Diammonium Glycyrrhizinate_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0439727
ARRDC3 arrestin domain containing 3 0.0320394
FAM13A family with sequence similarity 13, member A 0.0291435
RPL3 ribosomal protein L3 0.0278735
EEF2 eukaryotic translation elongation factor 2 0.0274692
TSC22D2 TSC22 domain family, member 2 0.025937
RPL4 ribosomal protein L4 0.0211879
VEGFA vascular endothelial growth factor A 0.0190905
PLEC plectin 0.0166977
HSPA8 heat shock 70kDa protein 8 0.016641
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0162516
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0161814
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0144765
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.014358
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0142941
MYH9 myosin, heavy chain 9, non-muscle 0.0140536
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0140438
IGFBP3 insulin-like growth factor binding protein 3 0.0137123
TPM3 tropomyosin 3 0.0133376
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0126407
MKRN1 makorin ring finger protein 1 0.0123558
KDM5B lysine (K)-specific demethylase 5B 0.0121305
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0114143
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0113473
CD109 CD109 molecule 0.011318
DDIT4 DNA-damage-inducible transcript 4 0.0113057
HMGB3 high mobility group box 3 0.0107517
BHLHE40 basic helix-loop-helix family, member e40 0.0105854
TFRC transferrin receptor 0.0104989
RPS2 ribosomal protein S2 0.0104365
BCL6 B-cell CLL/lymphoma 6 0.0104218
HYOU1 hypoxia up-regulated 1 0.0101558
CCNL1 cyclin L1 0.0101155
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.010078
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00994146
AHDC1 AT hook, DNA binding motif, containing 1 0.00993299
LIMCH1 LIM and calponin homology domains 1 0.00961776
UBAP2L ubiquitin associated protein 2-like 0.00960542
SRP54 signal recognition particle 54kDa 0.00938083
JMY junction mediating and regulatory protein, p53 cofactor 0.00937823
TUFT1 tuftelin 1 0.00926332
CASC3 cancer susceptibility candidate 3 0.00909082
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00889841
PGM3 phosphoglucomutase 3 0.00862449
EIF4H eukaryotic translation initiation factor 4H 0.00847543
RPS12 ribosomal protein S12 0.00835563
ATF3 activating transcription factor 3 0.00807294
RNF145 ring finger protein 145 0.00804969
CLDND1 claudin domain containing 1 0.00794063
DHFR dihydrofolate reductase 0.00793603
MBNL2 muscleblind-like splicing regulator 2 0.00787184
RPS7 ribosomal protein S7 0.00752503
FLNC filamin C, gamma 0.00752173
LAPTM4A lysosomal protein transmembrane 4 alpha 0.00743605
NFE2L1 nuclear factor, erythroid 2-like 1 0.00730572
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.00722781
EIF4B eukaryotic translation initiation factor 4B 0.00722204
RACK1 receptor for activated C kinase 1 0.00711266
CENPC centromere protein C 0.00710846
CTBP2 C-terminal binding protein 2 0.00708706
NUP153 nucleoporin 153kDa 0.00703879
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00697125
NUMA1 nuclear mitotic apparatus protein 1 0.00696509
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00688102
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.00685928
SARNP SAP domain containing ribonucleoprotein 0.0068191
MSI2 musashi RNA-binding protein 2 0.00680672
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.00680364
TC2N tandem C2 domains, nuclear 0.00677879
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.00675823
SEC23A Sec23 homolog A (S. cerevisiae) 0.00667861
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00665537
CCNY cyclin Y 0.0066439
SOD2 superoxide dismutase 2, mitochondrial 0.00663008
RPS15A ribosomal protein S15a 0.00661835
PELI1 pellino E3 ubiquitin protein ligase 1 0.00661147
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.00658428
KDM6A lysine (K)-specific demethylase 6A 0.00654464
SDE2 SDE2 telomere maintenance homolog (S. pombe) 0.00651662
YBX1 Y box binding protein 1 0.00643616
ACVR1 activin A receptor, type I 0.00635129
VSIG2 V-set and immunoglobulin domain containing 2 0.00632685
HELZ helicase with zinc finger 0.00629018
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.00624426
FXR1 fragile X mental retardation, autosomal homolog 1 0.00624368
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0062386
FBXO42 F-box protein 42 0.00621378
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.00617553
WEE1 WEE1 G2 checkpoint kinase 0.0061487
MYLIP myosin regulatory light chain interacting protein 0.00613678
ARCN1 archain 1 0.00611829
MLEC malectin 0.0060724
TARS1 threonyl-tRNA synthetase 1 0.00606664
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.00604783
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00601106
