Diammonium Glycyrrhizinate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.0909554
RPS12 ribosomal protein S12 0.0906778
TMSB10 thymosin beta 10 0.0853312
RPS3 ribosomal protein S3 0.0803604
RPL11 ribosomal protein L11 0.0700974
EEF2 eukaryotic translation elongation factor 2 0.0698347
RPL26 ribosomal protein L26 0.0690274
RPL3 ribosomal protein L3 0.067439
NDRG1 N-myc downstream regulated 1 0.0663897
LDHA lactate dehydrogenase A 0.061443
FTL ferritin, light polypeptide 0.0599877
RACK1 receptor for activated C kinase 1 0.059507
RPS19 ribosomal protein S19 0.0571838
RPL9 ribosomal protein L9 0.0565314
B2M beta-2-microglobulin 0.0494939
RPL36 ribosomal protein L36 0.048942
RPL18 ribosomal protein L18 0.0477609
RPL37A ribosomal protein L37a 0.0474992
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0460047
SOX9 SRY (sex determining region Y)-box 9 0.0425201
RPL12 ribosomal protein L12 0.0414979
TPI1 triosephosphate isomerase 1 0.0412865
MT2A metallothionein 2A 0.0407774
RPS17 ribosomal protein S17 0.0397463
RPL21 ribosomal protein L21 0.0381615
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0381469
RPL7 ribosomal protein L7 0.0367171
KLF6 Kruppel-like factor 6 0.0346294
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0345962
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0339589
ISG15 ISG15 ubiquitin-like modifier 0.0333348
AREG amphiregulin 0.0321403
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0315175
RPL13A ribosomal protein L13a 0.0307226
RPS4X ribosomal protein S4, X-linked 0.029872
LOC112694756 uncharaterized LOC112694756 0.028944
RPL31 ribosomal protein L31 0.0282728
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0266247
RPL30 ribosomal protein L30 0.0262104
RPL37 ribosomal protein L37 0.0257221
RPL4 ribosomal protein L4 0.0254804
HSPA8 heat shock 70kDa protein 8 0.0246965
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0236179
CSDE1 cold shock domain containing E1, RNA-binding 0.0228981
LOC102724023 ES1 protein homolog, mitochondrial 0.0228899
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0226183
RPS15A ribosomal protein S15a 0.022575
EPCAM epithelial cell adhesion molecule 0.0223056
CLDN4 claudin 4 0.0218017
TUBB4B tubulin, beta 4B class IVb 0.0217508
YBX1 Y box binding protein 1 0.0216309
RPS27 ribosomal protein S27 0.0211185
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0210068
RPS2 ribosomal protein S2 0.0206686
S100P S100 calcium binding protein P 0.0205891
NACA nascent polypeptide-associated complex alpha subunit 0.0205015
CSNK1A1 casein kinase 1, alpha 1 0.020427
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0203017
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0202856
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0202025
EREG epiregulin 0.0201436
RPL27 ribosomal protein L27 0.0201052
EEF1G eukaryotic translation elongation factor 1 gamma 0.0198405
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0196164
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.019608
RPS26 ribosomal protein S26 0.0195569
TXNIP thioredoxin interacting protein 0.0194039
TPM3 tropomyosin 3 0.0192988
FAT1 FAT atypical cadherin 1 0.0187921
ZFP36 ZFP36 ring finger protein 0.018215
PNN pinin, desmosome associated protein 0.0181922
TRIB1 tribbles pseudokinase 1 0.0180778
ENO2 enolase 2 (gamma, neuronal) 0.0174203
SERINC1 serine incorporator 1 0.0173016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0172037
BRD2 bromodomain containing 2 0.0171159
OCIAD2 OCIA domain containing 2 0.0168987
HLA-A major histocompatibility complex, class I, A 0.0168806
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0168182
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.016801
FLNA filamin A, alpha 0.0164288
CD46 CD46 molecule, complement regulatory protein 0.0163966
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.016134
ZFP36L1 ZFP36 ring finger protein-like 1 0.0161316
GPBP1 GC-rich promoter binding protein 1 0.0159106
MCL1 myeloid cell leukemia 1 0.0158141
GPX4 glutathione peroxidase 4 0.0156842
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0155324
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0152483
LURAP1L leucine rich adaptor protein 1-like 0.0151785
OASL 2'-5'-oligoadenylate synthetase-like 0.0151348
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0149097
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0146891
PGK1 phosphoglycerate kinase 1 0.0146287
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.0143242
ARLN allregulin 0.014034
DUSP4 dual specificity phosphatase 4 0.0139572
PTPRF protein tyrosine phosphatase, receptor type, F 0.013699
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0136238
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0135814

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.23896
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.108486
