Diammonium Glycyrrhizinate_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOX lysyl oxidase 0.155275
AKAP12 A kinase (PRKA) anchor protein 12 0.151026
STC1 stanniocalcin 1 0.0694243
NDRG1 N-myc downstream regulated 1 0.0582676
TMSB10 thymosin beta 10 0.0544692
ENO1 enolase 1, (alpha) 0.0467683
GOLGA4 golgin A4 0.0457533
HDLBP high density lipoprotein binding protein 0.04402
IGFBP3 insulin-like growth factor binding protein 3 0.0434538
FAM20C family with sequence similarity 20, member C 0.0426294
MT2A metallothionein 2A 0.0418228
TTC3 tetratricopeptide repeat domain 3 0.0398897
B2M beta-2-microglobulin 0.0387641
RPS12 ribosomal protein S12 0.0347411
RPL23 ribosomal protein L23 0.0338048
RACK1 receptor for activated C kinase 1 0.0322731
ANGPTL4 angiopoietin-like 4 0.0310537
RPL3 ribosomal protein L3 0.0303878
LRRC49 leucine rich repeat containing 49 0.0303329
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0300985
LDHA lactate dehydrogenase A 0.0297415
EEF2 eukaryotic translation elongation factor 2 0.028831
GOLGA3 golgin A3 0.0283965
AHNAK AHNAK nucleoprotein 0.0281837
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0276321
RPS3 ribosomal protein S3 0.026501
RPL4 ribosomal protein L4 0.0258811
AKAP9 A kinase (PRKA) anchor protein 9 0.0246949
CSDE1 cold shock domain containing E1, RNA-binding 0.0242567
RPL18 ribosomal protein L18 0.0230784
RPS17 ribosomal protein S17 0.0229801
RPL11 ribosomal protein L11 0.0224404
SON SON DNA binding protein 0.0216549
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0215776
PTPRF protein tyrosine phosphatase, receptor type, F 0.02133
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0200084
FAM114A1 family with sequence similarity 114, member A1 0.0196427
RPS19 ribosomal protein S19 0.0195687
ELP2 elongator acetyltransferase complex subunit 2 0.0193609
THBS1 thrombospondin 1 0.0193179
IARS1 isoleucyl-tRNA synthetase 1 0.0190671
EEA1 early endosome antigen 1 0.0189523
H1-0 H1.0 linker histone 0.018543
DDIT3 DNA-damage-inducible transcript 3 0.0179714
RPL26 ribosomal protein L26 0.0177292
ERRFI1 ERBB receptor feedback inhibitor 1 0.0175598
SEPTIN2 septin 2 0.0172249
SCFD2 sec1 family domain containing 2 0.0171877
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.017144
LIMCH1 LIM and calponin homology domains 1 0.0170049
TPI1 triosephosphate isomerase 1 0.0169887
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0169107
APOLD1 apolipoprotein L domain containing 1 0.0168406
ZFP36L1 ZFP36 ring finger protein-like 1 0.0168104
ADM adrenomedullin 0.0165662
MLPH melanophilin 0.016528
MYO9A myosin IXA 0.0163867
LMAN1 lectin, mannose-binding, 1 0.0163536
PGK1 phosphoglycerate kinase 1 0.0163127
PLIN2 perilipin 2 0.0161985
SEPTIN9 septin 9 0.0161212
RPL36 ribosomal protein L36 0.0160561
TARS1 threonyl-tRNA synthetase 1 0.0160046
CANX calnexin 0.0158687
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.0157375
ZNF146 zinc finger protein 146 0.0157372
SRP54 signal recognition particle 54kDa 0.015698
MON2 MON2 homolog (S. cerevisiae) 0.015696
RPL31 ribosomal protein L31 0.0152707
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0152155
CEMIP cell migration inducing protein, hyaluronan binding 0.015185
FBN1 fibrillin 1 0.0149847
RAI1 retinoic acid induced 1 0.0149674
ARHGAP35 Rho GTPase activating protein 35 0.0148307
ZMIZ1 zinc finger, MIZ-type containing 1 0.0147885
SRRM2 serine/arginine repetitive matrix 2 0.0147503
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0147453
LARS1 leucyl-tRNA synthetase 1 0.0147271
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0147131
TLN1 talin 1 0.0146502
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0144568
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0144284
MRPS6 mitochondrial ribosomal protein S6 0.0142719
GARS1 glycyl-tRNA synthetase 1 0.0142347
MARS1 methionyl-tRNA synthetase 1 0.0141546
HLA-A major histocompatibility complex, class I, A 0.0141113
CEP250 centrosomal protein 250kDa 0.0140859
USO1 USO1 vesicle transport factor 0.0139845
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0139081
RPS27 ribosomal protein S27 0.0139058
GALK2 galactokinase 2 0.0138387
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0137569
ZCCHC7 zinc finger, CCHC domain containing 7 0.0136697
COPA coatomer protein complex, subunit alpha 0.0136323
PLEC plectin 0.0136055
NFE2L1 nuclear factor, erythroid 2-like 1 0.0135534
ANKLE2 ankyrin repeat and LEM domain containing 2 0.013497
NSUN6 NOP2/Sun domain family, member 6 0.0134669
TMED3 transmembrane emp24 protein transport domain containing 3 0.0134034
FAM177A1 family with sequence similarity 177, member A1 0.0133885

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.161163
FNDC3B fibronectin type III domain containing 3B -0.152118
NAMPT nicotinamide phosphoribosyltransferase -0.138543
SDK1 sidekick cell adhesion molecule 1 -0.13832
