Diammonium Glycyrrhizinate_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Diammonium Glycyrrhizinate perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Diammonium Glycyrrhizinate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.113049
EEF2 eukaryotic translation elongation factor 2 0.0737599
RPS12 ribosomal protein S12 0.0707707
RPL23 ribosomal protein L23 0.0695238
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0691389
RPL3 ribosomal protein L3 0.065994
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0599935
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0574522
YBX1 Y box binding protein 1 0.0573972
RPS19 ribosomal protein S19 0.0549151
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0504044
AHNAK AHNAK nucleoprotein 0.0475937
RACK1 receptor for activated C kinase 1 0.0475347
DST dystonin 0.0471347
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0463988
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0453931
PGK1 phosphoglycerate kinase 1 0.0445098
FOXG1 forkhead box G1 0.0423512
SET SET nuclear proto-oncogene 0.0412768
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.040518
GPBP1 GC-rich promoter binding protein 1 0.040385
CALR calreticulin 0.0402176
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0396332
PEG10 paternally expressed 10 0.0386992
DDIT4 DNA-damage-inducible transcript 4 0.0376322
MACF1 microtubule-actin crosslinking factor 1 0.0375969
CSDE1 cold shock domain containing E1, RNA-binding 0.0369838
ANK2 ankyrin 2, neuronal 0.0364999
TFRC transferrin receptor 0.0364445
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0355959
GARS1 glycyl-tRNA synthetase 1 0.0355787
RPS3 ribosomal protein S3 0.0354804
EEF1G eukaryotic translation elongation factor 1 gamma 0.0353328
RPL11 ribosomal protein L11 0.0349041
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0344565
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0341562
PDIA6 protein disulfide isomerase family A, member 6 0.0340258
APLP2 amyloid beta (A4) precursor-like protein 2 0.0331472
CCN2 cellular communication network factor 2 0.0329095
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0327473
MYH9 myosin, heavy chain 9, non-muscle 0.0324328
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0317492
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0309859
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0309502
NFIA nuclear factor I/A 0.0306756
WNK1 WNK lysine deficient protein kinase 1 0.030235
ZSWIM6 zinc finger, SWIM-type containing 6 0.0302304
RPL21 ribosomal protein L21 0.0298055
RPL7 ribosomal protein L7 0.0297379
MRPS30 mitochondrial ribosomal protein S30 0.0296793
ENAH enabled homolog (Drosophila) 0.0289078
VMP1 vacuole membrane protein 1 0.0288326
FAT1 FAT atypical cadherin 1 0.0284293
PCBP2 poly(rC) binding protein 2 0.0281076
TSC22D2 TSC22 domain family, member 2 0.0280944
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0278402
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0277033
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0276853
RPL12 ribosomal protein L12 0.0276209
MATR3 matrin 3 0.0270904
HSPA4 heat shock 70kDa protein 4 0.0268383
PCM1 pericentriolar material 1 0.0268251
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.026757
CTBP2 C-terminal binding protein 2 0.0266437
HDAC9 histone deacetylase 9 0.0265484
HYOU1 hypoxia up-regulated 1 0.0265366
RPL37 ribosomal protein L37 0.0264154
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0263294
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0261158
NUP58 nucleoporin 58 0.0261013
APP amyloid beta (A4) precursor protein 0.0260219
LHFPL6 LHFPL tetraspan subfamily member 6 0.0259545
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0257431
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0254817
LDHA lactate dehydrogenase A 0.0254408
SMC1A structural maintenance of chromosomes 1A 0.0247384
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0247081
WDR43 WD repeat domain 43 0.0240645
TPM3 tropomyosin 3 0.0239066
NHSL1 NHS-like 1 0.0238567
SRRM2 serine/arginine repetitive matrix 2 0.0236818
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0235202
RPS27 ribosomal protein S27 0.0234807
KMT2C lysine (K)-specific methyltransferase 2C 0.0233311
RPL18 ribosomal protein L18 0.0232984
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0232666
GSPT1 G1 to S phase transition 1 0.0231221
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0230948
OSBPL10 oxysterol binding protein-like 10 0.023026
EIF4B eukaryotic translation initiation factor 4B 0.0228918
SMC3 structural maintenance of chromosomes 3 0.0226844
UBE2K ubiquitin-conjugating enzyme E2K 0.022374
ANKRD33B ankyrin repeat domain 33B 0.0222237
NOP58 NOP58 ribonucleoprotein 0.0221093
RPL30 ribosomal protein L30 0.0219884
LOC112694756 uncharaterized LOC112694756 0.021979
RBM25 RNA binding motif protein 25 0.0219739
SSRP1 structure specific recognition protein 1 0.021657
PDCD5 programmed cell death 5 0.0215715
FAM168B family with sequence similarity 168, member B 0.0213723

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.180555