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.107793
TPT1 tumor protein, translationally-controlled 1 -0.106974
GMDS GDP-mannose 4,6-dehydratase -0.104866
NALF1 NALCN channel auxiliary factor 1 -0.100561
GPHN gephyrin -0.0920738
ANXA2 annexin A2 -0.0918315
ALCAM activated leukocyte cell adhesion molecule -0.0898475
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0879449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0871717
GREB1L growth regulation by estrogen in breast cancer-like -0.0740104
ANTXR2 anthrax toxin receptor 2 -0.0721436
RPS6 ribosomal protein S6 -0.0709959
S100A6 S100 calcium binding protein A6 -0.0709663
ITGA6 integrin, alpha 6 -0.0687616
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.068269
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0672352
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0664406
PPARG peroxisome proliferator-activated receptor gamma -0.0628564
FRMD5 FERM domain containing 5 -0.0589972
ACTG1 actin gamma 1 -0.0586284
GCC2 GRIP and coiled-coil domain containing 2 -0.058382
PRSS3 protease, serine, 3 -0.0563625
PATJ PATJ crumbs cell polarity complex component -0.0546824
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0544199
TPM4 tropomyosin 4 -0.0530956
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0507854
FLNB filamin B, beta -0.0506264
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0505657
JMJD1C jumonji domain containing 1C -0.0504775
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0496789
CEMIP cell migration inducing protein, hyaluronan binding -0.04951
PDE4D phosphodiesterase 4D, cAMP-specific -0.0471981
PTPRK protein tyrosine phosphatase, receptor type, K -0.04709
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0465503
DIAPH2 diaphanous-related formin 2 -0.0464217
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0452224
SAMD5 sterile alpha motif domain containing 5 -0.0449731
RAB10 RAB10, member RAS oncogene family -0.0447604
FERMT1 fermitin family member 1 -0.0444498
MAML3 mastermind-like 3 (Drosophila) -0.0443043
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0442038
FHIT fragile histidine triad -0.0439579
NFIA nuclear factor I/A -0.0438989
CCSER1 coiled-coil serine-rich protein 1 -0.0436542
KRT8 keratin 8, type II -0.0424975
SMYD3 SET and MYND domain containing 3 -0.0419824
S100A10 S100 calcium binding protein A10 -0.0414811
TNS4 tensin 4 -0.0413604
FAF1 Fas (TNFRSF6) associated factor 1 -0.0409843
PSD3 pleckstrin and Sec7 domain containing 3 -0.0409223
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0406085
CCND1 cyclin D1 -0.0405632
RNF217 ring finger protein 217 -0.0402783
LPP LIM domain containing preferred translocation partner in lipoma -0.0402409
AGR2 anterior gradient 2 -0.0402075
KPNB1 karyopherin (importin) beta 1 -0.0401498
EHBP1 EH domain binding protein 1 -0.039767
GTF2IRD1 GTF2I repeat domain containing 1 -0.0396506
BPTF bromodomain PHD finger transcription factor -0.0394381
SH3D19 SH3 domain containing 19 -0.0384742
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0370135
MYO1E myosin IE -0.0367151
NF1 neurofibromin 1 -0.0366779
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0366752
DEK DEK proto-oncogene -0.0364918
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0361665
MSI2 musashi RNA-binding protein 2 -0.0356921
PTK2 protein tyrosine kinase 2 -0.035689
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0356583
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0354878
RREB1 ras responsive element binding protein 1 -0.0351311
CANX calnexin -0.0350506
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0349914
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0347854
SLC35F3 solute carrier family 35, member F3 -0.0341443
BIRC6 baculoviral IAP repeat containing 6 -0.0340956
MED13 mediator complex subunit 13 -0.0340476
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0338938
SBF2 SET binding factor 2 -0.0336028
RPS25 ribosomal protein S25 -0.0333068
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0331514
MECOM MDS1 and EVI1 complex locus -0.0330691
ABHD2 abhydrolase domain containing 2 -0.0328878
CUX1 cut-like homeobox 1 -0.0328229
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0326468
FOXP1 forkhead box P1 -0.0324865
TBC1D5 TBC1 domain family, member 5 -0.0324131
RAD51B RAD51 paralog B -0.0322667
PTMA prothymosin, alpha -0.0318333
PTPRR protein tyrosine phosphatase, receptor type, R -0.0318102
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0318021
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0315509
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0313486
FOXO1 forkhead box O1 -0.0308254
ASPH aspartate beta-hydroxylase -0.0308243
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0305619
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0303365
MAP4 microtubule-associated protein 4 -0.0303263