RYK receptor-like tyrosine kinase 0.00600749
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00599157
ELOVL5 ELOVL fatty acid elongase 5 0.00598659
BAG6 BCL2-associated athanogene 6 0.00597252
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0059691

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.326564
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.215716
TMSB10 thymosin beta 10 -0.168176
ACTG1 actin gamma 1 -0.164333
S100A6 S100 calcium binding protein A6 -0.123022
UBC ubiquitin C -0.11971
ASPH aspartate beta-hydroxylase -0.113561
TPT1 tumor protein, translationally-controlled 1 -0.111045
PTMA prothymosin, alpha -0.102081
KRT7 keratin 7, type II -0.0986169
FTL ferritin, light polypeptide -0.0939017
LAMB3 laminin, beta 3 -0.0938958
S100A10 S100 calcium binding protein A10 -0.0932982
TM4SF1 transmembrane 4 L six family member 1 -0.0921811
IFI27 interferon, alpha-inducible protein 27 -0.0855427
ENO1 enolase 1, (alpha) -0.0795166
RPL35A ribosomal protein L35a -0.0788267
POTEF POTE ankyrin domain family, member F -0.0768942
RPL34 ribosomal protein L34 -0.0701397
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0687274
CCND1 cyclin D1 -0.0670061
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0657521
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0655016
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0647971
HMGA1 high mobility group AT-hook 1 -0.0619784
MDK midkine (neurite growth-promoting factor 2) -0.0607548
FBXO32 F-box protein 32 -0.0604761
RPS23 ribosomal protein S23 -0.0603775
CSTB cystatin B (stefin B) -0.0593193
TMSB4X thymosin beta 4, X-linked -0.0589645
ALCAM activated leukocyte cell adhesion molecule -0.0584654
IFI6 interferon, alpha-inducible protein 6 -0.0580618
LPP LIM domain containing preferred translocation partner in lipoma -0.0577852
RPLP2 ribosomal protein, large, P2 -0.0562854
LAMC2 laminin, gamma 2 -0.0549202
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0534214
LY6E lymphocyte antigen 6 complex, locus E -0.0520464
CD2AP CD2-associated protein -0.0512362
MT2A metallothionein 2A -0.051016
DSG2 desmoglein 2 -0.0509992
ERBIN erbb2 interacting protein -0.0506037
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0499741
RPS24 ribosomal protein S24 -0.0497287
RPLP1 ribosomal protein, large, P1 -0.0493489
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0487912
ANXA2 annexin A2 -0.048338
EIF1 eukaryotic translation initiation factor 1 -0.0464956
KRT8 keratin 8, type II -0.0464808
S100A9 S100 calcium binding protein A9 -0.0457832
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0456503
RPL8 ribosomal protein L8 -0.0452194
HLA-B major histocompatibility complex, class I, B -0.0452006
RPS21 ribosomal protein S21 -0.0450526
LDHA lactate dehydrogenase A -0.0446676
SDC4 syndecan 4 -0.0440942
EXT1 exostosin glycosyltransferase 1 -0.0439485
RPS13 ribosomal protein S13 -0.0429256
IFI16 interferon, gamma-inducible protein 16 -0.0424855
AKAP13 A kinase (PRKA) anchor protein 13 -0.0418803
RPS8 ribosomal protein S8 -0.0414646
AHNAK AHNAK nucleoprotein -0.0413533
VIM vimentin -0.0408762
RPS27A ribosomal protein S27a -0.0408436
ARHGAP5 Rho GTPase activating protein 5 -0.0405503
ZBTB20 zinc finger and BTB domain containing 20 -0.0405137
RPS25 ribosomal protein S25 -0.040235
RPL19 ribosomal protein L19 -0.0399281
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0398456
MYO6 myosin VI -0.0388237
MAP1B microtubule-associated protein 1B -0.0384953
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0381789
RPL15 ribosomal protein L15 -0.0376925
CAPN2 calpain 2, (m/II) large subunit -0.0374421
KRT18 keratin 18, type I -0.0363693
NPEPPS aminopeptidase puromycin sensitive -0.0363106
RPL32 ribosomal protein L32 -0.0360682
IFITM1 interferon induced transmembrane protein 1 -0.0358028
NAV2 neuron navigator 2 -0.0357333
PGK1 phosphoglycerate kinase 1 -0.0356582
LMO7 LIM domain 7 -0.0353651
SP100 SP100 nuclear antigen -0.0353032
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0350956
SQSTM1 sequestosome 1 -0.034961
HSPB1 heat shock 27kDa protein 1 -0.0346465
VCL vinculin -0.0345224
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0344888
PTK2 protein tyrosine kinase 2 -0.0343295
IFITM3 interferon induced transmembrane protein 3 -0.0343064
KRT19 keratin 19, type I -0.034256
SVIL supervillin -0.0340646
FAM3C family with sequence similarity 3, member C -0.0337978
CCNI cyclin I -0.0337265
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0329109
RHOA ras homolog family member A -0.0328704
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0326329
SH3KBP1 SH3-domain kinase binding protein 1 -0.031821
RPS15 ribosomal protein S15 -0.0317363
TPM4 tropomyosin 4 -0.0315546
UBE2H ubiquitin-conjugating enzyme E2H -0.0313665
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.031288