 0.0165188
GLS2 glutaminase 2 (liver, mitochondrial) 0.0165073
SFTPA2 surfactant protein A2 0.0164307
PFN1 profilin 1 0.0163618
PLEC plectin 0.0162708
ANTXR1 anthrax toxin receptor 1 0.0161363
DST dystonin 0.0157899
RPL37 ribosomal protein L37 0.0157242
SMAD3 SMAD family member 3 0.0155923
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.015499
RPS14 ribosomal protein S14 0.0154496
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.014951
RPL27 ribosomal protein L27 0.0144796
ENO2 enolase 2 (gamma, neuronal) 0.0142714
APLP2 amyloid beta (A4) precursor-like protein 2 0.0141208
PRELID2 PRELI domain containing 2 0.0139661
RPL18 ribosomal protein L18 0.0136657
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0136368
TAGLN2 transgelin 2 0.0134368
EIF5 eukaryotic translation initiation factor 5 0.0133543
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.013284
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0130739
MSN moesin 0.0129451
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0128264
PDIA6 protein disulfide isomerase family A, member 6 0.0127922

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.217899
IGF2 insulin-like growth factor 2 -0.133765
VIM vimentin -0.104435
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0893808
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0868812
LAMB3 laminin, beta 3 -0.0787939
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0729569
COL5A1 collagen, type V, alpha 1 -0.0711988
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.069769
RAI14 retinoic acid induced 14 -0.06397
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.062322
COL6A2 collagen, type VI, alpha 2 -0.0612283
TPT1 tumor protein, translationally-controlled 1 -0.0595337
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0535119
CAVIN1 caveolae associated protein 1 -0.0529847
RRBP1 ribosome binding protein 1 -0.0513955
CDH13 cadherin 13 -0.050082
TUBB6 tubulin, beta 6 class V -0.0480429
EXT1 exostosin glycosyltransferase 1 -0.04774
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0469459
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0463939
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0460047
CLMP CXADR-like membrane protein -0.0447772
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0425891
ANXA2 annexin A2 -0.0424872
ASPH aspartate beta-hydroxylase -0.041705
EGR1 early growth response 1 -0.0415487
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0406028
CANX calnexin -0.0405148
COL7A1 collagen, type VII, alpha 1 -0.0403803
LOX lysyl oxidase -0.0399199
ZMYND8 zinc finger, MYND-type containing 8 -0.0398292
TNNC1 troponin C type 1 (slow) -0.0398164
OGA O-GlcNAcase -0.0396232
ACTG1 actin gamma 1 -0.0380201
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0362886
ELL2 elongation factor, RNA polymerase II, 2 -0.0353542
RASA3 RAS p21 protein activator 3 -0.0351581
PCBP3 poly(rC) binding protein 3 -0.0350571
GNAS GNAS complex locus -0.0344097
OSMR oncostatin M receptor -0.0329355
BTG1 B-cell translocation gene 1, anti-proliferative -0.0327544
CCND1 cyclin D1 -0.0322029
WSB1 WD repeat and SOCS box containing 1 -0.0314112
TENM2 teneurin transmembrane protein 2 -0.0309718
RTN4 reticulon 4 -0.0309699
COL1A1 collagen, type I, alpha 1 -0.0305618
NAMPT nicotinamide phosphoribosyltransferase -0.0302152
MYO10 myosin X -0.0301934
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0298725
GLG1 golgi glycoprotein 1 -0.0290425
SETD5 SET domain containing 5 -0.0279206
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0278327
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0276015
KPNB1 karyopherin (importin) beta 1 -0.0274397
IGFBP3 insulin-like growth factor binding protein 3 -0.0274033
KDM3A lysine (K)-specific demethylase 3A -0.0272278
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0271259
ANKRD11 ankyrin repeat domain 11 -0.0267201
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0265895
RAB1A RAB1A, member RAS oncogene family -0.0264475
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0254778
COPB1 coatomer protein complex, subunit beta 1 -0.0254648
ZFAND3 zinc finger, AN1-type domain 3 -0.0252729
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0252079
VASP vasodilator-stimulated phosphoprotein -0.0251266
JMJD1C jumonji domain containing 1C -0.0250716
RAB7A RAB7A, member RAS oncogene family -0.0245724
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0244084
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0243329
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0234642
DNAAF9 dynein axonemal assembly factor 9 -0.0233516
BIRC6 baculoviral IAP repeat containing 6 -0.0232932
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0232841
RBM39 RNA binding motif protein 39 -0.0232378
SEC24D SEC24 family member D -0.0231534
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0231356
GRB10 growth factor receptor-bound protein 10 -0.0230692
TMEM165 transmembrane protein 165 -0.0230541
SEC31A SEC31 homolog A (S. cerevisiae) -0.0229833
MAP4 microtubule-associated protein 4 -0.0229533
NF1 neurofibromin 1 -0.0229076
TPM4 tropomyosin 4 -0.0227674
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0223372
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0220988
HIP1 huntingtin interacting protein 1 -0.0220451
RLF rearranged L-myc fusion -0.0219417
RAB2A RAB2A, member RAS oncogene family -0.0217914
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0217836
NAV1 neuron navigator 1 -0.0216256
CAPN2 calpain 2, (m/II) large subunit -0.0208481
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.020827
KLF7 Kruppel-like factor 7 (ubiquitous) -0.020786
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0207568
TAS2R14 taste receptor, type 2, member 14 -0.0207273
TRIO trio Rho guanine nucleotide exchange factor -0.0205701
ARHGAP22 Rho GTPase activating protein 22 -0.0205669
DUSP6 dual specificity phosphatase 6 -0.0204301
USP3 ubiquitin specific peptidase 3 -0.0203859
FBXO11 F-box protein 11 -0.0203253