Diammonium Glycyrrhizinate_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.204658
RPS12 ribosomal protein S12 0.0737818
FTL ferritin, light polypeptide 0.0733685
RACK1 receptor for activated C kinase 1 0.0676303
RPL36 ribosomal protein L36 0.0555055
RPS19 ribosomal protein S19 0.0533462
RPL37A ribosomal protein L37a 0.053301
RPL23 ribosomal protein L23 0.0511269
RPL12 ribosomal protein L12 0.0506775
RPL26 ribosomal protein L26 0.0478747
RPS3 ribosomal protein S3 0.0428587
RPL11 ribosomal protein L11 0.0424778
TPI1 triosephosphate isomerase 1 0.0400926
B2M beta-2-microglobulin 0.0390872
RPL37 ribosomal protein L37 0.0389866
ENO2 enolase 2 (gamma, neuronal) 0.0389126
HMGA1 high mobility group AT-hook 1 0.0367069
RPL31 ribosomal protein L31 0.03652
RPL35A ribosomal protein L35a 0.0362017
RPS27 ribosomal protein S27 0.0357226
SLK STE20-like kinase 0.0351783
PLIN2 perilipin 2 0.0345665
HLA-A major histocompatibility complex, class I, A 0.034507
ANGPTL4 angiopoietin-like 4 0.0324042
KLF6 Kruppel-like factor 6 0.0319951
RPS17 ribosomal protein S17 0.0313805
TMSB10 thymosin beta 10 0.0279236
RPS6 ribosomal protein S6 0.0269593
RPL18 ribosomal protein L18 0.0266465
ZFP36L1 ZFP36 ring finger protein-like 1 0.0263671
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0254804
IFITM1 interferon induced transmembrane protein 1 0.024229
RPL3 ribosomal protein L3 0.0242066
FAM162A family with sequence similarity 162, member A 0.0234653
RPL27 ribosomal protein L27 0.0224393
PCDH1 protocadherin 1 0.0217378
IFITM3 interferon induced transmembrane protein 3 0.0200294
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0196446
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0195636
RPS2 ribosomal protein S2 0.0183625
RPL30 ribosomal protein L30 0.0183355
IFI6 interferon, alpha-inducible protein 6 0.0180722
RPL35 ribosomal protein L35 0.017023
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.01701
RPS14 ribosomal protein S14 0.0170033
F2R coagulation factor II (thrombin) receptor 0.0167891
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0167437
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0167328
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0166447
HLA-B major histocompatibility complex, class I, B 0.0163256
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0161345
RPS7 ribosomal protein S7 0.0148253
UBXN4 UBX domain protein 4 0.0146419
MT1E metallothionein 1E 0.0146365
GPX4 glutathione peroxidase 4 0.0146199
NDRG1 N-myc downstream regulated 1 0.0140347
RPL13A ribosomal protein L13a 0.0139479
RPL9 ribosomal protein L9 0.0137909
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0133951
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0130199
RPL4 ribosomal protein L4 0.0127725
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0127034
RPL21 ribosomal protein L21 0.0125597
GYS1 glycogen synthase 1 (muscle) 0.0124142
RPL10A ribosomal protein L10a 0.0123792
ARLN allregulin 0.0121305
HLA-C major histocompatibility complex, class I, C 0.0120722
H1-0 H1.0 linker histone 0.011996
SOX9 SRY (sex determining region Y)-box 9 0.0118873
RPL34 ribosomal protein L34 0.0118221
PLAU plasminogen activator, urokinase 0.0117956
HMOX1 heme oxygenase 1 0.011763
NACA nascent polypeptide-associated complex alpha subunit 0.0117518
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0117314
IGFBP6 insulin-like growth factor binding protein 6 0.0115741
RPS26 ribosomal protein S26 0.0113511
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.0112903
DSTN destrin (actin depolymerizing factor) 0.011282
IFITM2 interferon induced transmembrane protein 2 0.0112774
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0110899
SEC62 SEC62 homolog (S. cerevisiae) 0.0110148
PLEC plectin 0.0109999
PODXL podocalyxin-like 0.0109992
ISG15 ISG15 ubiquitin-like modifier 0.0109571
TMSB4X thymosin beta 4, X-linked 0.0109401
CALD1 caldesmon 1 0.0108843
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0107967
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0107787
CAMLG calcium modulating ligand 0.0106828
RAD50 RAD50 homolog (S. cerevisiae) 0.0105368
CD46 CD46 molecule, complement regulatory protein 0.0105197
EGR1 early growth response 1 0.0104442
SNX3 sorting nexin 3 0.0104398
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0103088
RPS4X ribosomal protein S4, X-linked 0.0102045
CXCL5 chemokine (C-X-C motif) ligand 5 0.0101784
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0101116
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0100885
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0100164
CXCL2 chemokine (C-X-C motif) ligand 2 0.0100033

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.337747
TM4SF1 transmembrane 4 L six family member 1 -0.13784
VIM vimentin -0.124332
