Diammonium Glycyrrhizinate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.160738
RACK1 receptor for activated C kinase 1 0.111711
RPL4 ribosomal protein L4 0.0857398
RPL23 ribosomal protein L23 0.0783481
RPL26 ribosomal protein L26 0.0773411
RPS3 ribosomal protein S3 0.0771667
RPS19 ribosomal protein S19 0.0746155
RPL3 ribosomal protein L3 0.0738444
RPL11 ribosomal protein L11 0.0720998
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0645346
RPL13A ribosomal protein L13a 0.05929
RPL36 ribosomal protein L36 0.0563678
RPS17 ribosomal protein S17 0.0517529
RPS27 ribosomal protein S27 0.0511998
RPL37A ribosomal protein L37a 0.0487975
RPL37 ribosomal protein L37 0.0462594
EEF2 eukaryotic translation elongation factor 2 0.0437156
LAMB3 laminin, beta 3 0.0432986
S100P S100 calcium binding protein P 0.0424384
RPL12 ribosomal protein L12 0.0399763
RRBP1 ribosome binding protein 1 0.0394468
HSPA8 heat shock 70kDa protein 8 0.0363283
NACA nascent polypeptide-associated complex alpha subunit 0.0360104
RPL30 ribosomal protein L30 0.0357781
RPL18 ribosomal protein L18 0.035164
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0345269
EZR ezrin 0.0340047
RPL7 ribosomal protein L7 0.033371
LOC112694756 uncharaterized LOC112694756 0.0315538
RPLP1 ribosomal protein, large, P1 0.0299456
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0293531
RPS2 ribosomal protein S2 0.0292318
FTL ferritin, light polypeptide 0.028382
MT2A metallothionein 2A 0.0280555
RPS8 ribosomal protein S8 0.0278169
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0271427
NDRG1 N-myc downstream regulated 1 0.02657
SRRM2 serine/arginine repetitive matrix 2 0.0257749
RPL21 ribosomal protein L21 0.0251976
RPL14 ribosomal protein L14 0.0236815
RPS4X ribosomal protein S4, X-linked 0.0235576
RPS15A ribosomal protein S15a 0.023387
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0224024
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02227
EPCAM epithelial cell adhesion molecule 0.0222217
DDIT4 DNA-damage-inducible transcript 4 0.021773
KIF5B kinesin family member 5B 0.0213459
PGK1 phosphoglycerate kinase 1 0.0211563
RPL31 ribosomal protein L31 0.0211276
MYH9 myosin, heavy chain 9, non-muscle 0.0209743
FAT1 FAT atypical cadherin 1 0.0207654
GDF15 growth differentiation factor 15 0.020671
RPS7 ribosomal protein S7 0.0200429
DSPP dentin sialophosphoprotein 0.0192909
CSDE1 cold shock domain containing E1, RNA-binding 0.0187477
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0187363
RPL41 ribosomal protein L41 0.0187026
RPL27 ribosomal protein L27 0.0186436
TMSB10 thymosin beta 10 0.0184886
RPL36AL ribosomal protein L36a-like 0.0184296
COX6C cytochrome c oxidase subunit VIc 0.0182998
RPS14 ribosomal protein S14 0.0181484
LOC102724023 ES1 protein homolog, mitochondrial 0.0180153
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0179568
TPI1 triosephosphate isomerase 1 0.0172577
TSPAN8 tetraspanin 8 0.016852
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0164521
HLA-C major histocompatibility complex, class I, C 0.0162914
ARCN1 archain 1 0.01601
TRIM31 tripartite motif containing 31 0.0159713
UBB ubiquitin B 0.0159374
PLEC plectin 0.015853
RPL19 ribosomal protein L19 0.0157264
SHROOM3 shroom family member 3 0.015696
YBX1 Y box binding protein 1 0.0153737
RPL35 ribosomal protein L35 0.015346
ARRDC3 arrestin domain containing 3 0.0152538
YBX3 Y box binding protein 3 0.0150621
ESYT2 extended synaptotagmin-like protein 2 0.0147526
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.014704
AFDN afadin, adherens junction formation factor 0.0146614
KLF5 Kruppel-like factor 5 (intestinal) 0.0146011
EMP1 epithelial membrane protein 1 0.0145015
KLF6 Kruppel-like factor 6 0.014254
TTC3 tetratricopeptide repeat domain 3 0.0141692
LDHA lactate dehydrogenase A 0.0140722
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0139436
TMEM45B transmembrane protein 45B 0.0138226
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0137556
NOP53 NOP53 ribosome biogenesis factor 0.0137365
GARS1 glycyl-tRNA synthetase 1 0.013627
TNIP1 TNFAIP3 interacting protein 1 0.0134562
ARHGAP5 Rho GTPase activating protein 5 0.0133261
RPL9 ribosomal protein L9 0.0132707
CD46 CD46 molecule, complement regulatory protein 0.013209
CLINT1 clathrin interactor 1 0.0131493
CIB1 calcium and integrin binding 1 (calmyrin) 0.0129037
ASS1 argininosuccinate synthase 1 0.0124981
BHLHE40 basic helix-loop-helix family, member e40 0.0124449
ABHD17C abhydrolase domain containing 17C 0.0124132

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150573
PDE4D phosphodiesterase 4D, cAMP-specific -0.127653
TPT1 tumor protein, translationally-controlled 1 -0.123808
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.120981