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.180027
PCDH9 protocadherin 9 -0.144075
COL11A1 collagen, type XI, alpha 1 -0.135125
CDH10 cadherin 10, type 2 (T2-cadherin) -0.116492
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.111165
PCLO piccolo presynaptic cytomatrix protein -0.103009
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0980704
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0965195
ADGRV1 adhesion G protein-coupled receptor V1 -0.0857444
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0833331
VIM vimentin -0.0741396
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0729279
COL3A1 collagen, type III, alpha 1 -0.0615404
ADGRL2 adhesion G protein-coupled receptor L2 -0.0548348
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0546401
TPT1 tumor protein, translationally-controlled 1 -0.0531074
RAD51B RAD51 paralog B -0.0517133
PARD3B par-3 family cell polarity regulator beta -0.050538
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0502192
HMCN1 hemicentin 1 -0.0489495
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0481408
ZEB2 zinc finger E-box binding homeobox 2 -0.047968
CSMD3 CUB and Sushi multiple domains 3 -0.045877
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0456127
PLPP1 phospholipid phosphatase 1 -0.0451093
ACTG1 actin gamma 1 -0.0447065
MPG N-methylpurine-DNA glycosylase -0.0436629
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0432035
TTC28 tetratricopeptide repeat domain 28 -0.0430033
GPC3 glypican 3 -0.0429278
PDGFC platelet derived growth factor C -0.0428091
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0427308
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0422634
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0414496
MEF2C myocyte enhancer factor 2C -0.0413952
MYL12B myosin, light chain 12B, regulatory -0.0405506
MED12L mediator complex subunit 12-like -0.0389459
EMP1 epithelial membrane protein 1 -0.0385789
NRG1 neuregulin 1 -0.0381664
TENM3 teneurin transmembrane protein 3 -0.0377948
COL1A2 collagen, type I, alpha 2 -0.0372284
METAP2 methionyl aminopeptidase 2 -0.0371778
SPAG9 sperm associated antigen 9 -0.0371338
DSCAM Down syndrome cell adhesion molecule -0.0368936
PRELID2 PRELI domain containing 2 -0.0368536
ITGAV integrin, alpha V -0.0359796
SLIT2 slit homolog 2 (Drosophila) -0.033998
MAML2 mastermind-like 2 (Drosophila) -0.0334528
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0328969
USP53 ubiquitin specific peptidase 53 -0.0327786
H1-0 H1.0 linker histone -0.0311311
KLHL5 kelch-like family member 5 -0.0309145
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0308222
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0307755
NCOR1 nuclear receptor corepressor 1 -0.0302017
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.02972
DPYD dihydropyrimidine dehydrogenase -0.0293575
NEBL nebulette -0.0288894
FNDC3A fibronectin type III domain containing 3A -0.0288785
ADGRL3 adhesion G protein-coupled receptor L3 -0.0287647
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0287194
TRPS1 trichorhinophalangeal syndrome I -0.0285579
DENND4A DENN/MADD domain containing 4A -0.0281764
ANKRD12 ankyrin repeat domain 12 -0.0281346
BMPR1A bone morphogenetic protein receptor, type IA -0.0273426
EPHA5 EPH receptor A5 -0.0269893
KCTD16 potassium channel tetramerization domain containing 16 -0.0267144
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.026445
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0263774
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0262693
SLC38A2 solute carrier family 38, member 2 -0.0258208
DOCK5 dedicator of cytokinesis 5 -0.0257436
GNAS GNAS complex locus -0.025666
RSL1D1 ribosomal L1 domain containing 1 -0.0256496
PRR16 proline rich 16 -0.0255432
NKTR natural killer cell triggering receptor -0.0252075
PHF20 PHD finger protein 20 -0.025174
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0251264
PRKD1 protein kinase D1 -0.0247192
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0246911
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0246539
IFIH1 interferon induced with helicase C domain 1 -0.0244986
FNDC3B fibronectin type III domain containing 3B -0.0244857
CFDP1 craniofacial development protein 1 -0.0243825
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0243345
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0239161
RAB30 RAB30, member RAS oncogene family -0.0238731
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0237475
RASAL2 RAS protein activator like 2 -0.0236386
RAB10 RAB10, member RAS oncogene family -0.0236323
ARHGAP24 Rho GTPase activating protein 24 -0.0235238
RIMS2 regulating synaptic membrane exocytosis 2 -0.0234312
FBXO11 F-box protein 11 -0.0232386
FBXL2 F-box and leucine-rich repeat protein 2 -0.0230574
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E -0.0229497
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0226773
NF1 neurofibromin 1 -0.0225213
CAVIN1 caveolae associated protein 1 -0.0225044
TOX thymocyte selection-associated high mobility group box -0.0223732