PDE4D phosphodiesterase 4D, cAMP-specific -0.120674
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0977144
GLCCI1 glucocorticoid induced 1 -0.0925556
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0903262
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0896969
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0884418
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0852065
ELL2 elongation factor, RNA polymerase II, 2 -0.0789062
EFNA5 ephrin-A5 -0.0785869
KDM2A lysine (K)-specific demethylase 2A -0.078553
NRG1 neuregulin 1 -0.07763
PTK2 protein tyrosine kinase 2 -0.0744731
NRP1 neuropilin 1 -0.0695939
USP34 ubiquitin specific peptidase 34 -0.0684347
DPYD dihydropyrimidine dehydrogenase -0.0675406
OSMR oncostatin M receptor -0.0665789
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0639912
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0637107
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0635056
RAP1B RAP1B, member of RAS oncogene family -0.0608292
AKAP13 A kinase (PRKA) anchor protein 13 -0.0598974
PARD3 par-3 family cell polarity regulator -0.0580389
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0573146
KYNU kynureninase -0.053683
GRB10 growth factor receptor-bound protein 10 -0.0527849
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0519138
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0518069
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0510689
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0502216
CDH13 cadherin 13 -0.0476682
SIK3 SIK family kinase 3 -0.0474803
FTH1 ferritin, heavy polypeptide 1 -0.0467099
NUMB numb homolog (Drosophila) -0.0441327
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0440336
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0438351
VRK2 vaccinia related kinase 2 -0.0434012
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0429548
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0428799
GPC6 glypican 6 -0.0422989
CD44 CD44 molecule (Indian blood group) -0.0421928
ITGAV integrin, alpha V -0.0402592
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0401625
CLMP CXADR-like membrane protein -0.040154
MTSS1 metastasis suppressor 1 -0.0399841
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0389316
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0387521
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0387218
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0378801
FBXO11 F-box protein 11 -0.0378171
SNX9 sorting nexin 9 -0.0377104
PDLIM5 PDZ and LIM domain 5 -0.0376932
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0371843
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0369027
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0367614
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0361352
SREBF2 sterol regulatory element binding transcription factor 2 -0.0358456
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0356718
ATXN1 ataxin 1 -0.0352752
JMJD1C jumonji domain containing 1C -0.0348288
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0345721
SMAD3 SMAD family member 3 -0.0342271
TMEM165 transmembrane protein 165 -0.0339922
ETV6 ets variant 6 -0.0338749
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0336244
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0335816
PCNX1 pecanex 1 -0.0321316
PRKCA protein kinase C, alpha -0.0320746
RB1CC1 RB1-inducible coiled-coil 1 -0.0318824
DTNA dystrobrevin, alpha -0.0318612
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0317236
CDK14 cyclin-dependent kinase 14 -0.0317066
RBM39 RNA binding motif protein 39 -0.0316831
BMERB1 bMERB domain containing 1 -0.0316565
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0315728
HMGA2 high mobility group AT-hook 2 -0.0315592
RPS21 ribosomal protein S21 -0.0314098
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0310557
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0309261
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0308558
UBE2H ubiquitin-conjugating enzyme E2H -0.0306463
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0305384
ANTXR2 anthrax toxin receptor 2 -0.030353
NPC1 Niemann-Pick disease, type C1 -0.0303301
RAB27B RAB27B, member RAS oncogene family -0.030272
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0298932
KTN1 kinectin 1 (kinesin receptor) -0.0296828
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0294501
ZFAND3 zinc finger, AN1-type domain 3 -0.0292688
ASPH aspartate beta-hydroxylase -0.0291796
EXT1 exostosin glycosyltransferase 1 -0.0291708
LTBP1 latent transforming growth factor beta binding protein 1 -0.0289933
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0286582
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0285359
NCOA7 nuclear receptor coactivator 7 -0.0285109
MED13L mediator complex subunit 13-like -0.0284948
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0284148