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.111548
POTEF POTE ankyrin domain family, member F -0.102895
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0989106
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0930756
LMO7 LIM domain 7 -0.0928585
MYO1E myosin IE -0.0807228
UBC ubiquitin C -0.077944
THSD4 thrombospondin, type I, domain containing 4 -0.0779207
AKAP13 A kinase (PRKA) anchor protein 13 -0.075945
RPS27A ribosomal protein S27a -0.0687533
FBXO11 F-box protein 11 -0.0681287
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0664196
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0618822
PCBP2 poly(rC) binding protein 2 -0.0602761
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0590961
ACTG1 actin gamma 1 -0.0589462
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0572695
FRMD5 FERM domain containing 5 -0.0561427
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0555972
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0550515
GMDS GDP-mannose 4,6-dehydratase -0.0540377
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0537639
PTPRK protein tyrosine phosphatase, receptor type, K -0.0520382
RPS23 ribosomal protein S23 -0.051695
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0512888
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0510805
CUX1 cut-like homeobox 1 -0.0505284
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0500244
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0500036
SP100 SP100 nuclear antigen -0.0497311
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.049504
MCU mitochondrial calcium uniporter -0.0491805
RPS21 ribosomal protein S21 -0.0488224
JMJD1C jumonji domain containing 1C -0.0484878
RBM25 RNA binding motif protein 25 -0.0474388
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0463557
PERP PERP, TP53 apoptosis effector -0.0463422
SLC38A2 solute carrier family 38, member 2 -0.0461792
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0458301
UBE2H ubiquitin-conjugating enzyme E2H -0.0442916
PATJ PATJ crumbs cell polarity complex component -0.0439328
CALB1 calbindin 1, 28kDa -0.0437989
FNDC3B fibronectin type III domain containing 3B -0.0433772
CATSPERB catsper channel auxiliary subunit beta -0.0431379
LPP LIM domain containing preferred translocation partner in lipoma -0.0426567
RAB7A RAB7A, member RAS oncogene family -0.0424678
PDLIM5 PDZ and LIM domain 5 -0.0416343
P3H2 prolyl 3-hydroxylase 2 -0.0415706
RPLP2 ribosomal protein, large, P2 -0.0414203
RCOR1 REST corepressor 1 -0.0410426
ATP5F1B ATP synthase F1 subunit beta -0.0410194
FOXO1 forkhead box O1 -0.0403568
KRT8 keratin 8, type II -0.040323
DIAPH1 diaphanous-related formin 1 -0.0399479
RPS24 ribosomal protein S24 -0.0399301
PSD3 pleckstrin and Sec7 domain containing 3 -0.0398927
RIGI RNA sensor RIG-I -0.0395323
MSI2 musashi RNA-binding protein 2 -0.0390802
RPS25 ribosomal protein S25 -0.0388313
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0379405
RABGAP1L RAB GTPase activating protein 1-like -0.0369712
NPSR1 neuropeptide S receptor 1 -0.0369577
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0366916
TCF12 transcription factor 12 -0.0366884
DOCK5 dedicator of cytokinesis 5 -0.0366712
FAF1 Fas (TNFRSF6) associated factor 1 -0.0366453
DSG3 desmoglein 3 -0.036458
SFPQ splicing factor proline/glutamine-rich -0.035838
MED13L mediator complex subunit 13-like -0.035367
FER fer (fps/fes related) tyrosine kinase -0.0353502
INTS6 integrator complex subunit 6 -0.0352026
RIMKLB ribosomal modification protein rimK-like family member B -0.0347291
F3 coagulation factor III (thromboplastin, tissue factor) -0.0343245
MX1 MX dynamin-like GTPase 1 -0.0338059
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0337543
RAP1B RAP1B, member of RAS oncogene family -0.0337465
ANKRD17 ankyrin repeat domain 17 -0.0335871
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0333412
SVIL supervillin -0.0333201
AOPEP aminopeptidase O (putative) -0.0330348
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0327712
ASPH aspartate beta-hydroxylase -0.0324773
EXOC4 exocyst complex component 4 -0.0320185
ACTN4 actinin, alpha 4 -0.0318592
COG5 component of oligomeric golgi complex 5 -0.0318323
PTPRB protein tyrosine phosphatase, receptor type, B -0.0317206
N4BP2L2 NEDD4 binding protein 2-like 2 -0.03111
DLG1 discs, large homolog 1 (Drosophila) -0.031085
PTPRR protein tyrosine phosphatase, receptor type, R -0.0310196
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0308593
SH3D19 SH3 domain containing 19 -0.0308192
FUS FUS RNA binding protein -0.0308007
ERBIN erbb2 interacting protein -0.0306357
TUBA1B tubulin, alpha 1b -0.0306016
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0305537
PLSCR1 phospholipid scramblase 1 -0.0303715