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.121713
UBC ubiquitin C -0.112469
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0954556
TXNRD1 thioredoxin reductase 1 -0.0913922
PSD3 pleckstrin and Sec7 domain containing 3 -0.0727303
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0708139
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0684244
AHNAK AHNAK nucleoprotein -0.0662296
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0653516
USP34 ubiquitin specific peptidase 34 -0.0644801
CD44 CD44 molecule (Indian blood group) -0.0630052
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0579482
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0560185
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0559743
SPAG9 sperm associated antigen 9 -0.0559463
ZFAND3 zinc finger, AN1-type domain 3 -0.0557051
SFPQ splicing factor proline/glutamine-rich -0.0553992
POTEF POTE ankyrin domain family, member F -0.0552173
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0545854
RPS27A ribosomal protein S27a -0.0543753
APP amyloid beta (A4) precursor protein -0.0530548
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0517647
ACTG1 actin gamma 1 -0.0512038
FBXO11 F-box protein 11 -0.0494744
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0493486
FMNL2 formin-like 2 -0.0493467
ZMYND8 zinc finger, MYND-type containing 8 -0.0490845
BCAR3 breast cancer anti-estrogen resistance 3 -0.0487958
DST dystonin -0.0486719
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0482715
JMJD1C jumonji domain containing 1C -0.0478719
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0478274
TP63 tumor protein p63 -0.0477583
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0456369
CAPRIN2 caprin family member 2 -0.0442478
RTN4 reticulon 4 -0.0432315
WARS1 tryptophanyl-tRNA synthetase 1 -0.041913
ENO1 enolase 1, (alpha) -0.0418645
SRPK2 SRSF protein kinase 2 -0.041774
JUN jun proto-oncogene -0.0416246
PTK2 protein tyrosine kinase 2 -0.0403828
ZEB1 zinc finger E-box binding homeobox 1 -0.0390425
CMIP c-Maf inducing protein -0.0385722
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0381607
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0380661
EMP1 epithelial membrane protein 1 -0.0380507
FUS FUS RNA binding protein -0.0376546
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0372898
GSK3B glycogen synthase kinase 3 beta -0.0364479
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0361177
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0358175
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0354523
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0349912
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0348867
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0347897
EZR ezrin -0.0347723
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0347555
FLNB filamin B, beta -0.033749
RCOR1 REST corepressor 1 -0.033692
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0331729
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0331549
TRIO trio Rho guanine nucleotide exchange factor -0.0329743
OGA O-GlcNAcase -0.032744
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0324281
PDIA4 protein disulfide isomerase family A, member 4 -0.0323923
SDC4 syndecan 4 -0.032361
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0323405
FNIP1 folliculin interacting protein 1 -0.0323024
TRIP12 thyroid hormone receptor interactor 12 -0.0319339
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0318046
MACF1 microtubule-actin crosslinking factor 1 -0.031549
ADAM17 ADAM metallopeptidase domain 17 -0.0314219
NPAS2 neuronal PAS domain protein 2 -0.0312176
CANX calnexin -0.0309197
TAS2R14 taste receptor, type 2, member 14 -0.0308858
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0306544
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0305756
TOP1 topoisomerase (DNA) I -0.0305137
BICD1 bicaudal D homolog 1 (Drosophila) -0.0305114
CFLAR CASP8 and FADD-like apoptosis regulator -0.0302504
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0301626
PCBP2 poly(rC) binding protein 2 -0.0301452
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0298664
SLC38A2 solute carrier family 38, member 2 -0.0295719
RAB7A RAB7A, member RAS oncogene family -0.0295189
TNS3 tensin 3 -0.0294388
SMC4 structural maintenance of chromosomes 4 -0.0292381
FAF1 Fas (TNFRSF6) associated factor 1 -0.029153
ZBTB38 zinc finger and BTB domain containing 38 -0.0289822
RBM39 RNA binding motif protein 39 -0.0289692
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0289389
ZNF207 zinc finger protein 207 -0.0284333
TPT1 tumor protein, translationally-controlled 1 -0.0283851
EXOC4 exocyst complex component 4 -0.02807
GLS2 glutaminase 2 (liver, mitochondrial) -0.0279143
EHBP1 EH domain binding protein 1 -0.0278715
IPO7 importin 7 -0.027856