Diammonium Glycyrrhizinate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.112732
B2M beta-2-microglobulin 0.106064
NDRG1 N-myc downstream regulated 1 0.0893767
LMO7 LIM domain 7 0.0868151
STC1 stanniocalcin 1 0.0803077
PDE4D phosphodiesterase 4D, cAMP-specific 0.0790294
RPL11 ribosomal protein L11 0.0731733
TIMP3 TIMP metallopeptidase inhibitor 3 0.0726872
IFITM1 interferon induced transmembrane protein 1 0.0724235
IFITM3 interferon induced transmembrane protein 3 0.0689053
RPL37 ribosomal protein L37 0.0682013
FTL ferritin, light polypeptide 0.0674978
RPS12 ribosomal protein S12 0.066857
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0604242
RACK1 receptor for activated C kinase 1 0.0576482
RPS19 ribosomal protein S19 0.0530277
ALCAM activated leukocyte cell adhesion molecule 0.0524408
RPS6 ribosomal protein S6 0.0487055
FTH1 ferritin, heavy polypeptide 1 0.0482174
RPL21 ribosomal protein L21 0.0481229
RPL37A ribosomal protein L37a 0.0475322
RPL26 ribosomal protein L26 0.0462469
RPS3 ribosomal protein S3 0.0456208
RPL31 ribosomal protein L31 0.0447702
KLF5 Kruppel-like factor 5 (intestinal) 0.04417
TPT1 tumor protein, translationally-controlled 1 0.0405823
RPL12 ribosomal protein L12 0.0381066
RPL30 ribosomal protein L30 0.0378236
CSTB cystatin B (stefin B) 0.0371241
RPL36 ribosomal protein L36 0.0365673
RPL23 ribosomal protein L23 0.0365593
RPS27 ribosomal protein S27 0.0358721
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0354591
RPS17 ribosomal protein S17 0.0352747
MT1E metallothionein 1E 0.0347098
RPLP1 ribosomal protein, large, P1 0.0344498
RPL3 ribosomal protein L3 0.0341763
IFI27 interferon, alpha-inducible protein 27 0.0338236
RPL35 ribosomal protein L35 0.0336473
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0330086
RPL35A ribosomal protein L35a 0.0329651
RPS13 ribosomal protein S13 0.0327345
RPS4X ribosomal protein S4, X-linked 0.0320743
RPL7 ribosomal protein L7 0.0320387
RPS8 ribosomal protein S8 0.0318818
PDLIM5 PDZ and LIM domain 5 0.0315304
ANGPTL4 angiopoietin-like 4 0.031458
SLC35F3 solute carrier family 35, member F3 0.0312446
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0306572
RPS14 ribosomal protein S14 0.029553
HLA-B major histocompatibility complex, class I, B 0.0294315
IGFBP6 insulin-like growth factor binding protein 6 0.0293259
MTSS1 metastasis suppressor 1 0.0292514
HLA-A major histocompatibility complex, class I, A 0.0290389
CALB1 calbindin 1, 28kDa 0.0289204
TGM2 transglutaminase 2 0.0276201
RPL9 ribosomal protein L9 0.0274953
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0269343
IFI44L interferon-induced protein 44-like 0.0257092
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0251721
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0249224
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0241923
MEGF6 multiple EGF-like-domains 6 0.0238513
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0237564
HMGA1 high mobility group AT-hook 1 0.0234293
PRSS23 protease, serine, 23 0.0233834
ATP5F1E ATP synthase F1 subunit epsilon 0.0231631
MRPS6 mitochondrial ribosomal protein S6 0.0227535
TPI1 triosephosphate isomerase 1 0.0222254
RAD51B RAD51 paralog B 0.0221542
RPS15A ribosomal protein S15a 0.0219721
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0219053
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0214655
PCDH1 protocadherin 1 0.0213676
RPL13A ribosomal protein L13a 0.0210908
RPLP0 ribosomal protein, large, P0 0.020943
ATP5MK ATP synthase membrane subunit k 0.0207928
RPL27 ribosomal protein L27 0.020723
ZMIZ1 zinc finger, MIZ-type containing 1 0.0203244
INTS6 integrator complex subunit 6 0.0202493
IFI6 interferon, alpha-inducible protein 6 0.0202459
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0200987
ZBTB7A zinc finger and BTB domain containing 7A 0.01998
RPL34 ribosomal protein L34 0.0197727
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0196604
RPL18 ribosomal protein L18 0.0195442
LAMA5 laminin, alpha 5 0.0194344
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0192705
EGR1 early growth response 1 0.0192376
S100A11 S100 calcium binding protein A11 0.0192305
CST3 cystatin C 0.0189989
TMSB10 thymosin beta 10 0.0188331
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0185792
THBD thrombomodulin 0.0185459
DSPP dentin sialophosphoprotein 0.0184853
ISG15 ISG15 ubiquitin-like modifier 0.0182142
DHFR dihydrofolate reductase 0.0180602
TAPBP TAP binding protein (tapasin) 0.0180169
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.0178441
ENO2 enolase 2 (gamma, neuronal) 0.0176671

