Diammonium Glycyrrhizinate_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.188513
RPS3 ribosomal protein S3 0.130522
YBX3 Y box binding protein 3 0.110795
AKAP12 A kinase (PRKA) anchor protein 12 0.11029
MCL1 myeloid cell leukemia 1 0.100196
RPL23 ribosomal protein L23 0.0990755
RPL37 ribosomal protein L37 0.0957178
TPI1 triosephosphate isomerase 1 0.0930184
RAD51B RAD51 paralog B 0.0888966
RPS12 ribosomal protein S12 0.087537
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0862301
RPL37A ribosomal protein L37a 0.0817315
NAP1L1 nucleosome assembly protein 1-like 1 0.0811734
RPL26 ribosomal protein L26 0.0782776
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0752873
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0735269
VIM vimentin 0.07312
AEBP2 AE binding protein 2 0.0724422
RPL11 ribosomal protein L11 0.0678883
PDE4D phosphodiesterase 4D, cAMP-specific 0.0670834
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0657256
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0639048
RPS19 ribosomal protein S19 0.0620415
WNT2B wingless-type MMTV integration site family, member 2B 0.0612946
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0602074
INTS6 integrator complex subunit 6 0.0599567
RPS27 ribosomal protein S27 0.0570517
PTMA prothymosin, alpha 0.0567105
AFF3 AF4/FMR2 family, member 3 0.0560044
RPS4X ribosomal protein S4, X-linked 0.0506722
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0505238
ATXN1 ataxin 1 0.0499131
IFI6 interferon, alpha-inducible protein 6 0.0495657
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0490945
TPT1 tumor protein, translationally-controlled 1 0.0490347
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0487998
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0484967
RPS17 ribosomal protein S17 0.0481304
RPL3 ribosomal protein L3 0.0479266
ZSWIM6 zinc finger, SWIM-type containing 6 0.0472802
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0470785
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0470129
RACK1 receptor for activated C kinase 1 0.0464347
RPS8 ribosomal protein S8 0.0463674
ZCCHC7 zinc finger, CCHC domain containing 7 0.0447708
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.044717
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0439647
RPL12 ribosomal protein L12 0.043853
THSD4 thrombospondin, type I, domain containing 4 0.0437255
RPL27 ribosomal protein L27 0.0430568
RPL31 ribosomal protein L31 0.0420371
FTL ferritin, light polypeptide 0.0417761
TAS2R14 taste receptor, type 2, member 14 0.0416751
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0416483
RPS27A ribosomal protein S27a 0.0409655
RPL9 ribosomal protein L9 0.0401994
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0389661
HLA-B major histocompatibility complex, class I, B 0.0389482
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0380239
RPS21 ribosomal protein S21 0.037373
HOMER1 homer scaffolding protein 1 0.0366403
EXOC4 exocyst complex component 4 0.0357634
DENND1A DENN/MADD domain containing 1A 0.0356696
SMAD3 SMAD family member 3 0.0350575
RNF213 ring finger protein 213 0.0345383
MT2A metallothionein 2A 0.0341956
PRH1 proline-rich protein HaeIII subfamily 1 0.0339985
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0339205
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0337886
RPL19 ribosomal protein L19 0.0333466
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0326377
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0323808
GOLGB1 golgin B1 0.0322626
TBC1D22A TBC1 domain family, member 22A 0.0322095
HDAC4 histone deacetylase 4 0.0321503
RPL35A ribosomal protein L35a 0.0320224
RPL18 ribosomal protein L18 0.0309587
RPL36 ribosomal protein L36 0.030549
NEK10 NIMA-related kinase 10 0.0300243
NDRG1 N-myc downstream regulated 1 0.029892
RPL34 ribosomal protein L34 0.0298536
EGFR epidermal growth factor receptor 0.0298238
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0296755
EHBP1 EH domain binding protein 1 0.0295833
PRKCE protein kinase C, epsilon 0.0295676
ACTG1 actin gamma 1 0.0292788
ZBTB20 zinc finger and BTB domain containing 20 0.0289984
RPL13A ribosomal protein L13a 0.0285856
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0285264
ANO6 anoctamin 6 0.0284047
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0282938
MYL12B myosin, light chain 12B, regulatory 0.0280581
FNDC3B fibronectin type III domain containing 3B 0.0280207
IGF1R insulin-like growth factor 1 receptor 0.02764
MBD5 methyl-CpG binding domain protein 5 0.0274245
RPL35 ribosomal protein L35 0.02719
PRELID2 PRELI domain containing 2 0.0260282
RPS24 ribosomal protein S24 0.0258926
NACA nascent polypeptide-associated complex alpha subunit 0.0258824
RPLP1 ribosomal protein, large, P1 0.0258398

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.154248
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.125738