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.129896
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12121
ENO1 enolase 1, (alpha) -0.121005
AHNAK AHNAK nucleoprotein -0.113906
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110928
CD44 CD44 molecule (Indian blood group) -0.0999439
UBC ubiquitin C -0.0984593
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0964412
ITGA6 integrin, alpha 6 -0.0915747
CANX calnexin -0.0900157
NAMPT nicotinamide phosphoribosyltransferase -0.086187
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.077908
EMP1 epithelial membrane protein 1 -0.0755804
MYOF myoferlin -0.0716124
MYH9 myosin, heavy chain 9, non-muscle -0.071038
ANXA2 annexin A2 -0.0704475
KRT17 keratin 17, type I -0.0685544
MBNL1 muscleblind-like splicing regulator 1 -0.0675668
ASPH aspartate beta-hydroxylase -0.0670251
CLU clusterin -0.062899
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0626578
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0587226
CALU calumenin -0.0571451
FOXO1 forkhead box O1 -0.056703
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.055667
PLAT plasminogen activator, tissue -0.0540309
BCL2L1 BCL2-like 1 -0.0540029
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0539405
PTK2 protein tyrosine kinase 2 -0.0538152
KTN1 kinectin 1 (kinesin receptor) -0.0534241
DOCK5 dedicator of cytokinesis 5 -0.0504631
RBM39 RNA binding motif protein 39 -0.0492997
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0492436
ANLN anillin, actin binding protein -0.0486257
NEK7 NIMA-related kinase 7 -0.0486092
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0478512
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0475358
CD99 CD99 molecule -0.0468517
POTEF POTE ankyrin domain family, member F -0.0467568
SERINC3 serine incorporator 3 -0.0464625
FOXP1 forkhead box P1 -0.0463026
ITCH itchy E3 ubiquitin protein ligase -0.0462593
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0454197
MACF1 microtubule-actin crosslinking factor 1 -0.0451756
GOLGA4 golgin A4 -0.0446879
CALR calreticulin -0.042703
OGA O-GlcNAcase -0.0421652
SEC31A SEC31 homolog A (S. cerevisiae) -0.0414956
NCOA3 nuclear receptor coactivator 3 -0.0413172
NRG1 neuregulin 1 -0.0411839
SPAG9 sperm associated antigen 9 -0.0407729
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0406832
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0404793
CAV1 caveolin 1, caveolae protein, 22kDa -0.040301
PRELID2 PRELI domain containing 2 -0.0401216
STAU1 staufen double-stranded RNA binding protein 1 -0.0400387
COPB1 coatomer protein complex, subunit beta 1 -0.0395224
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0392027
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.039134
KDM3A lysine (K)-specific demethylase 3A -0.039042
LNPEP leucyl/cystinyl aminopeptidase -0.0388619
LMNA lamin A/C -0.0382236
TOP1 topoisomerase (DNA) I -0.0377366
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.037023
DPYD dihydropyrimidine dehydrogenase -0.0368572
PDIA3 protein disulfide isomerase family A, member 3 -0.0361533
UBE2H ubiquitin-conjugating enzyme E2H -0.0356204
NF1 neurofibromin 1 -0.0352705
TSC22D1 TSC22 domain family, member 1 -0.0351477
CUL4B cullin 4B -0.0349789
ANKRD33B ankyrin repeat domain 33B -0.0349072
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.033971
ANXA1 annexin A1 -0.0339254
PTMA prothymosin, alpha -0.0334864
ACTN4 actinin, alpha 4 -0.0332268
JMJD1C jumonji domain containing 1C -0.0330661
RPS27A ribosomal protein S27a -0.0328265
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0327359
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0324803
SMAD3 SMAD family member 3 -0.0324793
PGK1 phosphoglycerate kinase 1 -0.0323936
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0322421
TPX2 TPX2, microtubule-associated -0.0321132
MYO10 myosin X -0.0320075
GLG1 golgi glycoprotein 1 -0.0312543
LDHA lactate dehydrogenase A -0.0311052
DIDO1 death inducer-obliterator 1 -0.0309467
CAPRIN2 caprin family member 2 -0.0306889
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0303026
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0301385
ARHGAP29 Rho GTPase activating protein 29 -0.0296633
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0295241
PKM pyruvate kinase, muscle -0.0294029
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.029249
TRIO trio Rho guanine nucleotide exchange factor -0.0292397
KIAA1217 KIAA1217 -0.0292344
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0290505
TPM4 tropomyosin 4 -0.0290324
RTN4 reticulon 4 -0.0288425
CAPN2 calpain 2, (m/II) large subunit -0.028779