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0866355
RTN4 reticulon 4 -0.0647519
TFPI2 tissue factor pathway inhibitor 2 -0.0627666
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.059689
CDK17 cyclin-dependent kinase 17 -0.0557345
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0482444
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0469814
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0451352
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0446922
KPNB1 karyopherin (importin) beta 1 -0.0422933
CDCP1 CUB domain containing protein 1 -0.0405377
LATS2 large tumor suppressor kinase 2 -0.0404665
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0394039
TBK1 TANK-binding kinase 1 -0.039298
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0391598
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0380666
RUSC2 RUN and SH3 domain containing 2 -0.037678
CENPF centromere protein F, 350/400kDa -0.0374969
ERRFI1 ERBB receptor feedback inhibitor 1 -0.037402
XPO1 exportin 1 -0.0371739
OGA O-GlcNAcase -0.0370225
KTN1 kinectin 1 (kinesin receptor) -0.0367254
PHIP pleckstrin homology domain interacting protein -0.0357495
EML4 echinoderm microtubule associated protein like 4 -0.0354593
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0354416
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0350786
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0349481
TMEM165 transmembrane protein 165 -0.0336972
TPM4 tropomyosin 4 -0.0329302
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0324492
KDM3A lysine (K)-specific demethylase 3A -0.0323949
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0301232
ADAM9 ADAM metallopeptidase domain 9 -0.0288966
MMP12 matrix metallopeptidase 12 -0.0281892
DIAPH3 diaphanous-related formin 3 -0.028166
IPO7 importin 7 -0.0281064
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0279987
VDAC1 voltage-dependent anion channel 1 -0.0276549
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0274099
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0272493
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0266754
LIMA1 LIM domain and actin binding 1 -0.0266701
TMEM41B transmembrane protein 41B -0.0266077
MATR3 matrin 3 -0.0265272
PLS3 plastin 3 -0.0260206
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0258522
PDIA3 protein disulfide isomerase family A, member 3 -0.0258094
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0256999
SMC4 structural maintenance of chromosomes 4 -0.0254859
IMMT inner membrane protein, mitochondrial -0.0248958
ANXA5 annexin A5 -0.0246863
SCAF11 SR-related CTD-associated factor 11 -0.0246696
ZNF292 zinc finger protein 292 -0.0245021
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.0243675
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0243206
CCNL1 cyclin L1 -0.0242012
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0241501
IL6ST interleukin 6 signal transducer -0.0240472
LUZP1 leucine zipper protein 1 -0.0240397
RECQL RecQ helicase-like -0.0239444
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0237834
AKIRIN1 akirin 1 -0.0236439
SINHCAF SIN3-HDAC complex associated factor -0.0236228
POTEF POTE ankyrin domain family, member F -0.0233662
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0230257
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0230242
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0225633
TWF1 twinfilin actin binding protein 1 -0.0225632
ADAM17 ADAM metallopeptidase domain 17 -0.0224727
NAMPT nicotinamide phosphoribosyltransferase -0.0223769
MKI67 marker of proliferation Ki-67 -0.0221583
SRPK2 SRSF protein kinase 2 -0.022001
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0217061
KLF7 Kruppel-like factor 7 (ubiquitous) -0.021274
AVL9 AVL9 homolog (S. cerevisiase) -0.0211127
CTTNBP2NL CTTNBP2 N-terminal like -0.0207862
ANLN anillin, actin binding protein -0.0206221
NOP58 NOP58 ribonucleoprotein -0.0205833
CAVIN1 caveolae associated protein 1 -0.0204782
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0204727
KIF5B kinesin family member 5B -0.0203902
ZFR zinc finger RNA binding protein -0.0201585
TUBA1B tubulin, alpha 1b -0.0200875
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0200098
TMEM245 transmembrane protein 245 -0.0199921
PAWR PRKC, apoptosis, WT1, regulator -0.0199894
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0199388
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0197469
U2SURP U2 snRNP-associated SURP domain containing -0.0197281
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0196451
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0196225
NUP58 nucleoporin 58 -0.0195676
SRPK1 SRSF protein kinase 1 -0.0193659
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0193653
SLMAP sarcolemma associated protein -0.0193589
EIF4B eukaryotic translation initiation factor 4B -0.0193434
TAOK1 TAO kinase 1 -0.0192991
WBP11 WW domain binding protein 11 -0.0191928